Amino acid dipepetide frequency for Mycoplasma orale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.756AlaAla: 2.756 ± 0.127
0.343AlaCys: 0.343 ± 0.044
2.21AlaAsp: 2.21 ± 0.107
2.8AlaGlu: 2.8 ± 0.131
2.945AlaPhe: 2.945 ± 0.185
2.087AlaGly: 2.087 ± 0.114
0.669AlaHis: 0.669 ± 0.055
5.538AlaIle: 5.538 ± 0.176
6.476AlaLys: 6.476 ± 0.233
5.34AlaLeu: 5.34 ± 0.179
0.96AlaMet: 0.96 ± 0.059
4.085AlaAsn: 4.085 ± 0.154
1.114AlaPro: 1.114 ± 0.079
1.541AlaGln: 1.541 ± 0.097
1.801AlaArg: 1.801 ± 0.107
3.65AlaSer: 3.65 ± 0.141
2.866AlaThr: 2.866 ± 0.127
1.884AlaVal: 1.884 ± 0.105
0.37AlaTrp: 0.37 ± 0.042
1.99AlaTyr: 1.99 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.506CysAla: 0.506 ± 0.041
0.062CysCys: 0.062 ± 0.017
0.37CysAsp: 0.37 ± 0.041
0.418CysGlu: 0.418 ± 0.038
0.339CysPhe: 0.339 ± 0.036
0.405CysGly: 0.405 ± 0.047
0.114CysHis: 0.114 ± 0.024
0.515CysIle: 0.515 ± 0.042
0.568CysLys: 0.568 ± 0.056
0.7CysLeu: 0.7 ± 0.058
0.123CysMet: 0.123 ± 0.023
0.409CysAsn: 0.409 ± 0.041
0.233CysPro: 0.233 ± 0.036
0.22CysGln: 0.22 ± 0.031
0.15CysArg: 0.15 ± 0.025
0.427CysSer: 0.427 ± 0.05
0.352CysThr: 0.352 ± 0.039
0.343CysVal: 0.343 ± 0.041
0.053CysTrp: 0.053 ± 0.016
0.22CysTyr: 0.22 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
2.879AspAla: 2.879 ± 0.138
0.291AspCys: 0.291 ± 0.038
2.619AspAsp: 2.619 ± 0.148
4.473AspGlu: 4.473 ± 0.158
3.619AspPhe: 3.619 ± 0.134
2.316AspGly: 2.316 ± 0.103
0.709AspHis: 0.709 ± 0.053
5.714AspIle: 5.714 ± 0.169
6.093AspLys: 6.093 ± 0.159
5.375AspLeu: 5.375 ± 0.179
0.784AspMet: 0.784 ± 0.065
3.68AspAsn: 3.68 ± 0.127
1.735AspPro: 1.735 ± 0.115
1.321AspGln: 1.321 ± 0.069
1.118AspArg: 1.118 ± 0.061
3.038AspSer: 3.038 ± 0.125
2.289AspThr: 2.289 ± 0.103
2.782AspVal: 2.782 ± 0.102
0.493AspTrp: 0.493 ± 0.043
2.725AspTyr: 2.725 ± 0.124
0.0AspXaa: 0.0 ± 0.0
Glu
3.746GluAla: 3.746 ± 0.137
0.392GluCys: 0.392 ± 0.036
3.491GluAsp: 3.491 ± 0.111
5.472GluGlu: 5.472 ± 0.201
3.544GluPhe: 3.544 ± 0.12
2.412GluGly: 2.412 ± 0.118
0.933GluHis: 0.933 ± 0.057
7.528GluIle: 7.528 ± 0.185
8.017GluLys: 8.017 ± 0.209
7.207GluLeu: 7.207 ± 0.236
1.167GluMet: 1.167 ± 0.066
6.128GluAsn: 6.128 ± 0.204
1.352GluPro: 1.352 ± 0.09
2.219GluGln: 2.219 ± 0.116
1.796GluArg: 1.796 ± 0.106
3.174GluSer: 3.174 ± 0.131
3.293GluThr: 3.293 ± 0.125
3.575GluVal: 3.575 ± 0.137
0.55GluTrp: 0.55 ± 0.05
3.597GluTyr: 3.597 ± 0.154
0.0GluXaa: 0.0 ± 0.0
Phe
3.24PheAla: 3.24 ± 0.148
0.427PheCys: 0.427 ± 0.043
3.892PheAsp: 3.892 ± 0.123
4.011PheGlu: 4.011 ± 0.151
2.646PhePhe: 2.646 ± 0.134
2.655PheGly: 2.655 ± 0.126
0.625PheHis: 0.625 ± 0.046
5.102PheIle: 5.102 ± 0.188
5.358PheLys: 5.358 ± 0.168
4.878PheLeu: 4.878 ± 0.18
0.823PheMet: 0.823 ± 0.067
4.618PheAsn: 4.618 ± 0.147
1.255PhePro: 1.255 ± 0.074
1.127PheGln: 1.127 ± 0.077
1.316PheArg: 1.316 ± 0.074
4.552PheSer: 4.552 ± 0.188
2.302PheThr: 2.302 ± 0.116
2.963PheVal: 2.963 ± 0.114
0.59PheTrp: 0.59 ± 0.054
2.338PheTyr: 2.338 ± 0.1
0.0PheXaa: 0.0 ± 0.0
Gly
2.153GlyAla: 2.153 ± 0.112
0.251GlyCys: 0.251 ± 0.039
2.122GlyAsp: 2.122 ± 0.107
2.25GlyGlu: 2.25 ± 0.107
2.426GlyPhe: 2.426 ± 0.101
2.646GlyGly: 2.646 ± 0.136
0.924GlyHis: 0.924 ± 0.066
4.526GlyIle: 4.526 ± 0.165
5.107GlyLys: 5.107 ± 0.174
4.063GlyLeu: 4.063 ± 0.165
0.916GlyMet: 0.916 ± 0.064
2.452GlyAsn: 2.452 ± 0.106
0.929GlyPro: 0.929 ± 0.065
1.382GlyGln: 1.382 ± 0.078
1.501GlyArg: 1.501 ± 0.101
2.888GlySer: 2.888 ± 0.125
2.368GlyThr: 2.368 ± 0.11
2.104GlyVal: 2.104 ± 0.118
0.427GlyTrp: 0.427 ± 0.042
2.043GlyTyr: 2.043 ± 0.103
0.0GlyXaa: 0.0 ± 0.0
His
0.757HisAla: 0.757 ± 0.065
0.088HisCys: 0.088 ± 0.021
0.674HisAsp: 0.674 ± 0.059
0.74HisGlu: 0.74 ± 0.065
0.797HisPhe: 0.797 ± 0.074
0.744HisGly: 0.744 ± 0.059
0.255HisHis: 0.255 ± 0.034
1.255HisIle: 1.255 ± 0.075
1.237HisLys: 1.237 ± 0.087
1.224HisLeu: 1.224 ± 0.072
0.22HisMet: 0.22 ± 0.029
1.008HisAsn: 1.008 ± 0.065
0.546HisPro: 0.546 ± 0.048
0.321HisGln: 0.321 ± 0.04
0.414HisArg: 0.414 ± 0.04
0.995HisSer: 0.995 ± 0.073
0.687HisThr: 0.687 ± 0.05
0.559HisVal: 0.559 ± 0.053
0.145HisTrp: 0.145 ± 0.027
0.625HisTyr: 0.625 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
5.27IleAla: 5.27 ± 0.179
0.889IleCys: 0.889 ± 0.067
5.785IleAsp: 5.785 ± 0.157
6.599IleGlu: 6.599 ± 0.175
5.503IlePhe: 5.503 ± 0.227
4.226IleGly: 4.226 ± 0.171
1.123IleHis: 1.123 ± 0.074
9.324IleIle: 9.324 ± 0.297
10.539IleLys: 10.539 ± 0.218
9.016IleLeu: 9.016 ± 0.267
1.602IleMet: 1.602 ± 0.092
9.047IleAsn: 9.047 ± 0.223
2.756IlePro: 2.756 ± 0.13
2.501IleGln: 2.501 ± 0.112
2.457IleArg: 2.457 ± 0.104
7.229IleSer: 7.229 ± 0.181
5.08IleThr: 5.08 ± 0.167
5.477IleVal: 5.477 ± 0.187
0.819IleTrp: 0.819 ± 0.06
3.865IleTyr: 3.865 ± 0.144
0.0IleXaa: 0.0 ± 0.0
Lys
5.204LysAla: 5.204 ± 0.173
0.515LysCys: 0.515 ± 0.042
6.256LysAsp: 6.256 ± 0.182
9.483LysGlu: 9.483 ± 0.275
5.036LysPhe: 5.036 ± 0.194
3.768LysGly: 3.768 ± 0.14
1.391LysHis: 1.391 ± 0.082
10.887LysIle: 10.887 ± 0.245
11.873LysLys: 11.873 ± 0.273
10.064LysLeu: 10.064 ± 0.208
2.404LysMet: 2.404 ± 0.101
10.235LysAsn: 10.235 ± 0.23
3.046LysPro: 3.046 ± 0.13
3.333LysGln: 3.333 ± 0.136
2.857LysArg: 2.857 ± 0.116
6.071LysSer: 6.071 ± 0.138
5.609LysThr: 5.609 ± 0.189
5.719LysVal: 5.719 ± 0.19
0.955LysTrp: 0.955 ± 0.076
5.771LysTyr: 5.771 ± 0.18
0.0LysXaa: 0.0 ± 0.0
Leu
5.287LeuAla: 5.287 ± 0.171
0.797LeuCys: 0.797 ± 0.058
5.855LeuAsp: 5.855 ± 0.165
7.189LeuGlu: 7.189 ± 0.187
4.939LeuPhe: 4.939 ± 0.184
4.46LeuGly: 4.46 ± 0.15
1.285LeuHis: 1.285 ± 0.08
9.58LeuIle: 9.58 ± 0.264
10.095LeuLys: 10.095 ± 0.219
8.818LeuLeu: 8.818 ± 0.214
1.616LeuMet: 1.616 ± 0.089
8.285LeuAsn: 8.285 ± 0.221
3.095LeuPro: 3.095 ± 0.135
2.36LeuGln: 2.36 ± 0.1
2.624LeuArg: 2.624 ± 0.104
6.995LeuSer: 6.995 ± 0.165
4.829LeuThr: 4.829 ± 0.179
5.116LeuVal: 5.116 ± 0.162
0.586LeuTrp: 0.586 ± 0.052
3.46LeuTyr: 3.46 ± 0.137
0.0LeuXaa: 0.0 ± 0.0
Met
1.065MetAla: 1.065 ± 0.075
0.106MetCys: 0.106 ± 0.024
0.841MetAsp: 0.841 ± 0.062
0.933MetGlu: 0.933 ± 0.067
1.109MetPhe: 1.109 ± 0.076
0.634MetGly: 0.634 ± 0.055
0.216MetHis: 0.216 ± 0.032
1.431MetIle: 1.431 ± 0.082
1.897MetLys: 1.897 ± 0.087
1.897MetLeu: 1.897 ± 0.092
0.277MetMet: 0.277 ± 0.033
1.14MetAsn: 1.14 ± 0.084
0.722MetPro: 0.722 ± 0.051
0.608MetGln: 0.608 ± 0.058
0.392MetArg: 0.392 ± 0.042
1.259MetSer: 1.259 ± 0.073
0.995MetThr: 0.995 ± 0.063
0.819MetVal: 0.819 ± 0.056
0.123MetTrp: 0.123 ± 0.023
0.564MetTyr: 0.564 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
3.72AsnAla: 3.72 ± 0.13
0.489AsnCys: 0.489 ± 0.052
4.486AsnAsp: 4.486 ± 0.185
6.04AsnGlu: 6.04 ± 0.175
4.451AsnPhe: 4.451 ± 0.174
3.517AsnGly: 3.517 ± 0.144
0.784AsnHis: 0.784 ± 0.069
8.409AsnIle: 8.409 ± 0.249
10.398AsnLys: 10.398 ± 0.233
7.836AsnLeu: 7.836 ± 0.205
1.308AsnMet: 1.308 ± 0.077
7.59AsnAsn: 7.59 ± 0.259
2.285AsnPro: 2.285 ± 0.095
2.298AsnGln: 2.298 ± 0.092
1.757AsnArg: 1.757 ± 0.109
5.327AsnSer: 5.327 ± 0.2
3.121AsnThr: 3.121 ± 0.131
4.2AsnVal: 4.2 ± 0.162
0.748AsnTrp: 0.748 ± 0.065
3.905AsnTyr: 3.905 ± 0.152
0.0AsnXaa: 0.0 ± 0.0
Pro
1.33ProAla: 1.33 ± 0.084
0.15ProCys: 0.15 ± 0.024
1.246ProAsp: 1.246 ± 0.076
1.801ProGlu: 1.801 ± 0.078
1.497ProPhe: 1.497 ± 0.08
1.202ProGly: 1.202 ± 0.077
0.511ProHis: 0.511 ± 0.046
2.549ProIle: 2.549 ± 0.116
2.721ProLys: 2.721 ± 0.109
2.575ProLeu: 2.575 ± 0.113
0.313ProMet: 0.313 ± 0.042
2.21ProAsn: 2.21 ± 0.096
0.462ProPro: 0.462 ± 0.049
0.775ProGln: 0.775 ± 0.057
0.634ProArg: 0.634 ± 0.055
1.955ProSer: 1.955 ± 0.093
1.739ProThr: 1.739 ± 0.083
1.233ProVal: 1.233 ± 0.086
0.26ProTrp: 0.26 ± 0.036
1.334ProTyr: 1.334 ± 0.077
0.0ProXaa: 0.0 ± 0.0
Gln
1.4GlnAla: 1.4 ± 0.078
0.128GlnCys: 0.128 ± 0.024
1.303GlnAsp: 1.303 ± 0.077
1.836GlnGlu: 1.836 ± 0.099
1.466GlnPhe: 1.466 ± 0.089
1.123GlnGly: 1.123 ± 0.07
0.409GlnHis: 0.409 ± 0.047
3.104GlnIle: 3.104 ± 0.115
3.262GlnLys: 3.262 ± 0.121
2.553GlnLeu: 2.553 ± 0.122
0.445GlnMet: 0.445 ± 0.041
2.606GlnAsn: 2.606 ± 0.122
0.594GlnPro: 0.594 ± 0.058
0.784GlnGln: 0.784 ± 0.067
0.973GlnArg: 0.973 ± 0.062
1.422GlnSer: 1.422 ± 0.07
1.519GlnThr: 1.519 ± 0.085
1.325GlnVal: 1.325 ± 0.079
0.198GlnTrp: 0.198 ± 0.03
1.325GlnTyr: 1.325 ± 0.078
0.0GlnXaa: 0.0 ± 0.0
Arg
1.321ArgAla: 1.321 ± 0.063
0.15ArgCys: 0.15 ± 0.027
1.418ArgAsp: 1.418 ± 0.088
1.831ArgGlu: 1.831 ± 0.11
1.303ArgPhe: 1.303 ± 0.074
1.285ArgGly: 1.285 ± 0.09
0.361ArgHis: 0.361 ± 0.043
2.655ArgIle: 2.655 ± 0.117
2.91ArgLys: 2.91 ± 0.138
2.443ArgLeu: 2.443 ± 0.109
0.599ArgMet: 0.599 ± 0.054
2.118ArgAsn: 2.118 ± 0.108
0.696ArgPro: 0.696 ± 0.058
0.955ArgGln: 0.955 ± 0.059
0.96ArgArg: 0.96 ± 0.074
1.484ArgSer: 1.484 ± 0.085
1.352ArgThr: 1.352 ± 0.081
1.36ArgVal: 1.36 ± 0.083
0.225ArgTrp: 0.225 ± 0.033
1.202ArgTyr: 1.202 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
3.099SerAla: 3.099 ± 0.125
0.453SerCys: 0.453 ± 0.05
3.39SerAsp: 3.39 ± 0.129
4.156SerGlu: 4.156 ± 0.144
3.931SerPhe: 3.931 ± 0.16
3.046SerGly: 3.046 ± 0.158
0.797SerHis: 0.797 ± 0.054
6.234SerIle: 6.234 ± 0.216
7.568SerLys: 7.568 ± 0.179
7.286SerLeu: 7.286 ± 0.204
1.065SerMet: 1.065 ± 0.066
5.032SerAsn: 5.032 ± 0.194
1.691SerPro: 1.691 ± 0.088
1.941SerGln: 1.941 ± 0.098
1.642SerArg: 1.642 ± 0.085
4.979SerSer: 4.979 ± 0.199
3.491SerThr: 3.491 ± 0.135
3.029SerVal: 3.029 ± 0.112
0.568SerTrp: 0.568 ± 0.051
2.738SerTyr: 2.738 ± 0.127
0.0SerXaa: 0.0 ± 0.0
Thr
1.963ThrAla: 1.963 ± 0.102
0.269ThrCys: 0.269 ± 0.034
2.003ThrAsp: 2.003 ± 0.08
2.672ThrGlu: 2.672 ± 0.113
3.218ThrPhe: 3.218 ± 0.129
2.175ThrGly: 2.175 ± 0.117
0.784ThrHis: 0.784 ± 0.057
5.314ThrIle: 5.314 ± 0.178
5.798ThrLys: 5.798 ± 0.151
5.521ThrLeu: 5.521 ± 0.158
0.726ThrMet: 0.726 ± 0.062
4.411ThrAsn: 4.411 ± 0.129
1.413ThrPro: 1.413 ± 0.101
1.197ThrGln: 1.197 ± 0.072
1.259ThrArg: 1.259 ± 0.08
3.438ThrSer: 3.438 ± 0.16
3.196ThrThr: 3.196 ± 0.141
2.148ThrVal: 2.148 ± 0.126
0.427ThrTrp: 0.427 ± 0.051
2.192ThrTyr: 2.192 ± 0.106
0.0ThrXaa: 0.0 ± 0.0
Val
3.17ValAla: 3.17 ± 0.149
0.365ValCys: 0.365 ± 0.037
2.95ValAsp: 2.95 ± 0.127
3.381ValGlu: 3.381 ± 0.112
2.589ValPhe: 2.589 ± 0.118
2.386ValGly: 2.386 ± 0.105
0.713ValHis: 0.713 ± 0.055
4.622ValIle: 4.622 ± 0.158
5.168ValLys: 5.168 ± 0.15
4.838ValLeu: 4.838 ± 0.163
0.828ValMet: 0.828 ± 0.063
3.403ValAsn: 3.403 ± 0.135
1.325ValPro: 1.325 ± 0.095
1.435ValGln: 1.435 ± 0.08
1.36ValArg: 1.36 ± 0.068
3.694ValSer: 3.694 ± 0.131
2.646ValThr: 2.646 ± 0.124
2.928ValVal: 2.928 ± 0.125
0.467ValTrp: 0.467 ± 0.05
1.968ValTyr: 1.968 ± 0.108
0.0ValXaa: 0.0 ± 0.0
Trp
0.343TrpAla: 0.343 ± 0.036
0.057TrpCys: 0.057 ± 0.017
0.515TrpAsp: 0.515 ± 0.054
0.555TrpGlu: 0.555 ± 0.051
0.564TrpPhe: 0.564 ± 0.05
0.335TrpGly: 0.335 ± 0.037
0.114TrpHis: 0.114 ± 0.025
0.845TrpIle: 0.845 ± 0.065
0.911TrpLys: 0.911 ± 0.073
0.806TrpLeu: 0.806 ± 0.061
0.211TrpMet: 0.211 ± 0.031
0.748TrpAsn: 0.748 ± 0.059
0.203TrpPro: 0.203 ± 0.028
0.251TrpGln: 0.251 ± 0.035
0.326TrpArg: 0.326 ± 0.044
0.396TrpSer: 0.396 ± 0.044
0.541TrpThr: 0.541 ± 0.051
0.506TrpVal: 0.506 ± 0.049
0.128TrpTrp: 0.128 ± 0.025
0.37TrpTyr: 0.37 ± 0.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.219TyrAla: 2.219 ± 0.107
0.308TyrCys: 0.308 ± 0.039
2.628TyrAsp: 2.628 ± 0.095
2.954TyrGlu: 2.954 ± 0.114
2.795TyrPhe: 2.795 ± 0.14
2.056TyrGly: 2.056 ± 0.089
0.572TyrHis: 0.572 ± 0.054
3.975TyrIle: 3.975 ± 0.149
4.482TyrLys: 4.482 ± 0.152
4.829TyrLeu: 4.829 ± 0.169
0.638TyrMet: 0.638 ± 0.042
3.46TyrAsn: 3.46 ± 0.144
1.043TyrPro: 1.043 ± 0.063
1.206TyrGln: 1.206 ± 0.074
1.29TyrArg: 1.29 ± 0.082
3.165TyrSer: 3.165 ± 0.124
1.849TyrThr: 1.849 ± 0.106
2.166TyrVal: 2.166 ± 0.083
0.594TyrTrp: 0.594 ± 0.056
2.021TyrTyr: 2.021 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 631 proteins (227152 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski