Amino acid dipepetide frequency for Neospora caninum (strain Liverpool)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.201AlaAla: 15.201 ± 0.11	2.3AlaCys: 2.3 ± 0.026	4.802AlaAsp: 4.802 ± 0.034	7.895AlaGlu: 7.895 ± 0.058	3.832AlaPhe: 3.832 ± 0.031	9.02AlaGly: 9.02 ± 0.065	2.057AlaHis: 2.057 ± 0.021	2.14AlaIle: 2.14 ± 0.028	3.776AlaLys: 3.776 ± 0.052	9.151AlaLeu: 9.151 ± 0.06	1.345AlaMet: 1.345 ± 0.019	2.189AlaAsn: 2.189 ± 0.02	7.222AlaPro: 7.222 ± 0.064	3.749AlaGln: 3.749 ± 0.03	7.751AlaArg: 7.751 ± 0.053	13.765AlaSer: 13.765 ± 0.094	5.445AlaThr: 5.445 ± 0.037	6.589AlaVal: 6.589 ± 0.047	1.071AlaTrp: 1.071 ± 0.016	1.435AlaTyr: 1.435 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.904CysAla: 1.904 ± 0.021	0.554CysCys: 0.554 ± 0.013	0.752CysAsp: 0.752 ± 0.013	1.051CysGlu: 1.051 ± 0.015	0.709CysPhe: 0.709 ± 0.012	1.652CysGly: 1.652 ± 0.022	0.366CysHis: 0.366 ± 0.008	0.545CysIle: 0.545 ± 0.011	0.538CysLys: 0.538 ± 0.013	1.968CysLeu: 1.968 ± 0.019	0.331CysMet: 0.331 ± 0.009	0.35CysAsn: 0.35 ± 0.008	1.305CysPro: 1.305 ± 0.038	0.563CysGln: 0.563 ± 0.012	1.522CysArg: 1.522 ± 0.02	1.936CysSer: 1.936 ± 0.022	0.941CysThr: 0.941 ± 0.012	1.38CysVal: 1.38 ± 0.016	0.221CysTrp: 0.221 ± 0.007	0.305CysTyr: 0.305 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	6.496AspAla: 6.496 ± 0.043	0.869AspCys: 0.869 ± 0.015	2.902AspAsp: 2.902 ± 0.031	4.856AspGlu: 4.856 ± 0.047	1.686AspPhe: 1.686 ± 0.02	4.792AspGly: 4.792 ± 0.038	0.692AspHis: 0.692 ± 0.015	1.357AspIle: 1.357 ± 0.023	1.694AspLys: 1.694 ± 0.022	3.849AspLeu: 3.849 ± 0.031	0.707AspMet: 0.707 ± 0.013	0.899AspAsn: 0.899 ± 0.013	2.564AspPro: 2.564 ± 0.025	1.383AspGln: 1.383 ± 0.017	3.714AspArg: 3.714 ± 0.029	4.341AspSer: 4.341 ± 0.035	2.322AspThr: 2.322 ± 0.02	3.078AspVal: 3.078 ± 0.026	0.548AspTrp: 0.548 ± 0.01	0.668AspTyr: 0.668 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	8.957GluAla: 8.957 ± 0.06	0.92GluCys: 0.92 ± 0.016	4.881GluAsp: 4.881 ± 0.042	9.58GluGlu: 9.58 ± 0.125	1.423GluPhe: 1.423 ± 0.019	6.771GluGly: 6.771 ± 0.052	1.293GluHis: 1.293 ± 0.021	1.896GluIle: 1.896 ± 0.023	4.852GluLys: 4.852 ± 0.059	4.523GluLeu: 4.523 ± 0.04	1.147GluMet: 1.147 ± 0.015	2.216GluAsn: 2.216 ± 0.022	3.029GluPro: 3.029 ± 0.028	2.929GluGln: 2.929 ± 0.029	7.316GluArg: 7.316 ± 0.079	5.04GluSer: 5.04 ± 0.04	5.245GluThr: 5.245 ± 0.046	3.415GluVal: 3.415 ± 0.031	0.583GluTrp: 0.583 ± 0.011	0.769GluTyr: 0.769 ± 0.013	0.0GluXaa: 0.0 ± 0.0
Phe	3.228PheAla: 3.228 ± 0.028	0.796PheCys: 0.796 ± 0.014	1.559PheAsp: 1.559 ± 0.021	1.658PheGlu: 1.658 ± 0.019	1.802PhePhe: 1.802 ± 0.022	2.1PheGly: 2.1 ± 0.026	0.768PheHis: 0.768 ± 0.012	0.836PheIle: 0.836 ± 0.015	0.838PheLys: 0.838 ± 0.016	3.907PheLeu: 3.907 ± 0.036	0.439PheMet: 0.439 ± 0.011	0.654PheAsn: 0.654 ± 0.014	2.616PhePro: 2.616 ± 0.024	1.094PheGln: 1.094 ± 0.013	2.028PheArg: 2.028 ± 0.023	3.958PheSer: 3.958 ± 0.036	1.286PheThr: 1.286 ± 0.017	2.21PheVal: 2.21 ± 0.024	0.396PheTrp: 0.396 ± 0.008	0.686PheTyr: 0.686 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	8.835GlyAla: 8.835 ± 0.066	1.357GlyCys: 1.357 ± 0.017	5.412GlyAsp: 5.412 ± 0.046	7.407GlyGlu: 7.407 ± 0.067	2.186GlyPhe: 2.186 ± 0.024	8.183GlyGly: 8.183 ± 0.076	1.516GlyHis: 1.516 ± 0.018	1.762GlyIle: 1.762 ± 0.024	3.537GlyLys: 3.537 ± 0.031	5.365GlyLeu: 5.365 ± 0.038	1.001GlyMet: 1.001 ± 0.016	2.141GlyAsn: 2.141 ± 0.021	4.053GlyPro: 4.053 ± 0.047	2.568GlyGln: 2.568 ± 0.023	6.95GlyArg: 6.95 ± 0.064	7.27GlySer: 7.27 ± 0.053	4.067GlyThr: 4.067 ± 0.034	4.788GlyVal: 4.788 ± 0.036	0.706GlyTrp: 0.706 ± 0.012	1.057GlyTyr: 1.057 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.832HisAla: 2.832 ± 0.024	0.393HisCys: 0.393 ± 0.009	0.851HisAsp: 0.851 ± 0.016	1.327HisGlu: 1.327 ± 0.022	0.803HisPhe: 0.803 ± 0.013	1.666HisGly: 1.666 ± 0.018	0.542HisHis: 0.542 ± 0.014	0.596HisIle: 0.596 ± 0.012	0.6HisLys: 0.6 ± 0.011	2.199HisLeu: 2.199 ± 0.018	0.317HisMet: 0.317 ± 0.008	0.417HisAsn: 0.417 ± 0.01	1.582HisPro: 1.582 ± 0.021	0.841HisGln: 0.841 ± 0.014	1.706HisArg: 1.706 ± 0.018	1.826HisSer: 1.826 ± 0.025	1.009HisThr: 1.009 ± 0.015	1.382HisVal: 1.382 ± 0.016	0.221HisTrp: 0.221 ± 0.007	0.34HisTyr: 0.34 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	2.123IleAla: 2.123 ± 0.023	0.595IleCys: 0.595 ± 0.011	1.311IleAsp: 1.311 ± 0.019	1.536IleGlu: 1.536 ± 0.023	0.991IlePhe: 0.991 ± 0.018	1.449IleGly: 1.449 ± 0.023	0.617IleHis: 0.617 ± 0.011	0.731IleIle: 0.731 ± 0.016	0.876IleLys: 0.876 ± 0.016	2.473IleLeu: 2.473 ± 0.029	0.359IleMet: 0.359 ± 0.01	0.582IleAsn: 0.582 ± 0.014	1.5IlePro: 1.5 ± 0.023	1.037IleGln: 1.037 ± 0.016	1.729IleArg: 1.729 ± 0.022	1.994IleSer: 1.994 ± 0.023	0.951IleThr: 0.951 ± 0.017	1.584IleVal: 1.584 ± 0.02	0.279IleTrp: 0.279 ± 0.008	0.529IleTyr: 0.529 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.022LysAla: 4.022 ± 0.045	0.565LysCys: 0.565 ± 0.012	2.047LysAsp: 2.047 ± 0.023	3.736LysGlu: 3.736 ± 0.05	0.876LysPhe: 0.876 ± 0.016	2.916LysGly: 2.916 ± 0.039	0.849LysHis: 0.849 ± 0.013	1.144LysIle: 1.144 ± 0.021	3.219LysLys: 3.219 ± 0.059	2.911LysLeu: 2.911 ± 0.031	0.684LysMet: 0.684 ± 0.014	1.225LysAsn: 1.225 ± 0.016	1.86LysPro: 1.86 ± 0.026	1.784LysGln: 1.784 ± 0.019	3.833LysArg: 3.833 ± 0.034	2.413LysSer: 2.413 ± 0.028	2.359LysThr: 2.359 ± 0.025	1.89LysVal: 1.89 ± 0.031	0.356LysTrp: 0.356 ± 0.007	0.614LysTyr: 0.614 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	8.77LeuAla: 8.77 ± 0.065	1.829LeuCys: 1.829 ± 0.02	3.801LeuAsp: 3.801 ± 0.031	5.368LeuGlu: 5.368 ± 0.041	3.486LeuPhe: 3.486 ± 0.033	5.464LeuGly: 5.464 ± 0.038	2.467LeuHis: 2.467 ± 0.022	1.932LeuIle: 1.932 ± 0.028	3.097LeuLys: 3.097 ± 0.035	10.652LeuLeu: 10.652 ± 0.091	1.176LeuMet: 1.176 ± 0.019	1.757LeuAsn: 1.757 ± 0.023	7.096LeuPro: 7.096 ± 0.044	4.402LeuGln: 4.402 ± 0.043	7.111LeuArg: 7.111 ± 0.045	9.168LeuSer: 9.168 ± 0.054	3.708LeuThr: 3.708 ± 0.031	4.929LeuVal: 4.929 ± 0.042	1.024LeuTrp: 1.024 ± 0.014	1.501LeuTyr: 1.501 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.331MetAla: 1.331 ± 0.019	0.238MetCys: 0.238 ± 0.006	0.647MetAsp: 0.647 ± 0.012	0.988MetGlu: 0.988 ± 0.014	0.394MetPhe: 0.394 ± 0.01	0.832MetGly: 0.832 ± 0.017	0.403MetHis: 0.403 ± 0.01	0.389MetIle: 0.389 ± 0.01	0.758MetLys: 0.758 ± 0.015	1.244MetLeu: 1.244 ± 0.018	0.299MetMet: 0.299 ± 0.01	0.411MetAsn: 0.411 ± 0.009	0.832MetPro: 0.832 ± 0.017	0.769MetGln: 0.769 ± 0.01	1.133MetArg: 1.133 ± 0.015	0.952MetSer: 0.952 ± 0.014	0.671MetThr: 0.671 ± 0.015	0.682MetVal: 0.682 ± 0.014	0.164MetTrp: 0.164 ± 0.005	0.287MetTyr: 0.287 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.743AsnAla: 2.743 ± 0.023	0.427AsnCys: 0.427 ± 0.008	1.021AsnAsp: 1.021 ± 0.015	1.632AsnGlu: 1.632 ± 0.019	0.775AsnPhe: 0.775 ± 0.014	2.036AsnGly: 2.036 ± 0.02	0.409AsnHis: 0.409 ± 0.009	0.674AsnIle: 0.674 ± 0.014	0.842AsnLys: 0.842 ± 0.014	1.982AsnLeu: 1.982 ± 0.022	0.364AsnMet: 0.364 ± 0.01	0.509AsnAsn: 0.509 ± 0.011	1.523AsnPro: 1.523 ± 0.017	0.79AsnGln: 0.79 ± 0.014	1.663AsnArg: 1.663 ± 0.018	1.819AsnSer: 1.819 ± 0.018	1.015AsnThr: 1.015 ± 0.017	1.448AsnVal: 1.448 ± 0.02	0.245AsnTrp: 0.245 ± 0.007	0.391AsnTyr: 0.391 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	7.718ProAla: 7.718 ± 0.052	1.225ProCys: 1.225 ± 0.02	2.593ProAsp: 2.593 ± 0.021	4.069ProGlu: 4.069 ± 0.032	2.471ProPhe: 2.471 ± 0.028	5.279ProGly: 5.279 ± 0.05	1.591ProHis: 1.591 ± 0.02	1.106ProIle: 1.106 ± 0.018	1.765ProLys: 1.765 ± 0.04	5.939ProLeu: 5.939 ± 0.037	0.618ProMet: 0.618 ± 0.016	1.238ProAsn: 1.238 ± 0.015	6.42ProPro: 6.42 ± 0.061	2.552ProGln: 2.552 ± 0.029	4.989ProArg: 4.989 ± 0.045	9.411ProSer: 9.411 ± 0.07	3.105ProThr: 3.105 ± 0.028	3.967ProVal: 3.967 ± 0.031	0.627ProTrp: 0.627 ± 0.011	0.912ProTyr: 0.912 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	4.085GlnAla: 4.085 ± 0.032	0.567GlnCys: 0.567 ± 0.012	1.735GlnAsp: 1.735 ± 0.018	3.127GlnGlu: 3.127 ± 0.031	0.971GlnPhe: 0.971 ± 0.017	2.751GlnGly: 2.751 ± 0.027	0.926GlnHis: 0.926 ± 0.013	1.087GlnIle: 1.087 ± 0.016	1.944GlnLys: 1.944 ± 0.021	3.584GlnLeu: 3.584 ± 0.034	0.712GlnMet: 0.712 ± 0.012	1.046GlnAsn: 1.046 ± 0.015	2.271GlnPro: 2.271 ± 0.022	2.412GlnGln: 2.412 ± 0.036	3.75GlnArg: 3.75 ± 0.035	2.801GlnSer: 2.801 ± 0.027	2.297GlnThr: 2.297 ± 0.021	2.005GlnVal: 2.005 ± 0.02	0.394GlnTrp: 0.394 ± 0.008	0.51GlnTyr: 0.51 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	7.271ArgAla: 7.271 ± 0.056	1.342ArgCys: 1.342 ± 0.017	4.433ArgAsp: 4.433 ± 0.039	7.743ArgGlu: 7.743 ± 0.077	2.244ArgPhe: 2.244 ± 0.024	7.331ArgGly: 7.331 ± 0.065	1.965ArgHis: 1.965 ± 0.023	1.827ArgIle: 1.827 ± 0.021	3.59ArgLys: 3.59 ± 0.033	7.362ArgLeu: 7.362 ± 0.046	1.133ArgMet: 1.133 ± 0.014	1.935ArgAsn: 1.935 ± 0.017	4.512ArgPro: 4.512 ± 0.039	3.889ArgGln: 3.889 ± 0.032	9.486ArgArg: 9.486 ± 0.096	6.589ArgSer: 6.589 ± 0.058	3.628ArgThr: 3.628 ± 0.026	4.168ArgVal: 4.168 ± 0.027	0.802ArgTrp: 0.802 ± 0.013	1.012ArgTyr: 1.012 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	11.2SerAla: 11.2 ± 0.069	1.993SerCys: 1.993 ± 0.026	3.974SerAsp: 3.974 ± 0.03	5.598SerGlu: 5.598 ± 0.041	3.637SerPhe: 3.637 ± 0.032	7.839SerGly: 7.839 ± 0.054	1.884SerHis: 1.884 ± 0.021	1.785SerIle: 1.785 ± 0.021	2.406SerLys: 2.406 ± 0.025	9.8SerLeu: 9.8 ± 0.06	0.94SerMet: 0.94 ± 0.014	1.629SerAsn: 1.629 ± 0.016	10.047SerPro: 10.047 ± 0.084	3.2SerGln: 3.2 ± 0.028	7.838SerArg: 7.838 ± 0.064	16.806SerSer: 16.806 ± 0.2	4.458SerThr: 4.458 ± 0.035	5.674SerVal: 5.674 ± 0.033	0.974SerTrp: 0.974 ± 0.015	1.075SerTyr: 1.075 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	5.651ThrAla: 5.651 ± 0.034	1.003ThrCys: 1.003 ± 0.017	2.442ThrAsp: 2.442 ± 0.021	3.687ThrGlu: 3.687 ± 0.032	1.466ThrPhe: 1.466 ± 0.018	4.261ThrGly: 4.261 ± 0.035	1.094ThrHis: 1.094 ± 0.015	1.087ThrIle: 1.087 ± 0.019	1.79ThrLys: 1.79 ± 0.025	4.22ThrLeu: 4.22 ± 0.036	0.573ThrMet: 0.573 ± 0.01	1.083ThrAsn: 1.083 ± 0.016	3.806ThrPro: 3.806 ± 0.029	1.927ThrGln: 1.927 ± 0.019	3.72ThrArg: 3.72 ± 0.027	4.446ThrSer: 4.446 ± 0.032	2.402ThrThr: 2.402 ± 0.042	3.049ThrVal: 3.049 ± 0.031	0.509ThrTrp: 0.509 ± 0.01	0.765ThrTyr: 0.765 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	6.277ValAla: 6.277 ± 0.04	1.385ValCys: 1.385 ± 0.018	3.102ValAsp: 3.102 ± 0.029	4.006ValGlu: 4.006 ± 0.035	2.178ValPhe: 2.178 ± 0.026	3.915ValGly: 3.915 ± 0.036	1.473ValHis: 1.473 ± 0.018	1.425ValIle: 1.425 ± 0.021	2.118ValLys: 2.118 ± 0.026	5.194ValLeu: 5.194 ± 0.041	0.777ValMet: 0.777 ± 0.015	1.329ValAsn: 1.329 ± 0.017	3.955ValPro: 3.955 ± 0.037	2.114ValGln: 2.114 ± 0.022	3.749ValArg: 3.749 ± 0.026	6.271ValSer: 6.271 ± 0.038	2.601ValThr: 2.601 ± 0.025	3.593ValVal: 3.593 ± 0.038	0.653ValTrp: 0.653 ± 0.012	1.219ValTyr: 1.219 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.765TrpAla: 0.765 ± 0.011	0.202TrpCys: 0.202 ± 0.006	0.437TrpAsp: 0.437 ± 0.01	0.632TrpGlu: 0.632 ± 0.011	0.293TrpPhe: 0.293 ± 0.007	0.795TrpGly: 0.795 ± 0.012	0.207TrpHis: 0.207 ± 0.006	0.38TrpIle: 0.38 ± 0.008	0.532TrpLys: 0.532 ± 0.012	0.961TrpLeu: 0.961 ± 0.013	0.22TrpMet: 0.22 ± 0.007	0.323TrpAsn: 0.323 ± 0.009	0.527TrpPro: 0.527 ± 0.011	0.447TrpGln: 0.447 ± 0.008	1.123TrpArg: 1.123 ± 0.018	0.813TrpSer: 0.813 ± 0.014	0.635TrpThr: 0.635 ± 0.012	0.499TrpVal: 0.499 ± 0.011	0.185TrpTrp: 0.185 ± 0.006	0.166TrpTyr: 0.166 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.329TyrAla: 1.329 ± 0.019	0.335TyrCys: 0.335 ± 0.016	0.715TyrAsp: 0.715 ± 0.012	0.887TyrGlu: 0.887 ± 0.015	0.636TyrPhe: 0.636 ± 0.011	1.109TyrGly: 1.109 ± 0.019	0.33TyrHis: 0.33 ± 0.007	0.544TyrIle: 0.544 ± 0.012	0.533TyrLys: 0.533 ± 0.013	1.457TyrLeu: 1.457 ± 0.022	0.281TyrMet: 0.281 ± 0.008	0.375TyrAsn: 0.375 ± 0.01	0.875TyrPro: 0.875 ± 0.016	0.524TyrGln: 0.524 ± 0.01	1.147TyrArg: 1.147 ± 0.018	1.14TyrSer: 1.14 ± 0.016	0.836TyrThr: 0.836 ± 0.015	1.006TyrVal: 1.006 ± 0.017	0.183TyrTrp: 0.183 ± 0.006	0.386TyrTyr: 0.386 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6933 proteins (5937456 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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