Amino acid dipepetide frequency for Halothece sp. (strain PCC 7418) (Synechococcus sp. (strain PCC 7418))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.754AlaAla: 5.754 ± 0.091	0.732AlaCys: 0.732 ± 0.028	3.693AlaAsp: 3.693 ± 0.067	5.542AlaGlu: 5.542 ± 0.072	2.918AlaPhe: 2.918 ± 0.051	5.202AlaGly: 5.202 ± 0.075	1.261AlaHis: 1.261 ± 0.033	6.394AlaIle: 6.394 ± 0.079	3.792AlaLys: 3.792 ± 0.064	8.436AlaLeu: 8.436 ± 0.095	1.658AlaMet: 1.658 ± 0.042	2.964AlaAsn: 2.964 ± 0.058	2.532AlaPro: 2.532 ± 0.057	4.583AlaGln: 4.583 ± 0.074	3.569AlaArg: 3.569 ± 0.058	4.492AlaSer: 4.492 ± 0.071	4.404AlaThr: 4.404 ± 0.074	5.526AlaVal: 5.526 ± 0.071	0.914AlaTrp: 0.914 ± 0.03	2.315AlaTyr: 2.315 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.662CysAla: 0.662 ± 0.023	0.165CysCys: 0.165 ± 0.013	0.528CysAsp: 0.528 ± 0.025	0.559CysGlu: 0.559 ± 0.025	0.41CysPhe: 0.41 ± 0.018	0.725CysGly: 0.725 ± 0.026	0.281CysHis: 0.281 ± 0.016	0.481CysIle: 0.481 ± 0.022	0.259CysLys: 0.259 ± 0.015	1.099CysLeu: 1.099 ± 0.035	0.126CysMet: 0.126 ± 0.01	0.343CysAsn: 0.343 ± 0.019	0.555CysPro: 0.555 ± 0.027	0.661CysGln: 0.661 ± 0.026	0.505CysArg: 0.505 ± 0.022	0.632CysSer: 0.632 ± 0.024	0.432CysThr: 0.432 ± 0.02	0.544CysVal: 0.544 ± 0.023	0.142CysTrp: 0.142 ± 0.011	0.38CysTyr: 0.38 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.286AspAla: 3.286 ± 0.059	0.521AspCys: 0.521 ± 0.022	2.449AspAsp: 2.449 ± 0.065	3.37AspGlu: 3.37 ± 0.058	2.377AspPhe: 2.377 ± 0.057	3.124AspGly: 3.124 ± 0.089	1.068AspHis: 1.068 ± 0.032	2.996AspIle: 2.996 ± 0.058	1.617AspLys: 1.617 ± 0.035	6.11AspLeu: 6.11 ± 0.074	0.704AspMet: 0.704 ± 0.025	1.918AspAsn: 1.918 ± 0.047	2.862AspPro: 2.862 ± 0.062	3.015AspGln: 3.015 ± 0.04	3.233AspArg: 3.233 ± 0.063	3.013AspSer: 3.013 ± 0.052	2.449AspThr: 2.449 ± 0.057	3.075AspVal: 3.075 ± 0.053	0.969AspTrp: 0.969 ± 0.031	2.088AspTyr: 2.088 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.31GluAla: 6.31 ± 0.092	0.442GluCys: 0.442 ± 0.02	3.561GluAsp: 3.561 ± 0.068	6.225GluGlu: 6.225 ± 0.107	2.441GluPhe: 2.441 ± 0.046	4.158GluGly: 4.158 ± 0.084	1.02GluHis: 1.02 ± 0.032	5.193GluIle: 5.193 ± 0.075	4.426GluLys: 4.426 ± 0.07	7.205GluLeu: 7.205 ± 0.073	1.575GluMet: 1.575 ± 0.041	3.392GluAsn: 3.392 ± 0.056	2.364GluPro: 2.364 ± 0.062	4.329GluGln: 4.329 ± 0.079	3.36GluArg: 3.36 ± 0.064	3.868GluSer: 3.868 ± 0.071	5.482GluThr: 5.482 ± 0.078	4.695GluVal: 4.695 ± 0.071	0.763GluTrp: 0.763 ± 0.028	1.768GluTyr: 1.768 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.063PheAla: 3.063 ± 0.057	0.51PheCys: 0.51 ± 0.024	2.261PheAsp: 2.261 ± 0.052	2.205PheGlu: 2.205 ± 0.049	1.851PhePhe: 1.851 ± 0.044	2.895PheGly: 2.895 ± 0.058	0.768PheHis: 0.768 ± 0.023	2.241PheIle: 2.241 ± 0.048	1.358PheLys: 1.358 ± 0.035	4.467PheLeu: 4.467 ± 0.078	0.637PheMet: 0.637 ± 0.022	1.782PheAsn: 1.782 ± 0.04	2.233PhePro: 2.233 ± 0.044	2.116PheGln: 2.116 ± 0.043	1.851PheArg: 1.851 ± 0.038	3.023PheSer: 3.023 ± 0.057	2.307PheThr: 2.307 ± 0.054	2.36PheVal: 2.36 ± 0.049	0.725PheTrp: 0.725 ± 0.027	1.379PheTyr: 1.379 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.403GlyAla: 4.403 ± 0.067	0.753GlyCys: 0.753 ± 0.028	3.342GlyAsp: 3.342 ± 0.075	5.135GlyGlu: 5.135 ± 0.079	3.0GlyPhe: 3.0 ± 0.052	4.863GlyGly: 4.863 ± 0.091	1.168GlyHis: 1.168 ± 0.029	5.018GlyIle: 5.018 ± 0.076	4.029GlyLys: 4.029 ± 0.062	7.028GlyLeu: 7.028 ± 0.082	1.55GlyMet: 1.55 ± 0.038	2.905GlyAsn: 2.905 ± 0.062	1.138GlyPro: 1.138 ± 0.032	2.767GlyGln: 2.767 ± 0.054	3.043GlyArg: 3.043 ± 0.054	3.862GlySer: 3.862 ± 0.068	3.821GlyThr: 3.821 ± 0.072	4.736GlyVal: 4.736 ± 0.08	1.131GlyTrp: 1.131 ± 0.032	2.372GlyTyr: 2.372 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.966HisAla: 0.966 ± 0.03	0.318HisCys: 0.318 ± 0.017	0.798HisAsp: 0.798 ± 0.026	0.919HisGlu: 0.919 ± 0.03	0.888HisPhe: 0.888 ± 0.032	1.132HisGly: 1.132 ± 0.03	0.687HisHis: 0.687 ± 0.031	0.919HisIle: 0.919 ± 0.031	0.586HisLys: 0.586 ± 0.024	2.46HisLeu: 2.46 ± 0.055	0.212HisMet: 0.212 ± 0.013	0.671HisAsn: 0.671 ± 0.027	1.425HisPro: 1.425 ± 0.042	1.319HisGln: 1.319 ± 0.04	1.13HisArg: 1.13 ± 0.03	1.276HisSer: 1.276 ± 0.036	0.807HisThr: 0.807 ± 0.024	0.731HisVal: 0.731 ± 0.027	0.401HisTrp: 0.401 ± 0.02	0.81HisTyr: 0.81 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.696IleAla: 6.696 ± 0.083	0.625IleCys: 0.625 ± 0.024	3.436IleAsp: 3.436 ± 0.064	4.356IleGlu: 4.356 ± 0.062	2.518IlePhe: 2.518 ± 0.046	4.254IleGly: 4.254 ± 0.066	1.139IleHis: 1.139 ± 0.032	4.036IleIle: 4.036 ± 0.072	2.689IleLys: 2.689 ± 0.053	6.575IleLeu: 6.575 ± 0.09	0.92IleMet: 0.92 ± 0.031	2.845IleAsn: 2.845 ± 0.057	3.677IlePro: 3.677 ± 0.048	3.004IleGln: 3.004 ± 0.061	3.026IleArg: 3.026 ± 0.05	4.231IleSer: 4.231 ± 0.069	3.861IleThr: 3.861 ± 0.061	3.75IleVal: 3.75 ± 0.066	0.751IleTrp: 0.751 ± 0.026	1.899IleTyr: 1.899 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.727LysAla: 3.727 ± 0.052	0.282LysCys: 0.282 ± 0.016	2.022LysAsp: 2.022 ± 0.046	3.374LysGlu: 3.374 ± 0.061	1.365LysPhe: 1.365 ± 0.036	2.798LysGly: 2.798 ± 0.047	0.779LysHis: 0.779 ± 0.027	3.197LysIle: 3.197 ± 0.058	2.528LysLys: 2.528 ± 0.054	4.698LysLeu: 4.698 ± 0.079	0.952LysMet: 0.952 ± 0.028	2.043LysAsn: 2.043 ± 0.048	2.281LysPro: 2.281 ± 0.045	3.13LysGln: 3.13 ± 0.059	2.687LysArg: 2.687 ± 0.06	2.556LysSer: 2.556 ± 0.046	3.195LysThr: 3.195 ± 0.052	2.894LysVal: 2.894 ± 0.049	0.469LysTrp: 0.469 ± 0.021	1.165LysTyr: 1.165 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	8.825LeuAla: 8.825 ± 0.106	0.943LeuCys: 0.943 ± 0.029	5.635LeuAsp: 5.635 ± 0.071	8.318LeuGlu: 8.318 ± 0.098	4.096LeuPhe: 4.096 ± 0.07	7.561LeuGly: 7.561 ± 0.088	1.756LeuHis: 1.756 ± 0.041	6.925LeuIle: 6.925 ± 0.093	5.639LeuLys: 5.639 ± 0.086	10.992LeuLeu: 10.992 ± 0.14	2.142LeuMet: 2.142 ± 0.045	4.769LeuAsn: 4.769 ± 0.068	5.556LeuPro: 5.556 ± 0.073	5.715LeuGln: 5.715 ± 0.084	5.285LeuArg: 5.285 ± 0.078	7.94LeuSer: 7.94 ± 0.088	6.536LeuThr: 6.536 ± 0.089	6.885LeuVal: 6.885 ± 0.092	1.351LeuTrp: 1.351 ± 0.04	2.725LeuTyr: 2.725 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.571MetAla: 1.571 ± 0.036	0.089MetCys: 0.089 ± 0.009	0.792MetAsp: 0.792 ± 0.025	1.11MetGlu: 1.11 ± 0.032	0.552MetPhe: 0.552 ± 0.023	1.494MetGly: 1.494 ± 0.04	0.217MetHis: 0.217 ± 0.013	1.352MetIle: 1.352 ± 0.038	0.985MetLys: 0.985 ± 0.033	1.734MetLeu: 1.734 ± 0.043	0.513MetMet: 0.513 ± 0.022	0.842MetAsn: 0.842 ± 0.029	0.712MetPro: 0.712 ± 0.026	0.839MetGln: 0.839 ± 0.03	0.948MetArg: 0.948 ± 0.03	1.469MetSer: 1.469 ± 0.038	1.452MetThr: 1.452 ± 0.036	1.309MetVal: 1.309 ± 0.035	0.149MetTrp: 0.149 ± 0.012	0.347MetTyr: 0.347 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.898AsnAla: 2.898 ± 0.053	0.504AsnCys: 0.504 ± 0.022	1.802AsnAsp: 1.802 ± 0.046	2.161AsnGlu: 2.161 ± 0.048	1.851AsnPhe: 1.851 ± 0.052	2.486AsnGly: 2.486 ± 0.058	0.987AsnHis: 0.987 ± 0.027	2.351AsnIle: 2.351 ± 0.05	1.41AsnLys: 1.41 ± 0.04	5.342AsnLeu: 5.342 ± 0.083	0.63AsnMet: 0.63 ± 0.025	1.917AsnAsn: 1.917 ± 0.048	2.825AsnPro: 2.825 ± 0.048	3.029AsnGln: 3.029 ± 0.057	2.403AsnArg: 2.403 ± 0.048	2.628AsnSer: 2.628 ± 0.056	2.087AsnThr: 2.087 ± 0.05	2.186AsnVal: 2.186 ± 0.049	0.815AsnTrp: 0.815 ± 0.025	1.54AsnTyr: 1.54 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.821ProAla: 2.821 ± 0.057	0.388ProCys: 0.388 ± 0.017	3.001ProAsp: 3.001 ± 0.058	4.595ProGlu: 4.595 ± 0.09	1.877ProPhe: 1.877 ± 0.04	2.319ProGly: 2.319 ± 0.052	1.021ProHis: 1.021 ± 0.029	3.002ProIle: 3.002 ± 0.052	2.228ProLys: 2.228 ± 0.049	4.875ProLeu: 4.875 ± 0.072	0.753ProMet: 0.753 ± 0.027	2.173ProAsn: 2.173 ± 0.047	2.387ProPro: 2.387 ± 0.051	2.797ProGln: 2.797 ± 0.06	1.859ProArg: 1.859 ± 0.046	3.06ProSer: 3.06 ± 0.053	2.792ProThr: 2.792 ± 0.05	2.953ProVal: 2.953 ± 0.054	0.667ProTrp: 0.667 ± 0.027	1.491ProTyr: 1.491 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.717GlnAla: 4.717 ± 0.075	0.386GlnCys: 0.386 ± 0.019	2.417GlnAsp: 2.417 ± 0.044	4.555GlnGlu: 4.555 ± 0.073	2.152GlnPhe: 2.152 ± 0.046	3.796GlnGly: 3.796 ± 0.062	0.915GlnHis: 0.915 ± 0.03	3.257GlnIle: 3.257 ± 0.058	2.916GlnLys: 2.916 ± 0.057	6.358GlnLeu: 6.358 ± 0.077	1.138GlnMet: 1.138 ± 0.031	2.174GlnAsn: 2.174 ± 0.046	2.713GlnPro: 2.713 ± 0.061	4.451GlnGln: 4.451 ± 0.099	3.214GlnArg: 3.214 ± 0.063	3.109GlnSer: 3.109 ± 0.054	3.391GlnThr: 3.391 ± 0.065	3.889GlnVal: 3.889 ± 0.064	0.916GlnTrp: 0.916 ± 0.025	1.388GlnTyr: 1.388 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.511ArgAla: 3.511 ± 0.061	0.489ArgCys: 0.489 ± 0.024	2.828ArgAsp: 2.828 ± 0.054	3.79ArgGlu: 3.79 ± 0.066	2.25ArgPhe: 2.25 ± 0.05	2.923ArgGly: 2.923 ± 0.048	0.948ArgHis: 0.948 ± 0.031	3.048ArgIle: 3.048 ± 0.055	2.424ArgLys: 2.424 ± 0.052	5.907ArgLeu: 5.907 ± 0.075	0.961ArgMet: 0.961 ± 0.028	2.04ArgAsn: 2.04 ± 0.039	1.945ArgPro: 1.945 ± 0.043	3.107ArgGln: 3.107 ± 0.056	3.005ArgArg: 3.005 ± 0.064	3.141ArgSer: 3.141 ± 0.054	2.252ArgThr: 2.252 ± 0.043	3.454ArgVal: 3.454 ± 0.068	0.864ArgTrp: 0.864 ± 0.028	1.918ArgTyr: 1.918 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.745SerAla: 4.745 ± 0.064	0.634SerCys: 0.634 ± 0.023	3.392SerAsp: 3.392 ± 0.058	4.463SerGlu: 4.463 ± 0.072	2.58SerPhe: 2.58 ± 0.045	4.392SerGly: 4.392 ± 0.072	1.343SerHis: 1.343 ± 0.038	3.342SerIle: 3.342 ± 0.058	2.338SerLys: 2.338 ± 0.044	7.499SerLeu: 7.499 ± 0.09	1.089SerMet: 1.089 ± 0.035	2.516SerAsn: 2.516 ± 0.053	3.722SerPro: 3.722 ± 0.055	3.928SerGln: 3.928 ± 0.068	3.18SerArg: 3.18 ± 0.059	4.424SerSer: 4.424 ± 0.076	3.049SerThr: 3.049 ± 0.056	3.928SerVal: 3.928 ± 0.06	0.892SerTrp: 0.892 ± 0.03	1.913SerTyr: 1.913 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.814ThrAla: 4.814 ± 0.072	0.5ThrCys: 0.5 ± 0.022	2.768ThrAsp: 2.768 ± 0.055	4.003ThrGlu: 4.003 ± 0.071	2.248ThrPhe: 2.248 ± 0.047	4.139ThrGly: 4.139 ± 0.071	1.047ThrHis: 1.047 ± 0.028	3.778ThrIle: 3.778 ± 0.054	2.074ThrLys: 2.074 ± 0.044	6.811ThrLeu: 6.811 ± 0.094	0.85ThrMet: 0.85 ± 0.028	2.051ThrAsn: 2.051 ± 0.043	3.538ThrPro: 3.538 ± 0.056	2.907ThrGln: 2.907 ± 0.055	2.538ThrArg: 2.538 ± 0.047	3.465ThrSer: 3.465 ± 0.058	3.471ThrThr: 3.471 ± 0.061	4.538ThrVal: 4.538 ± 0.076	0.684ThrTrp: 0.684 ± 0.026	1.684ThrTyr: 1.684 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	5.314ValAla: 5.314 ± 0.077	0.648ValCys: 0.648 ± 0.025	3.351ValAsp: 3.351 ± 0.061	4.754ValGlu: 4.754 ± 0.082	2.573ValPhe: 2.573 ± 0.05	4.699ValGly: 4.699 ± 0.076	0.977ValHis: 0.977 ± 0.032	4.427ValIle: 4.427 ± 0.061	3.114ValLys: 3.114 ± 0.052	6.291ValLeu: 6.291 ± 0.085	1.387ValMet: 1.387 ± 0.041	2.774ValAsn: 2.774 ± 0.046	2.691ValPro: 2.691 ± 0.051	2.683ValGln: 2.683 ± 0.046	3.131ValArg: 3.131 ± 0.056	4.42ValSer: 4.42 ± 0.051	4.051ValThr: 4.051 ± 0.07	4.448ValVal: 4.448 ± 0.065	0.779ValTrp: 0.779 ± 0.028	1.836ValTyr: 1.836 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.701TrpAla: 0.701 ± 0.028	0.151TrpCys: 0.151 ± 0.012	0.615TrpAsp: 0.615 ± 0.021	1.264TrpGlu: 1.264 ± 0.035	0.643TrpPhe: 0.643 ± 0.028	1.019TrpGly: 1.019 ± 0.036	0.304TrpHis: 0.304 ± 0.015	0.779TrpIle: 0.779 ± 0.026	0.646TrpLys: 0.646 ± 0.025	2.045TrpLeu: 2.045 ± 0.047	0.276TrpMet: 0.276 ± 0.016	0.523TrpAsn: 0.523 ± 0.022	0.209TrpPro: 0.209 ± 0.013	1.132TrpGln: 1.132 ± 0.04	0.86TrpArg: 0.86 ± 0.028	0.856TrpSer: 0.856 ± 0.029	0.606TrpThr: 0.606 ± 0.024	0.885TrpVal: 0.885 ± 0.029	0.241TrpTrp: 0.241 ± 0.014	0.407TrpTyr: 0.407 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.896TyrAla: 1.896 ± 0.047	0.407TyrCys: 0.407 ± 0.018	1.552TyrAsp: 1.552 ± 0.036	1.882TyrGlu: 1.882 ± 0.041	1.442TyrPhe: 1.442 ± 0.036	2.086TyrGly: 2.086 ± 0.046	0.769TyrHis: 0.769 ± 0.027	1.551TyrIle: 1.551 ± 0.037	1.083TyrLys: 1.083 ± 0.033	3.661TyrLeu: 3.661 ± 0.062	0.402TyrMet: 0.402 ± 0.018	1.21TyrAsn: 1.21 ± 0.037	1.695TyrPro: 1.695 ± 0.037	2.343TyrGln: 2.343 ± 0.053	1.979TyrArg: 1.979 ± 0.039	1.904TyrSer: 1.904 ± 0.035	1.463TyrThr: 1.463 ± 0.035	1.561TyrVal: 1.561 ± 0.039	0.538TyrTrp: 0.538 ± 0.021	1.181TyrTyr: 1.181 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3701 proteins (1179075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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