Amino acid dipepetide frequency for Picalivirus A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.051AlaAla: 5.051 ± 1.607
0.722AlaCys: 0.722 ± 0.391
3.247AlaAsp: 3.247 ± 0.412
3.968AlaGlu: 3.968 ± 0.022
4.69AlaPhe: 4.69 ± 0.369
4.329AlaGly: 4.329 ± 1.998
1.804AlaHis: 1.804 ± 0.47
5.051AlaIle: 5.051 ± 2.736
2.525AlaLys: 2.525 ± 0.644
10.462AlaLeu: 10.462 ± 1.325
1.804AlaMet: 1.804 ± 0.253
3.968AlaAsn: 3.968 ± 0.022
5.411AlaPro: 5.411 ± 1.411
3.247AlaGln: 3.247 ± 0.311
3.608AlaArg: 3.608 ± 1.231
7.215AlaSer: 7.215 ± 1.158
4.69AlaThr: 4.69 ± 2.526
5.051AlaVal: 5.051 ± 0.565
0.361AlaTrp: 0.361 ± 0.195
4.329AlaTyr: 4.329 ± 0.55
0.0AlaXaa: 0.0 ± 0.0
Cys
1.082CysAla: 1.082 ± 0.586
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.082CysGlu: 1.082 ± 0.586
1.082CysPhe: 1.082 ± 0.586
0.361CysGly: 0.361 ± 0.195
0.0CysHis: 0.0 ± 0.0
0.722CysIle: 0.722 ± 0.391
0.361CysLys: 0.361 ± 0.195
0.361CysLeu: 0.361 ± 0.528
0.0CysMet: 0.0 ± 0.0
0.361CysAsn: 0.361 ± 0.528
0.722CysPro: 0.722 ± 0.333
0.361CysGln: 0.361 ± 0.528
0.722CysArg: 0.722 ± 1.057
1.804CysSer: 1.804 ± 0.977
0.361CysThr: 0.361 ± 0.195
0.722CysVal: 0.722 ± 0.391
0.361CysTrp: 0.361 ± 0.528
1.804CysTyr: 1.804 ± 0.253
0.0CysXaa: 0.0 ± 0.0
Asp
3.608AspAla: 3.608 ± 0.217
0.722AspCys: 0.722 ± 0.391
6.133AspAsp: 6.133 ± 0.427
1.804AspGlu: 1.804 ± 0.253
2.886AspPhe: 2.886 ± 0.116
3.968AspGly: 3.968 ± 0.702
0.0AspHis: 0.0 ± 0.0
3.608AspIle: 3.608 ± 1.955
0.722AspLys: 0.722 ± 0.333
5.051AspLeu: 5.051 ± 0.883
1.804AspMet: 1.804 ± 0.47
1.443AspAsn: 1.443 ± 0.782
7.576AspPro: 7.576 ± 1.209
1.082AspGln: 1.082 ± 0.137
3.608AspArg: 3.608 ± 0.217
6.854AspSer: 6.854 ± 0.094
3.968AspThr: 3.968 ± 0.702
2.525AspVal: 2.525 ± 0.644
1.082AspTrp: 1.082 ± 0.586
0.722AspTyr: 0.722 ± 0.391
0.0AspXaa: 0.0 ± 0.0
Glu
3.247GluAla: 3.247 ± 0.311
0.361GluCys: 0.361 ± 0.528
3.247GluAsp: 3.247 ± 0.311
0.722GluGlu: 0.722 ± 0.391
1.443GluPhe: 1.443 ± 0.782
1.443GluGly: 1.443 ± 0.058
0.361GluHis: 0.361 ± 0.195
2.886GluIle: 2.886 ± 0.116
1.804GluLys: 1.804 ± 0.977
4.69GluLeu: 4.69 ± 0.354
0.722GluMet: 0.722 ± 0.391
1.082GluAsn: 1.082 ± 0.586
2.886GluPro: 2.886 ± 0.84
1.082GluGln: 1.082 ± 0.586
1.082GluArg: 1.082 ± 0.137
2.165GluSer: 2.165 ± 0.275
3.247GluThr: 3.247 ± 1.136
3.247GluVal: 3.247 ± 1.035
0.722GluTrp: 0.722 ± 0.391
1.082GluTyr: 1.082 ± 0.586
0.0GluXaa: 0.0 ± 0.0
Phe
5.772PheAla: 5.772 ± 0.492
1.082PheCys: 1.082 ± 1.585
2.525PheAsp: 2.525 ± 0.08
0.722PheGlu: 0.722 ± 0.391
1.804PhePhe: 1.804 ± 1.194
2.525PheGly: 2.525 ± 0.08
1.082PheHis: 1.082 ± 0.137
3.247PheIle: 3.247 ± 0.311
2.165PheLys: 2.165 ± 0.449
5.051PheLeu: 5.051 ± 1.289
0.0PheMet: 0.0 ± 0.0
1.082PheAsn: 1.082 ± 0.137
3.968PhePro: 3.968 ± 0.702
1.443PheGln: 1.443 ± 0.058
1.443PheArg: 1.443 ± 1.39
5.051PheSer: 5.051 ± 1.289
4.329PheThr: 4.329 ± 0.174
5.772PheVal: 5.772 ± 1.216
0.0PheTrp: 0.0 ± 0.0
2.165PheTyr: 2.165 ± 1.173
0.0PheXaa: 0.0 ± 0.0
Gly
2.165GlyAla: 2.165 ± 0.999
0.0GlyCys: 0.0 ± 0.0
4.69GlyAsp: 4.69 ± 1.078
0.722GlyGlu: 0.722 ± 0.333
3.968GlyPhe: 3.968 ± 1.469
0.722GlyGly: 0.722 ± 1.057
1.082GlyHis: 1.082 ± 0.137
2.525GlyIle: 2.525 ± 0.644
1.804GlyLys: 1.804 ± 0.253
4.69GlyLeu: 4.69 ± 1.802
0.361GlyMet: 0.361 ± 0.195
1.443GlyAsn: 1.443 ± 0.058
1.804GlyPro: 1.804 ± 1.194
1.082GlyGln: 1.082 ± 0.586
1.443GlyArg: 1.443 ± 0.058
3.968GlySer: 3.968 ± 1.426
5.051GlyThr: 5.051 ± 0.883
3.968GlyVal: 3.968 ± 0.745
0.0GlyTrp: 0.0 ± 0.0
1.082GlyTyr: 1.082 ± 0.861
0.0GlyXaa: 0.0 ± 0.0
His
1.804HisAla: 1.804 ± 0.977
2.165HisCys: 2.165 ± 0.449
1.443HisAsp: 1.443 ± 0.782
0.361HisGlu: 0.361 ± 0.195
0.0HisPhe: 0.0 ± 0.0
1.804HisGly: 1.804 ± 0.253
1.082HisHis: 1.082 ± 0.586
0.722HisIle: 0.722 ± 0.391
0.722HisLys: 0.722 ± 0.391
1.804HisLeu: 1.804 ± 0.47
0.361HisMet: 0.361 ± 0.195
1.082HisAsn: 1.082 ± 0.861
1.082HisPro: 1.082 ± 0.586
1.082HisGln: 1.082 ± 0.137
1.082HisArg: 1.082 ± 0.586
1.082HisSer: 1.082 ± 0.586
0.722HisThr: 0.722 ± 0.333
2.165HisVal: 2.165 ± 0.275
0.0HisTrp: 0.0 ± 0.0
1.804HisTyr: 1.804 ± 0.253
0.0HisXaa: 0.0 ± 0.0
Ile
5.411IleAla: 5.411 ± 0.036
0.361IleCys: 0.361 ± 0.195
2.165IleAsp: 2.165 ± 0.449
1.804IleGlu: 1.804 ± 0.977
1.443IlePhe: 1.443 ± 0.782
1.443IleGly: 1.443 ± 0.782
1.443IleHis: 1.443 ± 0.782
3.247IleIle: 3.247 ± 1.035
1.804IleLys: 1.804 ± 0.977
4.329IleLeu: 4.329 ± 0.55
0.0IleMet: 0.0 ± 0.0
2.525IleAsn: 2.525 ± 1.368
4.329IlePro: 4.329 ± 0.174
1.082IleGln: 1.082 ± 0.586
2.886IleArg: 2.886 ± 0.116
4.329IleSer: 4.329 ± 1.998
4.329IleThr: 4.329 ± 0.898
2.165IleVal: 2.165 ± 0.449
0.361IleTrp: 0.361 ± 0.528
0.722IleTyr: 0.722 ± 0.391
0.0IleXaa: 0.0 ± 0.0
Lys
2.525LysAla: 2.525 ± 1.368
0.361LysCys: 0.361 ± 0.195
1.804LysAsp: 1.804 ± 0.977
3.968LysGlu: 3.968 ± 1.426
1.082LysPhe: 1.082 ± 0.137
1.804LysGly: 1.804 ± 0.977
0.722LysHis: 0.722 ± 0.391
1.804LysIle: 1.804 ± 0.253
2.165LysLys: 2.165 ± 1.173
2.165LysLeu: 2.165 ± 1.173
0.722LysMet: 0.722 ± 0.44
1.082LysAsn: 1.082 ± 0.137
2.525LysPro: 2.525 ± 1.368
0.361LysGln: 0.361 ± 0.195
2.165LysArg: 2.165 ± 1.173
3.608LysSer: 3.608 ± 2.389
2.886LysThr: 2.886 ± 0.84
2.165LysVal: 2.165 ± 1.173
0.361LysTrp: 0.361 ± 0.528
1.804LysTyr: 1.804 ± 0.253
0.361LysXaa: 0.361 ± 0.528
Leu
9.74LeuAla: 9.74 ± 1.237
1.443LeuCys: 1.443 ± 0.666
4.329LeuAsp: 4.329 ± 0.898
2.886LeuGlu: 2.886 ± 0.608
2.525LeuPhe: 2.525 ± 1.368
4.329LeuGly: 4.329 ± 1.274
2.165LeuHis: 2.165 ± 0.449
3.608LeuIle: 3.608 ± 0.507
5.051LeuLys: 5.051 ± 1.289
6.854LeuLeu: 6.854 ± 0.629
2.886LeuMet: 2.886 ± 0.608
1.804LeuAsn: 1.804 ± 0.253
9.74LeuPro: 9.74 ± 0.514
3.608LeuGln: 3.608 ± 0.217
4.69LeuArg: 4.69 ± 1.093
14.069LeuSer: 14.069 ± 1.063
6.854LeuThr: 6.854 ± 0.094
6.494LeuVal: 6.494 ± 0.825
0.722LeuTrp: 0.722 ± 0.333
4.329LeuTyr: 4.329 ± 0.898
0.0LeuXaa: 0.0 ± 0.0
Met
1.443MetAla: 1.443 ± 0.782
0.361MetCys: 0.361 ± 0.195
1.443MetAsp: 1.443 ± 0.058
0.0MetGlu: 0.0 ± 0.0
1.082MetPhe: 1.082 ± 0.137
0.722MetGly: 0.722 ± 0.333
0.722MetHis: 0.722 ± 0.333
0.722MetIle: 0.722 ± 1.057
0.722MetLys: 0.722 ± 0.391
2.165MetLeu: 2.165 ± 0.275
0.0MetMet: 0.0 ± 0.0
0.361MetAsn: 0.361 ± 0.195
0.0MetPro: 0.0 ± 0.0
0.361MetGln: 0.361 ± 0.195
1.443MetArg: 1.443 ± 0.666
1.443MetSer: 1.443 ± 0.058
1.082MetThr: 1.082 ± 0.137
0.361MetVal: 0.361 ± 0.195
0.722MetTrp: 0.722 ± 0.391
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.165AsnAla: 2.165 ± 1.723
0.0AsnCys: 0.0 ± 0.0
2.165AsnAsp: 2.165 ± 0.275
0.361AsnGlu: 0.361 ± 0.195
2.886AsnPhe: 2.886 ± 0.116
1.082AsnGly: 1.082 ± 0.137
1.443AsnHis: 1.443 ± 0.782
0.722AsnIle: 0.722 ± 0.391
1.082AsnLys: 1.082 ± 0.586
1.804AsnLeu: 1.804 ± 0.977
0.361AsnMet: 0.361 ± 0.195
1.082AsnAsn: 1.082 ± 0.861
2.525AsnPro: 2.525 ± 0.08
0.722AsnGln: 0.722 ± 0.391
2.525AsnArg: 2.525 ± 0.08
1.804AsnSer: 1.804 ± 0.47
3.247AsnThr: 3.247 ± 0.412
3.968AsnVal: 3.968 ± 0.745
0.0AsnTrp: 0.0 ± 0.0
1.082AsnTyr: 1.082 ± 0.861
0.0AsnXaa: 0.0 ± 0.0
Pro
4.69ProAla: 4.69 ± 2.526
0.361ProCys: 0.361 ± 0.195
7.215ProAsp: 7.215 ± 1.738
1.804ProGlu: 1.804 ± 0.977
3.247ProPhe: 3.247 ± 0.311
2.886ProGly: 2.886 ± 0.608
1.082ProHis: 1.082 ± 0.586
3.608ProIle: 3.608 ± 0.217
1.804ProLys: 1.804 ± 0.253
7.576ProLeu: 7.576 ± 0.239
0.361ProMet: 0.361 ± 0.195
1.804ProAsn: 1.804 ± 0.47
5.772ProPro: 5.772 ± 1.68
1.443ProGln: 1.443 ± 0.058
4.329ProArg: 4.329 ± 1.622
11.183ProSer: 11.183 ± 1.179
6.133ProThr: 6.133 ± 0.297
7.576ProVal: 7.576 ± 1.686
1.082ProTrp: 1.082 ± 0.861
3.608ProTyr: 3.608 ± 1.665
0.0ProXaa: 0.0 ± 0.0
Gln
3.247GlnAla: 3.247 ± 0.311
0.361GlnCys: 0.361 ± 0.195
1.804GlnAsp: 1.804 ± 0.47
1.082GlnGlu: 1.082 ± 0.137
1.443GlnPhe: 1.443 ± 0.666
1.443GlnGly: 1.443 ± 0.058
1.443GlnHis: 1.443 ± 0.782
0.722GlnIle: 0.722 ± 0.333
1.082GlnLys: 1.082 ± 0.586
1.082GlnLeu: 1.082 ± 0.586
0.0GlnMet: 0.0 ± 0.0
1.082GlnAsn: 1.082 ± 0.586
2.525GlnPro: 2.525 ± 0.08
0.0GlnGln: 0.0 ± 0.0
0.722GlnArg: 0.722 ± 0.333
3.247GlnSer: 3.247 ± 1.759
1.804GlnThr: 1.804 ± 0.47
2.886GlnVal: 2.886 ± 0.116
0.0GlnTrp: 0.0 ± 0.0
1.443GlnTyr: 1.443 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
4.69ArgAla: 4.69 ± 2.541
0.722ArgCys: 0.722 ± 0.391
1.804ArgAsp: 1.804 ± 0.977
2.165ArgGlu: 2.165 ± 0.275
3.968ArgPhe: 3.968 ± 2.193
1.804ArgGly: 1.804 ± 1.194
1.804ArgHis: 1.804 ± 0.253
1.082ArgIle: 1.082 ± 0.586
2.886ArgLys: 2.886 ± 0.116
7.215ArgLeu: 7.215 ± 0.29
1.443ArgMet: 1.443 ± 0.058
0.361ArgAsn: 0.361 ± 0.195
3.247ArgPro: 3.247 ± 1.136
1.443ArgGln: 1.443 ± 0.058
3.247ArgArg: 3.247 ± 1.035
6.494ArgSer: 6.494 ± 1.347
5.411ArgThr: 5.411 ± 0.036
2.525ArgVal: 2.525 ± 0.644
0.361ArgTrp: 0.361 ± 0.528
1.082ArgTyr: 1.082 ± 0.586
0.0ArgXaa: 0.0 ± 0.0
Ser
5.411SerAla: 5.411 ± 0.036
1.082SerCys: 1.082 ± 0.586
7.215SerAsp: 7.215 ± 2.461
3.968SerGlu: 3.968 ± 0.745
6.494SerPhe: 6.494 ± 1.347
5.772SerGly: 5.772 ± 3.387
2.165SerHis: 2.165 ± 0.449
4.329SerIle: 4.329 ± 0.55
4.329SerLys: 4.329 ± 0.898
13.348SerLeu: 13.348 ± 1.454
1.443SerMet: 1.443 ± 0.058
2.165SerAsn: 2.165 ± 0.275
10.462SerPro: 10.462 ± 0.846
2.525SerGln: 2.525 ± 0.803
6.133SerArg: 6.133 ± 1.02
14.069SerSer: 14.069 ± 1.063
7.937SerThr: 7.937 ± 1.491
6.133SerVal: 6.133 ± 1.02
2.165SerTrp: 2.165 ± 0.449
3.247SerTyr: 3.247 ± 1.136
0.0SerXaa: 0.0 ± 0.0
Thr
8.297ThrAla: 8.297 ± 0.571
1.443ThrCys: 1.443 ± 0.782
2.886ThrAsp: 2.886 ± 1.332
4.69ThrGlu: 4.69 ± 0.369
5.051ThrPhe: 5.051 ± 1.607
1.443ThrGly: 1.443 ± 0.666
2.165ThrHis: 2.165 ± 0.275
2.886ThrIle: 2.886 ± 0.608
0.361ThrLys: 0.361 ± 0.195
5.411ThrLeu: 5.411 ± 0.036
1.443ThrMet: 1.443 ± 0.058
2.165ThrAsn: 2.165 ± 0.999
3.608ThrPro: 3.608 ± 0.941
3.608ThrGln: 3.608 ± 0.507
6.494ThrArg: 6.494 ± 0.623
8.658ThrSer: 8.658 ± 1.1
6.133ThrThr: 6.133 ± 1.02
3.968ThrVal: 3.968 ± 1.469
1.443ThrTrp: 1.443 ± 0.058
3.608ThrTyr: 3.608 ± 0.507
0.0ThrXaa: 0.0 ± 0.0
Val
7.215ValAla: 7.215 ± 0.29
0.361ValCys: 0.361 ± 0.195
2.886ValAsp: 2.886 ± 0.84
3.247ValGlu: 3.247 ± 0.311
3.247ValPhe: 3.247 ± 0.311
2.886ValGly: 2.886 ± 0.116
0.361ValHis: 0.361 ± 0.195
2.525ValIle: 2.525 ± 0.644
3.247ValLys: 3.247 ± 0.412
8.297ValLeu: 8.297 ± 0.876
1.082ValMet: 1.082 ± 0.425
2.886ValAsn: 2.886 ± 1.332
6.133ValPro: 6.133 ± 1.744
2.165ValGln: 2.165 ± 1.173
3.608ValArg: 3.608 ± 0.507
9.019ValSer: 9.019 ± 2.352
3.968ValThr: 3.968 ± 1.469
6.494ValVal: 6.494 ± 2.273
0.361ValTrp: 0.361 ± 0.195
1.804ValTyr: 1.804 ± 0.47
0.0ValXaa: 0.0 ± 0.0
Trp
0.722TrpAla: 0.722 ± 0.391
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
1.082TrpPhe: 1.082 ± 0.586
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.361TrpIle: 0.361 ± 0.195
1.082TrpLys: 1.082 ± 0.137
1.082TrpLeu: 1.082 ± 0.137
0.0TrpMet: 0.0 ± 0.0
0.722TrpAsn: 0.722 ± 0.391
0.361TrpPro: 0.361 ± 0.528
0.361TrpGln: 0.361 ± 0.195
1.082TrpArg: 1.082 ± 0.586
1.804TrpSer: 1.804 ± 1.194
0.722TrpThr: 0.722 ± 0.333
0.722TrpVal: 0.722 ± 0.333
0.0TrpTrp: 0.0 ± 0.0
0.722TrpTyr: 0.722 ± 0.333
0.361TrpXaa: 0.361 ± 0.528
Tyr
3.247TyrAla: 3.247 ± 0.412
0.361TyrCys: 0.361 ± 0.528
2.165TyrAsp: 2.165 ± 0.275
2.165TyrGlu: 2.165 ± 1.173
1.804TyrPhe: 1.804 ± 0.253
1.804TyrGly: 1.804 ± 0.253
1.443TyrHis: 1.443 ± 0.058
1.804TyrIle: 1.804 ± 0.47
0.722TyrLys: 0.722 ± 0.391
4.69TyrLeu: 4.69 ± 0.354
0.0TyrMet: 0.0 ± 0.0
2.525TyrAsn: 2.525 ± 0.803
2.525TyrPro: 2.525 ± 0.644
0.361TyrGln: 0.361 ± 0.528
1.082TyrArg: 1.082 ± 0.586
2.525TyrSer: 2.525 ± 0.803
2.886TyrThr: 2.886 ± 0.116
3.247TyrVal: 3.247 ± 0.311
1.082TyrTrp: 1.082 ± 0.137
1.443TyrTyr: 1.443 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.361XaaPro: 0.361 ± 0.528
0.0XaaGln: 0.0 ± 0.0
0.361XaaArg: 0.361 ± 0.528
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski