Amino acid dipepetide frequency for Seinonella peptonophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.236AlaAla: 5.236 ± 0.1
0.618AlaCys: 0.618 ± 0.026
3.101AlaAsp: 3.101 ± 0.056
4.298AlaGlu: 4.298 ± 0.074
2.963AlaPhe: 2.963 ± 0.055
4.732AlaGly: 4.732 ± 0.078
1.486AlaHis: 1.486 ± 0.038
5.805AlaIle: 5.805 ± 0.087
4.353AlaLys: 4.353 ± 0.074
6.86AlaLeu: 6.86 ± 0.083
1.807AlaMet: 1.807 ± 0.043
2.47AlaAsn: 2.47 ± 0.047
1.938AlaPro: 1.938 ± 0.045
2.712AlaGln: 2.712 ± 0.047
2.966AlaArg: 2.966 ± 0.058
3.83AlaSer: 3.83 ± 0.055
3.495AlaThr: 3.495 ± 0.068
4.532AlaVal: 4.532 ± 0.08
0.784AlaTrp: 0.784 ± 0.026
2.356AlaTyr: 2.356 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.475CysAla: 0.475 ± 0.021
0.13CysCys: 0.13 ± 0.012
0.403CysAsp: 0.403 ± 0.019
0.473CysGlu: 0.473 ± 0.023
0.463CysPhe: 0.463 ± 0.022
0.699CysGly: 0.699 ± 0.031
0.244CysHis: 0.244 ± 0.017
0.607CysIle: 0.607 ± 0.027
0.417CysLys: 0.417 ± 0.02
0.898CysLeu: 0.898 ± 0.03
0.223CysMet: 0.223 ± 0.016
0.327CysAsn: 0.327 ± 0.016
0.364CysPro: 0.364 ± 0.021
0.399CysGln: 0.399 ± 0.021
0.379CysArg: 0.379 ± 0.021
0.644CysSer: 0.644 ± 0.024
0.41CysThr: 0.41 ± 0.019
0.5CysVal: 0.5 ± 0.023
0.134CysTrp: 0.134 ± 0.012
0.335CysTyr: 0.335 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
2.746AspAla: 2.746 ± 0.051
0.412AspCys: 0.412 ± 0.021
2.296AspAsp: 2.296 ± 0.058
3.745AspGlu: 3.745 ± 0.072
2.201AspPhe: 2.201 ± 0.047
3.042AspGly: 3.042 ± 0.065
1.615AspHis: 1.615 ± 0.039
3.116AspIle: 3.116 ± 0.061
2.253AspLys: 2.253 ± 0.052
5.238AspLeu: 5.238 ± 0.071
1.029AspMet: 1.029 ± 0.032
1.293AspAsn: 1.293 ± 0.038
2.233AspPro: 2.233 ± 0.049
3.785AspGln: 3.785 ± 0.079
2.823AspArg: 2.823 ± 0.053
2.412AspSer: 2.412 ± 0.055
1.959AspThr: 1.959 ± 0.05
3.026AspVal: 3.026 ± 0.051
0.796AspTrp: 0.796 ± 0.026
1.814AspTyr: 1.814 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.601GluAla: 4.601 ± 0.081
0.426GluCys: 0.426 ± 0.023
2.787GluAsp: 2.787 ± 0.051
5.62GluGlu: 5.62 ± 0.101
2.068GluPhe: 2.068 ± 0.048
3.517GluGly: 3.517 ± 0.068
1.659GluHis: 1.659 ± 0.045
5.26GluIle: 5.26 ± 0.082
5.215GluLys: 5.215 ± 0.089
6.996GluLeu: 6.996 ± 0.093
2.078GluMet: 2.078 ± 0.041
2.774GluAsn: 2.774 ± 0.045
2.003GluPro: 2.003 ± 0.042
4.682GluGln: 4.682 ± 0.097
3.979GluArg: 3.979 ± 0.063
3.418GluSer: 3.418 ± 0.056
3.196GluThr: 3.196 ± 0.058
4.515GluVal: 4.515 ± 0.074
0.979GluTrp: 0.979 ± 0.035
2.046GluTyr: 2.046 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.238PheAla: 3.238 ± 0.058
0.454PheCys: 0.454 ± 0.02
2.337PheAsp: 2.337 ± 0.05
2.369PheGlu: 2.369 ± 0.046
2.287PhePhe: 2.287 ± 0.06
2.889PheGly: 2.889 ± 0.059
1.284PheHis: 1.284 ± 0.043
3.458PheIle: 3.458 ± 0.076
1.702PheLys: 1.702 ± 0.044
4.625PheLeu: 4.625 ± 0.086
0.99PheMet: 0.99 ± 0.034
1.387PheAsn: 1.387 ± 0.044
1.852PhePro: 1.852 ± 0.037
2.218PheGln: 2.218 ± 0.046
2.037PheArg: 2.037 ± 0.036
3.157PheSer: 3.157 ± 0.058
2.443PheThr: 2.443 ± 0.051
2.888PheVal: 2.888 ± 0.051
0.522PheTrp: 0.522 ± 0.023
1.649PheTyr: 1.649 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.271GlyAla: 4.271 ± 0.074
0.698GlyCys: 0.698 ± 0.029
2.897GlyAsp: 2.897 ± 0.062
4.072GlyGlu: 4.072 ± 0.078
3.114GlyPhe: 3.114 ± 0.057
4.49GlyGly: 4.49 ± 0.088
1.432GlyHis: 1.432 ± 0.04
5.355GlyIle: 5.355 ± 0.088
4.817GlyLys: 4.817 ± 0.079
6.448GlyLeu: 6.448 ± 0.086
1.916GlyMet: 1.916 ± 0.043
2.507GlyAsn: 2.507 ± 0.056
1.635GlyPro: 1.635 ± 0.038
2.572GlyGln: 2.572 ± 0.058
3.018GlyArg: 3.018 ± 0.058
3.843GlySer: 3.843 ± 0.067
3.594GlyThr: 3.594 ± 0.071
4.662GlyVal: 4.662 ± 0.076
0.92GlyTrp: 0.92 ± 0.03
2.537GlyTyr: 2.537 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.494HisAla: 1.494 ± 0.035
0.242HisCys: 0.242 ± 0.017
1.165HisAsp: 1.165 ± 0.033
1.418HisGlu: 1.418 ± 0.035
1.296HisPhe: 1.296 ± 0.034
1.54HisGly: 1.54 ± 0.038
0.89HisHis: 0.89 ± 0.036
1.663HisIle: 1.663 ± 0.045
1.023HisLys: 1.023 ± 0.033
2.977HisLeu: 2.977 ± 0.059
0.559HisMet: 0.559 ± 0.025
0.76HisAsn: 0.76 ± 0.028
1.549HisPro: 1.549 ± 0.043
1.516HisGln: 1.516 ± 0.043
1.386HisArg: 1.386 ± 0.041
1.469HisSer: 1.469 ± 0.034
1.137HisThr: 1.137 ± 0.033
1.557HisVal: 1.557 ± 0.04
0.383HisTrp: 0.383 ± 0.02
0.929HisTyr: 0.929 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.833IleAla: 5.833 ± 0.07
0.862IleCys: 0.862 ± 0.028
4.55IleAsp: 4.55 ± 0.068
5.606IleGlu: 5.606 ± 0.073
3.224IlePhe: 3.224 ± 0.064
5.67IleGly: 5.67 ± 0.086
2.103IleHis: 2.103 ± 0.047
5.112IleIle: 5.112 ± 0.094
3.884IleLys: 3.884 ± 0.06
7.404IleLeu: 7.404 ± 0.106
1.57IleMet: 1.57 ± 0.041
2.719IleAsn: 2.719 ± 0.064
3.504IlePro: 3.504 ± 0.056
3.841IleGln: 3.841 ± 0.066
3.934IleArg: 3.934 ± 0.066
5.034IleSer: 5.034 ± 0.078
4.08IleThr: 4.08 ± 0.064
4.946IleVal: 4.946 ± 0.071
0.914IleTrp: 0.914 ± 0.033
2.585IleTyr: 2.585 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
3.758LysAla: 3.758 ± 0.059
0.364LysCys: 0.364 ± 0.019
2.856LysAsp: 2.856 ± 0.06
5.503LysGlu: 5.503 ± 0.073
1.578LysPhe: 1.578 ± 0.043
3.809LysGly: 3.809 ± 0.067
1.323LysHis: 1.323 ± 0.039
4.319LysIle: 4.319 ± 0.062
5.406LysLys: 5.406 ± 0.098
5.502LysLeu: 5.502 ± 0.069
1.922LysMet: 1.922 ± 0.037
2.746LysAsn: 2.746 ± 0.059
2.347LysPro: 2.347 ± 0.049
3.953LysGln: 3.953 ± 0.071
3.78LysArg: 3.78 ± 0.068
3.205LysSer: 3.205 ± 0.057
3.051LysThr: 3.051 ± 0.06
3.93LysVal: 3.93 ± 0.072
0.922LysTrp: 0.922 ± 0.03
1.905LysTyr: 1.905 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
7.498LeuAla: 7.498 ± 0.093
0.929LeuCys: 0.929 ± 0.035
5.116LeuAsp: 5.116 ± 0.069
6.565LeuGlu: 6.565 ± 0.077
5.312LeuPhe: 5.312 ± 0.097
6.477LeuGly: 6.477 ± 0.091
2.54LeuHis: 2.54 ± 0.048
7.853LeuIle: 7.853 ± 0.093
5.901LeuLys: 5.901 ± 0.09
11.52LeuLeu: 11.52 ± 0.158
2.516LeuMet: 2.516 ± 0.056
3.815LeuAsn: 3.815 ± 0.07
4.693LeuPro: 4.693 ± 0.086
4.941LeuGln: 4.941 ± 0.076
4.821LeuArg: 4.821 ± 0.068
7.297LeuSer: 7.297 ± 0.085
5.929LeuThr: 5.929 ± 0.071
6.36LeuVal: 6.36 ± 0.084
1.128LeuTrp: 1.128 ± 0.034
3.318LeuTyr: 3.318 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.643MetAla: 1.643 ± 0.037
0.125MetCys: 0.125 ± 0.012
1.23MetAsp: 1.23 ± 0.035
1.766MetGlu: 1.766 ± 0.036
0.945MetPhe: 0.945 ± 0.031
1.751MetGly: 1.751 ± 0.039
0.443MetHis: 0.443 ± 0.021
2.472MetIle: 2.472 ± 0.052
2.238MetLys: 2.238 ± 0.048
2.464MetLeu: 2.464 ± 0.049
0.85MetMet: 0.85 ± 0.029
1.39MetAsn: 1.39 ± 0.038
0.915MetPro: 0.915 ± 0.033
1.035MetGln: 1.035 ± 0.03
1.202MetArg: 1.202 ± 0.037
1.62MetSer: 1.62 ± 0.042
1.356MetThr: 1.356 ± 0.035
1.816MetVal: 1.816 ± 0.036
0.191MetTrp: 0.191 ± 0.015
0.632MetTyr: 0.632 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.168AsnAla: 2.168 ± 0.054
0.312AsnCys: 0.312 ± 0.018
1.782AsnAsp: 1.782 ± 0.045
2.61AsnGlu: 2.61 ± 0.052
1.27AsnPhe: 1.27 ± 0.036
2.638AsnGly: 2.638 ± 0.061
1.232AsnHis: 1.232 ± 0.038
2.606AsnIle: 2.606 ± 0.05
2.202AsnLys: 2.202 ± 0.049
3.767AsnLeu: 3.767 ± 0.055
0.9AsnMet: 0.9 ± 0.027
1.41AsnAsn: 1.41 ± 0.051
2.15AsnPro: 2.15 ± 0.059
2.883AsnGln: 2.883 ± 0.056
2.512AsnArg: 2.512 ± 0.05
1.965AsnSer: 1.965 ± 0.05
1.669AsnThr: 1.669 ± 0.045
2.114AsnVal: 2.114 ± 0.046
0.651AsnTrp: 0.651 ± 0.027
1.196AsnTyr: 1.196 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.387ProAla: 2.387 ± 0.048
0.242ProCys: 0.242 ± 0.013
2.174ProAsp: 2.174 ± 0.05
2.871ProGlu: 2.871 ± 0.047
2.012ProPhe: 2.012 ± 0.044
2.404ProGly: 2.404 ± 0.06
1.03ProHis: 1.03 ± 0.032
3.374ProIle: 3.374 ± 0.059
2.445ProLys: 2.445 ± 0.054
4.055ProLeu: 4.055 ± 0.061
0.838ProMet: 0.838 ± 0.028
1.771ProAsn: 1.771 ± 0.043
1.294ProPro: 1.294 ± 0.037
1.66ProGln: 1.66 ± 0.04
1.51ProArg: 1.51 ± 0.038
2.633ProSer: 2.633 ± 0.054
2.438ProThr: 2.438 ± 0.06
2.556ProVal: 2.556 ± 0.049
0.455ProTrp: 0.455 ± 0.022
1.468ProTyr: 1.468 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.655GlnAla: 3.655 ± 0.066
0.308GlnCys: 0.308 ± 0.018
1.878GlnAsp: 1.878 ± 0.048
3.486GlnGlu: 3.486 ± 0.062
2.021GlnPhe: 2.021 ± 0.044
2.812GlnGly: 2.812 ± 0.066
1.22GlnHis: 1.22 ± 0.035
4.175GlnIle: 4.175 ± 0.072
3.551GlnLys: 3.551 ± 0.068
6.309GlnLeu: 6.309 ± 0.111
1.49GlnMet: 1.49 ± 0.035
1.891GlnAsn: 1.891 ± 0.047
2.009GlnPro: 2.009 ± 0.057
3.562GlnGln: 3.562 ± 0.112
2.448GlnArg: 2.448 ± 0.05
3.108GlnSer: 3.108 ± 0.063
2.818GlnThr: 2.818 ± 0.062
3.561GlnVal: 3.561 ± 0.065
0.682GlnTrp: 0.682 ± 0.026
1.53GlnTyr: 1.53 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.807ArgAla: 2.807 ± 0.048
0.421ArgCys: 0.421 ± 0.021
2.251ArgAsp: 2.251 ± 0.048
3.545ArgGlu: 3.545 ± 0.071
2.486ArgPhe: 2.486 ± 0.052
2.695ArgGly: 2.695 ± 0.055
1.063ArgHis: 1.063 ± 0.032
3.853ArgIle: 3.853 ± 0.068
3.548ArgLys: 3.548 ± 0.066
5.628ArgLeu: 5.628 ± 0.092
1.52ArgMet: 1.52 ± 0.041
2.065ArgAsn: 2.065 ± 0.044
1.694ArgPro: 1.694 ± 0.041
2.436ArgGln: 2.436 ± 0.054
2.68ArgArg: 2.68 ± 0.064
2.918ArgSer: 2.918 ± 0.053
2.388ArgThr: 2.388 ± 0.048
3.3ArgVal: 3.3 ± 0.062
0.704ArgTrp: 0.704 ± 0.027
2.003ArgTyr: 2.003 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
3.473SerAla: 3.473 ± 0.059
0.492SerCys: 0.492 ± 0.025
2.726SerAsp: 2.726 ± 0.059
3.426SerGlu: 3.426 ± 0.068
3.24SerPhe: 3.24 ± 0.054
4.086SerGly: 4.086 ± 0.066
1.422SerHis: 1.422 ± 0.036
5.232SerIle: 5.232 ± 0.06
3.729SerLys: 3.729 ± 0.074
6.866SerLeu: 6.866 ± 0.092
1.736SerMet: 1.736 ± 0.042
2.388SerAsn: 2.388 ± 0.052
2.39SerPro: 2.39 ± 0.053
2.533SerGln: 2.533 ± 0.047
2.729SerArg: 2.729 ± 0.056
4.066SerSer: 4.066 ± 0.065
3.404SerThr: 3.404 ± 0.074
3.775SerVal: 3.775 ± 0.062
0.822SerTrp: 0.822 ± 0.03
2.126SerTyr: 2.126 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
3.635ThrAla: 3.635 ± 0.069
0.452ThrCys: 0.452 ± 0.02
2.483ThrAsp: 2.483 ± 0.049
3.202ThrGlu: 3.202 ± 0.058
2.402ThrPhe: 2.402 ± 0.045
3.91ThrGly: 3.91 ± 0.06
1.236ThrHis: 1.236 ± 0.033
4.424ThrIle: 4.424 ± 0.069
3.17ThrLys: 3.17 ± 0.056
5.198ThrLeu: 5.198 ± 0.067
1.201ThrMet: 1.201 ± 0.032
2.045ThrAsn: 2.045 ± 0.046
2.472ThrPro: 2.472 ± 0.05
2.116ThrGln: 2.116 ± 0.06
2.044ThrArg: 2.044 ± 0.043
3.281ThrSer: 3.281 ± 0.056
3.05ThrThr: 3.05 ± 0.059
3.575ThrVal: 3.575 ± 0.065
0.66ThrTrp: 0.66 ± 0.03
1.883ThrTyr: 1.883 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.715ValAla: 4.715 ± 0.073
0.605ValCys: 0.605 ± 0.025
3.555ValAsp: 3.555 ± 0.058
4.469ValGlu: 4.469 ± 0.084
2.592ValPhe: 2.592 ± 0.055
4.509ValGly: 4.509 ± 0.073
1.432ValHis: 1.432 ± 0.04
5.256ValIle: 5.256 ± 0.089
3.917ValLys: 3.917 ± 0.061
6.164ValLeu: 6.164 ± 0.079
1.733ValMet: 1.733 ± 0.038
2.519ValAsn: 2.519 ± 0.047
2.698ValPro: 2.698 ± 0.052
2.775ValGln: 2.775 ± 0.055
3.038ValArg: 3.038 ± 0.06
4.092ValSer: 4.092 ± 0.071
3.759ValThr: 3.759 ± 0.075
4.838ValVal: 4.838 ± 0.078
0.751ValTrp: 0.751 ± 0.03
1.977ValTyr: 1.977 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.677TrpAla: 0.677 ± 0.027
0.102TrpCys: 0.102 ± 0.01
0.55TrpAsp: 0.55 ± 0.025
0.816TrpGlu: 0.816 ± 0.03
0.668TrpPhe: 0.668 ± 0.029
0.82TrpGly: 0.82 ± 0.03
0.251TrpHis: 0.251 ± 0.016
1.205TrpIle: 1.205 ± 0.038
0.922TrpLys: 0.922 ± 0.033
1.608TrpLeu: 1.608 ± 0.047
0.434TrpMet: 0.434 ± 0.022
0.647TrpAsn: 0.647 ± 0.025
0.271TrpPro: 0.271 ± 0.017
0.57TrpGln: 0.57 ± 0.024
0.633TrpArg: 0.633 ± 0.027
0.831TrpSer: 0.831 ± 0.034
0.601TrpThr: 0.601 ± 0.022
0.888TrpVal: 0.888 ± 0.031
0.203TrpTrp: 0.203 ± 0.013
0.383TrpTyr: 0.383 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.035TyrAla: 2.035 ± 0.045
0.33TyrCys: 0.33 ± 0.016
1.698TyrAsp: 1.698 ± 0.043
1.958TyrGlu: 1.958 ± 0.05
1.643TyrPhe: 1.643 ± 0.042
2.309TyrGly: 2.309 ± 0.049
1.048TyrHis: 1.048 ± 0.032
2.231TyrIle: 2.231 ± 0.052
1.481TyrLys: 1.481 ± 0.041
4.003TyrLeu: 4.003 ± 0.065
0.772TyrMet: 0.772 ± 0.028
1.112TyrAsn: 1.112 ± 0.035
1.609TyrPro: 1.609 ± 0.043
2.326TyrGln: 2.326 ± 0.051
2.084TyrArg: 2.084 ± 0.045
1.84TyrSer: 1.84 ± 0.039
1.662TyrThr: 1.662 ± 0.041
2.055TyrVal: 2.055 ± 0.046
0.477TyrTrp: 0.477 ± 0.024
1.359TyrTyr: 1.359 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3703 proteins (1053506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski