Amino acid dipepetide frequency for Helicobacter hepaticus (strain ATCC 51449 / 3B1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.598AlaAla: 3.598 ± 0.107	0.958AlaCys: 0.958 ± 0.05	2.952AlaAsp: 2.952 ± 0.088	2.693AlaGlu: 2.693 ± 0.078	3.982AlaPhe: 3.982 ± 0.094	3.84AlaGly: 3.84 ± 0.108	1.97AlaHis: 1.97 ± 0.065	5.702AlaIle: 5.702 ± 0.117	6.081AlaLys: 6.081 ± 0.112	9.39AlaLeu: 9.39 ± 0.161	1.986AlaMet: 1.986 ± 0.065	3.549AlaAsn: 3.549 ± 0.089	2.291AlaPro: 2.291 ± 0.074	4.346AlaGln: 4.346 ± 0.104	2.878AlaArg: 2.878 ± 0.079	4.213AlaSer: 4.213 ± 0.082	3.192AlaThr: 3.192 ± 0.077	3.311AlaVal: 3.311 ± 0.094	0.513AlaTrp: 0.513 ± 0.034	3.034AlaTyr: 3.034 ± 0.082	0.0AlaXaa: 0.0 ± 0.0
Cys	1.218CysAla: 1.218 ± 0.046	0.169CysCys: 0.169 ± 0.017	0.847CysAsp: 0.847 ± 0.037	1.055CysGlu: 1.055 ± 0.048	0.777CysPhe: 0.777 ± 0.044	1.138CysGly: 1.138 ± 0.044	0.271CysHis: 0.271 ± 0.028	1.132CysIle: 1.132 ± 0.051	0.892CysLys: 0.892 ± 0.041	1.1CysLeu: 1.1 ± 0.049	0.346CysMet: 0.346 ± 0.023	0.556CysAsn: 0.556 ± 0.035	0.458CysPro: 0.458 ± 0.034	0.379CysGln: 0.379 ± 0.026	0.321CysArg: 0.321 ± 0.024	0.813CysSer: 0.813 ± 0.039	0.504CysThr: 0.504 ± 0.027	1.075CysVal: 1.075 ± 0.051	0.081CysTrp: 0.081 ± 0.015	0.445CysTyr: 0.445 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.857AspAla: 2.857 ± 0.076	0.66AspCys: 0.66 ± 0.033	2.22AspAsp: 2.22 ± 0.066	4.044AspGlu: 4.044 ± 0.094	3.266AspPhe: 3.266 ± 0.066	2.412AspGly: 2.412 ± 0.079	0.35AspHis: 0.35 ± 0.023	5.252AspIle: 5.252 ± 0.111	4.73AspLys: 4.73 ± 0.103	4.07AspLeu: 4.07 ± 0.085	1.645AspMet: 1.645 ± 0.056	2.438AspAsn: 2.438 ± 0.067	0.935AspPro: 0.935 ± 0.044	0.47AspGln: 0.47 ± 0.03	1.549AspArg: 1.549 ± 0.056	4.014AspSer: 4.014 ± 0.086	2.788AspThr: 2.788 ± 0.086	2.93AspVal: 2.93 ± 0.077	0.37AspTrp: 0.37 ± 0.028	2.198AspTyr: 2.198 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	4.165GluAla: 4.165 ± 0.104	0.974GluCys: 0.974 ± 0.044	2.692GluAsp: 2.692 ± 0.074	4.387GluGlu: 4.387 ± 0.116	2.869GluPhe: 2.869 ± 0.074	3.459GluGly: 3.459 ± 0.083	1.561GluHis: 1.561 ± 0.054	6.284GluIle: 6.284 ± 0.119	4.271GluLys: 4.271 ± 0.102	6.19GluLeu: 6.19 ± 0.13	1.645GluMet: 1.645 ± 0.065	3.924GluAsn: 3.924 ± 0.097	1.382GluPro: 1.382 ± 0.057	2.79GluGln: 2.79 ± 0.081	2.925GluArg: 2.925 ± 0.079	5.762GluSer: 5.762 ± 0.104	1.906GluThr: 1.906 ± 0.062	4.161GluVal: 4.161 ± 0.102	0.623GluTrp: 0.623 ± 0.037	2.58GluTyr: 2.58 ± 0.077	0.0GluXaa: 0.0 ± 0.0
Phe	3.944PheAla: 3.944 ± 0.087	0.886PheCys: 0.886 ± 0.042	2.896PheAsp: 2.896 ± 0.069	3.42PheGlu: 3.42 ± 0.084	2.819PhePhe: 2.819 ± 0.087	3.817PheGly: 3.817 ± 0.089	0.877PheHis: 0.877 ± 0.04	4.407PheIle: 4.407 ± 0.096	3.223PheLys: 3.223 ± 0.072	5.187PheLeu: 5.187 ± 0.121	1.328PheMet: 1.328 ± 0.045	2.525PheAsn: 2.525 ± 0.077	1.301PhePro: 1.301 ± 0.05	1.026PheGln: 1.026 ± 0.048	1.394PheArg: 1.394 ± 0.052	3.797PheSer: 3.797 ± 0.085	2.182PheThr: 2.182 ± 0.055	3.512PheVal: 3.512 ± 0.089	0.511PheTrp: 0.511 ± 0.03	2.277PheTyr: 2.277 ± 0.066	0.0PheXaa: 0.0 ± 0.0
Gly	4.748GlyAla: 4.748 ± 0.114	0.777GlyCys: 0.777 ± 0.041	2.842GlyAsp: 2.842 ± 0.072	4.109GlyGlu: 4.109 ± 0.097	3.625GlyPhe: 3.625 ± 0.088	4.568GlyGly: 4.568 ± 0.116	1.105GlyHis: 1.105 ± 0.046	5.78GlyIle: 5.78 ± 0.12	4.463GlyLys: 4.463 ± 0.099	5.496GlyLeu: 5.496 ± 0.107	1.552GlyMet: 1.552 ± 0.061	2.645GlyAsn: 2.645 ± 0.075	0.694GlyPro: 0.694 ± 0.039	1.575GlyGln: 1.575 ± 0.055	2.063GlyArg: 2.063 ± 0.061	3.734GlySer: 3.734 ± 0.086	2.376GlyThr: 2.376 ± 0.064	4.716GlyVal: 4.716 ± 0.112	0.45GlyTrp: 0.45 ± 0.028	2.55GlyTyr: 2.55 ± 0.076	0.0GlyXaa: 0.0 ± 0.0
His	0.876HisAla: 0.876 ± 0.043	0.332HisCys: 0.332 ± 0.026	0.56HisAsp: 0.56 ± 0.032	0.537HisGlu: 0.537 ± 0.032	1.755HisPhe: 1.755 ± 0.066	0.739HisGly: 0.739 ± 0.042	0.619HisHis: 0.619 ± 0.035	3.029HisIle: 3.029 ± 0.074	1.999HisLys: 1.999 ± 0.057	2.543HisLeu: 2.543 ± 0.066	0.38HisMet: 0.38 ± 0.026	1.597HisAsn: 1.597 ± 0.052	0.795HisPro: 0.795 ± 0.038	0.849HisGln: 0.849 ± 0.04	0.861HisArg: 0.861 ± 0.045	1.814HisSer: 1.814 ± 0.054	1.8HisThr: 1.8 ± 0.062	0.266HisVal: 0.266 ± 0.022	0.174HisTrp: 0.174 ± 0.019	1.073HisTyr: 1.073 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	7.315IleAla: 7.315 ± 0.125	1.351IleCys: 1.351 ± 0.053	4.746IleAsp: 4.746 ± 0.111	5.808IleGlu: 5.808 ± 0.114	4.235IlePhe: 4.235 ± 0.106	5.266IleGly: 5.266 ± 0.109	1.64IleHis: 1.64 ± 0.056	6.535IleIle: 6.535 ± 0.126	6.372IleLys: 6.372 ± 0.107	9.069IleLeu: 9.069 ± 0.15	1.796IleMet: 1.796 ± 0.061	4.199IleAsn: 4.199 ± 0.093	3.088IlePro: 3.088 ± 0.078	2.909IleGln: 2.909 ± 0.074	2.471IleArg: 2.471 ± 0.066	5.566IleSer: 5.566 ± 0.101	4.513IleThr: 4.513 ± 0.099	4.805IleVal: 4.805 ± 0.106	0.621IleTrp: 0.621 ± 0.034	3.359IleTyr: 3.359 ± 0.093	0.0IleXaa: 0.0 ± 0.0
Lys	5.719LysAla: 5.719 ± 0.107	0.707LysCys: 0.707 ± 0.038	4.735LysAsp: 4.735 ± 0.089	6.705LysGlu: 6.705 ± 0.131	2.2LysPhe: 2.2 ± 0.057	4.21LysGly: 4.21 ± 0.088	1.672LysHis: 1.672 ± 0.056	6.515LysIle: 6.515 ± 0.113	5.772LysLys: 5.772 ± 0.117	6.002LysLeu: 6.002 ± 0.09	2.026LysMet: 2.026 ± 0.063	5.121LysAsn: 5.121 ± 0.114	2.478LysPro: 2.478 ± 0.072	3.101LysGln: 3.101 ± 0.075	3.036LysArg: 3.036 ± 0.077	5.101LysSer: 5.101 ± 0.093	3.42LysThr: 3.42 ± 0.08	4.068LysVal: 4.068 ± 0.076	0.551LysTrp: 0.551 ± 0.038	2.494LysTyr: 2.494 ± 0.061	0.0LysXaa: 0.0 ± 0.0
Leu	7.115LeuAla: 7.115 ± 0.119	1.895LeuCys: 1.895 ± 0.061	5.304LeuAsp: 5.304 ± 0.105	7.357LeuGlu: 7.357 ± 0.135	4.965LeuPhe: 4.965 ± 0.127	6.499LeuGly: 6.499 ± 0.13	2.51LeuHis: 2.51 ± 0.065	7.009LeuIle: 7.009 ± 0.124	8.435LeuLys: 8.435 ± 0.141	9.975LeuLeu: 9.975 ± 0.197	2.151LeuMet: 2.151 ± 0.069	5.405LeuAsn: 5.405 ± 0.113	3.942LeuPro: 3.942 ± 0.099	4.461LeuGln: 4.461 ± 0.099	3.867LeuArg: 3.867 ± 0.085	8.363LeuSer: 8.363 ± 0.138	4.211LeuThr: 4.211 ± 0.085	4.714LeuVal: 4.714 ± 0.102	0.935LeuTrp: 0.935 ± 0.037	3.763LeuTyr: 3.763 ± 0.091	0.0LeuXaa: 0.0 ± 0.0
Met	1.64MetAla: 1.64 ± 0.052	0.389MetCys: 0.389 ± 0.027	1.039MetAsp: 1.039 ± 0.048	1.235MetGlu: 1.235 ± 0.047	1.043MetPhe: 1.043 ± 0.056	1.593MetGly: 1.593 ± 0.058	0.441MetHis: 0.441 ± 0.031	1.832MetIle: 1.832 ± 0.06	1.658MetLys: 1.658 ± 0.057	2.945MetLeu: 2.945 ± 0.073	0.565MetMet: 0.565 ± 0.034	1.193MetAsn: 1.193 ± 0.052	1.206MetPro: 1.206 ± 0.04	1.505MetGln: 1.505 ± 0.054	1.357MetArg: 1.357 ± 0.054	1.821MetSer: 1.821 ± 0.076	0.768MetThr: 0.768 ± 0.036	1.165MetVal: 1.165 ± 0.044	0.21MetTrp: 0.21 ± 0.022	0.639MetTyr: 0.639 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	4.958AsnAla: 4.958 ± 0.103	0.42AsnCys: 0.42 ± 0.032	2.67AsnAsp: 2.67 ± 0.065	3.614AsnGlu: 3.614 ± 0.092	2.273AsnPhe: 2.273 ± 0.076	3.088AsnGly: 3.088 ± 0.079	1.023AsnHis: 1.023 ± 0.044	4.777AsnIle: 4.777 ± 0.091	3.725AsnLys: 3.725 ± 0.083	5.37AsnLeu: 5.37 ± 0.103	1.139AsnMet: 1.139 ± 0.053	2.675AsnAsn: 2.675 ± 0.066	2.679AsnPro: 2.679 ± 0.064	1.945AsnGln: 1.945 ± 0.07	1.561AsnArg: 1.561 ± 0.056	2.36AsnSer: 2.36 ± 0.064	3.303AsnThr: 3.303 ± 0.085	3.154AsnVal: 3.154 ± 0.101	0.31AsnTrp: 0.31 ± 0.022	1.766AsnTyr: 1.766 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.692ProAla: 1.692 ± 0.058	0.366ProCys: 0.366 ± 0.024	1.292ProAsp: 1.292 ± 0.049	1.41ProGlu: 1.41 ± 0.049	1.845ProPhe: 1.845 ± 0.054	0.912ProGly: 0.912 ± 0.042	1.191ProHis: 1.191 ± 0.052	2.692ProIle: 2.692 ± 0.067	2.826ProLys: 2.826 ± 0.08	4.192ProLeu: 4.192 ± 0.094	0.746ProMet: 0.746 ± 0.039	1.814ProAsn: 1.814 ± 0.048	1.251ProPro: 1.251 ± 0.053	2.035ProGln: 2.035 ± 0.068	1.017ProArg: 1.017 ± 0.042	2.483ProSer: 2.483 ± 0.072	2.029ProThr: 2.029 ± 0.062	1.452ProVal: 1.452 ± 0.064	0.192ProTrp: 0.192 ± 0.017	1.529ProTyr: 1.529 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.735GlnAla: 2.735 ± 0.067	0.445GlnCys: 0.445 ± 0.034	2.247GlnAsp: 2.247 ± 0.074	3.332GlnGlu: 3.332 ± 0.08	1.272GlnPhe: 1.272 ± 0.052	2.358GlnGly: 2.358 ± 0.071	0.745GlnHis: 0.745 ± 0.038	3.37GlnIle: 3.37 ± 0.078	3.931GlnLys: 3.931 ± 0.086	2.494GlnLeu: 2.494 ± 0.071	1.06GlnMet: 1.06 ± 0.039	2.914GlnAsn: 2.914 ± 0.07	0.973GlnPro: 0.973 ± 0.055	1.342GlnGln: 1.342 ± 0.051	1.552GlnArg: 1.552 ± 0.054	3.664GlnSer: 3.664 ± 0.086	1.995GlnThr: 1.995 ± 0.06	1.977GlnVal: 1.977 ± 0.056	0.413GlnTrp: 0.413 ± 0.025	1.263GlnTyr: 1.263 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.717ArgAla: 2.717 ± 0.083	0.325ArgCys: 0.325 ± 0.025	2.065ArgAsp: 2.065 ± 0.055	2.883ArgGlu: 2.883 ± 0.081	2.245ArgPhe: 2.245 ± 0.062	2.13ArgGly: 2.13 ± 0.071	0.734ArgHis: 0.734 ± 0.036	3.689ArgIle: 3.689 ± 0.076	2.191ArgLys: 2.191 ± 0.067	3.757ArgLeu: 3.757 ± 0.085	0.745ArgMet: 0.745 ± 0.033	1.724ArgAsn: 1.724 ± 0.057	0.929ArgPro: 0.929 ± 0.041	1.057ArgGln: 1.057 ± 0.045	1.306ArgArg: 1.306 ± 0.046	1.967ArgSer: 1.967 ± 0.058	1.412ArgThr: 1.412 ± 0.053	2.487ArgVal: 2.487 ± 0.068	0.287ArgTrp: 0.287 ± 0.025	1.703ArgTyr: 1.703 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.085SerAla: 5.085 ± 0.106	0.77SerCys: 0.77 ± 0.041	2.83SerAsp: 2.83 ± 0.074	3.476SerGlu: 3.476 ± 0.076	4.025SerPhe: 4.025 ± 0.096	4.251SerGly: 4.251 ± 0.093	1.945SerHis: 1.945 ± 0.055	6.047SerIle: 6.047 ± 0.116	5.105SerLys: 5.105 ± 0.093	8.046SerLeu: 8.046 ± 0.134	1.766SerMet: 1.766 ± 0.058	3.291SerAsn: 3.291 ± 0.089	2.424SerPro: 2.424 ± 0.069	3.041SerGln: 3.041 ± 0.074	2.178SerArg: 2.178 ± 0.065	4.583SerSer: 4.583 ± 0.095	3.267SerThr: 3.267 ± 0.074	4.238SerVal: 4.238 ± 0.098	0.506SerTrp: 0.506 ± 0.033	2.925SerTyr: 2.925 ± 0.078	0.0SerXaa: 0.0 ± 0.0
Thr	2.372ThrAla: 2.372 ± 0.079	0.468ThrCys: 0.468 ± 0.029	1.911ThrAsp: 1.911 ± 0.06	1.679ThrGlu: 1.679 ± 0.056	2.36ThrPhe: 2.36 ± 0.074	2.2ThrGly: 2.2 ± 0.074	1.889ThrHis: 1.889 ± 0.068	3.436ThrIle: 3.436 ± 0.088	3.364ThrLys: 3.364 ± 0.085	6.689ThrLeu: 6.689 ± 0.136	1.075ThrMet: 1.075 ± 0.04	2.388ThrAsn: 2.388 ± 0.074	2.736ThrPro: 2.736 ± 0.078	3.262ThrGln: 3.262 ± 0.08	1.732ThrArg: 1.732 ± 0.054	3.181ThrSer: 3.181 ± 0.072	2.345ThrThr: 2.345 ± 0.082	0.461ThrVal: 0.461 ± 0.042	0.291ThrTrp: 0.291 ± 0.024	2.049ThrTyr: 2.049 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.105ValAla: 4.105 ± 0.093	1.034ValCys: 1.034 ± 0.051	2.749ValAsp: 2.749 ± 0.079	3.219ValGlu: 3.219 ± 0.083	3.101ValPhe: 3.101 ± 0.075	4.123ValGly: 4.123 ± 0.096	0.886ValHis: 0.886 ± 0.04	4.568ValIle: 4.568 ± 0.097	3.269ValLys: 3.269 ± 0.084	5.873ValLeu: 5.873 ± 0.121	1.337ValMet: 1.337 ± 0.053	2.34ValAsn: 2.34 ± 0.064	1.793ValPro: 1.793 ± 0.059	2.069ValGln: 2.069 ± 0.062	2.451ValArg: 2.451 ± 0.063	4.009ValSer: 4.009 ± 0.095	1.635ValThr: 1.635 ± 0.064	3.553ValVal: 3.553 ± 0.099	0.529ValTrp: 0.529 ± 0.033	1.882ValTyr: 1.882 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.529TrpAla: 0.529 ± 0.035	0.129TrpCys: 0.129 ± 0.015	0.409TrpAsp: 0.409 ± 0.037	0.594TrpGlu: 0.594 ± 0.035	0.384TrpPhe: 0.384 ± 0.028	0.662TrpGly: 0.662 ± 0.036	0.258TrpHis: 0.258 ± 0.022	0.689TrpIle: 0.689 ± 0.036	0.406TrpLys: 0.406 ± 0.028	0.946TrpLeu: 0.946 ± 0.042	0.117TrpMet: 0.117 ± 0.016	0.47TrpAsn: 0.47 ± 0.031	0.056TrpPro: 0.056 ± 0.011	0.432TrpGln: 0.432 ± 0.027	0.362TrpArg: 0.362 ± 0.025	0.418TrpSer: 0.418 ± 0.029	0.197TrpThr: 0.197 ± 0.024	0.508TrpVal: 0.508 ± 0.032	0.136TrpTrp: 0.136 ± 0.017	0.348TrpTyr: 0.348 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.093TyrAla: 3.093 ± 0.083	0.52TyrCys: 0.52 ± 0.03	2.193TyrAsp: 2.193 ± 0.064	2.991TyrGlu: 2.991 ± 0.075	2.293TyrPhe: 2.293 ± 0.069	2.604TyrGly: 2.604 ± 0.073	0.906TyrHis: 0.906 ± 0.041	2.919TyrIle: 2.919 ± 0.081	2.921TyrLys: 2.921 ± 0.072	3.542TyrLeu: 3.542 ± 0.076	0.834TyrMet: 0.834 ± 0.04	2.042TyrAsn: 2.042 ± 0.068	1.556TyrPro: 1.556 ± 0.058	1.488TyrGln: 1.488 ± 0.058	1.471TyrArg: 1.471 ± 0.055	2.135TyrSer: 2.135 ± 0.063	2.046TyrThr: 2.046 ± 0.069	1.974TyrVal: 1.974 ± 0.058	0.348TyrTrp: 0.348 ± 0.027	1.64TyrTyr: 1.64 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1872 proteins (557311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---