Amino acid dipepetide frequency for Pseudomonas cremoricolorata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.493AlaAla: 13.493 ± 0.157	1.26AlaCys: 1.26 ± 0.035	6.056AlaAsp: 6.056 ± 0.076	7.118AlaGlu: 7.118 ± 0.079	3.843AlaPhe: 3.843 ± 0.056	9.344AlaGly: 9.344 ± 0.125	2.352AlaHis: 2.352 ± 0.039	4.892AlaIle: 4.892 ± 0.062	3.464AlaLys: 3.464 ± 0.069	14.777AlaLeu: 14.777 ± 0.162	2.844AlaMet: 2.844 ± 0.046	2.912AlaAsn: 2.912 ± 0.054	5.078AlaPro: 5.078 ± 0.096	6.269AlaGln: 6.269 ± 0.09	7.541AlaArg: 7.541 ± 0.092	6.598AlaSer: 6.598 ± 0.07	4.796AlaThr: 4.796 ± 0.065	7.873AlaVal: 7.873 ± 0.091	1.704AlaTrp: 1.704 ± 0.037	2.557AlaTyr: 2.557 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.171CysAla: 1.171 ± 0.032	0.134CysCys: 0.134 ± 0.01	0.524CysAsp: 0.524 ± 0.019	0.566CysGlu: 0.566 ± 0.024	0.316CysPhe: 0.316 ± 0.016	0.907CysGly: 0.907 ± 0.03	0.278CysHis: 0.278 ± 0.016	0.446CysIle: 0.446 ± 0.018	0.256CysLys: 0.256 ± 0.015	1.118CysLeu: 1.118 ± 0.03	0.188CysMet: 0.188 ± 0.012	0.255CysAsn: 0.255 ± 0.013	0.49CysPro: 0.49 ± 0.019	0.463CysGln: 0.463 ± 0.021	0.644CysArg: 0.644 ± 0.024	0.624CysSer: 0.624 ± 0.021	0.46CysThr: 0.46 ± 0.017	0.652CysVal: 0.652 ± 0.022	0.152CysTrp: 0.152 ± 0.012	0.275CysTyr: 0.275 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.223AspAla: 6.223 ± 0.084	0.56AspCys: 0.56 ± 0.023	3.226AspAsp: 3.226 ± 0.057	3.297AspGlu: 3.297 ± 0.05	2.04AspPhe: 2.04 ± 0.045	4.547AspGly: 4.547 ± 0.097	1.239AspHis: 1.239 ± 0.033	2.592AspIle: 2.592 ± 0.047	1.805AspLys: 1.805 ± 0.042	5.943AspLeu: 5.943 ± 0.073	1.184AspMet: 1.184 ± 0.03	1.573AspAsn: 1.573 ± 0.039	2.929AspPro: 2.929 ± 0.049	2.305AspGln: 2.305 ± 0.042	3.067AspArg: 3.067 ± 0.05	2.861AspSer: 2.861 ± 0.051	2.573AspThr: 2.573 ± 0.048	3.545AspVal: 3.545 ± 0.056	0.973AspTrp: 0.973 ± 0.026	1.758AspTyr: 1.758 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.445GluAla: 6.445 ± 0.08	0.407GluCys: 0.407 ± 0.018	2.435GluAsp: 2.435 ± 0.048	2.734GluGlu: 2.734 ± 0.069	1.597GluPhe: 1.597 ± 0.038	3.995GluGly: 3.995 ± 0.057	1.882GluHis: 1.882 ± 0.042	2.439GluIle: 2.439 ± 0.045	1.735GluLys: 1.735 ± 0.048	6.881GluLeu: 6.881 ± 0.082	1.133GluMet: 1.133 ± 0.028	1.289GluAsn: 1.289 ± 0.032	2.476GluPro: 2.476 ± 0.058	4.289GluGln: 4.289 ± 0.076	5.142GluArg: 5.142 ± 0.079	2.458GluSer: 2.458 ± 0.048	2.344GluThr: 2.344 ± 0.043	4.328GluVal: 4.328 ± 0.065	0.7GluTrp: 0.7 ± 0.025	1.152GluTyr: 1.152 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.103PheAla: 4.103 ± 0.057	0.428PheCys: 0.428 ± 0.022	2.528PheAsp: 2.528 ± 0.045	2.117PheGlu: 2.117 ± 0.043	1.347PhePhe: 1.347 ± 0.038	3.007PheGly: 3.007 ± 0.05	0.734PheHis: 0.734 ± 0.025	1.795PheIle: 1.795 ± 0.041	1.173PheLys: 1.173 ± 0.035	3.014PheLeu: 3.014 ± 0.058	0.798PheMet: 0.798 ± 0.027	1.279PheAsn: 1.279 ± 0.035	1.347PhePro: 1.347 ± 0.035	1.18PheGln: 1.18 ± 0.028	1.704PheArg: 1.704 ± 0.039	2.436PheSer: 2.436 ± 0.053	1.892PheThr: 1.892 ± 0.042	2.434PheVal: 2.434 ± 0.047	0.509PheTrp: 0.509 ± 0.023	0.965PheTyr: 0.965 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	7.761GlyAla: 7.761 ± 0.096	0.933GlyCys: 0.933 ± 0.032	3.989GlyAsp: 3.989 ± 0.061	4.97GlyGlu: 4.97 ± 0.091	3.205GlyPhe: 3.205 ± 0.053	5.923GlyGly: 5.923 ± 0.075	1.885GlyHis: 1.885 ± 0.039	3.825GlyIle: 3.825 ± 0.058	3.29GlyLys: 3.29 ± 0.063	9.604GlyLeu: 9.604 ± 0.096	2.151GlyMet: 2.151 ± 0.045	2.4GlyAsn: 2.4 ± 0.083	2.648GlyPro: 2.648 ± 0.048	3.92GlyGln: 3.92 ± 0.06	5.114GlyArg: 5.114 ± 0.062	4.761GlySer: 4.761 ± 0.12	3.756GlyThr: 3.756 ± 0.072	6.073GlyVal: 6.073 ± 0.069	1.341GlyTrp: 1.341 ± 0.031	2.437GlyTyr: 2.437 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.55HisAla: 2.55 ± 0.048	0.361HisCys: 0.361 ± 0.017	1.403HisAsp: 1.403 ± 0.039	1.221HisGlu: 1.221 ± 0.031	0.988HisPhe: 0.988 ± 0.026	2.145HisGly: 2.145 ± 0.042	0.641HisHis: 0.641 ± 0.025	0.932HisIle: 0.932 ± 0.027	0.602HisLys: 0.602 ± 0.023	2.794HisLeu: 2.794 ± 0.049	0.528HisMet: 0.528 ± 0.021	0.618HisAsn: 0.618 ± 0.025	1.441HisPro: 1.441 ± 0.038	1.03HisGln: 1.03 ± 0.029	1.381HisArg: 1.381 ± 0.034	1.374HisSer: 1.374 ± 0.037	1.017HisThr: 1.017 ± 0.029	1.449HisVal: 1.449 ± 0.033	0.488HisTrp: 0.488 ± 0.019	0.805HisTyr: 0.805 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.751IleAla: 5.751 ± 0.076	0.47IleCys: 0.47 ± 0.02	3.389IleAsp: 3.389 ± 0.055	3.233IleGlu: 3.233 ± 0.057	1.274IlePhe: 1.274 ± 0.036	4.311IleGly: 4.311 ± 0.054	0.959IleHis: 0.959 ± 0.027	1.909IleIle: 1.909 ± 0.045	1.571IleLys: 1.571 ± 0.043	3.677IleLeu: 3.677 ± 0.059	0.755IleMet: 0.755 ± 0.029	1.599IleAsn: 1.599 ± 0.037	1.987IlePro: 1.987 ± 0.042	1.402IleGln: 1.402 ± 0.034	2.646IleArg: 2.646 ± 0.049	2.738IleSer: 2.738 ± 0.051	2.43IleThr: 2.43 ± 0.052	3.083IleVal: 3.083 ± 0.054	0.443IleTrp: 0.443 ± 0.015	1.017IleTyr: 1.017 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.016LysAla: 4.016 ± 0.069	0.165LysCys: 0.165 ± 0.011	1.613LysAsp: 1.613 ± 0.04	1.449LysGlu: 1.449 ± 0.043	0.766LysPhe: 0.766 ± 0.027	2.477LysGly: 2.477 ± 0.052	0.744LysHis: 0.744 ± 0.024	1.373LysIle: 1.373 ± 0.039	1.134LysLys: 1.134 ± 0.037	3.373LysLeu: 3.373 ± 0.07	0.642LysMet: 0.642 ± 0.024	0.826LysAsn: 0.826 ± 0.03	1.903LysPro: 1.903 ± 0.045	1.443LysGln: 1.443 ± 0.039	2.343LysArg: 2.343 ± 0.053	1.603LysSer: 1.603 ± 0.037	1.649LysThr: 1.649 ± 0.036	2.642LysVal: 2.642 ± 0.054	0.303LysTrp: 0.303 ± 0.015	0.639LysTyr: 0.639 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.812LeuAla: 14.812 ± 0.156	1.266LeuCys: 1.266 ± 0.035	7.11LeuAsp: 7.11 ± 0.079	6.429LeuGlu: 6.429 ± 0.079	4.072LeuPhe: 4.072 ± 0.062	9.636LeuGly: 9.636 ± 0.091	2.734LeuHis: 2.734 ± 0.055	5.311LeuIle: 5.311 ± 0.064	3.906LeuLys: 3.906 ± 0.07	13.842LeuLeu: 13.842 ± 0.162	2.476LeuMet: 2.476 ± 0.047	3.497LeuAsn: 3.497 ± 0.048	6.45LeuPro: 6.45 ± 0.083	5.234LeuGln: 5.234 ± 0.077	8.093LeuArg: 8.093 ± 0.105	7.445LeuSer: 7.445 ± 0.082	5.715LeuThr: 5.715 ± 0.088	7.791LeuVal: 7.791 ± 0.076	1.43LeuTrp: 1.43 ± 0.041	2.576LeuTyr: 2.576 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.614MetAla: 2.614 ± 0.047	0.168MetCys: 0.168 ± 0.011	0.974MetAsp: 0.974 ± 0.033	0.863MetGlu: 0.863 ± 0.024	0.657MetPhe: 0.657 ± 0.022	1.591MetGly: 1.591 ± 0.037	0.497MetHis: 0.497 ± 0.02	1.093MetIle: 1.093 ± 0.027	0.799MetLys: 0.799 ± 0.025	2.655MetLeu: 2.655 ± 0.044	0.485MetMet: 0.485 ± 0.021	0.79MetAsn: 0.79 ± 0.026	1.328MetPro: 1.328 ± 0.031	1.043MetGln: 1.043 ± 0.033	1.488MetArg: 1.488 ± 0.034	1.685MetSer: 1.685 ± 0.036	1.368MetThr: 1.368 ± 0.032	1.456MetVal: 1.456 ± 0.035	0.162MetTrp: 0.162 ± 0.013	0.333MetTyr: 0.333 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.136AsnAla: 3.136 ± 0.057	0.245AsnCys: 0.245 ± 0.013	1.553AsnAsp: 1.553 ± 0.035	1.395AsnGlu: 1.395 ± 0.035	0.938AsnPhe: 0.938 ± 0.028	2.455AsnGly: 2.455 ± 0.06	0.597AsnHis: 0.597 ± 0.021	1.21AsnIle: 1.21 ± 0.032	0.811AsnLys: 0.811 ± 0.03	3.343AsnLeu: 3.343 ± 0.057	0.518AsnMet: 0.518 ± 0.02	0.804AsnAsn: 0.804 ± 0.027	1.922AsnPro: 1.922 ± 0.038	1.233AsnGln: 1.233 ± 0.037	1.836AsnArg: 1.836 ± 0.038	1.427AsnSer: 1.427 ± 0.034	1.419AsnThr: 1.419 ± 0.031	1.93AsnVal: 1.93 ± 0.044	0.447AsnTrp: 0.447 ± 0.018	0.759AsnTyr: 0.759 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.149ProAla: 6.149 ± 0.094	0.416ProCys: 0.416 ± 0.019	2.669ProAsp: 2.669 ± 0.066	2.955ProGlu: 2.955 ± 0.055	1.811ProPhe: 1.811 ± 0.04	4.135ProGly: 4.135 ± 0.058	1.101ProHis: 1.101 ± 0.034	1.864ProIle: 1.864 ± 0.038	1.401ProLys: 1.401 ± 0.036	5.882ProLeu: 5.882 ± 0.081	1.134ProMet: 1.134 ± 0.031	1.323ProAsn: 1.323 ± 0.03	1.933ProPro: 1.933 ± 0.061	2.36ProGln: 2.36 ± 0.048	2.868ProArg: 2.868 ± 0.045	2.707ProSer: 2.707 ± 0.043	2.223ProThr: 2.223 ± 0.043	3.738ProVal: 3.738 ± 0.053	0.771ProTrp: 0.771 ± 0.025	1.25ProTyr: 1.25 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	6.974GlnAla: 6.974 ± 0.088	0.354GlnCys: 0.354 ± 0.018	1.921GlnAsp: 1.921 ± 0.039	1.78GlnGlu: 1.78 ± 0.044	1.419GlnPhe: 1.419 ± 0.032	3.721GlnGly: 3.721 ± 0.057	1.341GlnHis: 1.341 ± 0.034	2.065GlnIle: 2.065 ± 0.042	1.058GlnLys: 1.058 ± 0.03	5.906GlnLeu: 5.906 ± 0.088	1.076GlnMet: 1.076 ± 0.024	1.011GlnAsn: 1.011 ± 0.03	2.657GlnPro: 2.657 ± 0.047	3.135GlnGln: 3.135 ± 0.079	4.459GlnArg: 4.459 ± 0.084	2.242GlnSer: 2.242 ± 0.048	2.061GlnThr: 2.061 ± 0.046	4.224GlnVal: 4.224 ± 0.074	0.817GlnTrp: 0.817 ± 0.029	1.036GlnTyr: 1.036 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.36ArgAla: 6.36 ± 0.079	0.65ArgCys: 0.65 ± 0.026	3.668ArgAsp: 3.668 ± 0.064	4.271ArgGlu: 4.271 ± 0.07	2.737ArgPhe: 2.737 ± 0.048	4.37ArgGly: 4.37 ± 0.068	1.828ArgHis: 1.828 ± 0.036	3.27ArgIle: 3.27 ± 0.061	2.022ArgLys: 2.022 ± 0.042	9.06ArgLeu: 9.06 ± 0.117	1.667ArgMet: 1.667 ± 0.038	1.913ArgAsn: 1.913 ± 0.034	2.937ArgPro: 2.937 ± 0.048	3.929ArgGln: 3.929 ± 0.072	4.7ArgArg: 4.7 ± 0.082	3.754ArgSer: 3.754 ± 0.055	2.802ArgThr: 2.802 ± 0.051	4.524ArgVal: 4.524 ± 0.062	1.151ArgTrp: 1.151 ± 0.033	2.094ArgTyr: 2.094 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.493SerAla: 6.493 ± 0.085	0.451SerCys: 0.451 ± 0.018	2.976SerAsp: 2.976 ± 0.051	3.083SerGlu: 3.083 ± 0.055	2.069SerPhe: 2.069 ± 0.041	5.182SerGly: 5.182 ± 0.088	1.408SerHis: 1.408 ± 0.034	2.587SerIle: 2.587 ± 0.05	1.743SerLys: 1.743 ± 0.04	7.016SerLeu: 7.016 ± 0.085	1.307SerMet: 1.307 ± 0.03	1.682SerAsn: 1.682 ± 0.039	2.686SerPro: 2.686 ± 0.044	2.514SerGln: 2.514 ± 0.038	3.651SerArg: 3.651 ± 0.062	3.353SerSer: 3.353 ± 0.063	2.838SerThr: 2.838 ± 0.048	4.139SerVal: 4.139 ± 0.075	0.743SerTrp: 0.743 ± 0.023	1.454SerTyr: 1.454 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.079ThrAla: 5.079 ± 0.077	0.492ThrCys: 0.492 ± 0.02	2.316ThrAsp: 2.316 ± 0.054	2.237ThrGlu: 2.237 ± 0.046	1.747ThrPhe: 1.747 ± 0.039	3.988ThrGly: 3.988 ± 0.06	1.038ThrHis: 1.038 ± 0.026	1.747ThrIle: 1.747 ± 0.04	0.942ThrLys: 0.942 ± 0.028	6.993ThrLeu: 6.993 ± 0.084	0.679ThrMet: 0.679 ± 0.021	1.02ThrAsn: 1.02 ± 0.031	3.187ThrPro: 3.187 ± 0.072	2.02ThrGln: 2.02 ± 0.034	3.135ThrArg: 3.135 ± 0.05	2.525ThrSer: 2.525 ± 0.048	2.363ThrThr: 2.363 ± 0.054	3.639ThrVal: 3.639 ± 0.086	0.735ThrTrp: 0.735 ± 0.026	1.201ThrTyr: 1.201 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.867ValAla: 7.867 ± 0.086	0.736ValCys: 0.736 ± 0.027	3.932ValAsp: 3.932 ± 0.064	4.494ValGlu: 4.494 ± 0.062	2.459ValPhe: 2.459 ± 0.047	5.306ValGly: 5.306 ± 0.069	1.501ValHis: 1.501 ± 0.034	3.71ValIle: 3.71 ± 0.062	2.273ValLys: 2.273 ± 0.051	8.608ValLeu: 8.608 ± 0.09	1.7ValMet: 1.7 ± 0.042	2.062ValAsn: 2.062 ± 0.036	3.335ValPro: 3.335 ± 0.051	3.1ValGln: 3.1 ± 0.062	4.639ValArg: 4.639 ± 0.067	4.422ValSer: 4.422 ± 0.077	3.547ValThr: 3.547 ± 0.06	5.585ValVal: 5.585 ± 0.107	0.861ValTrp: 0.861 ± 0.026	1.548ValTyr: 1.548 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.243TrpAla: 1.243 ± 0.034	0.168TrpCys: 0.168 ± 0.011	0.621TrpAsp: 0.621 ± 0.025	0.552TrpGlu: 0.552 ± 0.022	0.553TrpPhe: 0.553 ± 0.022	0.891TrpGly: 0.891 ± 0.028	0.416TrpHis: 0.416 ± 0.015	0.638TrpIle: 0.638 ± 0.02	0.404TrpLys: 0.404 ± 0.017	2.274TrpLeu: 2.274 ± 0.052	0.343TrpMet: 0.343 ± 0.017	0.429TrpAsn: 0.429 ± 0.017	0.673TrpPro: 0.673 ± 0.024	1.039TrpGln: 1.039 ± 0.033	1.196TrpArg: 1.196 ± 0.036	0.826TrpSer: 0.826 ± 0.029	0.586TrpThr: 0.586 ± 0.021	0.956TrpVal: 0.956 ± 0.028	0.251TrpTrp: 0.251 ± 0.015	0.336TrpTyr: 0.336 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.531TyrAla: 2.531 ± 0.047	0.255TyrCys: 0.255 ± 0.014	1.337TyrAsp: 1.337 ± 0.04	1.097TyrGlu: 1.097 ± 0.029	0.954TyrPhe: 0.954 ± 0.029	2.055TyrGly: 2.055 ± 0.048	0.594TyrHis: 0.594 ± 0.023	0.946TyrIle: 0.946 ± 0.031	0.716TyrLys: 0.716 ± 0.024	3.062TyrLeu: 3.062 ± 0.053	0.441TyrMet: 0.441 ± 0.017	0.697TyrAsn: 0.697 ± 0.025	1.284TyrPro: 1.284 ± 0.036	1.344TyrGln: 1.344 ± 0.034	2.06TyrArg: 2.06 ± 0.043	1.538TyrSer: 1.538 ± 0.037	1.244TyrThr: 1.244 ± 0.029	1.624TyrVal: 1.624 ± 0.037	0.414TyrTrp: 0.414 ± 0.017	0.679TyrTyr: 0.679 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4020 proteins (1324866 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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