Amino acid dipepetide frequency for Oxalobacteraceae bacterium IMCC9480

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.635AlaAla: 15.635 ± 0.167	1.132AlaCys: 1.132 ± 0.035	6.801AlaAsp: 6.801 ± 0.074	5.663AlaGlu: 5.663 ± 0.086	3.835AlaPhe: 3.835 ± 0.064	10.593AlaGly: 10.593 ± 0.123	2.459AlaHis: 2.459 ± 0.047	6.456AlaIle: 6.456 ± 0.075	3.698AlaLys: 3.698 ± 0.071	14.33AlaLeu: 14.33 ± 0.161	3.499AlaMet: 3.499 ± 0.054	3.059AlaAsn: 3.059 ± 0.061	5.11AlaPro: 5.11 ± 0.077	5.107AlaGln: 5.107 ± 0.072	7.765AlaArg: 7.765 ± 0.093	6.928AlaSer: 6.928 ± 0.084	6.441AlaThr: 6.441 ± 0.075	8.193AlaVal: 8.193 ± 0.098	1.388AlaTrp: 1.388 ± 0.036	2.445AlaTyr: 2.445 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.082CysAla: 1.082 ± 0.03	0.144CysCys: 0.144 ± 0.011	0.582CysAsp: 0.582 ± 0.023	0.418CysGlu: 0.418 ± 0.019	0.354CysPhe: 0.354 ± 0.016	0.901CysGly: 0.901 ± 0.031	0.295CysHis: 0.295 ± 0.017	0.465CysIle: 0.465 ± 0.02	0.254CysLys: 0.254 ± 0.015	0.861CysLeu: 0.861 ± 0.029	0.214CysMet: 0.214 ± 0.013	0.259CysAsn: 0.259 ± 0.015	0.438CysPro: 0.438 ± 0.02	0.282CysGln: 0.282 ± 0.017	0.611CysArg: 0.611 ± 0.028	0.531CysSer: 0.531 ± 0.023	0.52CysThr: 0.52 ± 0.024	0.648CysVal: 0.648 ± 0.026	0.12CysTrp: 0.12 ± 0.01	0.215CysTyr: 0.215 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.14AspAla: 7.14 ± 0.08	0.524AspCys: 0.524 ± 0.022	3.263AspAsp: 3.263 ± 0.062	3.02AspGlu: 3.02 ± 0.057	2.208AspPhe: 2.208 ± 0.04	4.968AspGly: 4.968 ± 0.08	1.29AspHis: 1.29 ± 0.033	3.162AspIle: 3.162 ± 0.053	2.138AspLys: 2.138 ± 0.042	5.563AspLeu: 5.563 ± 0.07	1.35AspMet: 1.35 ± 0.034	1.585AspAsn: 1.585 ± 0.038	2.784AspPro: 2.784 ± 0.056	2.06AspGln: 2.06 ± 0.047	3.136AspArg: 3.136 ± 0.058	2.705AspSer: 2.705 ± 0.045	2.921AspThr: 2.921 ± 0.063	4.128AspVal: 4.128 ± 0.061	0.9AspTrp: 0.9 ± 0.025	1.54AspTyr: 1.54 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.46GluAla: 5.46 ± 0.068	0.37GluCys: 0.37 ± 0.016	1.974GluAsp: 1.974 ± 0.044	2.228GluGlu: 2.228 ± 0.055	1.891GluPhe: 1.891 ± 0.045	2.963GluGly: 2.963 ± 0.05	1.188GluHis: 1.188 ± 0.027	2.937GluIle: 2.937 ± 0.057	2.14GluLys: 2.14 ± 0.053	5.51GluLeu: 5.51 ± 0.077	1.317GluMet: 1.317 ± 0.037	1.426GluAsn: 1.426 ± 0.038	1.989GluPro: 1.989 ± 0.043	2.815GluGln: 2.815 ± 0.057	3.929GluArg: 3.929 ± 0.067	2.526GluSer: 2.526 ± 0.053	2.422GluThr: 2.422 ± 0.053	3.543GluVal: 3.543 ± 0.06	0.593GluTrp: 0.593 ± 0.02	1.025GluTyr: 1.025 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.185PheAla: 4.185 ± 0.058	0.426PheCys: 0.426 ± 0.018	2.658PheAsp: 2.658 ± 0.044	1.886PheGlu: 1.886 ± 0.038	1.558PhePhe: 1.558 ± 0.046	3.602PheGly: 3.602 ± 0.059	0.704PheHis: 0.704 ± 0.025	1.793PheIle: 1.793 ± 0.042	1.311PheLys: 1.311 ± 0.031	3.287PheLeu: 3.287 ± 0.065	0.891PheMet: 0.891 ± 0.028	1.296PheAsn: 1.296 ± 0.029	1.521PhePro: 1.521 ± 0.04	1.068PheGln: 1.068 ± 0.027	1.939PheArg: 1.939 ± 0.041	2.51PheSer: 2.51 ± 0.045	1.95PheThr: 1.95 ± 0.038	2.694PheVal: 2.694 ± 0.052	0.472PheTrp: 0.472 ± 0.022	0.948PheTyr: 0.948 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.195GlyAla: 8.195 ± 0.112	0.825GlyCys: 0.825 ± 0.029	4.107GlyAsp: 4.107 ± 0.086	3.538GlyGlu: 3.538 ± 0.061	3.226GlyPhe: 3.226 ± 0.062	5.993GlyGly: 5.993 ± 0.111	1.75GlyHis: 1.75 ± 0.044	4.911GlyIle: 4.911 ± 0.076	3.781GlyLys: 3.781 ± 0.056	8.427GlyLeu: 8.427 ± 0.1	2.575GlyMet: 2.575 ± 0.05	2.608GlyAsn: 2.608 ± 0.053	2.515GlyPro: 2.515 ± 0.052	3.259GlyGln: 3.259 ± 0.05	4.596GlyArg: 4.596 ± 0.069	4.722GlySer: 4.722 ± 0.081	4.559GlyThr: 4.559 ± 0.075	5.972GlyVal: 5.972 ± 0.076	1.235GlyTrp: 1.235 ± 0.034	2.292GlyTyr: 2.292 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.828HisAla: 2.828 ± 0.051	0.306HisCys: 0.306 ± 0.017	1.399HisAsp: 1.399 ± 0.038	1.009HisGlu: 1.009 ± 0.029	0.927HisPhe: 0.927 ± 0.029	1.943HisGly: 1.943 ± 0.039	0.685HisHis: 0.685 ± 0.028	1.041HisIle: 1.041 ± 0.029	0.587HisLys: 0.587 ± 0.021	2.188HisLeu: 2.188 ± 0.043	0.527HisMet: 0.527 ± 0.019	0.54HisAsn: 0.54 ± 0.02	1.334HisPro: 1.334 ± 0.038	0.934HisGln: 0.934 ± 0.034	1.422HisArg: 1.422 ± 0.041	0.962HisSer: 0.962 ± 0.027	1.031HisThr: 1.031 ± 0.03	1.512HisVal: 1.512 ± 0.038	0.368HisTrp: 0.368 ± 0.017	0.623HisTyr: 0.623 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.536IleAla: 7.536 ± 0.083	0.484IleCys: 0.484 ± 0.017	4.098IleAsp: 4.098 ± 0.057	3.405IleGlu: 3.405 ± 0.063	1.607IlePhe: 1.607 ± 0.044	4.882IleGly: 4.882 ± 0.067	1.011IleHis: 1.011 ± 0.029	2.326IleIle: 2.326 ± 0.048	2.014IleLys: 2.014 ± 0.045	4.35IleLeu: 4.35 ± 0.067	0.977IleMet: 0.977 ± 0.03	1.94IleAsn: 1.94 ± 0.045	2.382IlePro: 2.382 ± 0.051	1.332IleGln: 1.332 ± 0.031	3.144IleArg: 3.144 ± 0.055	3.162IleSer: 3.162 ± 0.051	3.193IleThr: 3.193 ± 0.058	4.133IleVal: 4.133 ± 0.053	0.546IleTrp: 0.546 ± 0.02	1.101IleTyr: 1.101 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.754LysAla: 3.754 ± 0.081	0.19LysCys: 0.19 ± 0.014	1.779LysAsp: 1.779 ± 0.048	1.715LysGlu: 1.715 ± 0.04	1.131LysPhe: 1.131 ± 0.032	2.228LysGly: 2.228 ± 0.052	0.711LysHis: 0.711 ± 0.024	2.102LysIle: 2.102 ± 0.047	1.794LysLys: 1.794 ± 0.049	3.92LysLeu: 3.92 ± 0.063	1.151LysMet: 1.151 ± 0.035	1.313LysAsn: 1.313 ± 0.036	2.123LysPro: 2.123 ± 0.054	1.388LysGln: 1.388 ± 0.039	2.194LysArg: 2.194 ± 0.048	2.177LysSer: 2.177 ± 0.044	2.26LysThr: 2.26 ± 0.04	2.612LysVal: 2.612 ± 0.062	0.382LysTrp: 0.382 ± 0.019	0.761LysTyr: 0.761 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.18LeuAla: 14.18 ± 0.148	1.055LeuCys: 1.055 ± 0.027	6.212LeuAsp: 6.212 ± 0.088	4.855LeuGlu: 4.855 ± 0.072	3.866LeuPhe: 3.866 ± 0.066	7.937LeuGly: 7.937 ± 0.104	2.408LeuHis: 2.408 ± 0.043	5.417LeuIle: 5.417 ± 0.069	3.827LeuLys: 3.827 ± 0.069	11.947LeuLeu: 11.947 ± 0.155	2.726LeuMet: 2.726 ± 0.05	3.021LeuAsn: 3.021 ± 0.049	6.111LeuPro: 6.111 ± 0.08	4.582LeuGln: 4.582 ± 0.075	7.124LeuArg: 7.124 ± 0.086	6.65LeuSer: 6.65 ± 0.079	6.022LeuThr: 6.022 ± 0.08	7.783LeuVal: 7.783 ± 0.083	1.09LeuTrp: 1.09 ± 0.032	2.106LeuTyr: 2.106 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.254MetAla: 3.254 ± 0.058	0.166MetCys: 0.166 ± 0.012	1.177MetAsp: 1.177 ± 0.031	1.091MetGlu: 1.091 ± 0.03	0.77MetPhe: 0.77 ± 0.031	1.759MetGly: 1.759 ± 0.043	0.629MetHis: 0.629 ± 0.024	1.338MetIle: 1.338 ± 0.034	1.151MetLys: 1.151 ± 0.034	3.094MetLeu: 3.094 ± 0.048	0.784MetMet: 0.784 ± 0.028	0.958MetAsn: 0.958 ± 0.028	1.605MetPro: 1.605 ± 0.04	1.299MetGln: 1.299 ± 0.03	1.718MetArg: 1.718 ± 0.038	1.614MetSer: 1.614 ± 0.039	1.901MetThr: 1.901 ± 0.037	1.824MetVal: 1.824 ± 0.042	0.21MetTrp: 0.21 ± 0.014	0.403MetTyr: 0.403 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.489AsnAla: 3.489 ± 0.046	0.295AsnCys: 0.295 ± 0.017	1.704AsnAsp: 1.704 ± 0.051	1.342AsnGlu: 1.342 ± 0.037	1.123AsnPhe: 1.123 ± 0.033	2.567AsnGly: 2.567 ± 0.053	0.605AsnHis: 0.605 ± 0.022	1.545AsnIle: 1.545 ± 0.038	1.07AsnLys: 1.07 ± 0.037	3.156AsnLeu: 3.156 ± 0.057	0.692AsnMet: 0.692 ± 0.025	0.973AsnAsn: 0.973 ± 0.033	1.941AsnPro: 1.941 ± 0.043	1.13AsnGln: 1.13 ± 0.032	1.841AsnArg: 1.841 ± 0.041	1.46AsnSer: 1.46 ± 0.042	1.61AsnThr: 1.61 ± 0.041	2.087AsnVal: 2.087 ± 0.044	0.438AsnTrp: 0.438 ± 0.021	0.794AsnTyr: 0.794 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.571ProAla: 6.571 ± 0.097	0.352ProCys: 0.352 ± 0.019	3.272ProAsp: 3.272 ± 0.056	2.852ProGlu: 2.852 ± 0.049	1.748ProPhe: 1.748 ± 0.039	3.793ProGly: 3.793 ± 0.064	0.975ProHis: 0.975 ± 0.031	2.027ProIle: 2.027 ± 0.046	1.478ProLys: 1.478 ± 0.048	5.045ProLeu: 5.045 ± 0.072	1.256ProMet: 1.256 ± 0.035	1.245ProAsn: 1.245 ± 0.035	2.022ProPro: 2.022 ± 0.062	1.91ProGln: 1.91 ± 0.048	2.282ProArg: 2.282 ± 0.046	2.414ProSer: 2.414 ± 0.054	2.346ProThr: 2.346 ± 0.055	4.389ProVal: 4.389 ± 0.068	0.602ProTrp: 0.602 ± 0.022	1.077ProTyr: 1.077 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.12GlnAla: 5.12 ± 0.079	0.357GlnCys: 0.357 ± 0.017	1.708GlnAsp: 1.708 ± 0.039	1.726GlnGlu: 1.726 ± 0.041	1.604GlnPhe: 1.604 ± 0.043	2.543GlnGly: 2.543 ± 0.052	1.133GlnHis: 1.133 ± 0.028	2.253GlnIle: 2.253 ± 0.045	1.235GlnLys: 1.235 ± 0.035	4.781GlnLeu: 4.781 ± 0.072	1.055GlnMet: 1.055 ± 0.028	0.981GlnAsn: 0.981 ± 0.029	2.015GlnPro: 2.015 ± 0.044	2.53GlnGln: 2.53 ± 0.063	3.354GlnArg: 3.354 ± 0.071	2.227GlnSer: 2.227 ± 0.045	1.95GlnThr: 1.95 ± 0.046	3.185GlnVal: 3.185 ± 0.054	0.52GlnTrp: 0.52 ± 0.021	0.801GlnTyr: 0.801 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.566ArgAla: 6.566 ± 0.079	0.595ArgCys: 0.595 ± 0.025	3.66ArgAsp: 3.66 ± 0.061	3.368ArgGlu: 3.368 ± 0.062	2.574ArgPhe: 2.574 ± 0.042	3.886ArgGly: 3.886 ± 0.062	1.751ArgHis: 1.751 ± 0.046	3.969ArgIle: 3.969 ± 0.06	2.307ArgLys: 2.307 ± 0.049	7.258ArgLeu: 7.258 ± 0.081	1.784ArgMet: 1.784 ± 0.036	2.113ArgAsn: 2.113 ± 0.046	2.547ArgPro: 2.547 ± 0.051	3.104ArgGln: 3.104 ± 0.07	4.135ArgArg: 4.135 ± 0.072	3.541ArgSer: 3.541 ± 0.063	3.232ArgThr: 3.232 ± 0.056	4.233ArgVal: 4.233 ± 0.062	0.917ArgTrp: 0.917 ± 0.029	1.72ArgTyr: 1.72 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.88SerAla: 6.88 ± 0.082	0.48SerCys: 0.48 ± 0.02	3.038SerAsp: 3.038 ± 0.048	2.541SerGlu: 2.541 ± 0.046	2.107SerPhe: 2.107 ± 0.046	5.641SerGly: 5.641 ± 0.091	1.198SerHis: 1.198 ± 0.033	2.898SerIle: 2.898 ± 0.055	1.844SerLys: 1.844 ± 0.042	5.856SerLeu: 5.856 ± 0.069	1.638SerMet: 1.638 ± 0.039	1.744SerAsn: 1.744 ± 0.044	2.619SerPro: 2.619 ± 0.05	1.986SerGln: 1.986 ± 0.041	3.385SerArg: 3.385 ± 0.06	3.428SerSer: 3.428 ± 0.069	3.423SerThr: 3.423 ± 0.059	4.122SerVal: 4.122 ± 0.055	0.781SerTrp: 0.781 ± 0.026	1.341SerTyr: 1.341 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.121ThrAla: 6.121 ± 0.064	0.448ThrCys: 0.448 ± 0.02	3.013ThrAsp: 3.013 ± 0.051	2.457ThrGlu: 2.457 ± 0.039	1.878ThrPhe: 1.878 ± 0.043	5.075ThrGly: 5.075 ± 0.096	1.136ThrHis: 1.136 ± 0.032	3.018ThrIle: 3.018 ± 0.063	1.451ThrLys: 1.451 ± 0.045	6.772ThrLeu: 6.772 ± 0.09	1.421ThrMet: 1.421 ± 0.035	1.496ThrAsn: 1.496 ± 0.037	3.307ThrPro: 3.307 ± 0.054	1.91ThrGln: 1.91 ± 0.04	3.305ThrArg: 3.305 ± 0.054	3.061ThrSer: 3.061 ± 0.057	3.252ThrThr: 3.252 ± 0.054	4.347ThrVal: 4.347 ± 0.064	0.549ThrTrp: 0.549 ± 0.026	1.235ThrTyr: 1.235 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.05ValAla: 9.05 ± 0.088	0.643ValCys: 0.643 ± 0.022	4.163ValAsp: 4.163 ± 0.065	3.645ValGlu: 3.645 ± 0.06	2.694ValPhe: 2.694 ± 0.053	5.108ValGly: 5.108 ± 0.074	1.426ValHis: 1.426 ± 0.035	4.352ValIle: 4.352 ± 0.066	2.432ValLys: 2.432 ± 0.053	8.136ValLeu: 8.136 ± 0.101	2.096ValMet: 2.096 ± 0.04	2.248ValAsn: 2.248 ± 0.047	3.606ValPro: 3.606 ± 0.059	2.514ValGln: 2.514 ± 0.048	4.694ValArg: 4.694 ± 0.065	4.313ValSer: 4.313 ± 0.058	4.405ValThr: 4.405 ± 0.068	5.762ValVal: 5.762 ± 0.07	0.793ValTrp: 0.793 ± 0.025	1.413ValTyr: 1.413 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.938TrpAla: 0.938 ± 0.031	0.158TrpCys: 0.158 ± 0.01	0.537TrpAsp: 0.537 ± 0.023	0.49TrpGlu: 0.49 ± 0.019	0.526TrpPhe: 0.526 ± 0.023	0.751TrpGly: 0.751 ± 0.024	0.386TrpHis: 0.386 ± 0.02	0.713TrpIle: 0.713 ± 0.029	0.402TrpLys: 0.402 ± 0.022	1.755TrpLeu: 1.755 ± 0.045	0.396TrpMet: 0.396 ± 0.017	0.403TrpAsn: 0.403 ± 0.018	0.539TrpPro: 0.539 ± 0.02	0.829TrpGln: 0.829 ± 0.028	0.997TrpArg: 0.997 ± 0.029	0.754TrpSer: 0.754 ± 0.027	0.64TrpThr: 0.64 ± 0.026	0.747TrpVal: 0.747 ± 0.026	0.204TrpTrp: 0.204 ± 0.013	0.269TrpTyr: 0.269 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.554TyrAla: 2.554 ± 0.05	0.243TyrCys: 0.243 ± 0.012	1.238TyrAsp: 1.238 ± 0.036	0.997TyrGlu: 0.997 ± 0.035	1.07TyrPhe: 1.07 ± 0.033	1.953TyrGly: 1.953 ± 0.044	0.427TyrHis: 0.427 ± 0.021	0.901TyrIle: 0.901 ± 0.031	0.773TyrLys: 0.773 ± 0.031	2.684TyrLeu: 2.684 ± 0.052	0.393TyrMet: 0.393 ± 0.021	0.652TyrAsn: 0.652 ± 0.028	1.147TyrPro: 1.147 ± 0.03	1.037TyrGln: 1.037 ± 0.03	1.692TyrArg: 1.692 ± 0.042	1.266TyrSer: 1.266 ± 0.033	1.176TyrThr: 1.176 ± 0.03	1.579TyrVal: 1.579 ± 0.038	0.327TyrTrp: 0.327 ± 0.02	0.624TyrTyr: 0.624 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4019 proteins (1191506 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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