Amino acid dipepetide frequency for Human papillomavirus type 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.008AlaAla: 4.008 ± 0.995
1.603AlaCys: 1.603 ± 1.085
2.405AlaAsp: 2.405 ± 0.907
3.206AlaGlu: 3.206 ± 0.647
3.206AlaPhe: 3.206 ± 1.093
3.607AlaGly: 3.607 ± 1.086
2.004AlaHis: 2.004 ± 0.729
4.008AlaIle: 4.008 ± 1.053
3.206AlaLys: 3.206 ± 1.178
4.81AlaLeu: 4.81 ± 1.097
0.802AlaMet: 0.802 ± 0.428
1.603AlaAsn: 1.603 ± 0.554
5.611AlaPro: 5.611 ± 1.839
3.206AlaGln: 3.206 ± 0.619
3.607AlaArg: 3.607 ± 1.047
3.607AlaSer: 3.607 ± 0.765
4.008AlaThr: 4.008 ± 1.139
2.405AlaVal: 2.405 ± 0.704
0.802AlaTrp: 0.802 ± 0.397
1.603AlaTyr: 1.603 ± 0.754
0.0AlaXaa: 0.0 ± 0.0
Cys
2.806CysAla: 2.806 ± 1.166
1.202CysCys: 1.202 ± 1.45
0.401CysAsp: 0.401 ± 0.653
0.802CysGlu: 0.802 ± 0.56
2.004CysPhe: 2.004 ± 0.867
1.202CysGly: 1.202 ± 0.766
0.401CysHis: 0.401 ± 0.534
0.401CysIle: 0.401 ± 0.301
2.806CysLys: 2.806 ± 1.175
1.603CysLeu: 1.603 ± 1.076
1.603CysMet: 1.603 ± 0.546
1.202CysAsn: 1.202 ± 1.338
2.405CysPro: 2.405 ± 0.791
1.202CysGln: 1.202 ± 0.752
0.401CysArg: 0.401 ± 0.301
0.802CysSer: 0.802 ± 0.41
2.004CysThr: 2.004 ± 0.909
1.603CysVal: 1.603 ± 0.746
1.202CysTrp: 1.202 ± 0.568
1.603CysTyr: 1.603 ± 1.152
0.0CysXaa: 0.0 ± 0.0
Asp
3.206AspAla: 3.206 ± 1.232
0.802AspCys: 0.802 ± 0.397
2.806AspAsp: 2.806 ± 0.916
2.405AspGlu: 2.405 ± 1.285
0.802AspPhe: 0.802 ± 0.602
3.607AspGly: 3.607 ± 1.505
0.0AspHis: 0.0 ± 0.0
4.81AspIle: 4.81 ± 1.407
1.202AspLys: 1.202 ± 0.652
3.607AspLeu: 3.607 ± 0.722
1.202AspMet: 1.202 ± 0.568
1.603AspAsn: 1.603 ± 0.319
3.206AspPro: 3.206 ± 1.423
1.603AspGln: 1.603 ± 0.554
1.603AspArg: 1.603 ± 0.544
6.413AspSer: 6.413 ± 1.93
4.81AspThr: 4.81 ± 1.013
3.607AspVal: 3.607 ± 1.242
0.802AspTrp: 0.802 ± 0.397
2.806AspTyr: 2.806 ± 1.563
0.0AspXaa: 0.0 ± 0.0
Glu
6.012GluAla: 6.012 ± 2.291
0.401GluCys: 0.401 ± 0.301
4.409GluAsp: 4.409 ± 1.037
5.21GluGlu: 5.21 ± 1.047
1.202GluPhe: 1.202 ± 0.832
1.603GluGly: 1.603 ± 0.879
2.405GluHis: 2.405 ± 0.833
2.405GluIle: 2.405 ± 1.004
2.806GluLys: 2.806 ± 0.922
2.405GluLeu: 2.405 ± 0.865
2.004GluMet: 2.004 ± 0.735
2.004GluAsn: 2.004 ± 0.794
2.806GluPro: 2.806 ± 0.863
1.603GluGln: 1.603 ± 0.973
0.401GluArg: 0.401 ± 0.301
4.008GluSer: 4.008 ± 1.358
2.004GluThr: 2.004 ± 1.071
5.611GluVal: 5.611 ± 2.15
0.401GluTrp: 0.401 ± 0.301
1.603GluTyr: 1.603 ± 0.602
0.0GluXaa: 0.0 ± 0.0
Phe
1.603PheAla: 1.603 ± 1.012
0.802PheCys: 0.802 ± 0.56
2.806PheAsp: 2.806 ± 0.568
1.202PheGlu: 1.202 ± 0.612
2.806PhePhe: 2.806 ± 1.059
2.004PheGly: 2.004 ± 0.728
0.401PheHis: 0.401 ± 0.534
3.607PheIle: 3.607 ± 1.292
3.206PheLys: 3.206 ± 1.354
4.81PheLeu: 4.81 ± 0.886
1.202PheMet: 1.202 ± 0.417
2.004PheAsn: 2.004 ± 0.847
1.202PhePro: 1.202 ± 0.612
2.004PheGln: 2.004 ± 0.7
2.004PheArg: 2.004 ± 0.619
2.004PheSer: 2.004 ± 1.113
1.202PheThr: 1.202 ± 0.685
2.004PheVal: 2.004 ± 1.109
0.802PheTrp: 0.802 ± 0.397
1.202PheTyr: 1.202 ± 0.704
0.0PheXaa: 0.0 ± 0.0
Gly
1.603GlyAla: 1.603 ± 0.79
1.603GlyCys: 1.603 ± 0.669
3.206GlyAsp: 3.206 ± 1.661
2.806GlyGlu: 2.806 ± 0.816
2.004GlyPhe: 2.004 ± 0.554
2.806GlyGly: 2.806 ± 0.893
2.004GlyHis: 2.004 ± 0.926
2.806GlyIle: 2.806 ± 0.759
3.206GlyLys: 3.206 ± 0.521
4.409GlyLeu: 4.409 ± 1.302
1.603GlyMet: 1.603 ± 0.627
3.607GlyAsn: 3.607 ± 0.85
2.405GlyPro: 2.405 ± 1.3
2.405GlyGln: 2.405 ± 0.661
2.806GlyArg: 2.806 ± 0.989
5.611GlySer: 5.611 ± 1.279
7.615GlyThr: 7.615 ± 2.214
2.806GlyVal: 2.806 ± 0.816
0.401GlyTrp: 0.401 ± 0.301
3.206GlyTyr: 3.206 ± 1.082
0.0GlyXaa: 0.0 ± 0.0
His
1.603HisAla: 1.603 ± 0.544
0.802HisCys: 0.802 ± 0.876
0.802HisAsp: 0.802 ± 0.451
0.802HisGlu: 0.802 ± 0.567
1.603HisPhe: 1.603 ± 0.798
2.405HisGly: 2.405 ± 0.918
0.401HisHis: 0.401 ± 0.301
2.405HisIle: 2.405 ± 0.824
2.405HisLys: 2.405 ± 1.2
2.004HisLeu: 2.004 ± 1.283
0.0HisMet: 0.0 ± 0.0
2.806HisAsn: 2.806 ± 0.836
2.806HisPro: 2.806 ± 1.323
1.202HisGln: 1.202 ± 0.417
1.603HisArg: 1.603 ± 0.563
1.202HisSer: 1.202 ± 0.417
3.206HisThr: 3.206 ± 0.753
1.603HisVal: 1.603 ± 0.669
1.603HisTrp: 1.603 ± 1.028
2.405HisTyr: 2.405 ± 1.207
0.0HisXaa: 0.0 ± 0.0
Ile
3.607IleAla: 3.607 ± 1.31
2.004IleCys: 2.004 ± 0.783
2.405IleAsp: 2.405 ± 1.156
4.008IleGlu: 4.008 ± 1.72
1.202IlePhe: 1.202 ± 0.697
2.806IleGly: 2.806 ± 1.111
2.004IleHis: 2.004 ± 0.744
2.004IleIle: 2.004 ± 1.224
2.806IleLys: 2.806 ± 1.195
3.206IleLeu: 3.206 ± 1.725
0.0IleMet: 0.0 ± 0.0
2.405IleAsn: 2.405 ± 1.07
2.806IlePro: 2.806 ± 1.046
1.603IleGln: 1.603 ± 0.881
2.004IleArg: 2.004 ± 0.687
4.81IleSer: 4.81 ± 1.591
5.21IleThr: 5.21 ± 1.448
5.611IleVal: 5.611 ± 2.468
0.0IleTrp: 0.0 ± 0.0
2.405IleTyr: 2.405 ± 0.667
0.0IleXaa: 0.0 ± 0.0
Lys
2.405LysAla: 2.405 ± 0.786
2.806LysCys: 2.806 ± 1.404
2.004LysAsp: 2.004 ± 1.043
3.206LysGlu: 3.206 ± 1.205
2.405LysPhe: 2.405 ± 0.934
2.004LysGly: 2.004 ± 0.907
4.81LysHis: 4.81 ± 1.792
1.603LysIle: 1.603 ± 0.719
2.004LysLys: 2.004 ± 0.859
2.806LysLeu: 2.806 ± 1.051
0.401LysMet: 0.401 ± 0.301
1.202LysAsn: 1.202 ± 0.568
2.405LysPro: 2.405 ± 0.926
2.405LysGln: 2.405 ± 0.875
6.012LysArg: 6.012 ± 1.346
1.603LysSer: 1.603 ± 0.881
3.206LysThr: 3.206 ± 1.056
4.409LysVal: 4.409 ± 0.969
0.401LysTrp: 0.401 ± 0.35
3.607LysTyr: 3.607 ± 1.198
0.0LysXaa: 0.0 ± 0.0
Leu
2.004LeuAla: 2.004 ± 0.951
3.607LeuCys: 3.607 ± 1.92
5.21LeuAsp: 5.21 ± 1.002
3.607LeuGlu: 3.607 ± 1.167
4.008LeuPhe: 4.008 ± 0.983
5.21LeuGly: 5.21 ± 1.225
5.21LeuHis: 5.21 ± 1.812
5.611LeuIle: 5.611 ± 0.929
3.607LeuLys: 3.607 ± 1.269
11.623LeuLeu: 11.623 ± 4.817
1.603LeuMet: 1.603 ± 0.799
2.806LeuAsn: 2.806 ± 0.906
2.405LeuPro: 2.405 ± 1.032
4.81LeuGln: 4.81 ± 1.413
2.405LeuArg: 2.405 ± 0.801
4.409LeuSer: 4.409 ± 0.889
6.012LeuThr: 6.012 ± 2.267
4.81LeuVal: 4.81 ± 1.172
1.202LeuTrp: 1.202 ± 0.802
4.008LeuTyr: 4.008 ± 1.399
0.0LeuXaa: 0.0 ± 0.0
Met
2.405MetAla: 2.405 ± 0.803
0.401MetCys: 0.401 ± 0.301
1.603MetAsp: 1.603 ± 0.319
2.004MetGlu: 2.004 ± 1.499
0.401MetPhe: 0.401 ± 0.345
1.202MetGly: 1.202 ± 0.621
2.806MetHis: 2.806 ± 1.794
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.603MetLeu: 1.603 ± 1.275
0.401MetMet: 0.401 ± 0.596
1.202MetAsn: 1.202 ± 0.824
0.0MetPro: 0.0 ± 0.0
1.202MetGln: 1.202 ± 0.699
1.603MetArg: 1.603 ± 0.544
1.603MetSer: 1.603 ± 0.867
0.401MetThr: 0.401 ± 0.345
2.806MetVal: 2.806 ± 1.101
0.802MetTrp: 0.802 ± 0.41
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.008AsnAla: 4.008 ± 1.237
2.004AsnCys: 2.004 ± 1.292
2.405AsnAsp: 2.405 ± 1.391
0.802AsnGlu: 0.802 ± 0.503
1.202AsnPhe: 1.202 ± 0.665
2.004AsnGly: 2.004 ± 0.728
0.802AsnHis: 0.802 ± 0.726
3.607AsnIle: 3.607 ± 1.296
2.806AsnLys: 2.806 ± 1.623
2.405AsnLeu: 2.405 ± 0.723
1.202AsnMet: 1.202 ± 0.526
1.603AsnAsn: 1.603 ± 1.028
3.206AsnPro: 3.206 ± 1.177
1.202AsnGln: 1.202 ± 0.568
1.603AsnArg: 1.603 ± 1.002
4.409AsnSer: 4.409 ± 1.333
2.806AsnThr: 2.806 ± 0.9
0.802AsnVal: 0.802 ± 0.7
0.802AsnTrp: 0.802 ± 0.602
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
4.008ProAla: 4.008 ± 2.004
1.202ProCys: 1.202 ± 0.555
4.008ProAsp: 4.008 ± 1.641
2.405ProGlu: 2.405 ± 0.694
2.806ProPhe: 2.806 ± 1.087
1.603ProGly: 1.603 ± 0.651
0.802ProHis: 0.802 ± 0.567
2.806ProIle: 2.806 ± 0.621
3.206ProLys: 3.206 ± 0.7
7.214ProLeu: 7.214 ± 1.281
1.603ProMet: 1.603 ± 0.72
2.806ProAsn: 2.806 ± 1.007
8.417ProPro: 8.417 ± 1.637
1.202ProGln: 1.202 ± 0.823
2.004ProArg: 2.004 ± 0.756
2.806ProSer: 2.806 ± 1.534
4.409ProThr: 4.409 ± 1.453
6.413ProVal: 6.413 ± 2.971
1.202ProTrp: 1.202 ± 0.621
2.405ProTyr: 2.405 ± 1.332
0.0ProXaa: 0.0 ± 0.0
Gln
2.806GlnAla: 2.806 ± 0.882
1.202GlnCys: 1.202 ± 0.853
3.206GlnAsp: 3.206 ± 0.607
2.004GlnGlu: 2.004 ± 1.077
3.607GlnPhe: 3.607 ± 1.096
1.202GlnGly: 1.202 ± 0.752
1.603GlnHis: 1.603 ± 0.676
2.004GlnIle: 2.004 ± 0.929
1.202GlnLys: 1.202 ± 0.68
4.409GlnLeu: 4.409 ± 1.881
2.405GlnMet: 2.405 ± 0.803
0.401GlnAsn: 0.401 ± 0.301
3.607GlnPro: 3.607 ± 1.288
1.603GlnGln: 1.603 ± 1.126
2.405GlnArg: 2.405 ± 0.673
2.004GlnSer: 2.004 ± 0.517
3.607GlnThr: 3.607 ± 0.818
1.603GlnVal: 1.603 ± 0.659
1.202GlnTrp: 1.202 ± 0.903
1.202GlnTyr: 1.202 ± 0.803
0.0GlnXaa: 0.0 ± 0.0
Arg
4.008ArgAla: 4.008 ± 0.87
1.603ArgCys: 1.603 ± 1.076
0.401ArgAsp: 0.401 ± 0.301
1.202ArgGlu: 1.202 ± 0.752
0.802ArgPhe: 0.802 ± 0.56
3.607ArgGly: 3.607 ± 0.493
3.607ArgHis: 3.607 ± 1.112
1.202ArgIle: 1.202 ± 1.049
4.409ArgLys: 4.409 ± 0.959
5.21ArgLeu: 5.21 ± 0.924
0.0ArgMet: 0.0 ± 0.341
1.603ArgAsn: 1.603 ± 0.57
2.806ArgPro: 2.806 ± 1.04
1.603ArgGln: 1.603 ± 0.867
2.806ArgArg: 2.806 ± 1.346
1.603ArgSer: 1.603 ± 0.646
3.206ArgThr: 3.206 ± 0.918
1.603ArgVal: 1.603 ± 0.646
0.0ArgTrp: 0.0 ± 0.0
1.202ArgTyr: 1.202 ± 0.428
0.0ArgXaa: 0.0 ± 0.0
Ser
3.607SerAla: 3.607 ± 1.369
0.0SerCys: 0.0 ± 0.0
3.607SerAsp: 3.607 ± 1.401
4.81SerGlu: 4.81 ± 0.951
1.603SerPhe: 1.603 ± 0.577
7.615SerGly: 7.615 ± 2.364
2.806SerHis: 2.806 ± 1.046
5.21SerIle: 5.21 ± 1.311
1.603SerLys: 1.603 ± 0.602
4.81SerLeu: 4.81 ± 0.927
1.603SerMet: 1.603 ± 0.849
4.409SerAsn: 4.409 ± 1.947
3.607SerPro: 3.607 ± 0.759
1.603SerGln: 1.603 ± 0.724
2.405SerArg: 2.405 ± 1.292
9.619SerSer: 9.619 ± 1.925
7.615SerThr: 7.615 ± 2.267
4.409SerVal: 4.409 ± 1.218
0.0SerTrp: 0.0 ± 0.0
1.202SerTyr: 1.202 ± 0.61
0.0SerXaa: 0.0 ± 0.0
Thr
1.603ThrAla: 1.603 ± 0.709
3.607ThrCys: 3.607 ± 0.968
2.806ThrAsp: 2.806 ± 1.098
2.405ThrGlu: 2.405 ± 0.847
2.806ThrPhe: 2.806 ± 1.106
6.413ThrGly: 6.413 ± 2.345
0.401ThrHis: 0.401 ± 0.301
2.405ThrIle: 2.405 ± 0.794
3.607ThrLys: 3.607 ± 1.347
6.413ThrLeu: 6.413 ± 1.632
2.004ThrMet: 2.004 ± 0.981
3.607ThrAsn: 3.607 ± 1.443
6.814ThrPro: 6.814 ± 1.951
4.81ThrGln: 4.81 ± 1.09
2.806ThrArg: 2.806 ± 1.139
7.615ThrSer: 7.615 ± 2.519
10.02ThrThr: 10.02 ± 3.13
7.615ThrVal: 7.615 ± 1.313
1.603ThrTrp: 1.603 ± 1.216
3.206ThrTyr: 3.206 ± 0.898
0.0ThrXaa: 0.0 ± 0.0
Val
3.607ValAla: 3.607 ± 1.126
1.603ValCys: 1.603 ± 1.28
3.607ValAsp: 3.607 ± 1.92
5.611ValGlu: 5.611 ± 1.124
2.004ValPhe: 2.004 ± 0.996
4.409ValGly: 4.409 ± 2.239
0.401ValHis: 0.401 ± 0.363
2.806ValIle: 2.806 ± 0.688
3.206ValLys: 3.206 ± 1.305
4.81ValLeu: 4.81 ± 1.693
0.802ValMet: 0.802 ± 0.51
2.405ValAsn: 2.405 ± 0.934
4.81ValPro: 4.81 ± 1.356
6.814ValGln: 6.814 ± 1.603
1.603ValArg: 1.603 ± 0.706
6.012ValSer: 6.012 ± 1.654
7.615ValThr: 7.615 ± 2.118
6.012ValVal: 6.012 ± 1.213
1.603ValTrp: 1.603 ± 0.741
2.004ValTyr: 2.004 ± 0.503
0.0ValXaa: 0.0 ± 0.0
Trp
1.202TrpAla: 1.202 ± 0.376
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.802TrpGlu: 0.802 ± 0.41
0.802TrpPhe: 0.802 ± 0.602
2.004TrpGly: 2.004 ± 0.786
0.401TrpHis: 0.401 ± 0.363
1.603TrpIle: 1.603 ± 0.931
1.603TrpLys: 1.603 ± 0.719
2.806TrpLeu: 2.806 ± 1.207
0.0TrpMet: 0.0 ± 0.0
0.401TrpAsn: 0.401 ± 0.345
0.401TrpPro: 0.401 ± 0.45
0.401TrpGln: 0.401 ± 0.363
0.401TrpArg: 0.401 ± 0.345
0.0TrpSer: 0.0 ± 0.0
1.603TrpThr: 1.603 ± 1.003
0.802TrpVal: 0.802 ± 0.397
0.0TrpTrp: 0.0 ± 0.0
0.401TrpTyr: 0.401 ± 0.35
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.206TyrAla: 3.206 ± 2.053
0.401TyrCys: 0.401 ± 0.541
2.806TyrAsp: 2.806 ± 0.639
2.004TyrGlu: 2.004 ± 0.885
1.603TyrPhe: 1.603 ± 0.651
1.603TyrGly: 1.603 ± 0.624
0.401TyrHis: 0.401 ± 0.345
1.603TyrIle: 1.603 ± 1.332
2.806TyrLys: 2.806 ± 0.922
3.206TyrLeu: 3.206 ± 0.859
1.603TyrMet: 1.603 ± 0.603
0.0TyrAsn: 0.0 ± 0.0
1.603TyrPro: 1.603 ± 0.871
0.802TyrGln: 0.802 ± 0.43
2.405TyrArg: 2.405 ± 1.181
2.004TyrSer: 2.004 ± 0.677
2.004TyrThr: 2.004 ± 1.176
5.21TyrVal: 5.21 ± 1.255
0.802TyrTrp: 0.802 ± 0.397
1.202TyrTyr: 1.202 ± 0.9
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (2496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski