Amino acid dipepetide frequency for Spiroplasma litorale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.502AlaAla: 2.502 ± 0.126
0.45AlaCys: 0.45 ± 0.038
1.797AlaAsp: 1.797 ± 0.089
1.999AlaGlu: 1.999 ± 0.093
2.297AlaPhe: 2.297 ± 0.089
2.538AlaGly: 2.538 ± 0.115
0.528AlaHis: 0.528 ± 0.041
4.804AlaIle: 4.804 ± 0.139
4.404AlaLys: 4.404 ± 0.142
4.204AlaLeu: 4.204 ± 0.119
0.977AlaMet: 0.977 ± 0.052
2.835AlaAsn: 2.835 ± 0.09
1.133AlaPro: 1.133 ± 0.068
1.014AlaGln: 1.014 ± 0.056
1.272AlaArg: 1.272 ± 0.069
2.877AlaSer: 2.877 ± 0.104
2.627AlaThr: 2.627 ± 0.121
2.402AlaVal: 2.402 ± 0.114
0.344AlaTrp: 0.344 ± 0.03
1.672AlaTyr: 1.672 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.33CysAla: 0.33 ± 0.027
0.125CysCys: 0.125 ± 0.022
0.442CysAsp: 0.442 ± 0.036
0.517CysGlu: 0.517 ± 0.035
0.5CysPhe: 0.5 ± 0.035
0.605CysGly: 0.605 ± 0.04
0.114CysHis: 0.114 ± 0.016
0.725CysIle: 0.725 ± 0.051
0.791CysLys: 0.791 ± 0.06
0.664CysLeu: 0.664 ± 0.05
0.142CysMet: 0.142 ± 0.021
0.453CysAsn: 0.453 ± 0.035
0.183CysPro: 0.183 ± 0.026
0.175CysGln: 0.175 ± 0.024
0.133CysArg: 0.133 ± 0.019
0.591CysSer: 0.591 ± 0.039
0.292CysThr: 0.292 ± 0.031
0.392CysVal: 0.392 ± 0.031
0.064CysTrp: 0.064 ± 0.013
0.369CysTyr: 0.369 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.005AspAla: 2.005 ± 0.077
0.447AspCys: 0.447 ± 0.037
2.927AspAsp: 2.927 ± 0.099
4.093AspGlu: 4.093 ± 0.127
3.785AspPhe: 3.785 ± 0.116
2.652AspGly: 2.652 ± 0.099
0.511AspHis: 0.511 ± 0.035
5.59AspIle: 5.59 ± 0.133
5.89AspLys: 5.89 ± 0.148
5.876AspLeu: 5.876 ± 0.146
0.986AspMet: 0.986 ± 0.047
4.326AspAsn: 4.326 ± 0.135
1.372AspPro: 1.372 ± 0.063
1.488AspGln: 1.488 ± 0.061
1.286AspArg: 1.286 ± 0.063
3.482AspSer: 3.482 ± 0.1
2.063AspThr: 2.063 ± 0.089
3.138AspVal: 3.138 ± 0.105
0.641AspTrp: 0.641 ± 0.044
3.096AspTyr: 3.096 ± 0.091
0.0AspXaa: 0.0 ± 0.0
Glu
2.713GluAla: 2.713 ± 0.116
0.417GluCys: 0.417 ± 0.038
3.346GluAsp: 3.346 ± 0.126
5.007GluGlu: 5.007 ± 0.176
3.288GluPhe: 3.288 ± 0.104
2.685GluGly: 2.685 ± 0.096
0.664GluHis: 0.664 ± 0.048
7.167GluIle: 7.167 ± 0.193
7.606GluLys: 7.606 ± 0.162
6.415GluLeu: 6.415 ± 0.14
1.4GluMet: 1.4 ± 0.066
6.331GluAsn: 6.331 ± 0.136
1.355GluPro: 1.355 ± 0.061
1.68GluGln: 1.68 ± 0.071
1.611GluArg: 1.611 ± 0.091
3.799GluSer: 3.799 ± 0.093
2.794GluThr: 2.794 ± 0.084
4.043GluVal: 4.043 ± 0.107
0.616GluTrp: 0.616 ± 0.042
2.996GluTyr: 2.996 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
2.46PheAla: 2.46 ± 0.079
0.467PheCys: 0.467 ± 0.041
3.566PheAsp: 3.566 ± 0.089
3.532PheGlu: 3.532 ± 0.109
3.049PhePhe: 3.049 ± 0.131
2.78PheGly: 2.78 ± 0.104
0.411PheHis: 0.411 ± 0.034
5.995PheIle: 5.995 ± 0.201
6.026PheLys: 6.026 ± 0.154
5.351PheLeu: 5.351 ± 0.169
1.094PheMet: 1.094 ± 0.061
4.637PheAsn: 4.637 ± 0.142
0.969PhePro: 0.969 ± 0.05
1.175PheGln: 1.175 ± 0.057
1.214PheArg: 1.214 ± 0.059
4.368PheSer: 4.368 ± 0.137
2.627PheThr: 2.627 ± 0.093
3.191PheVal: 3.191 ± 0.1
0.475PheTrp: 0.475 ± 0.033
2.574PheTyr: 2.574 ± 0.101
0.0PheXaa: 0.0 ± 0.0
Gly
2.688GlyAla: 2.688 ± 0.126
0.411GlyCys: 0.411 ± 0.034
2.455GlyAsp: 2.455 ± 0.09
2.88GlyGlu: 2.88 ± 0.099
2.788GlyPhe: 2.788 ± 0.093
2.999GlyGly: 2.999 ± 0.142
0.728GlyHis: 0.728 ± 0.053
4.862GlyIle: 4.862 ± 0.145
4.215GlyLys: 4.215 ± 0.12
4.471GlyLeu: 4.471 ± 0.127
1.097GlyMet: 1.097 ± 0.059
2.76GlyAsn: 2.76 ± 0.101
1.041GlyPro: 1.041 ± 0.061
1.252GlyGln: 1.252 ± 0.063
1.391GlyArg: 1.391 ± 0.08
3.299GlySer: 3.299 ± 0.098
2.624GlyThr: 2.624 ± 0.109
3.385GlyVal: 3.385 ± 0.124
0.611GlyTrp: 0.611 ± 0.044
2.347GlyTyr: 2.347 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
0.497HisAla: 0.497 ± 0.039
0.1HisCys: 0.1 ± 0.015
0.539HisAsp: 0.539 ± 0.04
0.666HisGlu: 0.666 ± 0.043
0.591HisPhe: 0.591 ± 0.041
0.591HisGly: 0.591 ± 0.048
0.217HisHis: 0.217 ± 0.027
1.047HisIle: 1.047 ± 0.057
1.108HisLys: 1.108 ± 0.055
1.055HisLeu: 1.055 ± 0.049
0.217HisMet: 0.217 ± 0.025
0.858HisAsn: 0.858 ± 0.053
0.397HisPro: 0.397 ± 0.034
0.344HisGln: 0.344 ± 0.039
0.358HisArg: 0.358 ± 0.032
0.75HisSer: 0.75 ± 0.053
0.45HisThr: 0.45 ± 0.038
0.542HisVal: 0.542 ± 0.039
0.108HisTrp: 0.108 ± 0.015
0.492HisTyr: 0.492 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
4.807IleAla: 4.807 ± 0.138
0.955IleCys: 0.955 ± 0.061
6.817IleAsp: 6.817 ± 0.169
6.704IleGlu: 6.704 ± 0.158
5.879IlePhe: 5.879 ± 0.197
5.026IleGly: 5.026 ± 0.156
0.997IleHis: 0.997 ± 0.055
10.725IleIle: 10.725 ± 0.237
11.538IleLys: 11.538 ± 0.199
9.069IleLeu: 9.069 ± 0.231
1.969IleMet: 1.969 ± 0.077
9.761IleAsn: 9.761 ± 0.191
2.269IlePro: 2.269 ± 0.088
2.077IleGln: 2.077 ± 0.076
2.371IleArg: 2.371 ± 0.095
7.8IleSer: 7.8 ± 0.148
4.921IleThr: 4.921 ± 0.121
5.668IleVal: 5.668 ± 0.152
0.764IleTrp: 0.764 ± 0.056
4.243IleTyr: 4.243 ± 0.134
0.0IleXaa: 0.0 ± 0.0
Lys
3.791LysAla: 3.791 ± 0.115
0.511LysCys: 0.511 ± 0.044
6.654LysAsp: 6.654 ± 0.163
8.633LysGlu: 8.633 ± 0.169
4.751LysPhe: 4.751 ± 0.123
3.888LysGly: 3.888 ± 0.122
1.2LysHis: 1.2 ± 0.062
10.974LysIle: 10.974 ± 0.188
12.685LysLys: 12.685 ± 0.225
9.397LysLeu: 9.397 ± 0.168
2.366LysMet: 2.366 ± 0.082
11.163LysAsn: 11.163 ± 0.225
2.297LysPro: 2.297 ± 0.086
2.849LysGln: 2.849 ± 0.084
2.794LysArg: 2.794 ± 0.098
6.195LysSer: 6.195 ± 0.135
5.554LysThr: 5.554 ± 0.139
5.74LysVal: 5.74 ± 0.136
0.927LysTrp: 0.927 ± 0.049
5.393LysTyr: 5.393 ± 0.149
0.0LysXaa: 0.0 ± 0.0
Leu
4.265LeuAla: 4.265 ± 0.132
0.686LeuCys: 0.686 ± 0.043
5.007LeuAsp: 5.007 ± 0.123
5.965LeuGlu: 5.965 ± 0.144
5.346LeuPhe: 5.346 ± 0.177
4.393LeuGly: 4.393 ± 0.148
1.002LeuHis: 1.002 ± 0.052
9.811LeuIle: 9.811 ± 0.239
10.463LeuLys: 10.463 ± 0.198
8.489LeuLeu: 8.489 ± 0.174
1.902LeuMet: 1.902 ± 0.071
8.131LeuAsn: 8.131 ± 0.178
2.249LeuPro: 2.249 ± 0.078
2.063LeuGln: 2.063 ± 0.08
2.371LeuArg: 2.371 ± 0.075
7.226LeuSer: 7.226 ± 0.178
4.66LeuThr: 4.66 ± 0.113
5.173LeuVal: 5.173 ± 0.126
0.775LeuTrp: 0.775 ± 0.053
3.546LeuTyr: 3.546 ± 0.107
0.0LeuXaa: 0.0 ± 0.0
Met
1.136MetAla: 1.136 ± 0.061
0.158MetCys: 0.158 ± 0.019
0.93MetAsp: 0.93 ± 0.047
1.097MetGlu: 1.097 ± 0.063
1.066MetPhe: 1.066 ± 0.058
1.189MetGly: 1.189 ± 0.068
0.253MetHis: 0.253 ± 0.027
1.922MetIle: 1.922 ± 0.07
2.185MetLys: 2.185 ± 0.071
1.816MetLeu: 1.816 ± 0.087
0.439MetMet: 0.439 ± 0.038
1.5MetAsn: 1.5 ± 0.072
0.675MetPro: 0.675 ± 0.044
0.614MetGln: 0.614 ± 0.04
0.492MetArg: 0.492 ± 0.038
1.588MetSer: 1.588 ± 0.064
0.939MetThr: 0.939 ± 0.056
1.119MetVal: 1.119 ± 0.052
0.183MetTrp: 0.183 ± 0.024
0.861MetTyr: 0.861 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
2.949AsnAla: 2.949 ± 0.095
0.528AsnCys: 0.528 ± 0.04
4.99AsnAsp: 4.99 ± 0.149
5.837AsnGlu: 5.837 ± 0.139
4.757AsnPhe: 4.757 ± 0.157
3.485AsnGly: 3.485 ± 0.114
0.814AsnHis: 0.814 ± 0.052
9.067AsnIle: 9.067 ± 0.164
10.158AsnLys: 10.158 ± 0.198
7.964AsnLeu: 7.964 ± 0.196
1.45AsnMet: 1.45 ± 0.063
8.478AsnAsn: 8.478 ± 0.223
2.091AsnPro: 2.091 ± 0.088
2.466AsnGln: 2.466 ± 0.095
1.794AsnArg: 1.794 ± 0.074
5.848AsnSer: 5.848 ± 0.158
3.099AsnThr: 3.099 ± 0.097
4.129AsnVal: 4.129 ± 0.12
0.85AsnTrp: 0.85 ± 0.047
4.59AsnTyr: 4.59 ± 0.124
0.0AsnXaa: 0.0 ± 0.0
Pro
0.872ProAla: 0.872 ± 0.06
0.139ProCys: 0.139 ± 0.019
1.144ProAsp: 1.144 ± 0.059
1.622ProGlu: 1.622 ± 0.067
1.388ProPhe: 1.388 ± 0.071
1.338ProGly: 1.338 ± 0.067
0.303ProHis: 0.303 ± 0.032
2.663ProIle: 2.663 ± 0.087
2.022ProLys: 2.022 ± 0.08
2.105ProLeu: 2.105 ± 0.085
0.497ProMet: 0.497 ± 0.038
1.763ProAsn: 1.763 ± 0.077
0.478ProPro: 0.478 ± 0.044
0.65ProGln: 0.65 ± 0.064
0.486ProArg: 0.486 ± 0.042
1.719ProSer: 1.719 ± 0.069
1.441ProThr: 1.441 ± 0.074
1.425ProVal: 1.425 ± 0.07
0.289ProTrp: 0.289 ± 0.029
0.972ProTyr: 0.972 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
1.047GlnAla: 1.047 ± 0.06
0.092GlnCys: 0.092 ± 0.016
1.152GlnAsp: 1.152 ± 0.061
1.738GlnGlu: 1.738 ± 0.072
1.177GlnPhe: 1.177 ± 0.047
0.983GlnGly: 0.983 ± 0.06
0.253GlnHis: 0.253 ± 0.03
2.674GlnIle: 2.674 ± 0.088
2.844GlnLys: 2.844 ± 0.098
2.302GlnLeu: 2.302 ± 0.083
0.564GlnMet: 0.564 ± 0.044
2.183GlnAsn: 2.183 ± 0.087
0.555GlnPro: 0.555 ± 0.049
0.925GlnGln: 0.925 ± 0.117
0.803GlnArg: 0.803 ± 0.059
1.597GlnSer: 1.597 ± 0.069
1.319GlnThr: 1.319 ± 0.064
1.272GlnVal: 1.272 ± 0.057
0.283GlnTrp: 0.283 ± 0.033
1.033GlnTyr: 1.033 ± 0.06
0.0GlnXaa: 0.0 ± 0.0
Arg
1.158ArgAla: 1.158 ± 0.064
0.161ArgCys: 0.161 ± 0.023
1.341ArgAsp: 1.341 ± 0.065
1.736ArgGlu: 1.736 ± 0.079
1.422ArgPhe: 1.422 ± 0.057
1.155ArgGly: 1.155 ± 0.058
0.319ArgHis: 0.319 ± 0.029
2.444ArgIle: 2.444 ± 0.101
2.51ArgLys: 2.51 ± 0.077
2.288ArgLeu: 2.288 ± 0.09
0.636ArgMet: 0.636 ± 0.045
1.986ArgAsn: 1.986 ± 0.08
0.7ArgPro: 0.7 ± 0.053
0.669ArgGln: 0.669 ± 0.043
0.908ArgArg: 0.908 ± 0.056
1.433ArgSer: 1.433 ± 0.061
1.211ArgThr: 1.211 ± 0.067
1.558ArgVal: 1.558 ± 0.073
0.269ArgTrp: 0.269 ± 0.028
1.164ArgTyr: 1.164 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
2.635SerAla: 2.635 ± 0.092
0.658SerCys: 0.658 ± 0.045
3.455SerAsp: 3.455 ± 0.11
4.157SerGlu: 4.157 ± 0.118
4.546SerPhe: 4.546 ± 0.137
3.593SerGly: 3.593 ± 0.114
0.836SerHis: 0.836 ± 0.046
7.737SerIle: 7.737 ± 0.156
6.99SerLys: 6.99 ± 0.141
6.92SerLeu: 6.92 ± 0.167
1.35SerMet: 1.35 ± 0.059
5.484SerAsn: 5.484 ± 0.146
1.413SerPro: 1.413 ± 0.068
1.661SerGln: 1.661 ± 0.073
1.797SerArg: 1.797 ± 0.075
5.148SerSer: 5.148 ± 0.155
3.604SerThr: 3.604 ± 0.128
3.554SerVal: 3.554 ± 0.111
0.733SerTrp: 0.733 ± 0.048
3.205SerTyr: 3.205 ± 0.093
0.0SerXaa: 0.0 ± 0.0
Thr
1.961ThrAla: 1.961 ± 0.101
0.317ThrCys: 0.317 ± 0.032
2.344ThrAsp: 2.344 ± 0.101
2.508ThrGlu: 2.508 ± 0.079
2.794ThrPhe: 2.794 ± 0.103
2.755ThrGly: 2.755 ± 0.106
0.564ThrHis: 0.564 ± 0.037
5.243ThrIle: 5.243 ± 0.129
4.896ThrLys: 4.896 ± 0.127
4.604ThrLeu: 4.604 ± 0.118
0.93ThrMet: 0.93 ± 0.057
3.846ThrAsn: 3.846 ± 0.116
1.511ThrPro: 1.511 ± 0.066
1.186ThrGln: 1.186 ± 0.058
1.194ThrArg: 1.194 ± 0.063
3.799ThrSer: 3.799 ± 0.118
2.907ThrThr: 2.907 ± 0.091
2.51ThrVal: 2.51 ± 0.101
0.358ThrTrp: 0.358 ± 0.036
2.038ThrTyr: 2.038 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
2.849ValAla: 2.849 ± 0.108
0.505ValCys: 0.505 ± 0.044
3.341ValAsp: 3.341 ± 0.099
3.777ValGlu: 3.777 ± 0.117
3.052ValPhe: 3.052 ± 0.107
3.024ValGly: 3.024 ± 0.104
0.628ValHis: 0.628 ± 0.046
5.737ValIle: 5.737 ± 0.142
5.215ValLys: 5.215 ± 0.153
5.073ValLeu: 5.073 ± 0.125
1.1ValMet: 1.1 ± 0.05
4.093ValAsn: 4.093 ± 0.121
1.494ValPro: 1.494 ± 0.067
1.211ValGln: 1.211 ± 0.061
1.425ValArg: 1.425 ± 0.076
4.079ValSer: 4.079 ± 0.129
2.719ValThr: 2.719 ± 0.105
3.677ValVal: 3.677 ± 0.115
0.5ValTrp: 0.5 ± 0.038
2.385ValTyr: 2.385 ± 0.085
0.0ValXaa: 0.0 ± 0.0
Trp
0.361TrpAla: 0.361 ± 0.026
0.053TrpCys: 0.053 ± 0.012
0.508TrpAsp: 0.508 ± 0.046
0.5TrpGlu: 0.5 ± 0.041
0.636TrpPhe: 0.636 ± 0.045
0.433TrpGly: 0.433 ± 0.038
0.092TrpHis: 0.092 ± 0.017
0.966TrpIle: 0.966 ± 0.056
0.952TrpLys: 0.952 ± 0.05
0.95TrpLeu: 0.95 ± 0.058
0.239TrpMet: 0.239 ± 0.027
0.716TrpAsn: 0.716 ± 0.043
0.186TrpPro: 0.186 ± 0.021
0.194TrpGln: 0.194 ± 0.022
0.233TrpArg: 0.233 ± 0.027
0.647TrpSer: 0.647 ± 0.04
0.517TrpThr: 0.517 ± 0.042
0.644TrpVal: 0.644 ± 0.045
0.158TrpTrp: 0.158 ± 0.024
0.425TrpTyr: 0.425 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.652TyrAla: 1.652 ± 0.072
0.428TyrCys: 0.428 ± 0.033
2.902TyrAsp: 2.902 ± 0.108
2.966TyrGlu: 2.966 ± 0.097
2.849TyrPhe: 2.849 ± 0.103
2.191TyrGly: 2.191 ± 0.086
0.497TyrHis: 0.497 ± 0.049
4.207TyrIle: 4.207 ± 0.123
5.262TyrLys: 5.262 ± 0.144
4.51TyrLeu: 4.51 ± 0.118
0.805TyrMet: 0.805 ± 0.051
4.038TyrAsn: 4.038 ± 0.148
0.947TyrPro: 0.947 ± 0.05
1.102TyrGln: 1.102 ± 0.059
1.136TyrArg: 1.136 ± 0.054
3.23TyrSer: 3.23 ± 0.128
1.897TyrThr: 1.897 ± 0.066
2.322TyrVal: 2.322 ± 0.079
0.461TyrTrp: 0.461 ± 0.038
2.177TyrTyr: 2.177 ± 0.092
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1061 proteins (360111 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski