Amino acid dipepetide frequency for Dehalobacter sp. CF

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.454AlaAla: 7.454 ± 0.129	0.955AlaCys: 0.955 ± 0.035	4.136AlaAsp: 4.136 ± 0.072	5.854AlaGlu: 5.854 ± 0.093	2.907AlaPhe: 2.907 ± 0.062	6.26AlaGly: 6.26 ± 0.086	1.123AlaHis: 1.123 ± 0.041	5.078AlaIle: 5.078 ± 0.099	4.699AlaLys: 4.699 ± 0.075	7.938AlaLeu: 7.938 ± 0.116	1.964AlaMet: 1.964 ± 0.052	2.812AlaAsn: 2.812 ± 0.065	2.115AlaPro: 2.115 ± 0.058	2.532AlaGln: 2.532 ± 0.055	3.567AlaArg: 3.567 ± 0.063	4.281AlaSer: 4.281 ± 0.065	3.182AlaThr: 3.182 ± 0.066	6.442AlaVal: 6.442 ± 0.1	0.589AlaTrp: 0.589 ± 0.024	2.513AlaTyr: 2.513 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.775CysAla: 0.775 ± 0.03	0.248CysCys: 0.248 ± 0.017	0.588CysAsp: 0.588 ± 0.025	0.611CysGlu: 0.611 ± 0.027	0.483CysPhe: 0.483 ± 0.024	1.146CysGly: 1.146 ± 0.043	0.264CysHis: 0.264 ± 0.017	0.791CysIle: 0.791 ± 0.033	0.612CysLys: 0.612 ± 0.027	1.147CysLeu: 1.147 ± 0.04	0.288CysMet: 0.288 ± 0.021	0.469CysAsn: 0.469 ± 0.025	0.672CysPro: 0.672 ± 0.036	0.423CysGln: 0.423 ± 0.022	0.722CysArg: 0.722 ± 0.034	0.834CysSer: 0.834 ± 0.034	0.644CysThr: 0.644 ± 0.029	0.653CysVal: 0.653 ± 0.033	0.119CysTrp: 0.119 ± 0.012	0.423CysTyr: 0.423 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.377AspAla: 3.377 ± 0.067	0.681AspCys: 0.681 ± 0.03	2.432AspAsp: 2.432 ± 0.059	3.636AspGlu: 3.636 ± 0.069	2.558AspPhe: 2.558 ± 0.059	3.388AspGly: 3.388 ± 0.068	1.011AspHis: 1.011 ± 0.037	4.553AspIle: 4.553 ± 0.08	3.3AspLys: 3.3 ± 0.066	5.341AspLeu: 5.341 ± 0.085	1.361AspMet: 1.361 ± 0.042	2.041AspAsn: 2.041 ± 0.055	2.246AspPro: 2.246 ± 0.059	1.88AspGln: 1.88 ± 0.05	2.522AspArg: 2.522 ± 0.062	3.026AspSer: 3.026 ± 0.068	2.652AspThr: 2.652 ± 0.067	3.218AspVal: 3.218 ± 0.067	0.545AspTrp: 0.545 ± 0.031	2.31AspTyr: 2.31 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.32GluAla: 5.32 ± 0.076	0.612GluCys: 0.612 ± 0.029	3.422GluAsp: 3.422 ± 0.071	5.573GluGlu: 5.573 ± 0.113	2.419GluPhe: 2.419 ± 0.055	4.184GluGly: 4.184 ± 0.077	1.16GluHis: 1.16 ± 0.04	6.247GluIle: 6.247 ± 0.102	6.075GluLys: 6.075 ± 0.093	6.799GluLeu: 6.799 ± 0.094	2.201GluMet: 2.201 ± 0.053	3.641GluAsn: 3.641 ± 0.065	2.006GluPro: 2.006 ± 0.045	3.021GluGln: 3.021 ± 0.061	3.392GluArg: 3.392 ± 0.067	3.364GluSer: 3.364 ± 0.068	3.536GluThr: 3.536 ± 0.077	4.603GluVal: 4.603 ± 0.091	0.644GluTrp: 0.644 ± 0.031	2.498GluTyr: 2.498 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.899PheAla: 2.899 ± 0.064	0.588PheCys: 0.588 ± 0.027	2.173PheAsp: 2.173 ± 0.05	2.48PheGlu: 2.48 ± 0.053	1.945PhePhe: 1.945 ± 0.057	3.15PheGly: 3.15 ± 0.076	0.727PheHis: 0.727 ± 0.028	3.092PheIle: 3.092 ± 0.068	2.154PheLys: 2.154 ± 0.052	4.29PheLeu: 4.29 ± 0.082	0.981PheMet: 0.981 ± 0.039	1.641PheAsn: 1.641 ± 0.045	1.595PhePro: 1.595 ± 0.047	1.394PheGln: 1.394 ± 0.046	1.817PheArg: 1.817 ± 0.052	3.043PheSer: 3.043 ± 0.08	2.18PheThr: 2.18 ± 0.044	2.552PheVal: 2.552 ± 0.056	0.493PheTrp: 0.493 ± 0.026	1.48PheTyr: 1.48 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.715GlyAla: 4.715 ± 0.089	1.03GlyCys: 1.03 ± 0.04	3.211GlyAsp: 3.211 ± 0.071	4.427GlyGlu: 4.427 ± 0.079	3.137GlyPhe: 3.137 ± 0.059	4.821GlyGly: 4.821 ± 0.088	1.207GlyHis: 1.207 ± 0.042	6.52GlyIle: 6.52 ± 0.083	5.17GlyLys: 5.17 ± 0.083	7.006GlyLeu: 7.006 ± 0.092	2.124GlyMet: 2.124 ± 0.053	2.859GlyAsn: 2.859 ± 0.065	1.772GlyPro: 1.772 ± 0.049	2.562GlyGln: 2.562 ± 0.059	3.248GlyArg: 3.248 ± 0.069	4.303GlySer: 4.303 ± 0.072	4.119GlyThr: 4.119 ± 0.075	4.751GlyVal: 4.751 ± 0.078	0.741GlyTrp: 0.741 ± 0.027	2.904GlyTyr: 2.904 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.091HisAla: 1.091 ± 0.034	0.288HisCys: 0.288 ± 0.019	0.875HisAsp: 0.875 ± 0.029	0.987HisGlu: 0.987 ± 0.037	0.775HisPhe: 0.775 ± 0.03	1.231HisGly: 1.231 ± 0.039	0.468HisHis: 0.468 ± 0.025	1.256HisIle: 1.256 ± 0.037	0.926HisLys: 0.926 ± 0.035	1.879HisLeu: 1.879 ± 0.055	0.413HisMet: 0.413 ± 0.021	0.673HisAsn: 0.673 ± 0.028	0.98HisPro: 0.98 ± 0.039	0.688HisGln: 0.688 ± 0.027	0.797HisArg: 0.797 ± 0.032	1.019HisSer: 1.019 ± 0.031	0.899HisThr: 0.899 ± 0.033	0.971HisVal: 0.971 ± 0.041	0.185HisTrp: 0.185 ± 0.015	0.726HisTyr: 0.726 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.206IleAla: 6.206 ± 0.102	0.974IleCys: 0.974 ± 0.035	4.154IleAsp: 4.154 ± 0.075	5.137IleGlu: 5.137 ± 0.091	3.086IlePhe: 3.086 ± 0.066	5.489IleGly: 5.489 ± 0.083	1.34IleHis: 1.34 ± 0.037	5.925IleIle: 5.925 ± 0.096	4.598IleLys: 4.598 ± 0.098	7.998IleLeu: 7.998 ± 0.113	1.966IleMet: 1.966 ± 0.057	3.44IleAsn: 3.44 ± 0.066	3.548IlePro: 3.548 ± 0.066	2.719IleGln: 2.719 ± 0.055	3.789IleArg: 3.789 ± 0.073	5.238IleSer: 5.238 ± 0.081	4.349IleThr: 4.349 ± 0.068	5.121IleVal: 5.121 ± 0.088	0.629IleTrp: 0.629 ± 0.026	2.462IleTyr: 2.462 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.192LysAla: 5.192 ± 0.075	0.616LysCys: 0.616 ± 0.029	3.623LysAsp: 3.623 ± 0.058	5.496LysGlu: 5.496 ± 0.094	1.853LysPhe: 1.853 ± 0.046	4.067LysGly: 4.067 ± 0.067	1.064LysHis: 1.064 ± 0.04	5.501LysIle: 5.501 ± 0.076	5.018LysLys: 5.018 ± 0.087	5.586LysLeu: 5.586 ± 0.094	2.067LysMet: 2.067 ± 0.052	3.449LysAsn: 3.449 ± 0.071	2.246LysPro: 2.246 ± 0.051	2.469LysGln: 2.469 ± 0.056	2.8LysArg: 2.8 ± 0.054	3.415LysSer: 3.415 ± 0.077	3.801LysThr: 3.801 ± 0.067	4.531LysVal: 4.531 ± 0.081	0.579LysTrp: 0.579 ± 0.023	2.422LysTyr: 2.422 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	8.545LeuAla: 8.545 ± 0.114	1.157LeuCys: 1.157 ± 0.04	5.237LeuAsp: 5.237 ± 0.081	6.888LeuGlu: 6.888 ± 0.103	4.088LeuPhe: 4.088 ± 0.081	6.986LeuGly: 6.986 ± 0.09	1.626LeuHis: 1.626 ± 0.045	7.203LeuIle: 7.203 ± 0.111	6.926LeuLys: 6.926 ± 0.09	9.943LeuLeu: 9.943 ± 0.146	2.47LeuMet: 2.47 ± 0.053	4.458LeuAsn: 4.458 ± 0.072	4.151LeuPro: 4.151 ± 0.078	3.607LeuGln: 3.607 ± 0.073	4.447LeuArg: 4.447 ± 0.086	6.734LeuSer: 6.734 ± 0.097	5.752LeuThr: 5.752 ± 0.082	6.077LeuVal: 6.077 ± 0.081	0.868LeuTrp: 0.868 ± 0.033	2.961LeuTyr: 2.961 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.265MetAla: 2.265 ± 0.054	0.208MetCys: 0.208 ± 0.016	1.558MetAsp: 1.558 ± 0.043	1.867MetGlu: 1.867 ± 0.057	0.951MetPhe: 0.951 ± 0.031	1.781MetGly: 1.781 ± 0.051	0.367MetHis: 0.367 ± 0.019	2.159MetIle: 2.159 ± 0.055	1.979MetLys: 1.979 ± 0.053	2.588MetLeu: 2.588 ± 0.055	0.842MetMet: 0.842 ± 0.036	1.351MetAsn: 1.351 ± 0.046	1.063MetPro: 1.063 ± 0.038	0.937MetGln: 0.937 ± 0.035	1.142MetArg: 1.142 ± 0.035	1.586MetSer: 1.586 ± 0.052	1.518MetThr: 1.518 ± 0.043	1.833MetVal: 1.833 ± 0.049	0.145MetTrp: 0.145 ± 0.013	0.626MetTyr: 0.626 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.11AsnAla: 3.11 ± 0.073	0.553AsnCys: 0.553 ± 0.024	2.028AsnAsp: 2.028 ± 0.049	2.602AsnGlu: 2.602 ± 0.058	1.648AsnPhe: 1.648 ± 0.048	3.012AsnGly: 3.012 ± 0.059	0.86AsnHis: 0.86 ± 0.03	3.856AsnIle: 3.856 ± 0.074	2.882AsnLys: 2.882 ± 0.062	4.322AsnLeu: 4.322 ± 0.074	1.221AsnMet: 1.221 ± 0.034	2.113AsnAsn: 2.113 ± 0.06	2.107AsnPro: 2.107 ± 0.046	1.799AsnGln: 1.799 ± 0.041	2.143AsnArg: 2.143 ± 0.052	2.545AsnSer: 2.545 ± 0.058	2.336AsnThr: 2.336 ± 0.05	2.655AsnVal: 2.655 ± 0.059	0.435AsnTrp: 0.435 ± 0.024	1.701AsnTyr: 1.701 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.761ProAla: 2.761 ± 0.065	0.419ProCys: 0.419 ± 0.025	2.576ProAsp: 2.576 ± 0.061	3.643ProGlu: 3.643 ± 0.068	1.602ProPhe: 1.602 ± 0.046	2.824ProGly: 2.824 ± 0.062	0.63ProHis: 0.63 ± 0.026	2.287ProIle: 2.287 ± 0.056	2.11ProLys: 2.11 ± 0.054	3.592ProLeu: 3.592 ± 0.063	0.848ProMet: 0.848 ± 0.034	1.436ProAsn: 1.436 ± 0.035	1.071ProPro: 1.071 ± 0.038	1.313ProGln: 1.313 ± 0.041	1.372ProArg: 1.372 ± 0.043	2.182ProSer: 2.182 ± 0.055	1.714ProThr: 1.714 ± 0.05	3.184ProVal: 3.184 ± 0.062	0.389ProTrp: 0.389 ± 0.023	1.397ProTyr: 1.397 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.153GlnAla: 3.153 ± 0.068	0.314GlnCys: 0.314 ± 0.02	1.993GlnAsp: 1.993 ± 0.048	3.081GlnGlu: 3.081 ± 0.068	1.141GlnPhe: 1.141 ± 0.036	2.402GlnGly: 2.402 ± 0.058	0.562GlnHis: 0.562 ± 0.027	2.724GlnIle: 2.724 ± 0.055	2.91GlnLys: 2.91 ± 0.067	3.268GlnLeu: 3.268 ± 0.072	1.018GlnMet: 1.018 ± 0.031	1.944GlnAsn: 1.944 ± 0.057	1.132GlnPro: 1.132 ± 0.035	1.529GlnGln: 1.529 ± 0.051	1.806GlnArg: 1.806 ± 0.051	2.042GlnSer: 2.042 ± 0.055	1.952GlnThr: 1.952 ± 0.055	2.365GlnVal: 2.365 ± 0.064	0.338GlnTrp: 0.338 ± 0.02	1.262GlnTyr: 1.262 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.684ArgAla: 2.684 ± 0.055	0.501ArgCys: 0.501 ± 0.028	2.291ArgAsp: 2.291 ± 0.057	3.837ArgGlu: 3.837 ± 0.08	1.975ArgPhe: 1.975 ± 0.045	2.642ArgGly: 2.642 ± 0.059	0.829ArgHis: 0.829 ± 0.031	3.982ArgIle: 3.982 ± 0.079	3.392ArgLys: 3.392 ± 0.07	4.867ArgLeu: 4.867 ± 0.089	1.44ArgMet: 1.44 ± 0.045	2.183ArgAsn: 2.183 ± 0.053	1.533ArgPro: 1.533 ± 0.046	1.934ArgGln: 1.934 ± 0.052	2.311ArgArg: 2.311 ± 0.057	2.465ArgSer: 2.465 ± 0.056	2.359ArgThr: 2.359 ± 0.056	2.782ArgVal: 2.782 ± 0.059	0.505ArgTrp: 0.505 ± 0.024	1.8ArgTyr: 1.8 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.409SerAla: 4.409 ± 0.078	0.646SerCys: 0.646 ± 0.029	2.961SerAsp: 2.961 ± 0.062	4.031SerGlu: 4.031 ± 0.075	2.841SerPhe: 2.841 ± 0.056	5.215SerGly: 5.215 ± 0.081	1.026SerHis: 1.026 ± 0.039	4.412SerIle: 4.412 ± 0.084	3.502SerLys: 3.502 ± 0.065	6.173SerLeu: 6.173 ± 0.088	1.518SerMet: 1.518 ± 0.043	2.281SerAsn: 2.281 ± 0.054	2.358SerPro: 2.358 ± 0.058	2.169SerGln: 2.169 ± 0.056	2.922SerArg: 2.922 ± 0.059	4.179SerSer: 4.179 ± 0.086	3.017SerThr: 3.017 ± 0.057	4.174SerVal: 4.174 ± 0.068	0.597SerTrp: 0.597 ± 0.023	2.116SerTyr: 2.116 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.681ThrAla: 4.681 ± 0.083	0.553ThrCys: 0.553 ± 0.026	2.932ThrAsp: 2.932 ± 0.06	3.581ThrGlu: 3.581 ± 0.079	2.103ThrPhe: 2.103 ± 0.065	4.609ThrGly: 4.609 ± 0.074	0.911ThrHis: 0.911 ± 0.038	3.732ThrIle: 3.732 ± 0.064	2.826ThrLys: 2.826 ± 0.056	5.129ThrLeu: 5.129 ± 0.077	1.281ThrMet: 1.281 ± 0.039	2.128ThrAsn: 2.128 ± 0.054	2.281ThrPro: 2.281 ± 0.051	1.568ThrGln: 1.568 ± 0.043	2.147ThrArg: 2.147 ± 0.053	3.082ThrSer: 3.082 ± 0.065	2.777ThrThr: 2.777 ± 0.074	4.262ThrVal: 4.262 ± 0.074	0.444ThrTrp: 0.444 ± 0.024	1.695ThrTyr: 1.695 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.599ValAla: 4.599 ± 0.085	0.926ValCys: 0.926 ± 0.032	3.441ValAsp: 3.441 ± 0.069	4.162ValGlu: 4.162 ± 0.08	3.07ValPhe: 3.07 ± 0.085	4.261ValGly: 4.261 ± 0.075	1.085ValHis: 1.085 ± 0.037	5.722ValIle: 5.722 ± 0.087	4.196ValLys: 4.196 ± 0.073	7.414ValLeu: 7.414 ± 0.103	1.788ValMet: 1.788 ± 0.047	2.978ValAsn: 2.978 ± 0.065	2.587ValPro: 2.587 ± 0.063	2.411ValGln: 2.411 ± 0.056	3.111ValArg: 3.111 ± 0.067	4.505ValSer: 4.505 ± 0.07	3.639ValThr: 3.639 ± 0.07	4.533ValVal: 4.533 ± 0.082	0.618ValTrp: 0.618 ± 0.029	2.185ValTyr: 2.185 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.632TrpAla: 0.632 ± 0.031	0.11TrpCys: 0.11 ± 0.012	0.503TrpAsp: 0.503 ± 0.024	0.632TrpGlu: 0.632 ± 0.029	0.332TrpPhe: 0.332 ± 0.023	0.65TrpGly: 0.65 ± 0.03	0.163TrpHis: 0.163 ± 0.012	0.632TrpIle: 0.632 ± 0.026	0.611TrpLys: 0.611 ± 0.028	1.106TrpLeu: 1.106 ± 0.039	0.236TrpMet: 0.236 ± 0.016	0.503TrpAsn: 0.503 ± 0.023	0.318TrpPro: 0.318 ± 0.021	0.464TrpGln: 0.464 ± 0.024	0.473TrpArg: 0.473 ± 0.023	0.526TrpSer: 0.526 ± 0.026	0.468TrpThr: 0.468 ± 0.027	0.553TrpVal: 0.553 ± 0.026	0.107TrpTrp: 0.107 ± 0.012	0.325TrpTyr: 0.325 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.533TyrAla: 2.533 ± 0.053	0.532TyrCys: 0.532 ± 0.027	1.942TyrAsp: 1.942 ± 0.051	2.19TyrGlu: 2.19 ± 0.047	1.759TyrPhe: 1.759 ± 0.058	2.51TyrGly: 2.51 ± 0.056	0.704TyrHis: 0.704 ± 0.028	2.497TyrIle: 2.497 ± 0.052	1.909TyrLys: 1.909 ± 0.05	3.743TyrLeu: 3.743 ± 0.079	0.739TyrMet: 0.739 ± 0.032	1.526TyrAsn: 1.526 ± 0.046	1.572TyrPro: 1.572 ± 0.045	1.514TyrGln: 1.514 ± 0.05	1.783TyrArg: 1.783 ± 0.048	2.178TyrSer: 2.178 ± 0.059	1.828TyrThr: 1.828 ± 0.05	1.972TyrVal: 1.972 ± 0.049	0.376TyrTrp: 0.376 ± 0.023	1.427TyrTyr: 1.427 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2936 proteins (860573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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