Amino acid dipepetide frequency for Pseudoalteromonas citrea DSM 8771

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.806AlaAla: 6.806 ± 0.083	1.005AlaCys: 1.005 ± 0.029	4.442AlaAsp: 4.442 ± 0.058	4.76AlaGlu: 4.76 ± 0.065	3.37AlaPhe: 3.37 ± 0.049	5.509AlaGly: 5.509 ± 0.087	2.063AlaHis: 2.063 ± 0.041	5.826AlaIle: 5.826 ± 0.069	5.041AlaLys: 5.041 ± 0.059	9.828AlaLeu: 9.828 ± 0.098	2.301AlaMet: 2.301 ± 0.04	3.824AlaAsn: 3.824 ± 0.056	2.851AlaPro: 2.851 ± 0.052	4.946AlaGln: 4.946 ± 0.076	3.224AlaArg: 3.224 ± 0.052	5.337AlaSer: 5.337 ± 0.063	4.537AlaThr: 4.537 ± 0.071	5.334AlaVal: 5.334 ± 0.068	0.872AlaTrp: 0.872 ± 0.025	2.534AlaTyr: 2.534 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.856CysAla: 0.856 ± 0.029	0.163CysCys: 0.163 ± 0.013	0.668CysAsp: 0.668 ± 0.022	0.705CysGlu: 0.705 ± 0.027	0.485CysPhe: 0.485 ± 0.018	0.769CysGly: 0.769 ± 0.028	0.36CysHis: 0.36 ± 0.016	0.707CysIle: 0.707 ± 0.024	0.526CysLys: 0.526 ± 0.021	1.013CysLeu: 1.013 ± 0.026	0.228CysMet: 0.228 ± 0.01	0.482CysAsn: 0.482 ± 0.018	0.376CysPro: 0.376 ± 0.017	0.511CysGln: 0.511 ± 0.021	0.418CysArg: 0.418 ± 0.019	0.742CysSer: 0.742 ± 0.025	0.531CysThr: 0.531 ± 0.021	0.66CysVal: 0.66 ± 0.02	0.112CysTrp: 0.112 ± 0.008	0.373CysTyr: 0.373 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.458AspAla: 4.458 ± 0.053	0.509AspCys: 0.509 ± 0.019	3.242AspAsp: 3.242 ± 0.056	3.813AspGlu: 3.813 ± 0.058	2.53AspPhe: 2.53 ± 0.044	3.617AspGly: 3.617 ± 0.068	1.165AspHis: 1.165 ± 0.033	4.394AspIle: 4.394 ± 0.062	3.443AspLys: 3.443 ± 0.053	5.162AspLeu: 5.162 ± 0.051	1.342AspMet: 1.342 ± 0.029	2.811AspAsn: 2.811 ± 0.046	1.931AspPro: 1.931 ± 0.039	1.748AspGln: 1.748 ± 0.035	1.793AspArg: 1.793 ± 0.039	3.54AspSer: 3.54 ± 0.057	3.19AspThr: 3.19 ± 0.058	4.001AspVal: 4.001 ± 0.056	0.732AspTrp: 0.732 ± 0.024	2.083AspTyr: 2.083 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	4.606GluAla: 4.606 ± 0.074	0.507GluCys: 0.507 ± 0.02	2.41GluAsp: 2.41 ± 0.045	2.957GluGlu: 2.957 ± 0.064	2.58GluPhe: 2.58 ± 0.044	3.203GluGly: 3.203 ± 0.053	1.955GluHis: 1.955 ± 0.037	3.587GluIle: 3.587 ± 0.05	3.46GluLys: 3.46 ± 0.053	7.182GluLeu: 7.182 ± 0.084	1.297GluMet: 1.297 ± 0.032	2.584GluAsn: 2.584 ± 0.046	1.844GluPro: 1.844 ± 0.036	4.788GluGln: 4.788 ± 0.07	3.021GluArg: 3.021 ± 0.056	3.608GluSer: 3.608 ± 0.047	2.79GluThr: 2.79 ± 0.055	4.064GluVal: 4.064 ± 0.053	0.583GluTrp: 0.583 ± 0.018	1.958GluTyr: 1.958 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.593PheAla: 3.593 ± 0.048	0.529PheCys: 0.529 ± 0.02	3.008PheAsp: 3.008 ± 0.045	2.674PheGlu: 2.674 ± 0.043	1.698PhePhe: 1.698 ± 0.039	2.784PheGly: 2.784 ± 0.046	0.78PheHis: 0.78 ± 0.02	2.914PheIle: 2.914 ± 0.048	2.37PheLys: 2.37 ± 0.043	3.249PheLeu: 3.249 ± 0.054	0.999PheMet: 0.999 ± 0.027	2.469PheAsn: 2.469 ± 0.039	1.258PhePro: 1.258 ± 0.03	1.208PheGln: 1.208 ± 0.026	1.29PheArg: 1.29 ± 0.032	3.825PheSer: 3.825 ± 0.049	2.653PheThr: 2.653 ± 0.047	2.698PheVal: 2.698 ± 0.043	0.482PheTrp: 0.482 ± 0.02	1.449PheTyr: 1.449 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	4.871GlyAla: 4.871 ± 0.071	0.831GlyCys: 0.831 ± 0.022	3.481GlyAsp: 3.481 ± 0.06	3.93GlyGlu: 3.93 ± 0.06	3.165GlyPhe: 3.165 ± 0.043	4.133GlyGly: 4.133 ± 0.077	1.518GlyHis: 1.518 ± 0.036	4.067GlyIle: 4.067 ± 0.053	3.712GlyLys: 3.712 ± 0.061	6.442GlyLeu: 6.442 ± 0.079	1.654GlyMet: 1.654 ± 0.039	2.68GlyAsn: 2.68 ± 0.055	1.528GlyPro: 1.528 ± 0.037	2.831GlyGln: 2.831 ± 0.048	2.596GlyArg: 2.596 ± 0.044	3.958GlySer: 3.958 ± 0.056	3.321GlyThr: 3.321 ± 0.061	4.775GlyVal: 4.775 ± 0.059	0.787GlyTrp: 0.787 ± 0.023	2.485GlyTyr: 2.485 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.843HisAla: 1.843 ± 0.039	0.391HisCys: 0.391 ± 0.017	1.327HisAsp: 1.327 ± 0.038	1.271HisGlu: 1.271 ± 0.031	1.29HisPhe: 1.29 ± 0.028	1.594HisGly: 1.594 ± 0.039	0.831HisHis: 0.831 ± 0.027	1.766HisIle: 1.766 ± 0.031	1.224HisLys: 1.224 ± 0.029	2.457HisLeu: 2.457 ± 0.042	0.506HisMet: 0.506 ± 0.02	1.198HisAsn: 1.198 ± 0.029	1.059HisPro: 1.059 ± 0.028	1.252HisGln: 1.252 ± 0.032	0.964HisArg: 0.964 ± 0.025	1.834HisSer: 1.834 ± 0.043	1.475HisThr: 1.475 ± 0.033	1.464HisVal: 1.464 ± 0.034	0.364HisTrp: 0.364 ± 0.019	1.044HisTyr: 1.044 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.269IleAla: 6.269 ± 0.066	0.698IleCys: 0.698 ± 0.02	4.447IleAsp: 4.447 ± 0.059	4.787IleGlu: 4.787 ± 0.065	2.174IlePhe: 2.174 ± 0.043	4.144IleGly: 4.144 ± 0.055	1.323IleHis: 1.323 ± 0.034	3.533IleIle: 3.533 ± 0.059	3.889IleLys: 3.889 ± 0.053	5.094IleLeu: 5.094 ± 0.064	1.266IleMet: 1.266 ± 0.029	3.553IleAsn: 3.553 ± 0.051	2.303IlePro: 2.303 ± 0.033	2.19IleGln: 2.19 ± 0.043	2.51IleArg: 2.51 ± 0.045	4.864IleSer: 4.864 ± 0.065	4.073IleThr: 4.073 ± 0.054	3.919IleVal: 3.919 ± 0.06	0.645IleTrp: 0.645 ± 0.024	1.849IleTyr: 1.849 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.852LysAla: 4.852 ± 0.063	0.369LysCys: 0.369 ± 0.017	2.684LysAsp: 2.684 ± 0.038	3.232LysGlu: 3.232 ± 0.05	1.674LysPhe: 1.674 ± 0.035	3.234LysGly: 3.234 ± 0.056	1.543LysHis: 1.543 ± 0.032	3.115LysIle: 3.115 ± 0.053	3.27LysLys: 3.27 ± 0.066	5.881LysLeu: 5.881 ± 0.068	1.255LysMet: 1.255 ± 0.033	2.628LysAsn: 2.628 ± 0.042	2.379LysPro: 2.379 ± 0.04	3.404LysGln: 3.404 ± 0.052	2.8LysArg: 2.8 ± 0.053	3.639LysSer: 3.639 ± 0.051	3.11LysThr: 3.11 ± 0.051	4.176LysVal: 4.176 ± 0.052	0.554LysTrp: 0.554 ± 0.018	1.675LysTyr: 1.675 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.678LeuAla: 9.678 ± 0.087	1.239LeuCys: 1.239 ± 0.029	5.895LeuAsp: 5.895 ± 0.07	5.936LeuGlu: 5.936 ± 0.072	4.272LeuPhe: 4.272 ± 0.069	6.279LeuGly: 6.279 ± 0.07	2.272LeuHis: 2.272 ± 0.046	6.202LeuIle: 6.202 ± 0.083	5.877LeuLys: 5.877 ± 0.069	10.686LeuLeu: 10.686 ± 0.119	2.296LeuMet: 2.296 ± 0.043	5.364LeuAsn: 5.364 ± 0.065	4.617LeuPro: 4.617 ± 0.062	4.13LeuGln: 4.13 ± 0.066	3.894LeuArg: 3.894 ± 0.052	8.685LeuSer: 8.685 ± 0.092	6.589LeuThr: 6.589 ± 0.068	6.508LeuVal: 6.508 ± 0.07	0.989LeuTrp: 0.989 ± 0.028	2.962LeuTyr: 2.962 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.198MetAla: 2.198 ± 0.042	0.187MetCys: 0.187 ± 0.011	1.015MetAsp: 1.015 ± 0.025	1.006MetGlu: 1.006 ± 0.025	0.78MetPhe: 0.78 ± 0.025	1.412MetGly: 1.412 ± 0.036	0.538MetHis: 0.538 ± 0.018	1.287MetIle: 1.287 ± 0.031	1.263MetLys: 1.263 ± 0.031	2.549MetLeu: 2.549 ± 0.041	0.636MetMet: 0.636 ± 0.021	1.003MetAsn: 1.003 ± 0.026	1.09MetPro: 1.09 ± 0.03	1.2MetGln: 1.2 ± 0.03	1.081MetArg: 1.081 ± 0.027	1.877MetSer: 1.877 ± 0.035	1.464MetThr: 1.464 ± 0.028	1.506MetVal: 1.506 ± 0.034	0.22MetTrp: 0.22 ± 0.011	0.567MetTyr: 0.567 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.97AsnAla: 3.97 ± 0.055	0.452AsnCys: 0.452 ± 0.019	2.788AsnAsp: 2.788 ± 0.06	2.761AsnGlu: 2.761 ± 0.046	1.68AsnPhe: 1.68 ± 0.036	3.099AsnGly: 3.099 ± 0.057	1.094AsnHis: 1.094 ± 0.031	3.341AsnIle: 3.341 ± 0.052	2.868AsnLys: 2.868 ± 0.053	4.219AsnLeu: 4.219 ± 0.062	1.066AsnMet: 1.066 ± 0.023	2.648AsnAsn: 2.648 ± 0.054	1.951AsnPro: 1.951 ± 0.038	2.177AsnGln: 2.177 ± 0.043	1.958AsnArg: 1.958 ± 0.038	3.129AsnSer: 3.129 ± 0.051	3.148AsnThr: 3.148 ± 0.049	2.875AsnVal: 2.875 ± 0.043	0.615AsnTrp: 0.615 ± 0.024	1.662AsnTyr: 1.662 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.791ProAla: 2.791 ± 0.05	0.346ProCys: 0.346 ± 0.017	2.194ProAsp: 2.194 ± 0.039	2.716ProGlu: 2.716 ± 0.047	1.662ProPhe: 1.662 ± 0.031	1.89ProGly: 1.89 ± 0.041	0.929ProHis: 0.929 ± 0.025	2.492ProIle: 2.492 ± 0.039	2.055ProLys: 2.055 ± 0.039	3.817ProLeu: 3.817 ± 0.053	0.831ProMet: 0.831 ± 0.024	1.877ProAsn: 1.877 ± 0.029	0.983ProPro: 0.983 ± 0.028	1.597ProGln: 1.597 ± 0.034	1.194ProArg: 1.194 ± 0.028	2.702ProSer: 2.702 ± 0.041	2.048ProThr: 2.048 ± 0.041	2.71ProVal: 2.71 ± 0.054	0.479ProTrp: 0.479 ± 0.017	1.318ProTyr: 1.318 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.542GlnAla: 4.542 ± 0.068	0.491GlnCys: 0.491 ± 0.019	2.213GlnAsp: 2.213 ± 0.042	2.242GlnGlu: 2.242 ± 0.044	2.122GlnPhe: 2.122 ± 0.041	3.221GlnGly: 3.221 ± 0.051	1.493GlnHis: 1.493 ± 0.037	2.619GlnIle: 2.619 ± 0.042	2.32GlnLys: 2.32 ± 0.039	6.108GlnLeu: 6.108 ± 0.097	0.981GlnMet: 0.981 ± 0.026	1.892GlnAsn: 1.892 ± 0.038	1.77GlnPro: 1.77 ± 0.039	3.575GlnGln: 3.575 ± 0.082	2.229GlnArg: 2.229 ± 0.036	3.447GlnSer: 3.447 ± 0.057	2.617GlnThr: 2.617 ± 0.048	3.542GlnVal: 3.542 ± 0.056	0.748GlnTrp: 0.748 ± 0.022	1.707GlnTyr: 1.707 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.232ArgAla: 3.232 ± 0.044	0.41ArgCys: 0.41 ± 0.018	2.17ArgAsp: 2.17 ± 0.039	2.383ArgGlu: 2.383 ± 0.046	2.148ArgPhe: 2.148 ± 0.036	2.289ArgGly: 2.289 ± 0.041	1.093ArgHis: 1.093 ± 0.032	2.647ArgIle: 2.647 ± 0.043	2.103ArgLys: 2.103 ± 0.04	4.504ArgLeu: 4.504 ± 0.059	0.938ArgMet: 0.938 ± 0.027	1.746ArgAsn: 1.746 ± 0.033	1.351ArgPro: 1.351 ± 0.036	1.927ArgGln: 1.927 ± 0.039	1.86ArgArg: 1.86 ± 0.044	2.454ArgSer: 2.454 ± 0.045	2.029ArgThr: 2.029 ± 0.035	2.993ArgVal: 2.993 ± 0.049	0.516ArgTrp: 0.516 ± 0.02	1.7ArgTyr: 1.7 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.027SerAla: 6.027 ± 0.075	0.707SerCys: 0.707 ± 0.026	4.08SerAsp: 4.08 ± 0.06	4.229SerGlu: 4.229 ± 0.055	2.975SerPhe: 2.975 ± 0.044	4.936SerGly: 4.936 ± 0.079	1.931SerHis: 1.931 ± 0.037	4.459SerIle: 4.459 ± 0.053	3.639SerLys: 3.639 ± 0.053	7.412SerLeu: 7.412 ± 0.095	1.586SerMet: 1.586 ± 0.035	3.305SerAsn: 3.305 ± 0.061	2.388SerPro: 2.388 ± 0.045	3.575SerGln: 3.575 ± 0.049	2.653SerArg: 2.653 ± 0.037	4.95SerSer: 4.95 ± 0.068	3.72SerThr: 3.72 ± 0.055	4.835SerVal: 4.835 ± 0.053	0.843SerTrp: 0.843 ± 0.026	2.426SerTyr: 2.426 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.592ThrAla: 4.592 ± 0.064	0.496ThrCys: 0.496 ± 0.02	3.1ThrAsp: 3.1 ± 0.06	3.199ThrGlu: 3.199 ± 0.045	2.281ThrPhe: 2.281 ± 0.038	3.932ThrGly: 3.932 ± 0.065	1.576ThrHis: 1.576 ± 0.032	3.47ThrIle: 3.47 ± 0.059	2.497ThrLys: 2.497 ± 0.04	6.963ThrLeu: 6.963 ± 0.073	1.104ThrMet: 1.104 ± 0.028	2.264ThrAsn: 2.264 ± 0.047	2.856ThrPro: 2.856 ± 0.051	3.167ThrGln: 3.167 ± 0.054	2.242ThrArg: 2.242 ± 0.035	3.819ThrSer: 3.819 ± 0.062	3.052ThrThr: 3.052 ± 0.058	3.95ThrVal: 3.95 ± 0.071	0.669ThrTrp: 0.669 ± 0.024	1.707ThrTyr: 1.707 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.986ValAla: 5.986 ± 0.069	0.786ValCys: 0.786 ± 0.027	3.885ValAsp: 3.885 ± 0.057	4.23ValGlu: 4.23 ± 0.067	2.864ValPhe: 2.864 ± 0.044	3.986ValGly: 3.986 ± 0.06	1.364ValHis: 1.364 ± 0.03	4.62ValIle: 4.62 ± 0.061	3.812ValLys: 3.812 ± 0.049	6.653ValLeu: 6.653 ± 0.083	1.687ValMet: 1.687 ± 0.036	3.42ValAsn: 3.42 ± 0.051	2.392ValPro: 2.392 ± 0.044	2.395ValGln: 2.395 ± 0.043	2.549ValArg: 2.549 ± 0.038	5.216ValSer: 5.216 ± 0.068	4.316ValThr: 4.316 ± 0.066	4.792ValVal: 4.792 ± 0.071	0.688ValTrp: 0.688 ± 0.02	1.985ValTyr: 1.985 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.745TrpAla: 0.745 ± 0.022	0.131TrpCys: 0.131 ± 0.01	0.527TrpAsp: 0.527 ± 0.02	0.471TrpGlu: 0.471 ± 0.018	0.57TrpPhe: 0.57 ± 0.023	0.646TrpGly: 0.646 ± 0.024	0.439TrpHis: 0.439 ± 0.017	0.52TrpIle: 0.52 ± 0.021	0.381TrpLys: 0.381 ± 0.016	1.662TrpLeu: 1.662 ± 0.036	0.265TrpMet: 0.265 ± 0.013	0.41TrpAsn: 0.41 ± 0.017	0.431TrpPro: 0.431 ± 0.018	1.202TrpGln: 1.202 ± 0.042	0.605TrpArg: 0.605 ± 0.025	0.739TrpSer: 0.739 ± 0.026	0.427TrpThr: 0.427 ± 0.019	0.819TrpVal: 0.819 ± 0.026	0.185TrpTrp: 0.185 ± 0.012	0.391TrpTyr: 0.391 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.498TyrAla: 2.498 ± 0.04	0.439TyrCys: 0.439 ± 0.016	1.929TyrAsp: 1.929 ± 0.042	1.682TyrGlu: 1.682 ± 0.037	1.611TyrPhe: 1.611 ± 0.03	2.089TyrGly: 2.089 ± 0.039	0.889TyrHis: 0.889 ± 0.026	1.961TyrIle: 1.961 ± 0.036	1.724TyrLys: 1.724 ± 0.04	3.487TyrLeu: 3.487 ± 0.051	0.641TyrMet: 0.641 ± 0.023	1.344TyrAsn: 1.344 ± 0.033	1.273TyrPro: 1.273 ± 0.03	2.057TyrGln: 2.057 ± 0.038	1.609TyrArg: 1.609 ± 0.036	2.31TyrSer: 2.31 ± 0.041	1.845TyrThr: 1.845 ± 0.038	2.005TyrVal: 2.005 ± 0.041	0.483TyrTrp: 0.483 ± 0.017	1.13TyrTyr: 1.13 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4457 proteins (1556861 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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