Amino acid dipepetide frequency for Skermanella stibiiresistens SB22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.119AlaAla: 17.119 ± 0.14	1.11AlaCys: 1.11 ± 0.024	7.143AlaAsp: 7.143 ± 0.056	7.717AlaGlu: 7.717 ± 0.074	4.06AlaPhe: 4.06 ± 0.048	11.284AlaGly: 11.284 ± 0.103	2.007AlaHis: 2.007 ± 0.035	5.967AlaIle: 5.967 ± 0.055	3.592AlaLys: 3.592 ± 0.05	13.092AlaLeu: 13.092 ± 0.096	3.459AlaMet: 3.459 ± 0.041	2.818AlaAsn: 2.818 ± 0.048	5.435AlaPro: 5.435 ± 0.056	3.213AlaGln: 3.213 ± 0.042	8.572AlaArg: 8.572 ± 0.08	6.268AlaSer: 6.268 ± 0.067	6.319AlaThr: 6.319 ± 0.088	9.689AlaVal: 9.689 ± 0.076	1.518AlaTrp: 1.518 ± 0.028	2.207AlaTyr: 2.207 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	0.937CysAla: 0.937 ± 0.021	0.096CysCys: 0.096 ± 0.006	0.503CysAsp: 0.503 ± 0.016	0.378CysGlu: 0.378 ± 0.015	0.306CysPhe: 0.306 ± 0.012	0.946CysGly: 0.946 ± 0.023	0.281CysHis: 0.281 ± 0.014	0.273CysIle: 0.273 ± 0.011	0.153CysLys: 0.153 ± 0.008	0.848CysLeu: 0.848 ± 0.021	0.162CysMet: 0.162 ± 0.008	0.168CysAsn: 0.168 ± 0.008	0.46CysPro: 0.46 ± 0.017	0.248CysGln: 0.248 ± 0.012	0.703CysArg: 0.703 ± 0.018	0.409CysSer: 0.409 ± 0.015	0.356CysThr: 0.356 ± 0.013	0.701CysVal: 0.701 ± 0.018	0.101CysTrp: 0.101 ± 0.006	0.207CysTyr: 0.207 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.886AspAla: 6.886 ± 0.067	0.433AspCys: 0.433 ± 0.016	3.378AspAsp: 3.378 ± 0.051	3.33AspGlu: 3.33 ± 0.041	2.097AspPhe: 2.097 ± 0.031	5.81AspGly: 5.81 ± 0.068	1.426AspHis: 1.426 ± 0.028	3.04AspIle: 3.04 ± 0.04	1.537AspLys: 1.537 ± 0.03	6.78AspLeu: 6.78 ± 0.059	1.388AspMet: 1.388 ± 0.026	1.192AspAsn: 1.192 ± 0.027	3.787AspPro: 3.787 ± 0.045	2.018AspGln: 2.018 ± 0.031	4.836AspArg: 4.836 ± 0.048	2.119AspSer: 2.119 ± 0.037	2.878AspThr: 2.878 ± 0.052	4.168AspVal: 4.168 ± 0.04	0.963AspTrp: 0.963 ± 0.022	1.337AspTyr: 1.337 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.151GluAla: 7.151 ± 0.072	0.321GluCys: 0.321 ± 0.012	2.794GluAsp: 2.794 ± 0.039	2.985GluGlu: 2.985 ± 0.044	1.766GluPhe: 1.766 ± 0.033	4.098GluGly: 4.098 ± 0.047	1.147GluHis: 1.147 ± 0.026	3.378GluIle: 3.378 ± 0.04	1.713GluLys: 1.713 ± 0.029	5.433GluLeu: 5.433 ± 0.057	1.499GluMet: 1.499 ± 0.028	1.352GluAsn: 1.352 ± 0.025	2.946GluPro: 2.946 ± 0.042	1.926GluGln: 1.926 ± 0.029	5.464GluArg: 5.464 ± 0.064	2.258GluSer: 2.258 ± 0.032	3.45GluThr: 3.45 ± 0.04	4.092GluVal: 4.092 ± 0.054	0.663GluTrp: 0.663 ± 0.017	0.938GluTyr: 0.938 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.956PheAla: 3.956 ± 0.044	0.369PheCys: 0.369 ± 0.014	2.57PheAsp: 2.57 ± 0.039	1.901PheGlu: 1.901 ± 0.029	1.216PhePhe: 1.216 ± 0.029	3.63PheGly: 3.63 ± 0.034	0.815PheHis: 0.815 ± 0.018	1.616PheIle: 1.616 ± 0.029	0.981PheLys: 0.981 ± 0.022	3.339PheLeu: 3.339 ± 0.045	0.794PheMet: 0.794 ± 0.019	0.985PheAsn: 0.985 ± 0.023	1.631PhePro: 1.631 ± 0.034	1.136PheGln: 1.136 ± 0.021	2.252PheArg: 2.252 ± 0.034	2.045PheSer: 2.045 ± 0.032	1.981PheThr: 1.981 ± 0.031	2.629PheVal: 2.629 ± 0.033	0.502PheTrp: 0.502 ± 0.016	0.773PheTyr: 0.773 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	9.756GlyAla: 9.756 ± 0.119	0.876GlyCys: 0.876 ± 0.024	4.963GlyAsp: 4.963 ± 0.056	4.597GlyGlu: 4.597 ± 0.051	3.646GlyPhe: 3.646 ± 0.046	8.309GlyGly: 8.309 ± 0.096	2.016GlyHis: 2.016 ± 0.03	4.785GlyIle: 4.785 ± 0.053	3.012GlyLys: 3.012 ± 0.047	9.148GlyLeu: 9.148 ± 0.072	2.642GlyMet: 2.642 ± 0.034	2.096GlyAsn: 2.096 ± 0.054	3.738GlyPro: 3.738 ± 0.044	2.853GlyGln: 2.853 ± 0.037	6.474GlyArg: 6.474 ± 0.062	4.781GlySer: 4.781 ± 0.073	5.278GlyThr: 5.278 ± 0.133	6.922GlyVal: 6.922 ± 0.066	1.43GlyTrp: 1.43 ± 0.028	2.209GlyTyr: 2.209 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.422HisAla: 2.422 ± 0.037	0.22HisCys: 0.22 ± 0.01	1.345HisAsp: 1.345 ± 0.028	1.039HisGlu: 1.039 ± 0.021	0.792HisPhe: 0.792 ± 0.022	2.092HisGly: 2.092 ± 0.032	0.645HisHis: 0.645 ± 0.017	0.899HisIle: 0.899 ± 0.02	0.455HisLys: 0.455 ± 0.016	2.21HisLeu: 2.21 ± 0.04	0.495HisMet: 0.495 ± 0.013	0.432HisAsn: 0.432 ± 0.013	1.44HisPro: 1.44 ± 0.026	0.646HisGln: 0.646 ± 0.015	1.577HisArg: 1.577 ± 0.025	0.903HisSer: 0.903 ± 0.019	0.922HisThr: 0.922 ± 0.02	1.567HisVal: 1.567 ± 0.029	0.323HisTrp: 0.323 ± 0.012	0.482HisTyr: 0.482 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.549IleAla: 6.549 ± 0.057	0.44IleCys: 0.44 ± 0.015	3.704IleAsp: 3.704 ± 0.043	3.317IleGlu: 3.317 ± 0.038	1.466IlePhe: 1.466 ± 0.029	5.224IleGly: 5.224 ± 0.058	1.099IleHis: 1.099 ± 0.021	2.12IleIle: 2.12 ± 0.032	1.4IleLys: 1.4 ± 0.028	4.582IleLeu: 4.582 ± 0.056	0.998IleMet: 0.998 ± 0.019	1.365IleAsn: 1.365 ± 0.025	2.526IlePro: 2.526 ± 0.034	1.508IleGln: 1.508 ± 0.026	3.373IleArg: 3.373 ± 0.036	2.678IleSer: 2.678 ± 0.039	2.843IleThr: 2.843 ± 0.05	4.015IleVal: 4.015 ± 0.043	0.567IleTrp: 0.567 ± 0.018	0.946IleTyr: 0.946 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.61LysAla: 3.61 ± 0.045	0.132LysCys: 0.132 ± 0.008	1.412LysAsp: 1.412 ± 0.03	1.273LysGlu: 1.273 ± 0.027	0.839LysPhe: 0.839 ± 0.02	2.27LysGly: 2.27 ± 0.039	0.524LysHis: 0.524 ± 0.013	1.399LysIle: 1.399 ± 0.027	0.83LysLys: 0.83 ± 0.024	3.088LysLeu: 3.088 ± 0.043	0.675LysMet: 0.675 ± 0.017	0.651LysAsn: 0.651 ± 0.017	2.044LysPro: 2.044 ± 0.031	0.824LysGln: 0.824 ± 0.022	2.198LysArg: 2.198 ± 0.04	1.606LysSer: 1.606 ± 0.031	1.603LysThr: 1.603 ± 0.032	2.339LysVal: 2.339 ± 0.041	0.286LysTrp: 0.286 ± 0.01	0.529LysTyr: 0.529 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.803LeuAla: 13.803 ± 0.09	0.878LeuCys: 0.878 ± 0.021	6.664LeuAsp: 6.664 ± 0.061	5.521LeuGlu: 5.521 ± 0.059	3.615LeuPhe: 3.615 ± 0.053	8.903LeuGly: 8.903 ± 0.069	1.866LeuHis: 1.866 ± 0.033	5.181LeuIle: 5.181 ± 0.057	2.979LeuLys: 2.979 ± 0.044	9.981LeuLeu: 9.981 ± 0.102	2.473LeuMet: 2.473 ± 0.037	2.596LeuAsn: 2.596 ± 0.032	5.682LeuPro: 5.682 ± 0.058	2.302LeuGln: 2.302 ± 0.035	7.639LeuArg: 7.639 ± 0.07	6.233LeuSer: 6.233 ± 0.064	6.191LeuThr: 6.191 ± 0.112	7.865LeuVal: 7.865 ± 0.072	1.137LeuTrp: 1.137 ± 0.023	1.93LeuTyr: 1.93 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	3.429MetAla: 3.429 ± 0.038	0.153MetCys: 0.153 ± 0.009	1.258MetAsp: 1.258 ± 0.025	1.224MetGlu: 1.224 ± 0.024	0.711MetPhe: 0.711 ± 0.017	1.937MetGly: 1.937 ± 0.031	0.366MetHis: 0.366 ± 0.015	1.437MetIle: 1.437 ± 0.025	0.78MetLys: 0.78 ± 0.019	2.545MetLeu: 2.545 ± 0.036	0.721MetMet: 0.721 ± 0.017	0.669MetAsn: 0.669 ± 0.019	1.594MetPro: 1.594 ± 0.027	0.517MetGln: 0.517 ± 0.016	1.875MetArg: 1.875 ± 0.029	1.549MetSer: 1.549 ± 0.026	1.997MetThr: 1.997 ± 0.031	2.08MetVal: 2.08 ± 0.033	0.194MetTrp: 0.194 ± 0.01	0.307MetTyr: 0.307 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.825AsnAla: 2.825 ± 0.049	0.232AsnCys: 0.232 ± 0.011	1.38AsnAsp: 1.38 ± 0.034	1.085AsnGlu: 1.085 ± 0.026	0.812AsnPhe: 0.812 ± 0.02	2.179AsnGly: 2.179 ± 0.048	0.552AsnHis: 0.552 ± 0.014	1.228AsnIle: 1.228 ± 0.024	0.649AsnLys: 0.649 ± 0.019	2.732AsnLeu: 2.732 ± 0.042	0.55AsnMet: 0.55 ± 0.016	0.67AsnAsn: 0.67 ± 0.02	1.764AsnPro: 1.764 ± 0.029	0.821AsnGln: 0.821 ± 0.021	1.863AsnArg: 1.863 ± 0.029	1.183AsnSer: 1.183 ± 0.027	1.265AsnThr: 1.265 ± 0.032	1.705AsnVal: 1.705 ± 0.031	0.358AsnTrp: 0.358 ± 0.014	0.55AsnTyr: 0.55 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	6.571ProAla: 6.571 ± 0.07	0.337ProCys: 0.337 ± 0.013	3.905ProAsp: 3.905 ± 0.047	3.676ProGlu: 3.676 ± 0.045	1.905ProPhe: 1.905 ± 0.03	4.8ProGly: 4.8 ± 0.05	1.074ProHis: 1.074 ± 0.024	2.437ProIle: 2.437 ± 0.034	1.473ProLys: 1.473 ± 0.032	5.098ProLeu: 5.098 ± 0.056	1.322ProMet: 1.322 ± 0.024	1.355ProAsn: 1.355 ± 0.026	3.126ProPro: 3.126 ± 0.053	1.245ProGln: 1.245 ± 0.026	3.153ProArg: 3.153 ± 0.043	2.891ProSer: 2.891 ± 0.036	2.862ProThr: 2.862 ± 0.039	4.62ProVal: 4.62 ± 0.048	0.736ProTrp: 0.736 ± 0.017	1.086ProTyr: 1.086 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.889GlnAla: 3.889 ± 0.042	0.201GlnCys: 0.201 ± 0.01	1.37GlnAsp: 1.37 ± 0.025	1.388GlnGlu: 1.388 ± 0.027	0.942GlnPhe: 0.942 ± 0.025	2.327GlnGly: 2.327 ± 0.035	0.589GlnHis: 0.589 ± 0.018	1.662GlnIle: 1.662 ± 0.026	0.784GlnLys: 0.784 ± 0.02	2.567GlnLeu: 2.567 ± 0.034	0.758GlnMet: 0.758 ± 0.018	0.688GlnAsn: 0.688 ± 0.018	1.817GlnPro: 1.817 ± 0.031	1.014GlnGln: 1.014 ± 0.024	2.429GlnArg: 2.429 ± 0.041	1.593GlnSer: 1.593 ± 0.027	1.642GlnThr: 1.642 ± 0.028	2.415GlnVal: 2.415 ± 0.032	0.337GlnTrp: 0.337 ± 0.014	0.545GlnTyr: 0.545 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	7.937ArgAla: 7.937 ± 0.076	0.584ArgCys: 0.584 ± 0.016	4.666ArgAsp: 4.666 ± 0.044	4.2ArgGlu: 4.2 ± 0.049	2.975ArgPhe: 2.975 ± 0.038	5.307ArgGly: 5.307 ± 0.052	2.02ArgHis: 2.02 ± 0.032	4.149ArgIle: 4.149 ± 0.042	2.0ArgLys: 2.0 ± 0.032	8.471ArgLeu: 8.471 ± 0.082	2.054ArgMet: 2.054 ± 0.033	1.819ArgAsn: 1.819 ± 0.03	3.646ArgPro: 3.646 ± 0.051	2.681ArgGln: 2.681 ± 0.039	6.609ArgArg: 6.609 ± 0.069	3.697ArgSer: 3.697 ± 0.049	3.659ArgThr: 3.659 ± 0.05	5.487ArgVal: 5.487 ± 0.056	1.016ArgTrp: 1.016 ± 0.026	1.646ArgTyr: 1.646 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.048SerAla: 6.048 ± 0.07	0.408SerCys: 0.408 ± 0.016	2.907SerAsp: 2.907 ± 0.039	2.458SerGlu: 2.458 ± 0.036	2.08SerPhe: 2.08 ± 0.03	5.624SerGly: 5.624 ± 0.112	1.206SerHis: 1.206 ± 0.025	2.566SerIle: 2.566 ± 0.035	1.34SerLys: 1.34 ± 0.03	5.488SerLeu: 5.488 ± 0.054	1.326SerMet: 1.326 ± 0.023	1.266SerAsn: 1.266 ± 0.029	2.852SerPro: 2.852 ± 0.04	1.46SerGln: 1.46 ± 0.024	3.825SerArg: 3.825 ± 0.05	2.892SerSer: 2.892 ± 0.05	2.619SerThr: 2.619 ± 0.04	4.008SerVal: 4.008 ± 0.05	0.709SerTrp: 0.709 ± 0.018	1.18SerTyr: 1.18 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	6.671ThrAla: 6.671 ± 0.083	0.427ThrCys: 0.427 ± 0.014	3.017ThrAsp: 3.017 ± 0.045	2.759ThrGlu: 2.759 ± 0.038	1.843ThrPhe: 1.843 ± 0.031	5.663ThrGly: 5.663 ± 0.105	1.023ThrHis: 1.023 ± 0.02	2.968ThrIle: 2.968 ± 0.054	1.386ThrLys: 1.386 ± 0.029	6.433ThrLeu: 6.433 ± 0.117	1.246ThrMet: 1.246 ± 0.025	1.344ThrAsn: 1.344 ± 0.029	3.422ThrPro: 3.422 ± 0.042	1.347ThrGln: 1.347 ± 0.027	3.551ThrArg: 3.551 ± 0.039	2.952ThrSer: 2.952 ± 0.053	3.092ThrThr: 3.092 ± 0.067	5.012ThrVal: 5.012 ± 0.088	0.674ThrTrp: 0.674 ± 0.019	1.139ThrTyr: 1.139 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	9.753ValAla: 9.753 ± 0.074	0.671ValCys: 0.671 ± 0.02	4.389ValAsp: 4.389 ± 0.041	4.92ValGlu: 4.92 ± 0.055	2.742ValPhe: 2.742 ± 0.039	6.239ValGly: 6.239 ± 0.059	1.444ValHis: 1.444 ± 0.03	4.163ValIle: 4.163 ± 0.051	2.143ValLys: 2.143 ± 0.035	7.843ValLeu: 7.843 ± 0.067	2.058ValMet: 2.058 ± 0.03	1.992ValAsn: 1.992 ± 0.03	4.083ValPro: 4.083 ± 0.045	2.047ValGln: 2.047 ± 0.032	5.236ValArg: 5.236 ± 0.057	4.395ValSer: 4.395 ± 0.058	5.194ValThr: 5.194 ± 0.084	6.529ValVal: 6.529 ± 0.07	0.925ValTrp: 0.925 ± 0.021	1.358ValTyr: 1.358 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.111TrpAla: 1.111 ± 0.028	0.128TrpCys: 0.128 ± 0.007	0.667TrpAsp: 0.667 ± 0.021	0.575TrpGlu: 0.575 ± 0.018	0.545TrpPhe: 0.545 ± 0.015	0.9TrpGly: 0.9 ± 0.024	0.328TrpHis: 0.328 ± 0.012	0.679TrpIle: 0.679 ± 0.019	0.376TrpLys: 0.376 ± 0.014	1.59TrpLeu: 1.59 ± 0.027	0.334TrpMet: 0.334 ± 0.014	0.422TrpAsn: 0.422 ± 0.02	0.653TrpPro: 0.653 ± 0.02	0.445TrpGln: 0.445 ± 0.017	1.291TrpArg: 1.291 ± 0.027	0.799TrpSer: 0.799 ± 0.02	0.817TrpThr: 0.817 ± 0.024	0.822TrpVal: 0.822 ± 0.018	0.231TrpTrp: 0.231 ± 0.011	0.284TrpTyr: 0.284 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.166TyrAla: 2.166 ± 0.032	0.217TyrCys: 0.217 ± 0.009	1.369TyrAsp: 1.369 ± 0.028	1.03TyrGlu: 1.03 ± 0.024	0.762TyrPhe: 0.762 ± 0.021	1.988TyrGly: 1.988 ± 0.027	0.478TyrHis: 0.478 ± 0.014	0.773TyrIle: 0.773 ± 0.019	0.549TyrLys: 0.549 ± 0.016	2.17TyrLeu: 2.17 ± 0.035	0.389TyrMet: 0.389 ± 0.015	0.525TyrAsn: 0.525 ± 0.016	1.029TyrPro: 1.029 ± 0.022	0.708TyrGln: 0.708 ± 0.019	1.702TyrArg: 1.702 ± 0.029	1.015TyrSer: 1.015 ± 0.021	0.999TyrThr: 0.999 ± 0.025	1.46TyrVal: 1.46 ± 0.027	0.325TyrTrp: 0.325 ± 0.014	0.533TyrTyr: 0.533 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7269 proteins (2267981 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---