Amino acid dipepetide frequency for Hathewaya histolytica (Clostridium histolyticum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.092AlaAla: 3.092 ± 0.078	0.632AlaCys: 0.632 ± 0.031	2.204AlaAsp: 2.204 ± 0.06	3.162AlaGlu: 3.162 ± 0.075	2.349AlaPhe: 2.349 ± 0.063	3.283AlaGly: 3.283 ± 0.083	0.752AlaHis: 0.752 ± 0.032	5.542AlaIle: 5.542 ± 0.097	4.553AlaLys: 4.553 ± 0.096	5.557AlaLeu: 5.557 ± 0.11	1.463AlaMet: 1.463 ± 0.055	2.217AlaAsn: 2.217 ± 0.059	1.286AlaPro: 1.286 ± 0.046	1.304AlaGln: 1.304 ± 0.048	1.803AlaArg: 1.803 ± 0.052	3.016AlaSer: 3.016 ± 0.068	2.481AlaThr: 2.481 ± 0.057	3.315AlaVal: 3.315 ± 0.071	0.329AlaTrp: 0.329 ± 0.021	2.021AlaTyr: 2.021 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.589CysAla: 0.589 ± 0.03	0.225CysCys: 0.225 ± 0.029	0.684CysAsp: 0.684 ± 0.03	0.82CysGlu: 0.82 ± 0.039	0.528CysPhe: 0.528 ± 0.029	1.066CysGly: 1.066 ± 0.04	0.211CysHis: 0.211 ± 0.018	1.227CysIle: 1.227 ± 0.049	1.028CysLys: 1.028 ± 0.038	0.816CysLeu: 0.816 ± 0.037	0.29CysMet: 0.29 ± 0.022	0.738CysAsn: 0.738 ± 0.032	0.446CysPro: 0.446 ± 0.028	0.198CysGln: 0.198 ± 0.019	0.432CysArg: 0.432 ± 0.026	0.817CysSer: 0.817 ± 0.034	0.627CysThr: 0.627 ± 0.031	0.622CysVal: 0.622 ± 0.025	0.06CysTrp: 0.06 ± 0.009	0.437CysTyr: 0.437 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	2.319AspAla: 2.319 ± 0.058	0.578AspCys: 0.578 ± 0.029	2.317AspAsp: 2.317 ± 0.053	4.027AspGlu: 4.027 ± 0.077	2.716AspPhe: 2.716 ± 0.062	3.115AspGly: 3.115 ± 0.085	0.604AspHis: 0.604 ± 0.028	6.358AspIle: 6.358 ± 0.098	5.825AspLys: 5.825 ± 0.092	4.749AspLeu: 4.749 ± 0.091	1.46AspMet: 1.46 ± 0.04	3.222AspAsn: 3.222 ± 0.066	1.319AspPro: 1.319 ± 0.035	0.774AspGln: 0.774 ± 0.031	1.833AspArg: 1.833 ± 0.055	3.075AspSer: 3.075 ± 0.078	2.546AspThr: 2.546 ± 0.058	3.36AspVal: 3.36 ± 0.074	0.329AspTrp: 0.329 ± 0.022	2.515AspTyr: 2.515 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	3.781GluAla: 3.781 ± 0.091	0.752GluCys: 0.752 ± 0.035	4.79GluAsp: 4.79 ± 0.081	8.041GluGlu: 8.041 ± 0.138	3.197GluPhe: 3.197 ± 0.056	4.489GluGly: 4.489 ± 0.083	1.025GluHis: 1.025 ± 0.036	7.223GluIle: 7.223 ± 0.1	8.455GluLys: 8.455 ± 0.116	7.012GluLeu: 7.012 ± 0.097	1.762GluMet: 1.762 ± 0.049	5.678GluAsn: 5.678 ± 0.111	1.461GluPro: 1.461 ± 0.05	1.732GluGln: 1.732 ± 0.053	2.758GluArg: 2.758 ± 0.061	3.773GluSer: 3.773 ± 0.074	2.881GluThr: 2.881 ± 0.059	5.406GluVal: 5.406 ± 0.107	0.386GluTrp: 0.386 ± 0.022	3.098GluTyr: 3.098 ± 0.077	0.0GluXaa: 0.0 ± 0.0
Phe	1.995PheAla: 1.995 ± 0.055	0.513PheCys: 0.513 ± 0.029	2.12PheAsp: 2.12 ± 0.055	2.514PheGlu: 2.514 ± 0.064	1.95PhePhe: 1.95 ± 0.061	2.662PheGly: 2.662 ± 0.064	0.58PheHis: 0.58 ± 0.028	5.034PheIle: 5.034 ± 0.105	4.505PheLys: 4.505 ± 0.087	4.365PheLeu: 4.365 ± 0.11	1.309PheMet: 1.309 ± 0.046	3.158PheAsn: 3.158 ± 0.076	1.153PhePro: 1.153 ± 0.039	0.926PheGln: 0.926 ± 0.036	1.227PheArg: 1.227 ± 0.042	3.296PheSer: 3.296 ± 0.078	2.346PheThr: 2.346 ± 0.061	2.356PheVal: 2.356 ± 0.058	0.31PheTrp: 0.31 ± 0.02	1.871PheTyr: 1.871 ± 0.06	0.0PheXaa: 0.0 ± 0.0
Gly	4.008GlyAla: 4.008 ± 0.096	0.886GlyCys: 0.886 ± 0.036	3.305GlyAsp: 3.305 ± 0.073	4.752GlyGlu: 4.752 ± 0.09	3.003GlyPhe: 3.003 ± 0.064	4.174GlyGly: 4.174 ± 0.096	0.984GlyHis: 0.984 ± 0.04	6.803GlyIle: 6.803 ± 0.105	5.909GlyLys: 5.909 ± 0.099	5.239GlyLeu: 5.239 ± 0.086	1.684GlyMet: 1.684 ± 0.05	3.451GlyAsn: 3.451 ± 0.086	1.231GlyPro: 1.231 ± 0.042	1.252GlyGln: 1.252 ± 0.045	2.398GlyArg: 2.398 ± 0.055	3.551GlySer: 3.551 ± 0.06	3.39GlyThr: 3.39 ± 0.068	4.752GlyVal: 4.752 ± 0.095	0.412GlyTrp: 0.412 ± 0.023	2.799GlyTyr: 2.799 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.614HisAla: 0.614 ± 0.028	0.199HisCys: 0.199 ± 0.016	0.67HisAsp: 0.67 ± 0.032	0.865HisGlu: 0.865 ± 0.036	0.643HisPhe: 0.643 ± 0.028	1.008HisGly: 1.008 ± 0.039	0.294HisHis: 0.294 ± 0.02	1.436HisIle: 1.436 ± 0.047	1.284HisLys: 1.284 ± 0.038	1.163HisLeu: 1.163 ± 0.038	0.425HisMet: 0.425 ± 0.024	0.939HisAsn: 0.939 ± 0.036	0.546HisPro: 0.546 ± 0.029	0.251HisGln: 0.251 ± 0.017	0.546HisArg: 0.546 ± 0.028	0.937HisSer: 0.937 ± 0.032	0.695HisThr: 0.695 ± 0.032	0.752HisVal: 0.752 ± 0.036	0.098HisTrp: 0.098 ± 0.012	0.522HisTyr: 0.522 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.183IleAla: 5.183 ± 0.102	1.241IleCys: 1.241 ± 0.054	5.576IleAsp: 5.576 ± 0.079	7.646IleGlu: 7.646 ± 0.11	4.483IlePhe: 4.483 ± 0.115	6.24IleGly: 6.24 ± 0.109	1.364IleHis: 1.364 ± 0.045	10.067IleIle: 10.067 ± 0.161	9.851IleLys: 9.851 ± 0.115	10.003IleLeu: 10.003 ± 0.152	2.399IleMet: 2.399 ± 0.067	6.469IleAsn: 6.469 ± 0.095	3.396IlePro: 3.396 ± 0.083	2.19IleGln: 2.19 ± 0.053	3.163IleArg: 3.163 ± 0.067	7.228IleSer: 7.228 ± 0.125	4.792IleThr: 4.792 ± 0.072	5.979IleVal: 5.979 ± 0.094	0.519IleTrp: 0.519 ± 0.026	3.719IleTyr: 3.719 ± 0.077	0.0IleXaa: 0.0 ± 0.0
Lys	4.697LysAla: 4.697 ± 0.095	0.863LysCys: 0.863 ± 0.037	6.531LysAsp: 6.531 ± 0.104	10.463LysGlu: 10.463 ± 0.131	3.68LysPhe: 3.68 ± 0.061	6.027LysGly: 6.027 ± 0.096	1.308LysHis: 1.308 ± 0.047	8.521LysIle: 8.521 ± 0.125	9.102LysLys: 9.102 ± 0.126	8.031LysLeu: 8.031 ± 0.093	2.393LysMet: 2.393 ± 0.051	7.25LysAsn: 7.25 ± 0.106	2.273LysPro: 2.273 ± 0.056	2.148LysGln: 2.148 ± 0.052	3.33LysArg: 3.33 ± 0.066	5.871LysSer: 5.871 ± 0.094	4.101LysThr: 4.101 ± 0.082	6.667LysVal: 6.667 ± 0.123	0.56LysTrp: 0.56 ± 0.027	4.147LysTyr: 4.147 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	4.485LeuAla: 4.485 ± 0.093	1.254LeuCys: 1.254 ± 0.043	5.291LeuAsp: 5.291 ± 0.094	6.639LeuGlu: 6.639 ± 0.097	3.723LeuPhe: 3.723 ± 0.089	6.494LeuGly: 6.494 ± 0.107	1.12LeuHis: 1.12 ± 0.036	8.521LeuIle: 8.521 ± 0.146	9.728LeuLys: 9.728 ± 0.133	7.699LeuLeu: 7.699 ± 0.127	2.38LeuMet: 2.38 ± 0.064	6.412LeuAsn: 6.412 ± 0.102	2.631LeuPro: 2.631 ± 0.065	2.129LeuGln: 2.129 ± 0.051	3.228LeuArg: 3.228 ± 0.069	6.676LeuSer: 6.676 ± 0.096	4.257LeuThr: 4.257 ± 0.085	5.361LeuVal: 5.361 ± 0.097	0.556LeuTrp: 0.556 ± 0.028	3.341LeuTyr: 3.341 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	1.602MetAla: 1.602 ± 0.047	0.295MetCys: 0.295 ± 0.02	1.587MetAsp: 1.587 ± 0.047	2.151MetGlu: 2.151 ± 0.052	0.971MetPhe: 0.971 ± 0.043	1.828MetGly: 1.828 ± 0.055	0.344MetHis: 0.344 ± 0.022	2.055MetIle: 2.055 ± 0.061	2.516MetLys: 2.516 ± 0.053	2.315MetLeu: 2.315 ± 0.066	0.56MetMet: 0.56 ± 0.027	1.675MetAsn: 1.675 ± 0.043	0.864MetPro: 0.864 ± 0.033	0.678MetGln: 0.678 ± 0.032	0.867MetArg: 0.867 ± 0.033	1.668MetSer: 1.668 ± 0.049	1.063MetThr: 1.063 ± 0.041	1.634MetVal: 1.634 ± 0.05	0.141MetTrp: 0.141 ± 0.014	0.954MetTyr: 0.954 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.701AsnAla: 2.701 ± 0.061	0.759AsnCys: 0.759 ± 0.037	2.545AsnAsp: 2.545 ± 0.059	4.195AsnGlu: 4.195 ± 0.087	2.844AsnPhe: 2.844 ± 0.073	3.451AsnGly: 3.451 ± 0.064	0.863AsnHis: 0.863 ± 0.033	7.676AsnIle: 7.676 ± 0.119	6.972AsnLys: 6.972 ± 0.116	6.347AsnLeu: 6.347 ± 0.103	1.71AsnMet: 1.71 ± 0.049	4.592AsnAsn: 4.592 ± 0.098	2.07AsnPro: 2.07 ± 0.056	1.279AsnGln: 1.279 ± 0.049	2.1AsnArg: 2.1 ± 0.056	4.231AsnSer: 4.231 ± 0.088	2.994AsnThr: 2.994 ± 0.071	3.423AsnVal: 3.423 ± 0.077	0.42AsnTrp: 0.42 ± 0.029	2.752AsnTyr: 2.752 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.213ProAla: 1.213 ± 0.047	0.347ProCys: 0.347 ± 0.023	1.198ProAsp: 1.198 ± 0.043	2.166ProGlu: 2.166 ± 0.058	1.305ProPhe: 1.305 ± 0.045	1.607ProGly: 1.607 ± 0.056	0.471ProHis: 0.471 ± 0.027	2.708ProIle: 2.708 ± 0.065	2.511ProLys: 2.511 ± 0.056	2.492ProLeu: 2.492 ± 0.059	0.716ProMet: 0.716 ± 0.026	1.489ProAsn: 1.489 ± 0.039	0.569ProPro: 0.569 ± 0.031	0.726ProGln: 0.726 ± 0.032	0.846ProArg: 0.846 ± 0.035	1.763ProSer: 1.763 ± 0.058	1.507ProThr: 1.507 ± 0.051	1.944ProVal: 1.944 ± 0.052	0.208ProTrp: 0.208 ± 0.016	1.343ProTyr: 1.343 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.096GlnAla: 1.096 ± 0.042	0.285GlnCys: 0.285 ± 0.02	1.103GlnAsp: 1.103 ± 0.039	1.633GlnGlu: 1.633 ± 0.048	0.92GlnPhe: 0.92 ± 0.043	1.491GlnGly: 1.491 ± 0.044	0.314GlnHis: 0.314 ± 0.02	2.012GlnIle: 2.012 ± 0.056	2.058GlnLys: 2.058 ± 0.054	1.819GlnLeu: 1.819 ± 0.046	0.573GlnMet: 0.573 ± 0.025	1.464GlnAsn: 1.464 ± 0.048	0.545GlnPro: 0.545 ± 0.026	0.5GlnGln: 0.5 ± 0.028	0.929GlnArg: 0.929 ± 0.04	1.378GlnSer: 1.378 ± 0.044	0.846GlnThr: 0.846 ± 0.036	1.27GlnVal: 1.27 ± 0.039	0.241GlnTrp: 0.241 ± 0.019	0.99GlnTyr: 0.99 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	1.846ArgAla: 1.846 ± 0.052	0.425ArgCys: 0.425 ± 0.025	1.941ArgAsp: 1.941 ± 0.053	3.352ArgGlu: 3.352 ± 0.068	1.404ArgPhe: 1.404 ± 0.044	2.135ArgGly: 2.135 ± 0.057	0.468ArgHis: 0.468 ± 0.023	3.279ArgIle: 3.279 ± 0.059	3.137ArgLys: 3.137 ± 0.066	2.873ArgLeu: 2.873 ± 0.063	0.911ArgMet: 0.911 ± 0.036	2.058ArgAsn: 2.058 ± 0.05	0.825ArgPro: 0.825 ± 0.034	0.826ArgGln: 0.826 ± 0.032	1.528ArgArg: 1.528 ± 0.048	1.58ArgSer: 1.58 ± 0.041	1.593ArgThr: 1.593 ± 0.055	2.323ArgVal: 2.323 ± 0.058	0.224ArgTrp: 0.224 ± 0.016	1.505ArgTyr: 1.505 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	2.993SerAla: 2.993 ± 0.07	0.635SerCys: 0.635 ± 0.036	2.844SerAsp: 2.844 ± 0.065	4.204SerGlu: 4.204 ± 0.08	3.148SerPhe: 3.148 ± 0.071	4.287SerGly: 4.287 ± 0.096	0.919SerHis: 0.919 ± 0.034	7.162SerIle: 7.162 ± 0.101	6.45SerLys: 6.45 ± 0.096	6.279SerLeu: 6.279 ± 0.094	1.768SerMet: 1.768 ± 0.053	3.783SerAsn: 3.783 ± 0.073	1.599SerPro: 1.599 ± 0.045	1.423SerGln: 1.423 ± 0.046	2.095SerArg: 2.095 ± 0.056	4.345SerSer: 4.345 ± 0.102	3.132SerThr: 3.132 ± 0.066	3.608SerVal: 3.608 ± 0.071	0.393SerTrp: 0.393 ± 0.022	2.703SerTyr: 2.703 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	2.502ThrAla: 2.502 ± 0.067	0.52ThrCys: 0.52 ± 0.029	2.14ThrAsp: 2.14 ± 0.055	3.187ThrGlu: 3.187 ± 0.062	2.177ThrPhe: 2.177 ± 0.05	3.491ThrGly: 3.491 ± 0.076	0.787ThrHis: 0.787 ± 0.032	4.731ThrIle: 4.731 ± 0.08	3.876ThrLys: 3.876 ± 0.074	4.993ThrLeu: 4.993 ± 0.09	1.197ThrMet: 1.197 ± 0.034	2.481ThrAsn: 2.481 ± 0.059	1.75ThrPro: 1.75 ± 0.048	0.938ThrGln: 0.938 ± 0.038	1.481ThrArg: 1.481 ± 0.047	3.075ThrSer: 3.075 ± 0.067	2.549ThrThr: 2.549 ± 0.076	3.12ThrVal: 3.12 ± 0.066	0.302ThrTrp: 0.302 ± 0.019	2.006ThrTyr: 2.006 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	3.466ValAla: 3.466 ± 0.084	0.829ValCys: 0.829 ± 0.035	3.555ValAsp: 3.555 ± 0.069	4.483ValGlu: 4.483 ± 0.08	2.739ValPhe: 2.739 ± 0.061	4.133ValGly: 4.133 ± 0.088	0.86ValHis: 0.86 ± 0.029	6.261ValIle: 6.261 ± 0.099	5.672ValLys: 5.672 ± 0.112	6.109ValLeu: 6.109 ± 0.095	1.52ValMet: 1.52 ± 0.042	3.505ValAsn: 3.505 ± 0.076	1.855ValPro: 1.855 ± 0.047	1.456ValGln: 1.456 ± 0.045	1.936ValArg: 1.936 ± 0.058	4.298ValSer: 4.298 ± 0.072	3.19ValThr: 3.19 ± 0.071	4.328ValVal: 4.328 ± 0.102	0.379ValTrp: 0.379 ± 0.026	2.267ValTyr: 2.267 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.341TrpAla: 0.341 ± 0.024	0.109TrpCys: 0.109 ± 0.014	0.375TrpAsp: 0.375 ± 0.022	0.419TrpGlu: 0.419 ± 0.025	0.282TrpPhe: 0.282 ± 0.021	0.452TrpGly: 0.452 ± 0.025	0.105TrpHis: 0.105 ± 0.012	0.591TrpIle: 0.591 ± 0.028	0.502TrpLys: 0.502 ± 0.026	0.497TrpLeu: 0.497 ± 0.029	0.183TrpMet: 0.183 ± 0.014	0.449TrpAsn: 0.449 ± 0.027	0.152TrpPro: 0.152 ± 0.015	0.154TrpGln: 0.154 ± 0.016	0.265TrpArg: 0.265 ± 0.018	0.39TrpSer: 0.39 ± 0.025	0.307TrpThr: 0.307 ± 0.025	0.347TrpVal: 0.347 ± 0.02	0.086TrpTrp: 0.086 ± 0.011	0.219TrpTyr: 0.219 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.839TyrAla: 1.839 ± 0.054	0.513TyrCys: 0.513 ± 0.026	2.264TyrAsp: 2.264 ± 0.072	2.985TyrGlu: 2.985 ± 0.066	2.131TyrPhe: 2.131 ± 0.062	2.546TyrGly: 2.546 ± 0.068	0.518TyrHis: 0.518 ± 0.026	4.303TyrIle: 4.303 ± 0.089	4.027TyrLys: 4.027 ± 0.081	3.567TyrLeu: 3.567 ± 0.081	1.063TyrMet: 1.063 ± 0.039	2.894TyrAsn: 2.894 ± 0.065	1.155TyrPro: 1.155 ± 0.041	0.582TyrGln: 0.582 ± 0.029	1.468TyrArg: 1.468 ± 0.046	2.801TyrSer: 2.801 ± 0.06	2.006TyrThr: 2.006 ± 0.062	2.272TyrVal: 2.272 ± 0.054	0.275TyrTrp: 0.275 ± 0.022	1.714TyrTyr: 1.714 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2563 proteins (768538 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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