Amino acid dipepetide frequency for Pseudoruegeria haliotis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.813AlaAla: 15.813 ± 0.167	1.112AlaCys: 1.112 ± 0.032	6.725AlaAsp: 6.725 ± 0.069	8.414AlaGlu: 8.414 ± 0.098	4.367AlaPhe: 4.367 ± 0.058	10.448AlaGly: 10.448 ± 0.094	2.161AlaHis: 2.161 ± 0.041	6.003AlaIle: 6.003 ± 0.072	3.292AlaLys: 3.292 ± 0.06	12.837AlaLeu: 12.837 ± 0.127	3.777AlaMet: 3.777 ± 0.062	2.834AlaAsn: 2.834 ± 0.048	5.69AlaPro: 5.69 ± 0.099	3.769AlaGln: 3.769 ± 0.055	8.485AlaArg: 8.485 ± 0.09	5.911AlaSer: 5.911 ± 0.065	6.239AlaThr: 6.239 ± 0.081	8.237AlaVal: 8.237 ± 0.086	1.446AlaTrp: 1.446 ± 0.03	2.404AlaTyr: 2.404 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.044CysAla: 1.044 ± 0.027	0.12CysCys: 0.12 ± 0.01	0.606CysAsp: 0.606 ± 0.021	0.478CysGlu: 0.478 ± 0.018	0.367CysPhe: 0.367 ± 0.014	0.996CysGly: 0.996 ± 0.029	0.291CysHis: 0.291 ± 0.016	0.433CysIle: 0.433 ± 0.017	0.208CysLys: 0.208 ± 0.012	0.848CysLeu: 0.848 ± 0.024	0.196CysMet: 0.196 ± 0.012	0.236CysAsn: 0.236 ± 0.014	0.522CysPro: 0.522 ± 0.021	0.254CysGln: 0.254 ± 0.013	0.608CysArg: 0.608 ± 0.023	0.477CysSer: 0.477 ± 0.018	0.465CysThr: 0.465 ± 0.019	0.649CysVal: 0.649 ± 0.022	0.123CysTrp: 0.123 ± 0.008	0.219CysTyr: 0.219 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.2AspAla: 7.2 ± 0.069	0.516AspCys: 0.516 ± 0.02	3.457AspAsp: 3.457 ± 0.07	3.452AspGlu: 3.452 ± 0.061	2.409AspPhe: 2.409 ± 0.046	6.079AspGly: 6.079 ± 0.094	1.376AspHis: 1.376 ± 0.031	3.143AspIle: 3.143 ± 0.056	1.635AspLys: 1.635 ± 0.039	6.475AspLeu: 6.475 ± 0.068	1.648AspMet: 1.648 ± 0.031	1.31AspAsn: 1.31 ± 0.033	3.782AspPro: 3.782 ± 0.05	1.607AspGln: 1.607 ± 0.035	4.585AspArg: 4.585 ± 0.072	2.44AspSer: 2.44 ± 0.045	3.254AspThr: 3.254 ± 0.066	4.483AspVal: 4.483 ± 0.064	1.205AspTrp: 1.205 ± 0.035	1.379AspTyr: 1.379 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	8.317GluAla: 8.317 ± 0.092	0.413GluCys: 0.413 ± 0.016	3.628GluAsp: 3.628 ± 0.059	3.803GluGlu: 3.803 ± 0.063	1.89GluPhe: 1.89 ± 0.038	4.867GluGly: 4.867 ± 0.072	1.238GluHis: 1.238 ± 0.034	3.918GluIle: 3.918 ± 0.054	1.988GluLys: 1.988 ± 0.036	5.296GluLeu: 5.296 ± 0.071	1.842GluMet: 1.842 ± 0.037	1.705GluAsn: 1.705 ± 0.035	2.718GluPro: 2.718 ± 0.052	2.078GluGln: 2.078 ± 0.038	4.569GluArg: 4.569 ± 0.057	2.446GluSer: 2.446 ± 0.048	4.041GluThr: 4.041 ± 0.055	4.651GluVal: 4.651 ± 0.062	0.747GluTrp: 0.747 ± 0.028	1.101GluTyr: 1.101 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.325PheAla: 4.325 ± 0.056	0.436PheCys: 0.436 ± 0.016	2.878PheAsp: 2.878 ± 0.05	2.263PheGlu: 2.263 ± 0.037	1.514PhePhe: 1.514 ± 0.04	3.829PheGly: 3.829 ± 0.05	0.784PheHis: 0.784 ± 0.025	1.613PheIle: 1.613 ± 0.033	0.904PheLys: 0.904 ± 0.027	3.717PheLeu: 3.717 ± 0.062	0.844PheMet: 0.844 ± 0.024	1.029PheAsn: 1.029 ± 0.03	1.648PhePro: 1.648 ± 0.032	1.021PheGln: 1.021 ± 0.024	2.382PheArg: 2.382 ± 0.042	2.164PheSer: 2.164 ± 0.043	2.054PheThr: 2.054 ± 0.038	2.839PheVal: 2.839 ± 0.057	0.614PheTrp: 0.614 ± 0.022	0.915PheTyr: 0.915 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.752GlyAla: 9.752 ± 0.093	0.902GlyCys: 0.902 ± 0.028	4.898GlyAsp: 4.898 ± 0.082	5.072GlyGlu: 5.072 ± 0.062	3.75GlyPhe: 3.75 ± 0.053	7.7GlyGly: 7.7 ± 0.144	1.964GlyHis: 1.964 ± 0.043	4.629GlyIle: 4.629 ± 0.058	3.134GlyLys: 3.134 ± 0.051	9.051GlyLeu: 9.051 ± 0.09	2.619GlyMet: 2.619 ± 0.049	2.432GlyAsn: 2.432 ± 0.058	3.76GlyPro: 3.76 ± 0.055	2.992GlyGln: 2.992 ± 0.05	5.922GlyArg: 5.922 ± 0.067	4.599GlySer: 4.599 ± 0.068	5.022GlyThr: 5.022 ± 0.081	6.428GlyVal: 6.428 ± 0.073	1.556GlyTrp: 1.556 ± 0.036	2.28GlyTyr: 2.28 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.264HisAla: 2.264 ± 0.046	0.26HisCys: 0.26 ± 0.013	1.273HisAsp: 1.273 ± 0.03	1.103HisGlu: 1.103 ± 0.027	0.876HisPhe: 0.876 ± 0.028	1.943HisGly: 1.943 ± 0.038	0.55HisHis: 0.55 ± 0.027	0.928HisIle: 0.928 ± 0.023	0.503HisLys: 0.503 ± 0.022	2.08HisLeu: 2.08 ± 0.043	0.578HisMet: 0.578 ± 0.02	0.447HisAsn: 0.447 ± 0.017	1.39HisPro: 1.39 ± 0.03	0.552HisGln: 0.552 ± 0.018	1.454HisArg: 1.454 ± 0.035	0.98HisSer: 0.98 ± 0.027	0.889HisThr: 0.889 ± 0.024	1.601HisVal: 1.601 ± 0.033	0.36HisTrp: 0.36 ± 0.017	0.505HisTyr: 0.505 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.815IleAla: 6.815 ± 0.069	0.611IleCys: 0.611 ± 0.025	3.535IleAsp: 3.535 ± 0.062	3.388IleGlu: 3.388 ± 0.049	1.81IlePhe: 1.81 ± 0.039	4.872IleGly: 4.872 ± 0.059	0.954IleHis: 0.954 ± 0.025	2.002IleIle: 2.002 ± 0.045	1.218IleLys: 1.218 ± 0.028	4.854IleLeu: 4.854 ± 0.068	1.023IleMet: 1.023 ± 0.033	1.318IleAsn: 1.318 ± 0.03	2.4IlePro: 2.4 ± 0.039	1.139IleGln: 1.139 ± 0.025	3.313IleArg: 3.313 ± 0.045	3.024IleSer: 3.024 ± 0.044	2.66IleThr: 2.66 ± 0.055	4.051IleVal: 4.051 ± 0.061	0.742IleTrp: 0.742 ± 0.023	1.112IleTyr: 1.112 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.743LysAla: 3.743 ± 0.067	0.207LysCys: 0.207 ± 0.012	1.744LysAsp: 1.744 ± 0.036	1.579LysGlu: 1.579 ± 0.039	0.883LysPhe: 0.883 ± 0.025	2.623LysGly: 2.623 ± 0.053	0.563LysHis: 0.563 ± 0.021	1.565LysIle: 1.565 ± 0.035	1.121LysLys: 1.121 ± 0.031	2.793LysLeu: 2.793 ± 0.046	0.815LysMet: 0.815 ± 0.024	0.706LysAsn: 0.706 ± 0.023	1.7LysPro: 1.7 ± 0.039	0.835LysGln: 0.835 ± 0.023	2.102LysArg: 2.102 ± 0.039	1.679LysSer: 1.679 ± 0.038	1.675LysThr: 1.675 ± 0.035	2.386LysVal: 2.386 ± 0.044	0.365LysTrp: 0.365 ± 0.015	0.599LysTyr: 0.599 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.54LeuAla: 12.54 ± 0.125	0.957LeuCys: 0.957 ± 0.029	6.244LeuAsp: 6.244 ± 0.07	5.838LeuGlu: 5.838 ± 0.07	3.563LeuPhe: 3.563 ± 0.058	8.489LeuGly: 8.489 ± 0.089	1.882LeuHis: 1.882 ± 0.04	4.649LeuIle: 4.649 ± 0.062	3.205LeuLys: 3.205 ± 0.051	9.196LeuLeu: 9.196 ± 0.115	2.396LeuMet: 2.396 ± 0.045	2.565LeuAsn: 2.565 ± 0.039	5.568LeuPro: 5.568 ± 0.067	2.748LeuGln: 2.748 ± 0.043	6.865LeuArg: 6.865 ± 0.071	6.597LeuSer: 6.597 ± 0.08	5.566LeuThr: 5.566 ± 0.063	7.324LeuVal: 7.324 ± 0.086	1.242LeuTrp: 1.242 ± 0.031	1.982LeuTyr: 1.982 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.432MetAla: 3.432 ± 0.052	0.2MetCys: 0.2 ± 0.013	1.419MetAsp: 1.419 ± 0.031	1.434MetGlu: 1.434 ± 0.031	0.784MetPhe: 0.784 ± 0.023	2.154MetGly: 2.154 ± 0.042	0.494MetHis: 0.494 ± 0.016	1.521MetIle: 1.521 ± 0.036	1.024MetLys: 1.024 ± 0.029	2.493MetLeu: 2.493 ± 0.047	0.732MetMet: 0.732 ± 0.022	0.847MetAsn: 0.847 ± 0.025	1.525MetPro: 1.525 ± 0.031	0.887MetGln: 0.887 ± 0.023	1.797MetArg: 1.797 ± 0.036	1.832MetSer: 1.832 ± 0.034	1.991MetThr: 1.991 ± 0.033	1.945MetVal: 1.945 ± 0.039	0.244MetTrp: 0.244 ± 0.013	0.334MetTyr: 0.334 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.04AsnAla: 3.04 ± 0.05	0.254AsnCys: 0.254 ± 0.014	1.534AsnAsp: 1.534 ± 0.044	1.27AsnGlu: 1.27 ± 0.026	0.904AsnPhe: 0.904 ± 0.024	2.437AsnGly: 2.437 ± 0.053	0.513AsnHis: 0.513 ± 0.023	1.291AsnIle: 1.291 ± 0.031	0.634AsnLys: 0.634 ± 0.022	2.543AsnLeu: 2.543 ± 0.036	0.72AsnMet: 0.72 ± 0.025	0.639AsnAsn: 0.639 ± 0.022	1.868AsnPro: 1.868 ± 0.037	0.678AsnGln: 0.678 ± 0.023	1.842AsnArg: 1.842 ± 0.035	1.269AsnSer: 1.269 ± 0.03	1.366AsnThr: 1.366 ± 0.034	1.905AsnVal: 1.905 ± 0.04	0.468AsnTrp: 0.468 ± 0.017	0.65AsnTyr: 0.65 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.687ProAla: 5.687 ± 0.078	0.366ProCys: 0.366 ± 0.015	4.127ProAsp: 4.127 ± 0.054	4.497ProGlu: 4.497 ± 0.06	2.018ProPhe: 2.018 ± 0.038	4.749ProGly: 4.749 ± 0.067	1.05ProHis: 1.05 ± 0.027	2.264ProIle: 2.264 ± 0.042	1.542ProLys: 1.542 ± 0.037	4.597ProLeu: 4.597 ± 0.053	1.352ProMet: 1.352 ± 0.029	1.353ProAsn: 1.353 ± 0.029	2.348ProPro: 2.348 ± 0.045	1.534ProGln: 1.534 ± 0.029	2.863ProArg: 2.863 ± 0.048	2.687ProSer: 2.687 ± 0.043	2.614ProThr: 2.614 ± 0.049	4.356ProVal: 4.356 ± 0.063	0.693ProTrp: 0.693 ± 0.023	1.106ProTyr: 1.106 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.646GlnAla: 3.646 ± 0.055	0.22GlnCys: 0.22 ± 0.013	1.663GlnAsp: 1.663 ± 0.04	1.593GlnGlu: 1.593 ± 0.036	1.039GlnPhe: 1.039 ± 0.026	2.426GlnGly: 2.426 ± 0.04	0.567GlnHis: 0.567 ± 0.016	1.817GlnIle: 1.817 ± 0.036	1.018GlnLys: 1.018 ± 0.027	2.6GlnLeu: 2.6 ± 0.048	0.984GlnMet: 0.984 ± 0.027	0.821GlnAsn: 0.821 ± 0.026	1.609GlnPro: 1.609 ± 0.032	1.062GlnGln: 1.062 ± 0.029	2.055GlnArg: 2.055 ± 0.04	1.693GlnSer: 1.693 ± 0.037	1.68GlnThr: 1.68 ± 0.032	2.372GlnVal: 2.372 ± 0.042	0.387GlnTrp: 0.387 ± 0.017	0.572GlnTyr: 0.572 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.601ArgAla: 7.601 ± 0.083	0.535ArgCys: 0.535 ± 0.02	4.318ArgAsp: 4.318 ± 0.055	4.002ArgGlu: 4.002 ± 0.055	2.757ArgPhe: 2.757 ± 0.053	4.75ArgGly: 4.75 ± 0.068	1.631ArgHis: 1.631 ± 0.034	3.965ArgIle: 3.965 ± 0.047	2.349ArgLys: 2.349 ± 0.043	7.359ArgLeu: 7.359 ± 0.095	2.016ArgMet: 2.016 ± 0.04	1.916ArgAsn: 1.916 ± 0.034	3.453ArgPro: 3.453 ± 0.058	2.319ArgGln: 2.319 ± 0.044	5.18ArgArg: 5.18 ± 0.073	3.599ArgSer: 3.599 ± 0.058	3.283ArgThr: 3.283 ± 0.049	4.748ArgVal: 4.748 ± 0.063	0.952ArgTrp: 0.952 ± 0.026	1.548ArgTyr: 1.548 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.953SerAla: 5.953 ± 0.063	0.454SerCys: 0.454 ± 0.019	3.496SerAsp: 3.496 ± 0.056	3.166SerGlu: 3.166 ± 0.043	2.246SerPhe: 2.246 ± 0.04	5.71SerGly: 5.71 ± 0.069	1.138SerHis: 1.138 ± 0.027	2.66SerIle: 2.66 ± 0.053	1.481SerLys: 1.481 ± 0.031	5.175SerLeu: 5.175 ± 0.062	1.418SerMet: 1.418 ± 0.03	1.408SerAsn: 1.408 ± 0.034	2.701SerPro: 2.701 ± 0.044	1.56SerGln: 1.56 ± 0.031	3.519SerArg: 3.519 ± 0.056	2.704SerSer: 2.704 ± 0.043	2.724SerThr: 2.724 ± 0.048	4.104SerVal: 4.104 ± 0.062	0.712SerTrp: 0.712 ± 0.02	1.234SerTyr: 1.234 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.224ThrAla: 6.224 ± 0.072	0.511ThrCys: 0.511 ± 0.019	3.176ThrAsp: 3.176 ± 0.064	3.106ThrGlu: 3.106 ± 0.047	2.172ThrPhe: 2.172 ± 0.046	5.509ThrGly: 5.509 ± 0.06	1.108ThrHis: 1.108 ± 0.03	2.811ThrIle: 2.811 ± 0.048	1.302ThrLys: 1.302 ± 0.034	6.051ThrLeu: 6.051 ± 0.067	1.302ThrMet: 1.302 ± 0.027	1.289ThrAsn: 1.289 ± 0.035	3.447ThrPro: 3.447 ± 0.059	1.471ThrGln: 1.471 ± 0.031	3.496ThrArg: 3.496 ± 0.053	2.924ThrSer: 2.924 ± 0.048	2.909ThrThr: 2.909 ± 0.061	4.112ThrVal: 4.112 ± 0.066	0.724ThrTrp: 0.724 ± 0.024	1.265ThrTyr: 1.265 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.882ValAla: 8.882 ± 0.083	0.699ValCys: 0.699 ± 0.025	4.389ValAsp: 4.389 ± 0.069	4.802ValGlu: 4.802 ± 0.058	2.98ValPhe: 2.98 ± 0.05	5.798ValGly: 5.798 ± 0.071	1.428ValHis: 1.428 ± 0.033	3.998ValIle: 3.998 ± 0.061	2.101ValLys: 2.101 ± 0.043	7.7ValLeu: 7.7 ± 0.082	1.933ValMet: 1.933 ± 0.041	1.927ValAsn: 1.927 ± 0.039	3.897ValPro: 3.897 ± 0.054	2.082ValGln: 2.082 ± 0.045	4.562ValArg: 4.562 ± 0.064	4.498ValSer: 4.498 ± 0.061	4.535ValThr: 4.535 ± 0.059	5.902ValVal: 5.902 ± 0.076	0.955ValTrp: 0.955 ± 0.03	1.448ValTyr: 1.448 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.323TrpAla: 1.323 ± 0.034	0.134TrpCys: 0.134 ± 0.009	0.832TrpAsp: 0.832 ± 0.026	0.697TrpGlu: 0.697 ± 0.024	0.546TrpPhe: 0.546 ± 0.019	1.008TrpGly: 1.008 ± 0.027	0.345TrpHis: 0.345 ± 0.015	0.76TrpIle: 0.76 ± 0.023	0.487TrpLys: 0.487 ± 0.019	1.588TrpLeu: 1.588 ± 0.038	0.438TrpMet: 0.438 ± 0.013	0.46TrpAsn: 0.46 ± 0.019	0.704TrpPro: 0.704 ± 0.027	0.585TrpGln: 0.585 ± 0.022	1.056TrpArg: 1.056 ± 0.028	0.846TrpSer: 0.846 ± 0.025	0.84TrpThr: 0.84 ± 0.027	0.912TrpVal: 0.912 ± 0.025	0.231TrpTrp: 0.231 ± 0.015	0.334TrpTyr: 0.334 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.361TyrAla: 2.361 ± 0.04	0.232TyrCys: 0.232 ± 0.014	1.49TyrAsp: 1.49 ± 0.037	1.3TyrGlu: 1.3 ± 0.035	0.897TyrPhe: 0.897 ± 0.025	2.075TyrGly: 2.075 ± 0.038	0.498TyrHis: 0.498 ± 0.02	0.872TyrIle: 0.872 ± 0.025	0.537TyrLys: 0.537 ± 0.02	2.167TyrLeu: 2.167 ± 0.039	0.454TyrMet: 0.454 ± 0.017	0.585TyrAsn: 0.585 ± 0.022	1.074TyrPro: 1.074 ± 0.028	0.654TyrGln: 0.654 ± 0.02	1.623TyrArg: 1.623 ± 0.033	1.193TyrSer: 1.193 ± 0.03	1.103TyrThr: 1.103 ± 0.028	1.51TyrVal: 1.51 ± 0.028	0.36TyrTrp: 0.36 ± 0.016	0.57TyrTyr: 0.57 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4715 proteins (1462637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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