Amino acid dipepetide frequency for Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.434AlaAla: 7.434 ± 0.093	0.959AlaCys: 0.959 ± 0.023	4.414AlaAsp: 4.414 ± 0.063	5.558AlaGlu: 5.558 ± 0.084	3.516AlaPhe: 3.516 ± 0.05	5.765AlaGly: 5.765 ± 0.081	1.677AlaHis: 1.677 ± 0.035	5.879AlaIle: 5.879 ± 0.072	5.036AlaLys: 5.036 ± 0.074	9.711AlaLeu: 9.711 ± 0.096	2.848AlaMet: 2.848 ± 0.055	3.601AlaAsn: 3.601 ± 0.045	2.882AlaPro: 2.882 ± 0.052	3.946AlaGln: 3.946 ± 0.053	3.528AlaArg: 3.528 ± 0.054	5.346AlaSer: 5.346 ± 0.064	4.487AlaThr: 4.487 ± 0.084	5.737AlaVal: 5.737 ± 0.087	1.0AlaTrp: 1.0 ± 0.025	2.324AlaTyr: 2.324 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.797CysAla: 0.797 ± 0.022	0.168CysCys: 0.168 ± 0.012	0.641CysAsp: 0.641 ± 0.021	0.651CysGlu: 0.651 ± 0.022	0.477CysPhe: 0.477 ± 0.015	0.934CysGly: 0.934 ± 0.03	0.368CysHis: 0.368 ± 0.023	0.576CysIle: 0.576 ± 0.02	0.449CysLys: 0.449 ± 0.018	0.989CysLeu: 0.989 ± 0.027	0.257CysMet: 0.257 ± 0.013	0.354CysAsn: 0.354 ± 0.015	0.438CysPro: 0.438 ± 0.02	0.456CysGln: 0.456 ± 0.018	0.467CysArg: 0.467 ± 0.019	0.757CysSer: 0.757 ± 0.026	0.484CysThr: 0.484 ± 0.018	0.702CysVal: 0.702 ± 0.021	0.141CysTrp: 0.141 ± 0.01	0.342CysTyr: 0.342 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.513AspAla: 4.513 ± 0.059	0.55AspCys: 0.55 ± 0.016	3.019AspAsp: 3.019 ± 0.061	4.047AspGlu: 4.047 ± 0.059	2.504AspPhe: 2.504 ± 0.044	3.867AspGly: 3.867 ± 0.113	1.122AspHis: 1.122 ± 0.033	3.854AspIle: 3.854 ± 0.05	3.316AspLys: 3.316 ± 0.049	5.15AspLeu: 5.15 ± 0.07	1.446AspMet: 1.446 ± 0.035	2.381AspAsn: 2.381 ± 0.049	2.065AspPro: 2.065 ± 0.043	1.971AspGln: 1.971 ± 0.042	2.185AspArg: 2.185 ± 0.036	3.265AspSer: 3.265 ± 0.059	2.712AspThr: 2.712 ± 0.058	4.21AspVal: 4.21 ± 0.068	0.867AspTrp: 0.867 ± 0.023	1.978AspTyr: 1.978 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.342GluAla: 5.342 ± 0.071	0.586GluCys: 0.586 ± 0.022	3.031GluAsp: 3.031 ± 0.054	4.323GluGlu: 4.323 ± 0.069	2.634GluPhe: 2.634 ± 0.05	3.738GluGly: 3.738 ± 0.06	1.65GluHis: 1.65 ± 0.035	3.766GluIle: 3.766 ± 0.064	4.081GluLys: 4.081 ± 0.056	7.333GluLeu: 7.333 ± 0.077	1.835GluMet: 1.835 ± 0.039	2.808GluAsn: 2.808 ± 0.045	2.247GluPro: 2.247 ± 0.042	4.082GluGln: 4.082 ± 0.065	3.487GluArg: 3.487 ± 0.057	3.934GluSer: 3.934 ± 0.055	3.221GluThr: 3.221 ± 0.058	4.537GluVal: 4.537 ± 0.057	0.851GluTrp: 0.851 ± 0.026	1.934GluTyr: 1.934 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.748PheAla: 3.748 ± 0.055	0.534PheCys: 0.534 ± 0.021	2.799PheAsp: 2.799 ± 0.048	2.771PheGlu: 2.771 ± 0.044	1.81PhePhe: 1.81 ± 0.042	3.294PheGly: 3.294 ± 0.059	0.859PheHis: 0.859 ± 0.023	2.638PheIle: 2.638 ± 0.05	2.027PheLys: 2.027 ± 0.039	3.428PheLeu: 3.428 ± 0.062	1.06PheMet: 1.06 ± 0.029	2.014PheAsn: 2.014 ± 0.043	1.44PhePro: 1.44 ± 0.037	1.348PheGln: 1.348 ± 0.03	1.538PheArg: 1.538 ± 0.034	3.344PheSer: 3.344 ± 0.055	2.429PheThr: 2.429 ± 0.057	3.037PheVal: 3.037 ± 0.052	0.53PheTrp: 0.53 ± 0.023	1.359PheTyr: 1.359 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.276GlyAla: 5.276 ± 0.076	0.897GlyCys: 0.897 ± 0.028	3.7GlyAsp: 3.7 ± 0.075	4.574GlyGlu: 4.574 ± 0.067	3.276GlyPhe: 3.276 ± 0.051	4.762GlyGly: 4.762 ± 0.074	1.511GlyHis: 1.511 ± 0.036	4.592GlyIle: 4.592 ± 0.062	4.001GlyLys: 4.001 ± 0.055	6.75GlyLeu: 6.75 ± 0.079	2.017GlyMet: 2.017 ± 0.039	2.66GlyAsn: 2.66 ± 0.057	1.559GlyPro: 1.559 ± 0.04	2.742GlyGln: 2.742 ± 0.047	3.061GlyArg: 3.061 ± 0.05	4.177GlySer: 4.177 ± 0.088	3.426GlyThr: 3.426 ± 0.069	5.217GlyVal: 5.217 ± 0.071	0.953GlyTrp: 0.953 ± 0.028	2.607GlyTyr: 2.607 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.671HisAla: 1.671 ± 0.038	0.323HisCys: 0.323 ± 0.014	1.142HisAsp: 1.142 ± 0.028	1.213HisGlu: 1.213 ± 0.027	1.144HisPhe: 1.144 ± 0.026	1.519HisGly: 1.519 ± 0.034	0.722HisHis: 0.722 ± 0.028	1.407HisIle: 1.407 ± 0.032	1.054HisLys: 1.054 ± 0.027	2.253HisLeu: 2.253 ± 0.045	0.506HisMet: 0.506 ± 0.018	0.916HisAsn: 0.916 ± 0.024	1.128HisPro: 1.128 ± 0.03	1.237HisGln: 1.237 ± 0.033	1.077HisArg: 1.077 ± 0.027	1.391HisSer: 1.391 ± 0.032	1.112HisThr: 1.112 ± 0.028	1.41HisVal: 1.41 ± 0.035	0.335HisTrp: 0.335 ± 0.016	0.857HisTyr: 0.857 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.243IleAla: 6.243 ± 0.082	0.694IleCys: 0.694 ± 0.022	4.088IleAsp: 4.088 ± 0.054	4.818IleGlu: 4.818 ± 0.068	2.239IlePhe: 2.239 ± 0.05	4.549IleGly: 4.549 ± 0.052	1.286IleHis: 1.286 ± 0.026	3.349IleIle: 3.349 ± 0.056	3.228IleLys: 3.228 ± 0.046	5.034IleLeu: 5.034 ± 0.077	1.309IleMet: 1.309 ± 0.031	2.86IleAsn: 2.86 ± 0.047	2.609IlePro: 2.609 ± 0.043	2.326IleGln: 2.326 ± 0.042	2.737IleArg: 2.737 ± 0.044	4.305IleSer: 4.305 ± 0.048	3.661IleThr: 3.661 ± 0.063	4.161IleVal: 4.161 ± 0.063	0.61IleTrp: 0.61 ± 0.02	1.691IleTyr: 1.691 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.923LysAla: 4.923 ± 0.07	0.357LysCys: 0.357 ± 0.017	2.848LysAsp: 2.848 ± 0.047	3.583LysGlu: 3.583 ± 0.047	1.671LysPhe: 1.671 ± 0.033	3.493LysGly: 3.493 ± 0.047	1.377LysHis: 1.377 ± 0.035	2.746LysIle: 2.746 ± 0.049	2.994LysLys: 2.994 ± 0.061	5.519LysLeu: 5.519 ± 0.067	1.506LysMet: 1.506 ± 0.03	2.214LysAsn: 2.214 ± 0.048	2.581LysPro: 2.581 ± 0.039	3.02LysGln: 3.02 ± 0.051	2.84LysArg: 2.84 ± 0.051	3.143LysSer: 3.143 ± 0.054	2.903LysThr: 2.903 ± 0.045	4.045LysVal: 4.045 ± 0.051	0.614LysTrp: 0.614 ± 0.024	1.469LysTyr: 1.469 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.553LeuAla: 9.553 ± 0.086	1.085LeuCys: 1.085 ± 0.031	5.733LeuAsp: 5.733 ± 0.072	6.483LeuGlu: 6.483 ± 0.076	4.258LeuPhe: 4.258 ± 0.068	6.836LeuGly: 6.836 ± 0.081	2.061LeuHis: 2.061 ± 0.036	6.055LeuIle: 6.055 ± 0.087	5.385LeuLys: 5.385 ± 0.075	10.027LeuLeu: 10.027 ± 0.122	2.829LeuMet: 2.829 ± 0.049	4.678LeuAsn: 4.678 ± 0.065	4.671LeuPro: 4.671 ± 0.062	3.54LeuGln: 3.54 ± 0.046	4.217LeuArg: 4.217 ± 0.06	7.848LeuSer: 7.848 ± 0.077	5.961LeuThr: 5.961 ± 0.075	7.106LeuVal: 7.106 ± 0.082	1.002LeuTrp: 1.002 ± 0.027	2.544LeuTyr: 2.544 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.617MetAla: 2.617 ± 0.043	0.236MetCys: 0.236 ± 0.012	1.311MetAsp: 1.311 ± 0.031	1.436MetGlu: 1.436 ± 0.033	1.015MetPhe: 1.015 ± 0.03	1.831MetGly: 1.831 ± 0.04	0.513MetHis: 0.513 ± 0.018	1.57MetIle: 1.57 ± 0.037	1.707MetLys: 1.707 ± 0.035	2.87MetLeu: 2.87 ± 0.048	0.881MetMet: 0.881 ± 0.026	1.209MetAsn: 1.209 ± 0.031	1.284MetPro: 1.284 ± 0.027	1.107MetGln: 1.107 ± 0.027	1.226MetArg: 1.226 ± 0.031	2.071MetSer: 2.071 ± 0.036	1.707MetThr: 1.707 ± 0.032	1.947MetVal: 1.947 ± 0.041	0.264MetTrp: 0.264 ± 0.015	0.588MetTyr: 0.588 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.565AsnAla: 3.565 ± 0.058	0.421AsnCys: 0.421 ± 0.017	2.41AsnAsp: 2.41 ± 0.057	2.545AsnGlu: 2.545 ± 0.039	1.613AsnPhe: 1.613 ± 0.04	3.093AsnGly: 3.093 ± 0.063	1.01AsnHis: 1.01 ± 0.029	2.744AsnIle: 2.744 ± 0.051	2.32AsnLys: 2.32 ± 0.041	3.966AsnLeu: 3.966 ± 0.052	1.081AsnMet: 1.081 ± 0.024	1.923AsnAsn: 1.923 ± 0.045	2.167AsnPro: 2.167 ± 0.046	2.192AsnGln: 2.192 ± 0.045	1.914AsnArg: 1.914 ± 0.036	2.45AsnSer: 2.45 ± 0.044	2.281AsnThr: 2.281 ± 0.041	2.954AsnVal: 2.954 ± 0.047	0.598AsnTrp: 0.598 ± 0.022	1.399AsnTyr: 1.399 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.99ProAla: 2.99 ± 0.054	0.337ProCys: 0.337 ± 0.015	2.19ProAsp: 2.19 ± 0.044	3.236ProGlu: 3.236 ± 0.052	1.721ProPhe: 1.721 ± 0.039	2.118ProGly: 2.118 ± 0.049	0.866ProHis: 0.866 ± 0.024	2.527ProIle: 2.527 ± 0.05	2.056ProLys: 2.056 ± 0.041	3.955ProLeu: 3.955 ± 0.058	1.112ProMet: 1.112 ± 0.029	1.829ProAsn: 1.829 ± 0.038	1.124ProPro: 1.124 ± 0.036	1.688ProGln: 1.688 ± 0.039	1.352ProArg: 1.352 ± 0.03	2.573ProSer: 2.573 ± 0.044	2.306ProThr: 2.306 ± 0.049	3.17ProVal: 3.17 ± 0.065	0.488ProTrp: 0.488 ± 0.02	1.283ProTyr: 1.283 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.229GlnAla: 4.229 ± 0.063	0.402GlnCys: 0.402 ± 0.017	2.163GlnAsp: 2.163 ± 0.042	2.628GlnGlu: 2.628 ± 0.043	1.776GlnPhe: 1.776 ± 0.033	2.956GlnGly: 2.956 ± 0.054	1.15GlnHis: 1.15 ± 0.027	2.526GlnIle: 2.526 ± 0.042	2.156GlnLys: 2.156 ± 0.042	4.975GlnLeu: 4.975 ± 0.066	1.221GlnMet: 1.221 ± 0.032	1.71GlnAsn: 1.71 ± 0.035	1.776GlnPro: 1.776 ± 0.041	2.807GlnGln: 2.807 ± 0.067	2.304GlnArg: 2.304 ± 0.043	2.906GlnSer: 2.906 ± 0.056	2.416GlnThr: 2.416 ± 0.041	3.175GlnVal: 3.175 ± 0.049	0.635GlnTrp: 0.635 ± 0.019	1.425GlnTyr: 1.425 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.377ArgAla: 3.377 ± 0.048	0.47ArgCys: 0.47 ± 0.02	2.483ArgAsp: 2.483 ± 0.049	3.086ArgGlu: 3.086 ± 0.049	2.226ArgPhe: 2.226 ± 0.04	2.537ArgGly: 2.537 ± 0.051	1.091ArgHis: 1.091 ± 0.029	2.943ArgIle: 2.943 ± 0.041	2.462ArgLys: 2.462 ± 0.046	4.745ArgLeu: 4.745 ± 0.062	1.22ArgMet: 1.22 ± 0.031	1.914ArgAsn: 1.914 ± 0.034	1.504ArgPro: 1.504 ± 0.037	2.03ArgGln: 2.03 ± 0.039	2.264ArgArg: 2.264 ± 0.055	2.616ArgSer: 2.616 ± 0.047	2.153ArgThr: 2.153 ± 0.033	3.305ArgVal: 3.305 ± 0.045	0.616ArgTrp: 0.616 ± 0.022	1.711ArgTyr: 1.711 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.381SerAla: 5.381 ± 0.065	0.614SerCys: 0.614 ± 0.022	3.663SerAsp: 3.663 ± 0.068	4.156SerGlu: 4.156 ± 0.054	2.844SerPhe: 2.844 ± 0.052	4.822SerGly: 4.822 ± 0.071	1.531SerHis: 1.531 ± 0.033	4.198SerIle: 4.198 ± 0.063	3.302SerLys: 3.302 ± 0.048	6.977SerLeu: 6.977 ± 0.072	1.828SerMet: 1.828 ± 0.036	2.763SerAsn: 2.763 ± 0.053	2.373SerPro: 2.373 ± 0.044	3.064SerGln: 3.064 ± 0.055	2.873SerArg: 2.873 ± 0.048	4.425SerSer: 4.425 ± 0.07	3.316SerThr: 3.316 ± 0.051	4.806SerVal: 4.806 ± 0.06	0.824SerTrp: 0.824 ± 0.022	2.11SerTyr: 2.11 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.464ThrAla: 4.464 ± 0.071	0.468ThrCys: 0.468 ± 0.016	2.851ThrAsp: 2.851 ± 0.059	3.12ThrGlu: 3.12 ± 0.053	2.286ThrPhe: 2.286 ± 0.042	3.986ThrGly: 3.986 ± 0.082	1.222ThrHis: 1.222 ± 0.031	3.473ThrIle: 3.473 ± 0.077	2.503ThrLys: 2.503 ± 0.045	6.301ThrLeu: 6.301 ± 0.087	1.279ThrMet: 1.279 ± 0.032	2.135ThrAsn: 2.135 ± 0.042	2.649ThrPro: 2.649 ± 0.043	2.575ThrGln: 2.575 ± 0.047	2.226ThrArg: 2.226 ± 0.038	3.463ThrSer: 3.463 ± 0.062	3.007ThrThr: 3.007 ± 0.078	3.878ThrVal: 3.878 ± 0.084	0.626ThrTrp: 0.626 ± 0.019	1.554ThrTyr: 1.554 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.404ValAla: 6.404 ± 0.088	0.814ValCys: 0.814 ± 0.021	4.217ValAsp: 4.217 ± 0.085	4.973ValGlu: 4.973 ± 0.068	2.965ValPhe: 2.965 ± 0.057	4.817ValGly: 4.817 ± 0.064	1.275ValHis: 1.275 ± 0.029	4.702ValIle: 4.702 ± 0.063	3.818ValLys: 3.818 ± 0.059	6.926ValLeu: 6.926 ± 0.061	2.086ValMet: 2.086 ± 0.037	3.015ValAsn: 3.015 ± 0.058	2.642ValPro: 2.642 ± 0.043	2.443ValGln: 2.443 ± 0.042	3.073ValArg: 3.073 ± 0.047	5.069ValSer: 5.069 ± 0.082	4.343ValThr: 4.343 ± 0.091	5.744ValVal: 5.744 ± 0.072	0.773ValTrp: 0.773 ± 0.023	1.864ValTyr: 1.864 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.843TrpAla: 0.843 ± 0.026	0.165TrpCys: 0.165 ± 0.009	0.613TrpAsp: 0.613 ± 0.02	0.574TrpGlu: 0.574 ± 0.023	0.61TrpPhe: 0.61 ± 0.022	0.766TrpGly: 0.766 ± 0.025	0.347TrpHis: 0.347 ± 0.014	0.676TrpIle: 0.676 ± 0.026	0.604TrpLys: 0.604 ± 0.019	1.691TrpLeu: 1.691 ± 0.037	0.388TrpMet: 0.388 ± 0.016	0.484TrpAsn: 0.484 ± 0.021	0.42TrpPro: 0.42 ± 0.017	0.871TrpGln: 0.871 ± 0.025	0.635TrpArg: 0.635 ± 0.021	0.731TrpSer: 0.731 ± 0.025	0.551TrpThr: 0.551 ± 0.023	0.872TrpVal: 0.872 ± 0.026	0.204TrpTrp: 0.204 ± 0.011	0.356TrpTyr: 0.356 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.037	0.369TyrCys: 0.369 ± 0.016	1.709TyrAsp: 1.709 ± 0.043	1.645TyrGlu: 1.645 ± 0.039	1.423TyrPhe: 1.423 ± 0.03	2.075TyrGly: 2.075 ± 0.042	0.778TyrHis: 0.778 ± 0.027	1.574TyrIle: 1.574 ± 0.033	1.347TyrLys: 1.347 ± 0.029	3.272TyrLeu: 3.272 ± 0.047	0.681TyrMet: 0.681 ± 0.021	1.177TyrAsn: 1.177 ± 0.032	1.36TyrPro: 1.36 ± 0.034	1.891TyrGln: 1.891 ± 0.033	1.75TyrArg: 1.75 ± 0.039	2.056TyrSer: 2.056 ± 0.047	1.587TyrThr: 1.587 ± 0.038	1.95TyrVal: 1.95 ± 0.034	0.474TyrTrp: 0.474 ± 0.019	1.026TyrTyr: 1.026 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4821 proteins (1490746 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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