Amino acid dipepetide frequency for Scytalidium sp. 3C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.405AlaAla: 9.405 ± 0.113	0.895AlaCys: 0.895 ± 0.024	4.095AlaAsp: 4.095 ± 0.046	5.471AlaGlu: 5.471 ± 0.072	3.05AlaPhe: 3.05 ± 0.043	6.104AlaGly: 6.104 ± 0.078	1.659AlaHis: 1.659 ± 0.029	4.559AlaIle: 4.559 ± 0.053	4.634AlaLys: 4.634 ± 0.062	7.601AlaLeu: 7.601 ± 0.069	1.997AlaMet: 1.997 ± 0.03	3.212AlaAsn: 3.212 ± 0.048	5.037AlaPro: 5.037 ± 0.08	3.479AlaGln: 3.479 ± 0.05	4.603AlaArg: 4.603 ± 0.062	7.058AlaSer: 7.058 ± 0.07	5.304AlaThr: 5.304 ± 0.064	5.299AlaVal: 5.299 ± 0.061	1.056AlaTrp: 1.056 ± 0.027	2.232AlaTyr: 2.232 ± 0.041	0.004AlaXaa: 0.004 ± 0.002
Cys	0.847CysAla: 0.847 ± 0.022	0.215CysCys: 0.215 ± 0.012	0.524CysAsp: 0.524 ± 0.016	0.531CysGlu: 0.531 ± 0.019	0.477CysPhe: 0.477 ± 0.017	0.806CysGly: 0.806 ± 0.022	0.253CysHis: 0.253 ± 0.012	0.65CysIle: 0.65 ± 0.018	0.459CysLys: 0.459 ± 0.017	1.051CysLeu: 1.051 ± 0.031	0.24CysMet: 0.24 ± 0.011	0.39CysAsn: 0.39 ± 0.017	0.51CysPro: 0.51 ± 0.017	0.381CysGln: 0.381 ± 0.014	0.551CysArg: 0.551 ± 0.021	0.729CysSer: 0.729 ± 0.023	0.602CysThr: 0.602 ± 0.022	0.646CysVal: 0.646 ± 0.021	0.171CysTrp: 0.171 ± 0.011	0.313CysTyr: 0.313 ± 0.016	0.001CysXaa: 0.001 ± 0.001
Asp	4.491AspAla: 4.491 ± 0.056	0.516AspCys: 0.516 ± 0.016	4.022AspAsp: 4.022 ± 0.075	4.489AspGlu: 4.489 ± 0.07	2.146AspPhe: 2.146 ± 0.034	3.935AspGly: 3.935 ± 0.051	1.139AspHis: 1.139 ± 0.026	3.198AspIle: 3.198 ± 0.042	2.455AspLys: 2.455 ± 0.038	5.002AspLeu: 5.002 ± 0.058	1.207AspMet: 1.207 ± 0.024	1.927AspAsn: 1.927 ± 0.031	3.329AspPro: 3.329 ± 0.045	1.827AspGln: 1.827 ± 0.033	2.919AspArg: 2.919 ± 0.055	4.017AspSer: 4.017 ± 0.059	2.856AspThr: 2.856 ± 0.04	3.677AspVal: 3.677 ± 0.048	0.792AspTrp: 0.792 ± 0.023	1.59AspTyr: 1.59 ± 0.03	0.007AspXaa: 0.007 ± 0.002
Glu	5.667GluAla: 5.667 ± 0.07	0.519GluCys: 0.519 ± 0.018	4.322GluAsp: 4.322 ± 0.066	6.008GluGlu: 6.008 ± 0.094	2.004GluPhe: 2.004 ± 0.033	4.053GluGly: 4.053 ± 0.06	1.369GluHis: 1.369 ± 0.026	3.402GluIle: 3.402 ± 0.048	4.382GluLys: 4.382 ± 0.062	5.433GluLeu: 5.433 ± 0.07	1.454GluMet: 1.454 ± 0.031	2.559GluAsn: 2.559 ± 0.038	2.749GluPro: 2.749 ± 0.055	2.566GluGln: 2.566 ± 0.043	4.001GluArg: 4.001 ± 0.069	4.376GluSer: 4.376 ± 0.064	3.432GluThr: 3.432 ± 0.043	3.773GluVal: 3.773 ± 0.048	0.848GluTrp: 0.848 ± 0.022	1.79GluTyr: 1.79 ± 0.03	0.001GluXaa: 0.001 ± 0.001
Phe	2.998PheAla: 2.998 ± 0.041	0.51PheCys: 0.51 ± 0.016	2.287PheAsp: 2.287 ± 0.029	2.259PheGlu: 2.259 ± 0.037	1.64PhePhe: 1.64 ± 0.039	3.026PheGly: 3.026 ± 0.057	0.808PheHis: 0.808 ± 0.021	1.912PheIle: 1.912 ± 0.039	1.712PheLys: 1.712 ± 0.035	3.292PheLeu: 3.292 ± 0.054	0.823PheMet: 0.823 ± 0.019	1.496PheAsn: 1.496 ± 0.031	1.814PhePro: 1.814 ± 0.032	1.36PheGln: 1.36 ± 0.029	1.764PheArg: 1.764 ± 0.033	2.964PheSer: 2.964 ± 0.046	2.137PheThr: 2.137 ± 0.039	2.347PheVal: 2.347 ± 0.039	0.583PheTrp: 0.583 ± 0.021	1.144PheTyr: 1.144 ± 0.029	0.002PheXaa: 0.002 ± 0.001
Gly	5.734GlyAla: 5.734 ± 0.078	0.776GlyCys: 0.776 ± 0.024	3.688GlyAsp: 3.688 ± 0.046	3.864GlyGlu: 3.864 ± 0.055	2.899GlyPhe: 2.899 ± 0.051	6.263GlyGly: 6.263 ± 0.1	1.533GlyHis: 1.533 ± 0.029	3.782GlyIle: 3.782 ± 0.051	3.861GlyLys: 3.861 ± 0.059	6.059GlyLeu: 6.059 ± 0.072	1.602GlyMet: 1.602 ± 0.033	2.78GlyAsn: 2.78 ± 0.05	3.344GlyPro: 3.344 ± 0.052	2.55GlyGln: 2.55 ± 0.045	4.0GlyArg: 4.0 ± 0.059	5.984GlySer: 5.984 ± 0.074	4.175GlyThr: 4.175 ± 0.054	4.54GlyVal: 4.54 ± 0.061	1.129GlyTrp: 1.129 ± 0.029	2.292GlyTyr: 2.292 ± 0.047	0.006GlyXaa: 0.006 ± 0.002
His	1.655HisAla: 1.655 ± 0.032	0.246HisCys: 0.246 ± 0.012	1.187HisAsp: 1.187 ± 0.029	1.248HisGlu: 1.248 ± 0.027	0.858HisPhe: 0.858 ± 0.023	1.492HisGly: 1.492 ± 0.031	0.774HisHis: 0.774 ± 0.024	1.189HisIle: 1.189 ± 0.029	0.991HisLys: 0.991 ± 0.027	2.022HisLeu: 2.022 ± 0.037	0.447HisMet: 0.447 ± 0.015	0.837HisAsn: 0.837 ± 0.023	1.562HisPro: 1.562 ± 0.035	0.845HisGln: 0.845 ± 0.024	1.318HisArg: 1.318 ± 0.029	1.711HisSer: 1.711 ± 0.037	1.198HisThr: 1.198 ± 0.027	1.299HisVal: 1.299 ± 0.026	0.29HisTrp: 0.29 ± 0.012	0.688HisTyr: 0.688 ± 0.019	0.001HisXaa: 0.001 ± 0.001
Ile	4.346IleAla: 4.346 ± 0.057	0.719IleCys: 0.719 ± 0.021	3.058IleAsp: 3.058 ± 0.045	3.141IleGlu: 3.141 ± 0.039	2.1IlePhe: 2.1 ± 0.041	3.404IleGly: 3.404 ± 0.057	1.219IleHis: 1.219 ± 0.025	2.811IleIle: 2.811 ± 0.046	2.597IleLys: 2.597 ± 0.043	4.724IleLeu: 4.724 ± 0.056	1.194IleMet: 1.194 ± 0.026	1.992IleAsn: 1.992 ± 0.034	3.195IlePro: 3.195 ± 0.039	1.985IleGln: 1.985 ± 0.039	2.749IleArg: 2.749 ± 0.038	4.007IleSer: 4.007 ± 0.051	2.97IleThr: 2.97 ± 0.036	3.353IleVal: 3.353 ± 0.051	0.733IleTrp: 0.733 ± 0.022	1.508IleTyr: 1.508 ± 0.028	0.001IleXaa: 0.001 ± 0.001
Lys	4.87LysAla: 4.87 ± 0.059	0.429LysCys: 0.429 ± 0.016	3.029LysAsp: 3.029 ± 0.052	4.094LysGlu: 4.094 ± 0.066	1.646LysPhe: 1.646 ± 0.034	3.317LysGly: 3.317 ± 0.053	1.137LysHis: 1.137 ± 0.029	2.621LysIle: 2.621 ± 0.036	3.961LysLys: 3.961 ± 0.087	4.498LysLeu: 4.498 ± 0.062	1.15LysMet: 1.15 ± 0.027	2.005LysAsn: 2.005 ± 0.034	2.935LysPro: 2.935 ± 0.051	2.032LysGln: 2.032 ± 0.034	3.404LysArg: 3.404 ± 0.048	3.839LysSer: 3.839 ± 0.058	3.063LysThr: 3.063 ± 0.048	3.136LysVal: 3.136 ± 0.043	0.676LysTrp: 0.676 ± 0.018	1.6LysTyr: 1.6 ± 0.029	0.004LysXaa: 0.004 ± 0.002
Leu	7.573LeuAla: 7.573 ± 0.07	1.032LeuCys: 1.032 ± 0.024	4.924LeuAsp: 4.924 ± 0.057	5.655LeuGlu: 5.655 ± 0.075	3.285LeuPhe: 3.285 ± 0.054	5.918LeuGly: 5.918 ± 0.069	1.998LeuHis: 1.998 ± 0.038	4.033LeuIle: 4.033 ± 0.056	4.706LeuLys: 4.706 ± 0.058	7.935LeuLeu: 7.935 ± 0.086	1.729LeuMet: 1.729 ± 0.034	3.351LeuAsn: 3.351 ± 0.047	5.143LeuPro: 5.143 ± 0.062	3.667LeuGln: 3.667 ± 0.057	5.238LeuArg: 5.238 ± 0.069	6.939LeuSer: 6.939 ± 0.076	4.82LeuThr: 4.82 ± 0.052	5.204LeuVal: 5.204 ± 0.055	1.088LeuTrp: 1.088 ± 0.028	2.426LeuTyr: 2.426 ± 0.045	0.004LeuXaa: 0.004 ± 0.001
Met	2.129MetAla: 2.129 ± 0.032	0.22MetCys: 0.22 ± 0.011	1.295MetAsp: 1.295 ± 0.028	1.349MetGlu: 1.349 ± 0.027	0.769MetPhe: 0.769 ± 0.024	1.528MetGly: 1.528 ± 0.036	0.465MetHis: 0.465 ± 0.016	1.143MetIle: 1.143 ± 0.029	1.072MetLys: 1.072 ± 0.027	1.846MetLeu: 1.846 ± 0.038	0.596MetMet: 0.596 ± 0.02	0.91MetAsn: 0.91 ± 0.024	1.12MetPro: 1.12 ± 0.029	0.862MetGln: 0.862 ± 0.024	1.204MetArg: 1.204 ± 0.026	1.865MetSer: 1.865 ± 0.036	1.302MetThr: 1.302 ± 0.027	1.313MetVal: 1.313 ± 0.03	0.247MetTrp: 0.247 ± 0.011	0.524MetTyr: 0.524 ± 0.017	0.002MetXaa: 0.002 ± 0.001
Asn	3.266AsnAla: 3.266 ± 0.043	0.41AsnCys: 0.41 ± 0.016	1.996AsnAsp: 1.996 ± 0.036	2.234AsnGlu: 2.234 ± 0.036	1.478AsnPhe: 1.478 ± 0.032	3.444AsnGly: 3.444 ± 0.052	0.804AsnHis: 0.804 ± 0.021	2.214AsnIle: 2.214 ± 0.034	1.75AsnLys: 1.75 ± 0.036	3.41AsnLeu: 3.41 ± 0.051	0.929AsnMet: 0.929 ± 0.024	1.631AsnAsn: 1.631 ± 0.033	2.566AsnPro: 2.566 ± 0.042	1.467AsnGln: 1.467 ± 0.031	1.961AsnArg: 1.961 ± 0.038	2.916AsnSer: 2.916 ± 0.04	2.331AsnThr: 2.331 ± 0.036	2.422AsnVal: 2.422 ± 0.037	0.582AsnTrp: 0.582 ± 0.017	1.185AsnTyr: 1.185 ± 0.031	0.002AsnXaa: 0.002 ± 0.001
Pro	5.419ProAla: 5.419 ± 0.076	0.381ProCys: 0.381 ± 0.017	3.002ProAsp: 3.002 ± 0.041	3.959ProGlu: 3.959 ± 0.06	1.901ProPhe: 1.901 ± 0.036	3.954ProGly: 3.954 ± 0.057	1.209ProHis: 1.209 ± 0.028	2.608ProIle: 2.608 ± 0.041	2.946ProLys: 2.946 ± 0.047	4.566ProLeu: 4.566 ± 0.057	1.044ProMet: 1.044 ± 0.03	2.324ProAsn: 2.324 ± 0.04	5.214ProPro: 5.214 ± 0.136	2.576ProGln: 2.576 ± 0.061	3.125ProArg: 3.125 ± 0.058	5.758ProSer: 5.758 ± 0.079	3.907ProThr: 3.907 ± 0.058	3.573ProVal: 3.573 ± 0.046	0.636ProTrp: 0.636 ± 0.02	1.548ProTyr: 1.548 ± 0.032	0.006ProXaa: 0.006 ± 0.002
Gln	3.506GlnAla: 3.506 ± 0.051	0.375GlnCys: 0.375 ± 0.016	2.017GlnAsp: 2.017 ± 0.034	2.494GlnGlu: 2.494 ± 0.041	1.27GlnPhe: 1.27 ± 0.028	2.426GlnGly: 2.426 ± 0.042	0.966GlnHis: 0.966 ± 0.027	1.988GlnIle: 1.988 ± 0.035	2.194GlnLys: 2.194 ± 0.04	3.391GlnLeu: 3.391 ± 0.05	0.894GlnMet: 0.894 ± 0.026	1.728GlnAsn: 1.728 ± 0.038	2.379GlnPro: 2.379 ± 0.051	2.521GlnGln: 2.521 ± 0.078	2.487GlnArg: 2.487 ± 0.049	3.095GlnSer: 3.095 ± 0.05	2.296GlnThr: 2.296 ± 0.038	2.117GlnVal: 2.117 ± 0.036	0.513GlnTrp: 0.513 ± 0.019	1.193GlnTyr: 1.193 ± 0.03	0.003GlnXaa: 0.003 ± 0.001
Arg	4.435ArgAla: 4.435 ± 0.059	0.541ArgCys: 0.541 ± 0.018	3.183ArgAsp: 3.183 ± 0.053	3.805ArgGlu: 3.805 ± 0.065	1.919ArgPhe: 1.919 ± 0.034	3.665ArgGly: 3.665 ± 0.064	1.353ArgHis: 1.353 ± 0.03	2.856ArgIle: 2.856 ± 0.041	3.515ArgLys: 3.515 ± 0.047	4.947ArgLeu: 4.947 ± 0.056	1.246ArgMet: 1.246 ± 0.025	2.228ArgAsn: 2.228 ± 0.039	3.275ArgPro: 3.275 ± 0.054	2.43ArgGln: 2.43 ± 0.04	4.579ArgArg: 4.579 ± 0.081	4.384ArgSer: 4.384 ± 0.069	3.038ArgThr: 3.038 ± 0.043	3.067ArgVal: 3.067 ± 0.039	0.778ArgTrp: 0.778 ± 0.023	1.587ArgTyr: 1.587 ± 0.027	0.002ArgXaa: 0.002 ± 0.001
Ser	6.667SerAla: 6.667 ± 0.067	0.701SerCys: 0.701 ± 0.018	4.038SerAsp: 4.038 ± 0.054	4.205SerGlu: 4.205 ± 0.05	2.935SerPhe: 2.935 ± 0.037	5.951SerGly: 5.951 ± 0.094	1.695SerHis: 1.695 ± 0.032	4.13SerIle: 4.13 ± 0.05	4.124SerLys: 4.124 ± 0.056	6.704SerLeu: 6.704 ± 0.077	1.675SerMet: 1.675 ± 0.032	3.242SerAsn: 3.242 ± 0.046	5.36SerPro: 5.36 ± 0.093	3.228SerGln: 3.228 ± 0.055	4.585SerArg: 4.585 ± 0.065	8.74SerSer: 8.74 ± 0.119	5.617SerThr: 5.617 ± 0.08	4.635SerVal: 4.635 ± 0.047	0.983SerTrp: 0.983 ± 0.024	2.109SerTyr: 2.109 ± 0.033	0.005SerXaa: 0.005 ± 0.002
Thr	5.27ThrAla: 5.27 ± 0.066	0.635ThrCys: 0.635 ± 0.021	2.707ThrAsp: 2.707 ± 0.037	3.259ThrGlu: 3.259 ± 0.041	2.236ThrPhe: 2.236 ± 0.039	4.39ThrGly: 4.39 ± 0.068	1.193ThrHis: 1.193 ± 0.026	3.227ThrIle: 3.227 ± 0.052	2.801ThrLys: 2.801 ± 0.043	4.959ThrLeu: 4.959 ± 0.062	1.265ThrMet: 1.265 ± 0.03	2.209ThrAsn: 2.209 ± 0.039	4.435ThrPro: 4.435 ± 0.06	2.089ThrGln: 2.089 ± 0.038	2.888ThrArg: 2.888 ± 0.042	5.336ThrSer: 5.336 ± 0.063	4.522ThrThr: 4.522 ± 0.128	3.863ThrVal: 3.863 ± 0.048	0.752ThrTrp: 0.752 ± 0.022	1.64ThrTyr: 1.64 ± 0.034	0.004ThrXaa: 0.004 ± 0.002
Val	5.22ValAla: 5.22 ± 0.062	0.679ValCys: 0.679 ± 0.02	3.652ValAsp: 3.652 ± 0.045	4.18ValGlu: 4.18 ± 0.055	2.412ValPhe: 2.412 ± 0.048	4.088ValGly: 4.088 ± 0.059	1.302ValHis: 1.302 ± 0.03	3.194ValIle: 3.194 ± 0.047	3.237ValLys: 3.237 ± 0.048	5.337ValLeu: 5.337 ± 0.069	1.33ValMet: 1.33 ± 0.027	2.353ValAsn: 2.353 ± 0.045	3.609ValPro: 3.609 ± 0.048	2.283ValGln: 2.283 ± 0.037	3.148ValArg: 3.148 ± 0.047	4.548ValSer: 4.548 ± 0.063	3.58ValThr: 3.58 ± 0.048	4.318ValVal: 4.318 ± 0.062	0.81ValTrp: 0.81 ± 0.022	1.753ValTyr: 1.753 ± 0.034	0.002ValXaa: 0.002 ± 0.001
Trp	1.068TrpAla: 1.068 ± 0.028	0.171TrpCys: 0.171 ± 0.01	0.82TrpAsp: 0.82 ± 0.022	0.778TrpGlu: 0.778 ± 0.022	0.544TrpPhe: 0.544 ± 0.019	0.93TrpGly: 0.93 ± 0.027	0.288TrpHis: 0.288 ± 0.013	0.78TrpIle: 0.78 ± 0.022	0.754TrpLys: 0.754 ± 0.02	1.204TrpLeu: 1.204 ± 0.033	0.328TrpMet: 0.328 ± 0.015	0.584TrpAsn: 0.584 ± 0.02	0.547TrpPro: 0.547 ± 0.019	0.52TrpGln: 0.52 ± 0.016	0.767TrpArg: 0.767 ± 0.02	0.949TrpSer: 0.949 ± 0.026	0.83TrpThr: 0.83 ± 0.022	0.807TrpVal: 0.807 ± 0.023	0.251TrpTrp: 0.251 ± 0.013	0.423TrpTyr: 0.423 ± 0.014	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.184TyrAla: 2.184 ± 0.036	0.372TyrCys: 0.372 ± 0.015	1.69TyrAsp: 1.69 ± 0.032	1.683TyrGlu: 1.683 ± 0.029	1.307TyrPhe: 1.307 ± 0.03	2.162TyrGly: 2.162 ± 0.041	0.693TyrHis: 0.693 ± 0.022	1.508TyrIle: 1.508 ± 0.031	1.294TyrLys: 1.294 ± 0.029	2.682TyrLeu: 2.682 ± 0.044	0.612TyrMet: 0.612 ± 0.016	1.24TyrAsn: 1.24 ± 0.025	1.526TyrPro: 1.526 ± 0.033	1.184TyrGln: 1.184 ± 0.027	1.534TyrArg: 1.534 ± 0.035	2.111TyrSer: 2.111 ± 0.034	1.697TyrThr: 1.697 ± 0.035	1.644TyrVal: 1.644 ± 0.031	0.424TyrTrp: 0.424 ± 0.015	1.035TyrTyr: 1.035 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.004XaaAsp: 0.004 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.002XaaIle: 0.002 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.006XaaLeu: 0.006 ± 0.002	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.008XaaArg: 0.008 ± 0.002	0.004XaaSer: 0.004 ± 0.001	0.004XaaThr: 0.004 ± 0.002	0.001XaaVal: 0.001 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 4330 proteins (1786973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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