Amino acid dipepetide frequency for Moraxella cuniculi DSM 21768

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.836AlaAla: 8.836 ± 0.168
1.202AlaCys: 1.202 ± 0.048
6.136AlaAsp: 6.136 ± 0.119
4.868AlaGlu: 4.868 ± 0.1
3.517AlaPhe: 3.517 ± 0.076
7.046AlaGly: 7.046 ± 0.136
1.841AlaHis: 1.841 ± 0.052
6.731AlaIle: 6.731 ± 0.113
6.476AlaLys: 6.476 ± 0.114
9.725AlaLeu: 9.725 ± 0.15
3.035AlaMet: 3.035 ± 0.07
4.531AlaAsn: 4.531 ± 0.096
2.785AlaPro: 2.785 ± 0.07
4.464AlaGln: 4.464 ± 0.083
4.006AlaArg: 4.006 ± 0.082
5.29AlaSer: 5.29 ± 0.105
5.992AlaThr: 5.992 ± 0.107
6.855AlaVal: 6.855 ± 0.12
1.204AlaTrp: 1.204 ± 0.045
2.889AlaTyr: 2.889 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 0.037
0.128CysCys: 0.128 ± 0.014
0.615CysAsp: 0.615 ± 0.035
0.49CysGlu: 0.49 ± 0.031
0.362CysPhe: 0.362 ± 0.024
0.782CysGly: 0.782 ± 0.039
0.396CysHis: 0.396 ± 0.024
0.571CysIle: 0.571 ± 0.034
0.33CysLys: 0.33 ± 0.021
1.039CysLeu: 1.039 ± 0.04
0.228CysMet: 0.228 ± 0.018
0.324CysAsn: 0.324 ± 0.022
0.479CysPro: 0.479 ± 0.028
0.718CysGln: 0.718 ± 0.037
0.443CysArg: 0.443 ± 0.025
0.533CysSer: 0.533 ± 0.029
0.489CysThr: 0.489 ± 0.025
0.697CysVal: 0.697 ± 0.028
0.081CysTrp: 0.081 ± 0.011
0.393CysTyr: 0.393 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.948AspAla: 4.948 ± 0.108
0.604AspCys: 0.604 ± 0.028
3.999AspAsp: 3.999 ± 0.097
4.581AspGlu: 4.581 ± 0.097
2.598AspPhe: 2.598 ± 0.074
4.462AspGly: 4.462 ± 0.097
0.772AspHis: 0.772 ± 0.029
3.981AspIle: 3.981 ± 0.089
4.304AspLys: 4.304 ± 0.088
4.785AspLeu: 4.785 ± 0.094
1.434AspMet: 1.434 ± 0.051
3.147AspAsn: 3.147 ± 0.076
1.674AspPro: 1.674 ± 0.057
1.278AspGln: 1.278 ± 0.045
2.199AspArg: 2.199 ± 0.06
3.103AspSer: 3.103 ± 0.07
3.464AspThr: 3.464 ± 0.075
3.432AspVal: 3.432 ± 0.083
0.829AspTrp: 0.829 ± 0.039
2.155AspTyr: 2.155 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.234GluAla: 4.234 ± 0.097
0.446GluCys: 0.446 ± 0.029
2.023GluAsp: 2.023 ± 0.065
2.146GluGlu: 2.146 ± 0.068
2.161GluPhe: 2.161 ± 0.053
2.66GluGly: 2.66 ± 0.072
1.335GluHis: 1.335 ± 0.045
3.77GluIle: 3.77 ± 0.082
2.855GluLys: 2.855 ± 0.081
5.768GluLeu: 5.768 ± 0.099
1.368GluMet: 1.368 ± 0.044
2.367GluAsn: 2.367 ± 0.057
1.951GluPro: 1.951 ± 0.057
3.823GluGln: 3.823 ± 0.095
2.885GluArg: 2.885 ± 0.073
2.54GluSer: 2.54 ± 0.07
2.455GluThr: 2.455 ± 0.066
3.33GluVal: 3.33 ± 0.073
0.543GluTrp: 0.543 ± 0.033
1.671GluTyr: 1.671 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
4.372PheAla: 4.372 ± 0.078
0.514PheCys: 0.514 ± 0.029
3.299PheAsp: 3.299 ± 0.077
2.214PheGlu: 2.214 ± 0.063
1.7PhePhe: 1.7 ± 0.06
3.71PheGly: 3.71 ± 0.082
0.651PheHis: 0.651 ± 0.032
2.563PheIle: 2.563 ± 0.068
1.42PheLys: 1.42 ± 0.045
3.421PheLeu: 3.421 ± 0.089
0.944PheMet: 0.944 ± 0.045
1.66PheAsn: 1.66 ± 0.059
0.918PhePro: 0.918 ± 0.042
0.989PheGln: 0.989 ± 0.039
1.408PheArg: 1.408 ± 0.045
2.409PheSer: 2.409 ± 0.064
1.715PheThr: 1.715 ± 0.051
3.15PheVal: 3.15 ± 0.09
0.537PheTrp: 0.537 ± 0.032
1.38PheTyr: 1.38 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
5.322GlyAla: 5.322 ± 0.128
0.753GlyCys: 0.753 ± 0.032
3.634GlyAsp: 3.634 ± 0.086
4.103GlyGlu: 4.103 ± 0.087
3.152GlyPhe: 3.152 ± 0.079
4.873GlyGly: 4.873 ± 0.124
1.21GlyHis: 1.21 ± 0.047
4.722GlyIle: 4.722 ± 0.082
4.439GlyLys: 4.439 ± 0.082
7.042GlyLeu: 7.042 ± 0.13
1.992GlyMet: 1.992 ± 0.063
2.872GlyAsn: 2.872 ± 0.088
0.782GlyPro: 0.782 ± 0.042
2.777GlyGln: 2.777 ± 0.077
3.377GlyArg: 3.377 ± 0.074
4.006GlySer: 4.006 ± 0.087
3.592GlyThr: 3.592 ± 0.103
5.955GlyVal: 5.955 ± 0.102
0.785GlyTrp: 0.785 ± 0.034
2.558GlyTyr: 2.558 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
2.114HisAla: 2.114 ± 0.056
0.234HisCys: 0.234 ± 0.019
1.246HisAsp: 1.246 ± 0.04
1.216HisGlu: 1.216 ± 0.045
0.883HisPhe: 0.883 ± 0.037
1.574HisGly: 1.574 ± 0.056
0.866HisHis: 0.866 ± 0.042
1.575HisIle: 1.575 ± 0.052
1.19HisLys: 1.19 ± 0.041
2.251HisLeu: 2.251 ± 0.065
0.339HisMet: 0.339 ± 0.024
1.0HisAsn: 1.0 ± 0.041
1.114HisPro: 1.114 ± 0.041
1.415HisGln: 1.415 ± 0.047
1.236HisArg: 1.236 ± 0.047
1.169HisSer: 1.169 ± 0.043
1.379HisThr: 1.379 ± 0.049
0.855HisVal: 0.855 ± 0.037
0.318HisTrp: 0.318 ± 0.024
0.801HisTyr: 0.801 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
7.462IleAla: 7.462 ± 0.118
0.796IleCys: 0.796 ± 0.038
4.87IleAsp: 4.87 ± 0.093
3.861IleGlu: 3.861 ± 0.081
2.405IlePhe: 2.405 ± 0.069
5.109IleGly: 5.109 ± 0.106
1.441IleHis: 1.441 ± 0.047
4.625IleIle: 4.625 ± 0.112
3.887IleLys: 3.887 ± 0.075
5.489IleLeu: 5.489 ± 0.098
1.414IleMet: 1.414 ± 0.049
3.675IleAsn: 3.675 ± 0.094
2.074IlePro: 2.074 ± 0.061
2.053IleGln: 2.053 ± 0.057
2.768IleArg: 2.768 ± 0.064
4.557IleSer: 4.557 ± 0.092
4.216IleThr: 4.216 ± 0.089
4.039IleVal: 4.039 ± 0.091
0.691IleTrp: 0.691 ± 0.03
2.0IleTyr: 2.0 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.983LysAla: 4.983 ± 0.102
0.295LysCys: 0.295 ± 0.022
3.03LysAsp: 3.03 ± 0.073
2.392LysGlu: 2.392 ± 0.071
1.939LysPhe: 1.939 ± 0.066
2.843LysGly: 2.843 ± 0.076
1.211LysHis: 1.211 ± 0.037
3.808LysIle: 3.808 ± 0.078
3.158LysLys: 3.158 ± 0.08
5.441LysLeu: 5.441 ± 0.089
1.354LysMet: 1.354 ± 0.042
3.074LysAsn: 3.074 ± 0.081
2.608LysPro: 2.608 ± 0.066
3.586LysGln: 3.586 ± 0.085
2.476LysArg: 2.476 ± 0.062
3.465LysSer: 3.465 ± 0.075
3.589LysThr: 3.589 ± 0.09
3.127LysVal: 3.127 ± 0.069
0.527LysTrp: 0.527 ± 0.031
1.563LysTyr: 1.563 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
11.233LeuAla: 11.233 ± 0.167
1.05LeuCys: 1.05 ± 0.041
5.824LeuAsp: 5.824 ± 0.103
4.194LeuGlu: 4.194 ± 0.092
3.774LeuPhe: 3.774 ± 0.094
7.398LeuGly: 7.398 ± 0.144
2.187LeuHis: 2.187 ± 0.055
6.571LeuIle: 6.571 ± 0.127
4.811LeuLys: 4.811 ± 0.087
10.563LeuLeu: 10.563 ± 0.218
2.598LeuMet: 2.598 ± 0.081
4.331LeuAsn: 4.331 ± 0.091
5.427LeuPro: 5.427 ± 0.108
4.639LeuGln: 4.639 ± 0.094
3.951LeuArg: 3.951 ± 0.081
7.832LeuSer: 7.832 ± 0.126
6.071LeuThr: 6.071 ± 0.099
6.288LeuVal: 6.288 ± 0.098
1.167LeuTrp: 1.167 ± 0.041
2.861LeuTyr: 2.861 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.755MetAla: 2.755 ± 0.071
0.17MetCys: 0.17 ± 0.016
1.084MetAsp: 1.084 ± 0.041
0.717MetGlu: 0.717 ± 0.032
0.731MetPhe: 0.731 ± 0.036
1.729MetGly: 1.729 ± 0.056
0.461MetHis: 0.461 ± 0.028
1.685MetIle: 1.685 ± 0.061
1.253MetLys: 1.253 ± 0.046
2.639MetLeu: 2.639 ± 0.078
0.846MetMet: 0.846 ± 0.038
1.236MetAsn: 1.236 ± 0.041
1.301MetPro: 1.301 ± 0.046
1.444MetGln: 1.444 ± 0.052
1.117MetArg: 1.117 ± 0.044
1.77MetSer: 1.77 ± 0.058
1.779MetThr: 1.779 ± 0.048
1.773MetVal: 1.773 ± 0.061
0.183MetTrp: 0.183 ± 0.017
0.581MetTyr: 0.581 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.222AsnAla: 4.222 ± 0.093
0.415AsnCys: 0.415 ± 0.026
2.411AsnAsp: 2.411 ± 0.063
2.332AsnGlu: 2.332 ± 0.061
1.677AsnPhe: 1.677 ± 0.053
2.764AsnGly: 2.764 ± 0.078
1.298AsnHis: 1.298 ± 0.045
3.194AsnIle: 3.194 ± 0.081
2.782AsnLys: 2.782 ± 0.074
4.442AsnLeu: 4.442 ± 0.088
0.895AsnMet: 0.895 ± 0.039
2.45AsnAsn: 2.45 ± 0.086
2.612AsnPro: 2.612 ± 0.071
2.867AsnGln: 2.867 ± 0.084
2.184AsnArg: 2.184 ± 0.065
2.412AsnSer: 2.412 ± 0.066
2.733AsnThr: 2.733 ± 0.085
2.118AsnVal: 2.118 ± 0.056
0.586AsnTrp: 0.586 ± 0.031
1.523AsnTyr: 1.523 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.706ProAla: 3.706 ± 0.091
0.349ProCys: 0.349 ± 0.025
2.327ProAsp: 2.327 ± 0.066
2.204ProGlu: 2.204 ± 0.066
1.52ProPhe: 1.52 ± 0.052
0.857ProGly: 0.857 ± 0.044
0.801ProHis: 0.801 ± 0.037
2.692ProIle: 2.692 ± 0.061
2.628ProLys: 2.628 ± 0.071
3.691ProLeu: 3.691 ± 0.078
1.102ProMet: 1.102 ± 0.045
2.262ProAsn: 2.262 ± 0.066
1.262ProPro: 1.262 ± 0.054
1.627ProGln: 1.627 ± 0.059
1.262ProArg: 1.262 ± 0.042
2.558ProSer: 2.558 ± 0.07
2.567ProThr: 2.567 ± 0.074
2.809ProVal: 2.809 ± 0.075
0.393ProTrp: 0.393 ± 0.025
1.245ProTyr: 1.245 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
6.071GlnAla: 6.071 ± 0.127
0.3GlnCys: 0.3 ± 0.021
2.281GlnAsp: 2.281 ± 0.066
2.158GlnGlu: 2.158 ± 0.067
1.816GlnPhe: 1.816 ± 0.048
3.225GlnGly: 3.225 ± 0.076
1.164GlnHis: 1.164 ± 0.04
3.491GlnIle: 3.491 ± 0.083
2.773GlnLys: 2.773 ± 0.075
5.255GlnLeu: 5.255 ± 0.108
1.377GlnMet: 1.377 ± 0.048
2.222GlnAsn: 2.222 ± 0.074
1.857GlnPro: 1.857 ± 0.055
2.744GlnGln: 2.744 ± 0.08
2.009GlnArg: 2.009 ± 0.06
3.048GlnSer: 3.048 ± 0.067
3.12GlnThr: 3.12 ± 0.073
3.219GlnVal: 3.219 ± 0.07
0.543GlnTrp: 0.543 ± 0.03
1.432GlnTyr: 1.432 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.724ArgAla: 3.724 ± 0.077
0.382ArgCys: 0.382 ± 0.026
2.086ArgAsp: 2.086 ± 0.055
2.237ArgGlu: 2.237 ± 0.064
2.096ArgPhe: 2.096 ± 0.057
2.458ArgGly: 2.458 ± 0.072
1.341ArgHis: 1.341 ± 0.048
3.106ArgIle: 3.106 ± 0.076
1.837ArgLys: 1.837 ± 0.053
5.518ArgLeu: 5.518 ± 0.119
1.067ArgMet: 1.067 ± 0.039
1.491ArgAsn: 1.491 ± 0.048
1.715ArgPro: 1.715 ± 0.06
2.828ArgGln: 2.828 ± 0.068
2.304ArgArg: 2.304 ± 0.071
2.303ArgSer: 2.303 ± 0.064
2.321ArgThr: 2.321 ± 0.062
2.767ArgVal: 2.767 ± 0.064
0.546ArgTrp: 0.546 ± 0.026
1.928ArgTyr: 1.928 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.12SerAla: 5.12 ± 0.107
0.546SerCys: 0.546 ± 0.032
3.439SerAsp: 3.439 ± 0.077
3.188SerGlu: 3.188 ± 0.07
2.534SerPhe: 2.534 ± 0.071
4.161SerGly: 4.161 ± 0.089
1.552SerHis: 1.552 ± 0.053
3.741SerIle: 3.741 ± 0.079
2.975SerLys: 2.975 ± 0.072
6.54SerLeu: 6.54 ± 0.132
1.479SerMet: 1.479 ± 0.046
2.468SerAsn: 2.468 ± 0.058
2.278SerPro: 2.278 ± 0.068
3.284SerGln: 3.284 ± 0.076
2.573SerArg: 2.573 ± 0.055
3.592SerSer: 3.592 ± 0.072
3.421SerThr: 3.421 ± 0.083
4.153SerVal: 4.153 ± 0.076
0.673SerTrp: 0.673 ± 0.03
2.058SerTyr: 2.058 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
6.59ThrAla: 6.59 ± 0.108
0.425ThrCys: 0.425 ± 0.024
3.376ThrAsp: 3.376 ± 0.085
2.371ThrGlu: 2.371 ± 0.067
1.589ThrPhe: 1.589 ± 0.049
4.627ThrGly: 4.627 ± 0.1
1.534ThrHis: 1.534 ± 0.061
3.744ThrIle: 3.744 ± 0.078
2.822ThrLys: 2.822 ± 0.072
6.378ThrLeu: 6.378 ± 0.106
1.14ThrMet: 1.14 ± 0.046
2.379ThrAsn: 2.379 ± 0.076
3.016ThrPro: 3.016 ± 0.074
2.755ThrGln: 2.755 ± 0.068
2.199ThrArg: 2.199 ± 0.056
2.811ThrSer: 2.811 ± 0.073
4.048ThrThr: 4.048 ± 0.114
3.916ThrVal: 3.916 ± 0.087
0.545ThrTrp: 0.545 ± 0.028
1.443ThrTyr: 1.443 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
7.235ValAla: 7.235 ± 0.114
0.782ValCys: 0.782 ± 0.034
3.643ValAsp: 3.643 ± 0.078
3.123ValGlu: 3.123 ± 0.079
2.542ValPhe: 2.542 ± 0.075
4.838ValGly: 4.838 ± 0.081
1.341ValHis: 1.341 ± 0.049
4.587ValIle: 4.587 ± 0.092
2.972ValLys: 2.972 ± 0.078
7.317ValLeu: 7.317 ± 0.121
1.84ValMet: 1.84 ± 0.06
2.73ValAsn: 2.73 ± 0.069
2.538ValPro: 2.538 ± 0.069
2.934ValGln: 2.934 ± 0.071
3.179ValArg: 3.179 ± 0.076
4.238ValSer: 4.238 ± 0.084
2.542ValThr: 2.542 ± 0.081
5.1ValVal: 5.1 ± 0.103
0.714ValTrp: 0.714 ± 0.032
1.954ValTyr: 1.954 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.904TrpAla: 0.904 ± 0.042
0.148TrpCys: 0.148 ± 0.013
0.47TrpAsp: 0.47 ± 0.032
0.391TrpGlu: 0.391 ± 0.024
0.548TrpPhe: 0.548 ± 0.031
0.636TrpGly: 0.636 ± 0.035
0.362TrpHis: 0.362 ± 0.026
0.622TrpIle: 0.622 ± 0.03
0.268TrpLys: 0.268 ± 0.024
1.924TrpLeu: 1.924 ± 0.07
0.216TrpMet: 0.216 ± 0.019
0.324TrpAsn: 0.324 ± 0.02
0.143TrpPro: 0.143 ± 0.016
1.385TrpGln: 1.385 ± 0.052
0.638TrpArg: 0.638 ± 0.029
0.571TrpSer: 0.571 ± 0.031
0.508TrpThr: 0.508 ± 0.024
0.84TrpVal: 0.84 ± 0.035
0.178TrpTrp: 0.178 ± 0.019
0.376TrpTyr: 0.376 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.814TyrAla: 2.814 ± 0.067
0.344TyrCys: 0.344 ± 0.024
1.954TyrAsp: 1.954 ± 0.069
1.543TyrGlu: 1.543 ± 0.049
1.435TyrPhe: 1.435 ± 0.056
2.196TyrGly: 2.196 ± 0.061
1.011TyrHis: 1.011 ± 0.046
1.651TyrIle: 1.651 ± 0.057
1.291TyrLys: 1.291 ± 0.043
3.543TyrLeu: 3.543 ± 0.079
0.583TyrMet: 0.583 ± 0.031
1.374TyrAsn: 1.374 ± 0.05
1.324TyrPro: 1.324 ± 0.046
2.494TyrGln: 2.494 ± 0.078
1.841TyrArg: 1.841 ± 0.066
1.571TyrSer: 1.571 ± 0.049
1.706TyrThr: 1.706 ± 0.051
1.726TyrVal: 1.726 ± 0.049
0.409TyrTrp: 0.409 ± 0.024
1.154TyrTyr: 1.154 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2140 proteins (657084 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski