Amino acid dipepetide frequency for Streptococcus phage Javan308

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.971AlaAla: 1.971 ± 0.377
0.606AlaCys: 0.606 ± 0.257
4.245AlaAsp: 4.245 ± 0.748
4.851AlaGlu: 4.851 ± 0.677
3.108AlaPhe: 3.108 ± 0.431
4.018AlaGly: 4.018 ± 0.773
1.061AlaHis: 1.061 ± 0.29
4.927AlaIle: 4.927 ± 0.628
5.685AlaLys: 5.685 ± 0.613
5.609AlaLeu: 5.609 ± 0.59
2.122AlaMet: 2.122 ± 0.574
2.426AlaAsn: 2.426 ± 0.526
2.198AlaPro: 2.198 ± 0.423
2.35AlaGln: 2.35 ± 0.398
2.426AlaArg: 2.426 ± 0.38
3.714AlaSer: 3.714 ± 0.585
4.624AlaThr: 4.624 ± 0.717
5.534AlaVal: 5.534 ± 0.931
0.985AlaTrp: 0.985 ± 0.287
1.971AlaTyr: 1.971 ± 0.34
0.0AlaXaa: 0.0 ± 0.0
Cys
0.379CysAla: 0.379 ± 0.256
0.076CysCys: 0.076 ± 0.067
0.379CysAsp: 0.379 ± 0.156
0.455CysGlu: 0.455 ± 0.186
0.303CysPhe: 0.303 ± 0.185
0.455CysGly: 0.455 ± 0.234
0.0CysHis: 0.0 ± 0.0
0.379CysIle: 0.379 ± 0.18
0.455CysLys: 0.455 ± 0.178
0.303CysLeu: 0.303 ± 0.16
0.076CysMet: 0.076 ± 0.074
0.455CysAsn: 0.455 ± 0.202
0.303CysPro: 0.303 ± 0.168
0.227CysGln: 0.227 ± 0.129
0.531CysArg: 0.531 ± 0.223
0.152CysSer: 0.152 ± 0.113
0.303CysThr: 0.303 ± 0.124
0.227CysVal: 0.227 ± 0.125
0.076CysTrp: 0.076 ± 0.072
0.076CysTyr: 0.076 ± 0.07
0.0CysXaa: 0.0 ± 0.0
Asp
3.108AspAla: 3.108 ± 0.504
0.455AspCys: 0.455 ± 0.238
3.563AspAsp: 3.563 ± 0.539
6.064AspGlu: 6.064 ± 0.593
3.184AspPhe: 3.184 ± 0.428
4.548AspGly: 4.548 ± 0.536
1.213AspHis: 1.213 ± 0.282
4.018AspIle: 4.018 ± 0.509
5.306AspLys: 5.306 ± 0.648
5.913AspLeu: 5.913 ± 0.735
1.592AspMet: 1.592 ± 0.301
3.184AspAsn: 3.184 ± 0.523
2.047AspPro: 2.047 ± 0.475
1.289AspGln: 1.289 ± 0.26
2.577AspArg: 2.577 ± 0.447
3.184AspSer: 3.184 ± 0.468
3.942AspThr: 3.942 ± 0.542
4.169AspVal: 4.169 ± 0.499
1.213AspTrp: 1.213 ± 0.285
2.805AspTyr: 2.805 ± 0.585
0.0AspXaa: 0.0 ± 0.0
Glu
6.519GluAla: 6.519 ± 0.606
0.152GluCys: 0.152 ± 0.108
4.776GluAsp: 4.776 ± 0.6
6.216GluGlu: 6.216 ± 0.937
3.942GluPhe: 3.942 ± 0.557
4.321GluGly: 4.321 ± 0.487
0.758GluHis: 0.758 ± 0.26
7.05GluIle: 7.05 ± 0.796
5.458GluLys: 5.458 ± 0.766
8.566GluLeu: 8.566 ± 0.733
1.971GluMet: 1.971 ± 0.38
3.563GluAsn: 3.563 ± 0.619
3.032GluPro: 3.032 ± 0.541
5.003GluGln: 5.003 ± 0.86
5.155GluArg: 5.155 ± 0.778
2.729GluSer: 2.729 ± 0.51
4.7GluThr: 4.7 ± 0.524
5.685GluVal: 5.685 ± 0.672
1.061GluTrp: 1.061 ± 0.295
3.411GluTyr: 3.411 ± 0.557
0.0GluXaa: 0.0 ± 0.0
Phe
2.502PheAla: 2.502 ± 0.429
0.303PheCys: 0.303 ± 0.14
2.956PheAsp: 2.956 ± 0.44
3.487PheGlu: 3.487 ± 0.56
1.44PhePhe: 1.44 ± 0.294
2.729PheGly: 2.729 ± 0.467
0.606PheHis: 0.606 ± 0.19
3.335PheIle: 3.335 ± 0.508
3.714PheLys: 3.714 ± 0.499
4.018PheLeu: 4.018 ± 0.546
1.364PheMet: 1.364 ± 0.342
1.743PheAsn: 1.743 ± 0.352
0.834PhePro: 0.834 ± 0.26
1.289PheGln: 1.289 ± 0.397
2.35PheArg: 2.35 ± 0.374
2.729PheSer: 2.729 ± 0.565
2.426PheThr: 2.426 ± 0.408
3.032PheVal: 3.032 ± 0.597
0.682PheTrp: 0.682 ± 0.222
1.668PheTyr: 1.668 ± 0.381
0.0PheXaa: 0.0 ± 0.0
Gly
3.866GlyAla: 3.866 ± 0.674
0.303GlyCys: 0.303 ± 0.133
2.956GlyAsp: 2.956 ± 0.548
3.487GlyGlu: 3.487 ± 0.573
3.032GlyPhe: 3.032 ± 0.489
4.245GlyGly: 4.245 ± 0.917
1.137GlyHis: 1.137 ± 0.255
3.487GlyIle: 3.487 ± 0.509
5.609GlyLys: 5.609 ± 0.784
4.776GlyLeu: 4.776 ± 0.687
1.743GlyMet: 1.743 ± 0.338
3.639GlyAsn: 3.639 ± 0.57
0.303GlyPro: 0.303 ± 0.153
2.047GlyGln: 2.047 ± 0.368
3.714GlyArg: 3.714 ± 0.467
3.335GlySer: 3.335 ± 0.619
3.563GlyThr: 3.563 ± 0.602
4.472GlyVal: 4.472 ± 0.629
1.289GlyTrp: 1.289 ± 0.399
3.108GlyTyr: 3.108 ± 0.375
0.0GlyXaa: 0.0 ± 0.0
His
0.758HisAla: 0.758 ± 0.202
0.0HisCys: 0.0 ± 0.0
1.061HisAsp: 1.061 ± 0.28
1.289HisGlu: 1.289 ± 0.283
0.303HisPhe: 0.303 ± 0.131
0.606HisGly: 0.606 ± 0.208
0.227HisHis: 0.227 ± 0.125
1.213HisIle: 1.213 ± 0.318
1.137HisLys: 1.137 ± 0.254
0.91HisLeu: 0.91 ± 0.249
0.379HisMet: 0.379 ± 0.151
0.455HisAsn: 0.455 ± 0.257
0.606HisPro: 0.606 ± 0.22
0.606HisGln: 0.606 ± 0.233
0.985HisArg: 0.985 ± 0.263
1.213HisSer: 1.213 ± 0.361
0.758HisThr: 0.758 ± 0.237
0.985HisVal: 0.985 ± 0.31
0.076HisTrp: 0.076 ± 0.079
0.91HisTyr: 0.91 ± 0.264
0.0HisXaa: 0.0 ± 0.0
Ile
4.397IleAla: 4.397 ± 0.92
0.455IleCys: 0.455 ± 0.188
5.913IleAsp: 5.913 ± 0.553
6.747IleGlu: 6.747 ± 0.794
2.881IlePhe: 2.881 ± 0.474
4.397IleGly: 4.397 ± 0.664
1.289IleHis: 1.289 ± 0.359
4.245IleIle: 4.245 ± 0.53
6.367IleLys: 6.367 ± 0.797
4.548IleLeu: 4.548 ± 0.545
0.834IleMet: 0.834 ± 0.31
3.108IleAsn: 3.108 ± 0.53
2.881IlePro: 2.881 ± 0.539
3.032IleGln: 3.032 ± 0.478
3.866IleArg: 3.866 ± 0.552
3.79IleSer: 3.79 ± 0.568
3.866IleThr: 3.866 ± 0.548
4.093IleVal: 4.093 ± 0.574
0.682IleTrp: 0.682 ± 0.249
2.35IleTyr: 2.35 ± 0.555
0.0IleXaa: 0.0 ± 0.0
Lys
5.306LysAla: 5.306 ± 0.62
0.531LysCys: 0.531 ± 0.213
4.7LysAsp: 4.7 ± 0.792
7.808LysGlu: 7.808 ± 0.847
2.577LysPhe: 2.577 ± 0.48
4.548LysGly: 4.548 ± 0.557
1.137LysHis: 1.137 ± 0.308
5.761LysIle: 5.761 ± 0.843
7.429LysLys: 7.429 ± 0.874
5.685LysLeu: 5.685 ± 0.616
1.743LysMet: 1.743 ± 0.328
4.851LysAsn: 4.851 ± 0.654
2.577LysPro: 2.577 ± 0.437
4.776LysGln: 4.776 ± 0.555
3.942LysArg: 3.942 ± 0.616
4.548LysSer: 4.548 ± 0.515
6.292LysThr: 6.292 ± 0.668
5.458LysVal: 5.458 ± 0.74
1.289LysTrp: 1.289 ± 0.246
3.108LysTyr: 3.108 ± 0.609
0.0LysXaa: 0.0 ± 0.0
Leu
5.913LeuAla: 5.913 ± 0.487
0.227LeuCys: 0.227 ± 0.154
7.201LeuAsp: 7.201 ± 0.595
8.49LeuGlu: 8.49 ± 1.022
3.942LeuPhe: 3.942 ± 0.53
4.472LeuGly: 4.472 ± 0.667
0.834LeuHis: 0.834 ± 0.238
5.837LeuIle: 5.837 ± 0.724
6.595LeuLys: 6.595 ± 0.749
4.776LeuLeu: 4.776 ± 0.57
1.44LeuMet: 1.44 ± 0.317
5.306LeuAsn: 5.306 ± 0.527
2.577LeuPro: 2.577 ± 0.496
3.866LeuGln: 3.866 ± 0.555
2.805LeuArg: 2.805 ± 0.428
5.155LeuSer: 5.155 ± 0.687
4.548LeuThr: 4.548 ± 0.526
5.079LeuVal: 5.079 ± 0.627
0.682LeuTrp: 0.682 ± 0.214
2.122LeuTyr: 2.122 ± 0.33
0.0LeuXaa: 0.0 ± 0.0
Met
2.274MetAla: 2.274 ± 0.646
0.0MetCys: 0.0 ± 0.0
1.516MetAsp: 1.516 ± 0.336
2.122MetGlu: 2.122 ± 0.365
0.758MetPhe: 0.758 ± 0.258
0.531MetGly: 0.531 ± 0.214
0.152MetHis: 0.152 ± 0.091
1.819MetIle: 1.819 ± 0.496
3.108MetLys: 3.108 ± 0.456
1.668MetLeu: 1.668 ± 0.357
0.531MetMet: 0.531 ± 0.206
1.592MetAsn: 1.592 ± 0.388
0.455MetPro: 0.455 ± 0.154
0.91MetGln: 0.91 ± 0.251
1.137MetArg: 1.137 ± 0.284
1.743MetSer: 1.743 ± 0.321
1.364MetThr: 1.364 ± 0.285
1.516MetVal: 1.516 ± 0.414
0.227MetTrp: 0.227 ± 0.117
0.682MetTyr: 0.682 ± 0.271
0.0MetXaa: 0.0 ± 0.0
Asn
3.335AsnAla: 3.335 ± 0.679
0.152AsnCys: 0.152 ± 0.1
2.805AsnAsp: 2.805 ± 0.523
3.184AsnGlu: 3.184 ± 0.502
2.729AsnPhe: 2.729 ± 0.46
4.472AsnGly: 4.472 ± 0.58
1.516AsnHis: 1.516 ± 0.412
3.714AsnIle: 3.714 ± 0.541
3.942AsnLys: 3.942 ± 0.512
4.169AsnLeu: 4.169 ± 0.569
1.213AsnMet: 1.213 ± 0.366
3.184AsnAsn: 3.184 ± 0.667
2.35AsnPro: 2.35 ± 0.437
2.502AsnGln: 2.502 ± 0.407
2.047AsnArg: 2.047 ± 0.444
2.805AsnSer: 2.805 ± 0.472
1.895AsnThr: 1.895 ± 0.424
3.26AsnVal: 3.26 ± 0.509
0.682AsnTrp: 0.682 ± 0.274
2.198AsnTyr: 2.198 ± 0.513
0.0AsnXaa: 0.0 ± 0.0
Pro
1.895ProAla: 1.895 ± 0.36
0.379ProCys: 0.379 ± 0.161
1.819ProAsp: 1.819 ± 0.354
3.032ProGlu: 3.032 ± 0.506
1.289ProPhe: 1.289 ± 0.321
1.213ProGly: 1.213 ± 0.27
0.606ProHis: 0.606 ± 0.268
1.668ProIle: 1.668 ± 0.358
2.502ProLys: 2.502 ± 0.547
2.122ProLeu: 2.122 ± 0.371
0.834ProMet: 0.834 ± 0.246
1.516ProAsn: 1.516 ± 0.315
0.758ProPro: 0.758 ± 0.271
1.061ProGln: 1.061 ± 0.222
1.213ProArg: 1.213 ± 0.278
2.35ProSer: 2.35 ± 0.593
2.047ProThr: 2.047 ± 0.435
1.743ProVal: 1.743 ± 0.3
0.303ProTrp: 0.303 ± 0.125
1.44ProTyr: 1.44 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
4.397GlnAla: 4.397 ± 0.557
0.227GlnCys: 0.227 ± 0.122
1.592GlnAsp: 1.592 ± 0.413
3.866GlnGlu: 3.866 ± 0.601
2.047GlnPhe: 2.047 ± 0.38
2.805GlnGly: 2.805 ± 0.56
0.455GlnHis: 0.455 ± 0.198
2.122GlnIle: 2.122 ± 0.464
3.335GlnLys: 3.335 ± 0.548
4.624GlnLeu: 4.624 ± 0.73
1.213GlnMet: 1.213 ± 0.311
1.819GlnAsn: 1.819 ± 0.419
1.137GlnPro: 1.137 ± 0.27
1.44GlnGln: 1.44 ± 0.364
1.289GlnArg: 1.289 ± 0.375
2.805GlnSer: 2.805 ± 0.489
1.668GlnThr: 1.668 ± 0.387
2.35GlnVal: 2.35 ± 0.445
0.303GlnTrp: 0.303 ± 0.153
1.971GlnTyr: 1.971 ± 0.379
0.0GlnXaa: 0.0 ± 0.0
Arg
2.35ArgAla: 2.35 ± 0.416
0.379ArgCys: 0.379 ± 0.155
2.502ArgAsp: 2.502 ± 0.357
4.093ArgGlu: 4.093 ± 0.676
2.274ArgPhe: 2.274 ± 0.647
2.047ArgGly: 2.047 ± 0.612
0.606ArgHis: 0.606 ± 0.258
2.35ArgIle: 2.35 ± 0.465
5.079ArgLys: 5.079 ± 0.571
5.609ArgLeu: 5.609 ± 0.7
1.592ArgMet: 1.592 ± 0.269
1.895ArgAsn: 1.895 ± 0.344
1.364ArgPro: 1.364 ± 0.34
1.668ArgGln: 1.668 ± 0.403
2.956ArgArg: 2.956 ± 0.53
2.35ArgSer: 2.35 ± 0.324
2.729ArgThr: 2.729 ± 0.448
3.335ArgVal: 3.335 ± 0.463
1.061ArgTrp: 1.061 ± 0.318
2.198ArgTyr: 2.198 ± 0.484
0.0ArgXaa: 0.0 ± 0.0
Ser
4.397SerAla: 4.397 ± 0.638
0.152SerCys: 0.152 ± 0.113
3.184SerAsp: 3.184 ± 0.517
4.548SerGlu: 4.548 ± 0.628
2.426SerPhe: 2.426 ± 0.56
4.093SerGly: 4.093 ± 0.554
0.91SerHis: 0.91 ± 0.284
4.851SerIle: 4.851 ± 0.606
4.245SerLys: 4.245 ± 0.825
4.169SerLeu: 4.169 ± 0.551
1.364SerMet: 1.364 ± 0.279
2.653SerAsn: 2.653 ± 0.392
1.213SerPro: 1.213 ± 0.312
2.35SerGln: 2.35 ± 0.415
2.502SerArg: 2.502 ± 0.346
2.577SerSer: 2.577 ± 0.386
3.108SerThr: 3.108 ± 0.459
4.321SerVal: 4.321 ± 0.606
0.531SerTrp: 0.531 ± 0.196
2.122SerTyr: 2.122 ± 0.363
0.0SerXaa: 0.0 ± 0.0
Thr
3.26ThrAla: 3.26 ± 0.636
0.303ThrCys: 0.303 ± 0.153
4.093ThrAsp: 4.093 ± 0.591
4.397ThrGlu: 4.397 ± 0.749
2.653ThrPhe: 2.653 ± 0.409
3.714ThrGly: 3.714 ± 0.607
0.682ThrHis: 0.682 ± 0.203
5.079ThrIle: 5.079 ± 0.562
4.397ThrLys: 4.397 ± 0.476
5.003ThrLeu: 5.003 ± 0.702
1.289ThrMet: 1.289 ± 0.383
3.108ThrAsn: 3.108 ± 0.513
2.426ThrPro: 2.426 ± 0.323
1.819ThrGln: 1.819 ± 0.409
2.426ThrArg: 2.426 ± 0.423
3.032ThrSer: 3.032 ± 0.442
3.26ThrThr: 3.26 ± 0.549
3.942ThrVal: 3.942 ± 0.645
0.758ThrTrp: 0.758 ± 0.239
2.426ThrTyr: 2.426 ± 0.407
0.0ThrXaa: 0.0 ± 0.0
Val
4.927ValAla: 4.927 ± 0.669
0.303ValCys: 0.303 ± 0.155
4.624ValAsp: 4.624 ± 0.57
5.534ValGlu: 5.534 ± 0.615
2.35ValPhe: 2.35 ± 0.356
4.093ValGly: 4.093 ± 0.549
0.606ValHis: 0.606 ± 0.181
4.397ValIle: 4.397 ± 0.499
5.534ValLys: 5.534 ± 0.64
5.079ValLeu: 5.079 ± 0.755
1.516ValMet: 1.516 ± 0.314
4.472ValAsn: 4.472 ± 0.551
1.668ValPro: 1.668 ± 0.366
2.653ValGln: 2.653 ± 0.431
3.335ValArg: 3.335 ± 0.656
4.397ValSer: 4.397 ± 0.482
4.397ValThr: 4.397 ± 0.594
4.472ValVal: 4.472 ± 0.62
0.455ValTrp: 0.455 ± 0.167
2.274ValTyr: 2.274 ± 0.405
0.0ValXaa: 0.0 ± 0.0
Trp
0.455TrpAla: 0.455 ± 0.164
0.227TrpCys: 0.227 ± 0.134
0.91TrpAsp: 0.91 ± 0.299
0.985TrpGlu: 0.985 ± 0.227
1.061TrpPhe: 1.061 ± 0.303
0.91TrpGly: 0.91 ± 0.289
0.303TrpHis: 0.303 ± 0.141
0.758TrpIle: 0.758 ± 0.204
1.289TrpLys: 1.289 ± 0.288
1.061TrpLeu: 1.061 ± 0.29
0.303TrpMet: 0.303 ± 0.148
0.682TrpAsn: 0.682 ± 0.234
0.076TrpPro: 0.076 ± 0.066
0.531TrpGln: 0.531 ± 0.18
0.834TrpArg: 0.834 ± 0.23
0.455TrpSer: 0.455 ± 0.187
0.531TrpThr: 0.531 ± 0.173
0.531TrpVal: 0.531 ± 0.191
0.227TrpTrp: 0.227 ± 0.192
0.985TrpTyr: 0.985 ± 0.418
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.426TyrAla: 2.426 ± 0.428
0.379TyrCys: 0.379 ± 0.183
2.577TyrAsp: 2.577 ± 0.426
3.411TyrGlu: 3.411 ± 0.473
0.91TyrPhe: 0.91 ± 0.288
1.895TyrGly: 1.895 ± 0.391
0.379TyrHis: 0.379 ± 0.129
2.729TyrIle: 2.729 ± 0.434
2.881TyrLys: 2.881 ± 0.416
3.26TyrLeu: 3.26 ± 0.474
0.91TyrMet: 0.91 ± 0.248
2.502TyrAsn: 2.502 ± 0.437
0.985TyrPro: 0.985 ± 0.266
2.047TyrGln: 2.047 ± 0.336
2.35TyrArg: 2.35 ± 0.54
2.653TyrSer: 2.653 ± 0.554
2.047TyrThr: 2.047 ± 0.318
2.956TyrVal: 2.956 ± 0.47
0.531TyrTrp: 0.531 ± 0.191
1.289TyrTyr: 1.289 ± 0.458
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (13193 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski