Amino acid dipepetide frequency for Proteus phage 10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.616AlaAla: 5.616 ± 0.472
0.769AlaCys: 0.769 ± 0.117
3.671AlaAsp: 3.671 ± 0.274
4.078AlaGlu: 4.078 ± 0.248
2.438AlaPhe: 2.438 ± 0.231
4.412AlaGly: 4.412 ± 0.344
1.175AlaHis: 1.175 ± 0.144
5.529AlaIle: 5.529 ± 0.262
4.542AlaLys: 4.542 ± 0.261
6.284AlaLeu: 6.284 ± 0.331
2.061AlaMet: 2.061 ± 0.178
3.642AlaAsn: 3.642 ± 0.231
2.423AlaPro: 2.423 ± 0.17
1.741AlaGln: 1.741 ± 0.172
2.917AlaArg: 2.917 ± 0.256
4.15AlaSer: 4.15 ± 0.281
4.049AlaThr: 4.049 ± 0.284
4.716AlaVal: 4.716 ± 0.308
0.406AlaTrp: 0.406 ± 0.075
2.481AlaTyr: 2.481 ± 0.2
0.0AlaXaa: 0.0 ± 0.0
Cys
0.508CysAla: 0.508 ± 0.079
0.145CysCys: 0.145 ± 0.042
0.827CysAsp: 0.827 ± 0.107
0.464CysGlu: 0.464 ± 0.086
0.29CysPhe: 0.29 ± 0.065
0.624CysGly: 0.624 ± 0.081
0.189CysHis: 0.189 ± 0.067
0.784CysIle: 0.784 ± 0.122
0.566CysLys: 0.566 ± 0.092
0.624CysLeu: 0.624 ± 0.094
0.29CysMet: 0.29 ± 0.066
0.508CysAsn: 0.508 ± 0.091
0.232CysPro: 0.232 ± 0.058
0.261CysGln: 0.261 ± 0.06
0.609CysArg: 0.609 ± 0.099
0.58CysSer: 0.58 ± 0.098
0.551CysThr: 0.551 ± 0.097
0.9CysVal: 0.9 ± 0.112
0.058CysTrp: 0.058 ± 0.026
0.639CysTyr: 0.639 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
4.005AspAla: 4.005 ± 0.233
0.609AspCys: 0.609 ± 0.096
4.005AspAsp: 4.005 ± 0.322
4.571AspGlu: 4.571 ± 0.288
2.525AspPhe: 2.525 ± 0.231
4.978AspGly: 4.978 ± 0.386
0.842AspHis: 0.842 ± 0.124
5.268AspIle: 5.268 ± 0.266
4.687AspLys: 4.687 ± 0.259
5.094AspLeu: 5.094 ± 0.312
1.538AspMet: 1.538 ± 0.169
3.817AspAsn: 3.817 ± 0.272
2.235AspPro: 2.235 ± 0.212
1.161AspGln: 1.161 ± 0.117
2.307AspArg: 2.307 ± 0.203
3.86AspSer: 3.86 ± 0.203
3.846AspThr: 3.846 ± 0.208
5.166AspVal: 5.166 ± 0.282
0.9AspTrp: 0.9 ± 0.101
2.743AspTyr: 2.743 ± 0.201
0.0AspXaa: 0.0 ± 0.0
Glu
4.557GluAla: 4.557 ± 0.312
0.537GluCys: 0.537 ± 0.084
3.41GluAsp: 3.41 ± 0.226
3.628GluGlu: 3.628 ± 0.255
2.583GluPhe: 2.583 ± 0.2
3.047GluGly: 3.047 ± 0.234
1.582GluHis: 1.582 ± 0.159
3.599GluIle: 3.599 ± 0.233
2.815GluLys: 2.815 ± 0.225
6.806GluLeu: 6.806 ± 0.336
1.756GluMet: 1.756 ± 0.14
2.583GluAsn: 2.583 ± 0.206
2.351GluPro: 2.351 ± 0.232
2.191GluGln: 2.191 ± 0.154
2.728GluArg: 2.728 ± 0.18
4.31GluSer: 4.31 ± 0.295
3.468GluThr: 3.468 ± 0.212
4.716GluVal: 4.716 ± 0.337
0.784GluTrp: 0.784 ± 0.111
2.452GluTyr: 2.452 ± 0.197
0.0GluXaa: 0.0 ± 0.0
Phe
1.887PheAla: 1.887 ± 0.166
0.421PheCys: 0.421 ± 0.084
2.481PheAsp: 2.481 ± 0.186
2.104PheGlu: 2.104 ± 0.167
0.914PhePhe: 0.914 ± 0.118
2.656PheGly: 2.656 ± 0.2
0.653PheHis: 0.653 ± 0.099
3.135PheIle: 3.135 ± 0.259
2.815PheLys: 2.815 ± 0.229
1.901PheLeu: 1.901 ± 0.173
0.871PheMet: 0.871 ± 0.117
2.598PheAsn: 2.598 ± 0.245
1.117PhePro: 1.117 ± 0.138
0.9PheGln: 0.9 ± 0.137
1.437PheArg: 1.437 ± 0.142
2.307PheSer: 2.307 ± 0.208
2.54PheThr: 2.54 ± 0.166
2.394PheVal: 2.394 ± 0.177
0.392PheTrp: 0.392 ± 0.071
1.19PheTyr: 1.19 ± 0.12
0.0PheXaa: 0.0 ± 0.0
Gly
3.773GlyAla: 3.773 ± 0.366
0.624GlyCys: 0.624 ± 0.099
4.76GlyAsp: 4.76 ± 0.343
4.441GlyGlu: 4.441 ± 0.403
2.67GlyPhe: 2.67 ± 0.202
5.369GlyGly: 5.369 ± 0.785
0.914GlyHis: 0.914 ± 0.116
4.295GlyIle: 4.295 ± 0.218
4.76GlyLys: 4.76 ± 0.378
6.051GlyLeu: 6.051 ± 0.307
1.945GlyMet: 1.945 ± 0.177
3.309GlyAsn: 3.309 ± 0.238
1.393GlyPro: 1.393 ± 0.251
1.393GlyGln: 1.393 ± 0.149
2.452GlyArg: 2.452 ± 0.22
5.326GlySer: 5.326 ± 0.389
3.309GlyThr: 3.309 ± 0.26
5.239GlyVal: 5.239 ± 0.287
0.943GlyTrp: 0.943 ± 0.125
3.526GlyTyr: 3.526 ± 0.229
0.0GlyXaa: 0.0 ± 0.0
His
0.972HisAla: 0.972 ± 0.128
0.16HisCys: 0.16 ± 0.05
1.321HisAsp: 1.321 ± 0.165
0.9HisGlu: 0.9 ± 0.115
0.624HisPhe: 0.624 ± 0.101
1.175HisGly: 1.175 ± 0.139
0.566HisHis: 0.566 ± 0.105
1.306HisIle: 1.306 ± 0.137
1.219HisLys: 1.219 ± 0.144
1.857HisLeu: 1.857 ± 0.185
0.595HisMet: 0.595 ± 0.087
1.335HisAsn: 1.335 ± 0.155
1.045HisPro: 1.045 ± 0.136
0.74HisGln: 0.74 ± 0.106
1.059HisArg: 1.059 ± 0.118
0.943HisSer: 0.943 ± 0.117
1.248HisThr: 1.248 ± 0.149
1.553HisVal: 1.553 ± 0.147
0.305HisTrp: 0.305 ± 0.065
1.03HisTyr: 1.03 ± 0.139
0.0HisXaa: 0.0 ± 0.0
Ile
4.658IleAla: 4.658 ± 0.275
0.609IleCys: 0.609 ± 0.082
5.326IleAsp: 5.326 ± 0.292
4.049IleGlu: 4.049 ± 0.222
1.495IlePhe: 1.495 ± 0.158
4.15IleGly: 4.15 ± 0.258
1.422IleHis: 1.422 ± 0.145
4.208IleIle: 4.208 ± 0.314
5.587IleLys: 5.587 ± 0.293
4.644IleLeu: 4.644 ± 0.264
1.654IleMet: 1.654 ± 0.161
5.007IleAsn: 5.007 ± 0.263
3.207IlePro: 3.207 ± 0.198
1.799IleGln: 1.799 ± 0.16
3.512IleArg: 3.512 ± 0.231
4.76IleSer: 4.76 ± 0.31
5.137IleThr: 5.137 ± 0.277
4.252IleVal: 4.252 ± 0.227
0.45IleTrp: 0.45 ± 0.092
2.641IleTyr: 2.641 ± 0.185
0.0IleXaa: 0.0 ± 0.0
Lys
4.76LysAla: 4.76 ± 0.271
0.377LysCys: 0.377 ± 0.073
4.354LysAsp: 4.354 ± 0.283
4.484LysGlu: 4.484 ± 0.276
2.293LysPhe: 2.293 ± 0.17
4.136LysGly: 4.136 ± 0.422
1.625LysHis: 1.625 ± 0.152
2.931LysIle: 2.931 ± 0.188
2.438LysLys: 2.438 ± 0.244
6.501LysLeu: 6.501 ± 0.342
1.828LysMet: 1.828 ± 0.144
2.931LysAsn: 2.931 ± 0.2
3.135LysPro: 3.135 ± 0.237
2.481LysGln: 2.481 ± 0.211
3.091LysArg: 3.091 ± 0.22
4.223LysSer: 4.223 ± 0.23
3.933LysThr: 3.933 ± 0.179
4.629LysVal: 4.629 ± 0.216
0.784LysTrp: 0.784 ± 0.113
2.612LysTyr: 2.612 ± 0.192
0.0LysXaa: 0.0 ± 0.0
Leu
6.066LeuAla: 6.066 ± 0.355
0.914LeuCys: 0.914 ± 0.105
5.34LeuAsp: 5.34 ± 0.31
5.253LeuGlu: 5.253 ± 0.283
2.96LeuPhe: 2.96 ± 0.175
5.369LeuGly: 5.369 ± 0.296
1.538LeuHis: 1.538 ± 0.139
5.311LeuIle: 5.311 ± 0.31
5.181LeuLys: 5.181 ± 0.279
6.356LeuLeu: 6.356 ± 0.335
2.554LeuMet: 2.554 ± 0.228
5.602LeuAsn: 5.602 ± 0.291
3.381LeuPro: 3.381 ± 0.217
2.177LeuGln: 2.177 ± 0.171
3.715LeuArg: 3.715 ± 0.242
7.038LeuSer: 7.038 ± 0.309
6.922LeuThr: 6.922 ± 0.359
5.355LeuVal: 5.355 ± 0.279
0.784LeuTrp: 0.784 ± 0.099
3.367LeuTyr: 3.367 ± 0.223
0.0LeuXaa: 0.0 ± 0.0
Met
2.351MetAla: 2.351 ± 0.188
0.276MetCys: 0.276 ± 0.065
1.654MetAsp: 1.654 ± 0.141
1.582MetGlu: 1.582 ± 0.147
0.972MetPhe: 0.972 ± 0.099
1.799MetGly: 1.799 ± 0.212
0.508MetHis: 0.508 ± 0.079
1.219MetIle: 1.219 ± 0.124
1.495MetLys: 1.495 ± 0.14
2.612MetLeu: 2.612 ± 0.219
0.827MetMet: 0.827 ± 0.117
1.669MetAsn: 1.669 ± 0.136
1.001MetPro: 1.001 ± 0.138
1.437MetGln: 1.437 ± 0.201
1.292MetArg: 1.292 ± 0.131
2.598MetSer: 2.598 ± 0.161
1.988MetThr: 1.988 ± 0.157
1.843MetVal: 1.843 ± 0.139
0.319MetTrp: 0.319 ± 0.065
1.364MetTyr: 1.364 ± 0.143
0.0MetXaa: 0.0 ± 0.0
Asn
3.962AsnAla: 3.962 ± 0.221
0.435AsnCys: 0.435 ± 0.078
3.425AsnAsp: 3.425 ± 0.223
3.222AsnGlu: 3.222 ± 0.208
1.437AsnPhe: 1.437 ± 0.129
3.918AsnGly: 3.918 ± 0.286
1.292AsnHis: 1.292 ± 0.144
3.933AsnIle: 3.933 ± 0.255
3.991AsnLys: 3.991 ± 0.254
5.079AsnLeu: 5.079 ± 0.315
1.582AsnMet: 1.582 ± 0.151
3.918AsnAsn: 3.918 ± 0.213
2.859AsnPro: 2.859 ± 0.224
2.075AsnGln: 2.075 ± 0.191
2.96AsnArg: 2.96 ± 0.193
3.309AsnSer: 3.309 ± 0.235
4.107AsnThr: 4.107 ± 0.261
3.773AsnVal: 3.773 ± 0.208
0.595AsnTrp: 0.595 ± 0.093
2.264AsnTyr: 2.264 ± 0.194
0.0AsnXaa: 0.0 ± 0.0
Pro
2.786ProAla: 2.786 ± 0.2
0.348ProCys: 0.348 ± 0.08
2.714ProAsp: 2.714 ± 0.195
2.801ProGlu: 2.801 ± 0.245
1.335ProPhe: 1.335 ± 0.149
3.105ProGly: 3.105 ± 0.404
0.827ProHis: 0.827 ± 0.109
2.757ProIle: 2.757 ± 0.202
2.598ProLys: 2.598 ± 0.222
2.888ProLeu: 2.888 ± 0.178
1.146ProMet: 1.146 ± 0.208
2.235ProAsn: 2.235 ± 0.202
1.379ProPro: 1.379 ± 0.17
1.335ProGln: 1.335 ± 0.218
1.408ProArg: 1.408 ± 0.171
2.772ProSer: 2.772 ± 0.199
2.438ProThr: 2.438 ± 0.184
3.12ProVal: 3.12 ± 0.216
0.566ProTrp: 0.566 ± 0.091
1.509ProTyr: 1.509 ± 0.15
0.0ProXaa: 0.0 ± 0.0
Gln
2.032GlnAla: 2.032 ± 0.195
0.247GlnCys: 0.247 ± 0.065
1.422GlnAsp: 1.422 ± 0.171
1.524GlnGlu: 1.524 ± 0.139
1.263GlnPhe: 1.263 ± 0.152
1.945GlnGly: 1.945 ± 0.231
0.697GlnHis: 0.697 ± 0.098
1.814GlnIle: 1.814 ± 0.146
1.393GlnLys: 1.393 ± 0.138
2.844GlnLeu: 2.844 ± 0.224
1.045GlnMet: 1.045 ± 0.189
1.219GlnAsn: 1.219 ± 0.134
1.799GlnPro: 1.799 ± 0.301
1.77GlnGln: 1.77 ± 0.352
1.408GlnArg: 1.408 ± 0.128
1.916GlnSer: 1.916 ± 0.178
1.872GlnThr: 1.872 ± 0.16
1.727GlnVal: 1.727 ± 0.168
0.334GlnTrp: 0.334 ± 0.077
1.451GlnTyr: 1.451 ± 0.138
0.0GlnXaa: 0.0 ± 0.0
Arg
2.772ArgAla: 2.772 ± 0.185
0.464ArgCys: 0.464 ± 0.121
2.612ArgAsp: 2.612 ± 0.192
2.554ArgGlu: 2.554 ± 0.22
1.814ArgPhe: 1.814 ± 0.166
2.278ArgGly: 2.278 ± 0.215
0.987ArgHis: 0.987 ± 0.113
3.251ArgIle: 3.251 ± 0.171
2.554ArgLys: 2.554 ± 0.222
4.136ArgLeu: 4.136 ± 0.263
1.509ArgMet: 1.509 ± 0.158
2.859ArgAsn: 2.859 ± 0.212
1.727ArgPro: 1.727 ± 0.198
1.451ArgGln: 1.451 ± 0.15
2.278ArgArg: 2.278 ± 0.212
2.583ArgSer: 2.583 ± 0.199
2.801ArgThr: 2.801 ± 0.223
3.468ArgVal: 3.468 ± 0.232
0.566ArgTrp: 0.566 ± 0.09
1.916ArgTyr: 1.916 ± 0.17
0.0ArgXaa: 0.0 ± 0.0
Ser
4.644SerAla: 4.644 ± 0.289
0.798SerCys: 0.798 ± 0.123
4.441SerAsp: 4.441 ± 0.237
3.831SerGlu: 3.831 ± 0.215
2.496SerPhe: 2.496 ± 0.178
4.789SerGly: 4.789 ± 0.286
1.219SerHis: 1.219 ± 0.143
5.616SerIle: 5.616 ± 0.349
4.528SerLys: 4.528 ± 0.266
5.761SerLeu: 5.761 ± 0.283
1.959SerMet: 1.959 ± 0.139
3.846SerAsn: 3.846 ± 0.225
2.322SerPro: 2.322 ± 0.244
1.596SerGln: 1.596 ± 0.185
3.323SerArg: 3.323 ± 0.214
4.557SerSer: 4.557 ± 0.271
4.6SerThr: 4.6 ± 0.231
5.282SerVal: 5.282 ± 0.273
0.639SerTrp: 0.639 ± 0.079
2.554SerTyr: 2.554 ± 0.192
0.0SerXaa: 0.0 ± 0.0
Thr
4.571ThrAla: 4.571 ± 0.292
0.551ThrCys: 0.551 ± 0.084
3.802ThrAsp: 3.802 ± 0.229
3.875ThrGlu: 3.875 ± 0.263
2.307ThrPhe: 2.307 ± 0.197
4.731ThrGly: 4.731 ± 0.297
1.437ThrHis: 1.437 ± 0.139
4.136ThrIle: 4.136 ± 0.26
3.875ThrLys: 3.875 ± 0.251
5.921ThrLeu: 5.921 ± 0.275
1.611ThrMet: 1.611 ± 0.152
3.831ThrAsn: 3.831 ± 0.249
3.947ThrPro: 3.947 ± 0.223
1.887ThrGln: 1.887 ± 0.162
2.699ThrArg: 2.699 ± 0.2
4.716ThrSer: 4.716 ± 0.298
4.919ThrThr: 4.919 ± 0.283
4.499ThrVal: 4.499 ± 0.287
0.711ThrTrp: 0.711 ± 0.112
2.322ThrTyr: 2.322 ± 0.213
0.0ThrXaa: 0.0 ± 0.0
Val
4.208ValAla: 4.208 ± 0.224
0.929ValCys: 0.929 ± 0.116
5.355ValAsp: 5.355 ± 0.314
3.759ValGlu: 3.759 ± 0.228
2.307ValPhe: 2.307 ± 0.193
4.47ValGly: 4.47 ± 0.294
1.045ValHis: 1.045 ± 0.121
5.718ValIle: 5.718 ± 0.308
5.021ValLys: 5.021 ± 0.234
5.471ValLeu: 5.471 ± 0.265
2.452ValMet: 2.452 ± 0.17
4.252ValAsn: 4.252 ± 0.265
2.496ValPro: 2.496 ± 0.191
1.611ValGln: 1.611 ± 0.152
2.714ValArg: 2.714 ± 0.216
5.616ValSer: 5.616 ± 0.35
5.137ValThr: 5.137 ± 0.244
5.442ValVal: 5.442 ± 0.354
0.755ValTrp: 0.755 ± 0.103
3.047ValTyr: 3.047 ± 0.228
0.0ValXaa: 0.0 ± 0.0
Trp
0.464TrpAla: 0.464 ± 0.089
0.087TrpCys: 0.087 ± 0.037
0.639TrpAsp: 0.639 ± 0.114
0.406TrpGlu: 0.406 ± 0.068
0.537TrpPhe: 0.537 ± 0.088
0.551TrpGly: 0.551 ± 0.081
0.319TrpHis: 0.319 ± 0.073
0.668TrpIle: 0.668 ± 0.106
0.537TrpLys: 0.537 ± 0.086
1.364TrpLeu: 1.364 ± 0.154
0.464TrpMet: 0.464 ± 0.086
0.435TrpAsn: 0.435 ± 0.074
0.261TrpPro: 0.261 ± 0.06
0.305TrpGln: 0.305 ± 0.057
0.537TrpArg: 0.537 ± 0.089
0.842TrpSer: 0.842 ± 0.1
0.711TrpThr: 0.711 ± 0.113
1.103TrpVal: 1.103 ± 0.143
0.174TrpTrp: 0.174 ± 0.05
0.508TrpTyr: 0.508 ± 0.09
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.511TyrAla: 2.511 ± 0.202
0.348TyrCys: 0.348 ± 0.073
2.598TyrAsp: 2.598 ± 0.199
2.38TyrGlu: 2.38 ± 0.175
1.451TyrPhe: 1.451 ± 0.158
2.989TyrGly: 2.989 ± 0.223
1.117TyrHis: 1.117 ± 0.128
3.091TyrIle: 3.091 ± 0.213
2.946TyrLys: 2.946 ± 0.195
2.989TyrLeu: 2.989 ± 0.212
1.103TyrMet: 1.103 ± 0.131
2.54TyrAsn: 2.54 ± 0.246
1.756TyrPro: 1.756 ± 0.185
1.408TyrGln: 1.408 ± 0.138
2.133TyrArg: 2.133 ± 0.19
2.394TyrSer: 2.394 ± 0.213
2.772TyrThr: 2.772 ± 0.181
2.627TyrVal: 2.627 ± 0.182
0.45TyrTrp: 0.45 ± 0.093
1.959TyrTyr: 1.959 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 232 proteins (68911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski