Amino acid dipepetide frequency for Streptococcus phage Javan506

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.332AlaAla: 4.332 ± 1.393
0.394AlaCys: 0.394 ± 0.208
4.883AlaAsp: 4.883 ± 0.71
5.907AlaGlu: 5.907 ± 0.822
1.575AlaPhe: 1.575 ± 0.387
3.15AlaGly: 3.15 ± 0.578
1.26AlaHis: 1.26 ± 0.354
5.198AlaIle: 5.198 ± 0.734
6.301AlaLys: 6.301 ± 0.781
6.694AlaLeu: 6.694 ± 0.882
2.205AlaMet: 2.205 ± 0.493
4.647AlaAsn: 4.647 ± 0.56
2.678AlaPro: 2.678 ± 0.442
4.017AlaGln: 4.017 ± 0.703
3.702AlaArg: 3.702 ± 0.475
4.804AlaSer: 4.804 ± 1.061
4.647AlaThr: 4.647 ± 0.664
4.489AlaVal: 4.489 ± 0.632
0.945AlaTrp: 0.945 ± 0.275
2.757AlaTyr: 2.757 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.473CysAla: 0.473 ± 0.173
0.158CysCys: 0.158 ± 0.095
0.315CysAsp: 0.315 ± 0.173
0.866CysGlu: 0.866 ± 0.237
0.551CysPhe: 0.551 ± 0.218
0.709CysGly: 0.709 ± 0.239
0.236CysHis: 0.236 ± 0.125
0.315CysIle: 0.315 ± 0.161
0.551CysLys: 0.551 ± 0.181
0.63CysLeu: 0.63 ± 0.266
0.158CysMet: 0.158 ± 0.098
0.473CysAsn: 0.473 ± 0.199
0.315CysPro: 0.315 ± 0.147
0.0CysGln: 0.0 ± 0.0
0.394CysArg: 0.394 ± 0.18
0.236CysSer: 0.236 ± 0.121
0.079CysThr: 0.079 ± 0.078
0.473CysVal: 0.473 ± 0.191
0.079CysTrp: 0.079 ± 0.076
0.079CysTyr: 0.079 ± 0.073
0.0CysXaa: 0.0 ± 0.0
Asp
4.962AspAla: 4.962 ± 0.706
0.394AspCys: 0.394 ± 0.189
4.489AspAsp: 4.489 ± 0.675
4.726AspGlu: 4.726 ± 0.567
2.52AspPhe: 2.52 ± 0.401
6.143AspGly: 6.143 ± 0.618
0.866AspHis: 0.866 ± 0.275
4.804AspIle: 4.804 ± 0.738
5.749AspLys: 5.749 ± 0.669
7.01AspLeu: 7.01 ± 0.952
1.181AspMet: 1.181 ± 0.254
3.859AspAsn: 3.859 ± 0.508
1.339AspPro: 1.339 ± 0.34
1.654AspGln: 1.654 ± 0.371
3.308AspArg: 3.308 ± 0.5
4.017AspSer: 4.017 ± 0.585
3.78AspThr: 3.78 ± 0.556
4.726AspVal: 4.726 ± 0.572
0.866AspTrp: 0.866 ± 0.288
3.387AspTyr: 3.387 ± 0.579
0.0AspXaa: 0.0 ± 0.0
Glu
4.726GluAla: 4.726 ± 0.591
0.315GluCys: 0.315 ± 0.147
3.465GluAsp: 3.465 ± 0.619
5.356GluGlu: 5.356 ± 0.733
2.599GluPhe: 2.599 ± 0.443
3.859GluGly: 3.859 ± 0.488
1.024GluHis: 1.024 ± 0.277
5.907GluIle: 5.907 ± 0.788
5.513GluLys: 5.513 ± 0.697
8.427GluLeu: 8.427 ± 0.814
1.496GluMet: 1.496 ± 0.439
3.308GluAsn: 3.308 ± 0.506
2.126GluPro: 2.126 ± 0.461
3.702GluGln: 3.702 ± 0.656
3.544GluArg: 3.544 ± 0.551
4.253GluSer: 4.253 ± 0.628
3.623GluThr: 3.623 ± 0.451
5.277GluVal: 5.277 ± 0.658
1.103GluTrp: 1.103 ± 0.291
2.442GluTyr: 2.442 ± 0.339
0.0GluXaa: 0.0 ± 0.0
Phe
2.442PheAla: 2.442 ± 0.513
0.473PheCys: 0.473 ± 0.217
3.938PheAsp: 3.938 ± 0.498
2.678PheGlu: 2.678 ± 0.568
0.551PhePhe: 0.551 ± 0.206
2.363PheGly: 2.363 ± 0.305
0.236PheHis: 0.236 ± 0.148
1.969PheIle: 1.969 ± 0.431
2.363PheLys: 2.363 ± 0.42
2.048PheLeu: 2.048 ± 0.437
0.63PheMet: 0.63 ± 0.237
1.733PheAsn: 1.733 ± 0.314
0.709PhePro: 0.709 ± 0.301
0.551PheGln: 0.551 ± 0.241
1.811PheArg: 1.811 ± 0.445
1.89PheSer: 1.89 ± 0.376
2.284PheThr: 2.284 ± 0.381
1.654PheVal: 1.654 ± 0.29
0.236PheTrp: 0.236 ± 0.177
1.103PheTyr: 1.103 ± 0.333
0.0PheXaa: 0.0 ± 0.0
Gly
4.647GlyAla: 4.647 ± 0.837
0.551GlyCys: 0.551 ± 0.201
3.623GlyAsp: 3.623 ± 0.599
3.938GlyGlu: 3.938 ± 0.596
2.442GlyPhe: 2.442 ± 0.344
3.78GlyGly: 3.78 ± 0.384
1.103GlyHis: 1.103 ± 0.271
5.277GlyIle: 5.277 ± 0.801
6.379GlyLys: 6.379 ± 0.547
4.726GlyLeu: 4.726 ± 0.703
1.339GlyMet: 1.339 ± 0.317
3.465GlyAsn: 3.465 ± 0.526
0.866GlyPro: 0.866 ± 0.224
3.229GlyGln: 3.229 ± 0.527
1.89GlyArg: 1.89 ± 0.357
3.465GlySer: 3.465 ± 0.371
3.387GlyThr: 3.387 ± 0.46
5.277GlyVal: 5.277 ± 0.762
1.496GlyTrp: 1.496 ± 0.368
2.363GlyTyr: 2.363 ± 0.568
0.0GlyXaa: 0.0 ± 0.0
His
1.181HisAla: 1.181 ± 0.319
0.158HisCys: 0.158 ± 0.111
0.788HisAsp: 0.788 ± 0.241
1.181HisGlu: 1.181 ± 0.365
1.26HisPhe: 1.26 ± 0.289
0.788HisGly: 0.788 ± 0.224
0.315HisHis: 0.315 ± 0.17
0.866HisIle: 0.866 ± 0.258
0.788HisLys: 0.788 ± 0.237
1.496HisLeu: 1.496 ± 0.354
0.158HisMet: 0.158 ± 0.11
0.551HisAsn: 0.551 ± 0.176
0.63HisPro: 0.63 ± 0.21
0.709HisGln: 0.709 ± 0.216
0.945HisArg: 0.945 ± 0.229
0.945HisSer: 0.945 ± 0.302
0.945HisThr: 0.945 ± 0.311
0.551HisVal: 0.551 ± 0.202
0.158HisTrp: 0.158 ± 0.111
0.551HisTyr: 0.551 ± 0.229
0.0HisXaa: 0.0 ± 0.0
Ile
5.513IleAla: 5.513 ± 0.804
0.394IleCys: 0.394 ± 0.183
7.088IleAsp: 7.088 ± 0.852
5.907IleGlu: 5.907 ± 0.714
1.733IlePhe: 1.733 ± 0.393
3.623IleGly: 3.623 ± 0.491
0.473IleHis: 0.473 ± 0.204
4.095IleIle: 4.095 ± 0.665
7.167IleLys: 7.167 ± 0.732
3.308IleLeu: 3.308 ± 0.631
0.945IleMet: 0.945 ± 0.293
5.749IleAsn: 5.749 ± 0.808
1.181IlePro: 1.181 ± 0.264
1.811IleGln: 1.811 ± 0.258
2.205IleArg: 2.205 ± 0.393
3.78IleSer: 3.78 ± 0.651
4.962IleThr: 4.962 ± 0.504
4.647IleVal: 4.647 ± 0.679
0.709IleTrp: 0.709 ± 0.268
2.835IleTyr: 2.835 ± 0.474
0.0IleXaa: 0.0 ± 0.0
Lys
8.191LysAla: 8.191 ± 0.713
0.551LysCys: 0.551 ± 0.192
5.119LysAsp: 5.119 ± 0.884
6.301LysGlu: 6.301 ± 0.776
1.89LysPhe: 1.89 ± 0.418
5.671LysGly: 5.671 ± 0.75
1.181LysHis: 1.181 ± 0.222
5.198LysIle: 5.198 ± 0.68
6.773LysLys: 6.773 ± 0.782
6.931LysLeu: 6.931 ± 0.679
2.048LysMet: 2.048 ± 0.367
5.513LysAsn: 5.513 ± 0.614
2.442LysPro: 2.442 ± 0.487
4.095LysGln: 4.095 ± 0.656
3.544LysArg: 3.544 ± 0.683
3.78LysSer: 3.78 ± 0.463
5.119LysThr: 5.119 ± 0.731
6.222LysVal: 6.222 ± 0.875
0.945LysTrp: 0.945 ± 0.24
4.095LysTyr: 4.095 ± 0.576
0.0LysXaa: 0.0 ± 0.0
Leu
6.931LeuAla: 6.931 ± 0.718
0.63LeuCys: 0.63 ± 0.22
7.482LeuAsp: 7.482 ± 0.864
6.773LeuGlu: 6.773 ± 0.875
2.678LeuPhe: 2.678 ± 0.417
5.513LeuGly: 5.513 ± 0.626
0.788LeuHis: 0.788 ± 0.291
4.41LeuIle: 4.41 ± 0.746
7.876LeuLys: 7.876 ± 0.919
5.828LeuLeu: 5.828 ± 0.956
1.181LeuMet: 1.181 ± 0.35
6.222LeuAsn: 6.222 ± 0.805
3.072LeuPro: 3.072 ± 0.492
2.835LeuGln: 2.835 ± 0.511
2.914LeuArg: 2.914 ± 0.414
5.671LeuSer: 5.671 ± 0.684
4.726LeuThr: 4.726 ± 0.431
4.647LeuVal: 4.647 ± 0.495
0.866LeuTrp: 0.866 ± 0.204
2.442LeuTyr: 2.442 ± 0.459
0.0LeuXaa: 0.0 ± 0.0
Met
1.26MetAla: 1.26 ± 0.273
0.158MetCys: 0.158 ± 0.11
1.418MetAsp: 1.418 ± 0.436
1.496MetGlu: 1.496 ± 0.306
0.079MetPhe: 0.079 ± 0.078
1.496MetGly: 1.496 ± 0.387
0.236MetHis: 0.236 ± 0.126
1.181MetIle: 1.181 ± 0.223
1.496MetLys: 1.496 ± 0.395
1.654MetLeu: 1.654 ± 0.325
0.236MetMet: 0.236 ± 0.139
1.339MetAsn: 1.339 ± 0.337
0.866MetPro: 0.866 ± 0.261
1.654MetGln: 1.654 ± 0.482
1.654MetArg: 1.654 ± 0.309
2.284MetSer: 2.284 ± 0.542
2.363MetThr: 2.363 ± 0.358
0.945MetVal: 0.945 ± 0.292
0.315MetTrp: 0.315 ± 0.138
0.236MetTyr: 0.236 ± 0.107
0.0MetXaa: 0.0 ± 0.0
Asn
4.095AsnAla: 4.095 ± 0.671
0.394AsnCys: 0.394 ± 0.204
3.702AsnAsp: 3.702 ± 0.532
2.678AsnGlu: 2.678 ± 0.598
1.969AsnPhe: 1.969 ± 0.464
4.174AsnGly: 4.174 ± 0.675
0.788AsnHis: 0.788 ± 0.293
3.702AsnIle: 3.702 ± 0.557
4.883AsnLys: 4.883 ± 0.554
4.332AsnLeu: 4.332 ± 0.461
1.969AsnMet: 1.969 ± 0.379
3.465AsnAsn: 3.465 ± 0.5
2.205AsnPro: 2.205 ± 0.428
2.678AsnGln: 2.678 ± 0.387
2.835AsnArg: 2.835 ± 0.493
3.387AsnSer: 3.387 ± 0.562
2.599AsnThr: 2.599 ± 0.551
2.993AsnVal: 2.993 ± 0.394
0.866AsnTrp: 0.866 ± 0.286
2.205AsnTyr: 2.205 ± 0.541
0.0AsnXaa: 0.0 ± 0.0
Pro
1.339ProAla: 1.339 ± 0.299
0.158ProCys: 0.158 ± 0.106
1.733ProAsp: 1.733 ± 0.4
2.126ProGlu: 2.126 ± 0.478
1.181ProPhe: 1.181 ± 0.343
1.26ProGly: 1.26 ± 0.378
0.473ProHis: 0.473 ± 0.184
2.205ProIle: 2.205 ± 0.454
3.15ProLys: 3.15 ± 0.512
2.599ProLeu: 2.599 ± 0.478
0.63ProMet: 0.63 ± 0.219
1.418ProAsn: 1.418 ± 0.346
1.103ProPro: 1.103 ± 0.457
1.575ProGln: 1.575 ± 0.401
1.024ProArg: 1.024 ± 0.285
2.048ProSer: 2.048 ± 0.395
1.969ProThr: 1.969 ± 0.54
2.284ProVal: 2.284 ± 0.436
0.0ProTrp: 0.0 ± 0.0
1.89ProTyr: 1.89 ± 0.382
0.0ProXaa: 0.0 ± 0.0
Gln
3.15GlnAla: 3.15 ± 0.448
0.473GlnCys: 0.473 ± 0.176
1.654GlnAsp: 1.654 ± 0.402
3.544GlnGlu: 3.544 ± 0.637
1.339GlnPhe: 1.339 ± 0.293
2.52GlnGly: 2.52 ± 0.572
1.024GlnHis: 1.024 ± 0.311
2.835GlnIle: 2.835 ± 0.477
4.253GlnLys: 4.253 ± 0.553
4.568GlnLeu: 4.568 ± 0.662
1.26GlnMet: 1.26 ± 0.308
1.654GlnAsn: 1.654 ± 0.356
1.26GlnPro: 1.26 ± 0.519
2.678GlnGln: 2.678 ± 0.772
2.363GlnArg: 2.363 ± 0.506
3.15GlnSer: 3.15 ± 0.584
3.072GlnThr: 3.072 ± 0.561
1.811GlnVal: 1.811 ± 0.392
0.788GlnTrp: 0.788 ± 0.209
0.945GlnTyr: 0.945 ± 0.282
0.0GlnXaa: 0.0 ± 0.0
Arg
2.678ArgAla: 2.678 ± 0.406
0.236ArgCys: 0.236 ± 0.138
2.205ArgAsp: 2.205 ± 0.36
3.387ArgGlu: 3.387 ± 0.512
1.339ArgPhe: 1.339 ± 0.31
2.442ArgGly: 2.442 ± 0.504
0.866ArgHis: 0.866 ± 0.243
2.993ArgIle: 2.993 ± 0.497
3.465ArgLys: 3.465 ± 0.443
3.938ArgLeu: 3.938 ± 0.501
1.024ArgMet: 1.024 ± 0.249
2.205ArgAsn: 2.205 ± 0.426
1.024ArgPro: 1.024 ± 0.356
1.969ArgGln: 1.969 ± 0.437
1.733ArgArg: 1.733 ± 0.352
1.89ArgSer: 1.89 ± 0.272
2.914ArgThr: 2.914 ± 0.426
3.072ArgVal: 3.072 ± 0.45
0.709ArgTrp: 0.709 ± 0.265
1.969ArgTyr: 1.969 ± 0.527
0.0ArgXaa: 0.0 ± 0.0
Ser
4.726SerAla: 4.726 ± 0.764
0.394SerCys: 0.394 ± 0.187
4.095SerAsp: 4.095 ± 0.495
4.253SerGlu: 4.253 ± 0.554
2.363SerPhe: 2.363 ± 0.433
4.489SerGly: 4.489 ± 0.763
1.024SerHis: 1.024 ± 0.314
4.332SerIle: 4.332 ± 0.636
4.332SerLys: 4.332 ± 0.48
5.513SerLeu: 5.513 ± 0.729
1.733SerMet: 1.733 ± 0.355
2.126SerAsn: 2.126 ± 0.396
1.181SerPro: 1.181 ± 0.329
2.835SerGln: 2.835 ± 0.477
1.811SerArg: 1.811 ± 0.458
2.678SerSer: 2.678 ± 0.559
3.859SerThr: 3.859 ± 0.766
3.544SerVal: 3.544 ± 0.474
0.866SerTrp: 0.866 ± 0.321
1.496SerTyr: 1.496 ± 0.334
0.0SerXaa: 0.0 ± 0.0
Thr
6.064ThrAla: 6.064 ± 0.779
0.236ThrCys: 0.236 ± 0.151
3.938ThrAsp: 3.938 ± 0.498
3.544ThrGlu: 3.544 ± 0.553
1.733ThrPhe: 1.733 ± 0.366
3.544ThrGly: 3.544 ± 0.467
0.945ThrHis: 0.945 ± 0.274
4.332ThrIle: 4.332 ± 0.501
4.174ThrLys: 4.174 ± 0.52
4.962ThrLeu: 4.962 ± 0.502
1.496ThrMet: 1.496 ± 0.364
2.678ThrAsn: 2.678 ± 0.338
3.15ThrPro: 3.15 ± 0.449
2.757ThrGln: 2.757 ± 0.392
2.284ThrArg: 2.284 ± 0.452
3.229ThrSer: 3.229 ± 0.518
3.938ThrThr: 3.938 ± 0.681
5.434ThrVal: 5.434 ± 0.742
0.709ThrTrp: 0.709 ± 0.175
2.599ThrTyr: 2.599 ± 0.51
0.0ThrXaa: 0.0 ± 0.0
Val
4.647ValAla: 4.647 ± 0.558
0.394ValCys: 0.394 ± 0.188
5.434ValAsp: 5.434 ± 0.676
4.883ValGlu: 4.883 ± 0.603
2.363ValPhe: 2.363 ± 0.476
5.041ValGly: 5.041 ± 0.542
0.866ValHis: 0.866 ± 0.238
5.434ValIle: 5.434 ± 0.718
5.356ValLys: 5.356 ± 0.701
4.883ValLeu: 4.883 ± 0.79
2.048ValMet: 2.048 ± 0.372
2.757ValAsn: 2.757 ± 0.341
2.205ValPro: 2.205 ± 0.523
1.654ValGln: 1.654 ± 0.294
2.442ValArg: 2.442 ± 0.359
3.702ValSer: 3.702 ± 0.416
4.095ValThr: 4.095 ± 0.464
4.332ValVal: 4.332 ± 0.578
0.394ValTrp: 0.394 ± 0.173
1.89ValTyr: 1.89 ± 0.434
0.0ValXaa: 0.0 ± 0.0
Trp
0.709TrpAla: 0.709 ± 0.24
0.079TrpCys: 0.079 ± 0.073
1.418TrpAsp: 1.418 ± 0.368
0.788TrpGlu: 0.788 ± 0.268
0.63TrpPhe: 0.63 ± 0.198
0.551TrpGly: 0.551 ± 0.269
0.551TrpHis: 0.551 ± 0.237
1.024TrpIle: 1.024 ± 0.287
1.181TrpLys: 1.181 ± 0.222
0.945TrpLeu: 0.945 ± 0.337
0.158TrpMet: 0.158 ± 0.14
0.63TrpAsn: 0.63 ± 0.178
0.158TrpPro: 0.158 ± 0.103
0.709TrpGln: 0.709 ± 0.204
0.473TrpArg: 0.473 ± 0.193
0.551TrpSer: 0.551 ± 0.235
1.103TrpThr: 1.103 ± 0.402
0.63TrpVal: 0.63 ± 0.187
0.0TrpTrp: 0.0 ± 0.0
0.394TrpTyr: 0.394 ± 0.19
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.52TyrAla: 2.52 ± 0.407
0.551TyrCys: 0.551 ± 0.242
3.072TyrAsp: 3.072 ± 0.486
1.733TyrGlu: 1.733 ± 0.37
0.866TyrPhe: 0.866 ± 0.329
2.126TyrGly: 2.126 ± 0.348
0.709TyrHis: 0.709 ± 0.251
2.048TyrIle: 2.048 ± 0.365
3.859TyrLys: 3.859 ± 0.72
2.993TyrLeu: 2.993 ± 0.54
0.394TyrMet: 0.394 ± 0.157
2.126TyrAsn: 2.126 ± 0.469
1.654TyrPro: 1.654 ± 0.38
3.229TyrGln: 3.229 ± 0.698
1.181TyrArg: 1.181 ± 0.314
1.89TyrSer: 1.89 ± 0.4
2.284TyrThr: 2.284 ± 0.592
1.811TyrVal: 1.811 ± 0.336
0.63TyrTrp: 0.63 ± 0.211
1.969TyrTyr: 1.969 ± 0.366
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (12698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski