Amino acid dipepetide frequency for Halopolyspora algeriensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.428AlaAla: 17.428 ± 0.182	1.096AlaCys: 1.096 ± 0.031	7.551AlaAsp: 7.551 ± 0.095	9.524AlaGlu: 9.524 ± 0.102	3.212AlaPhe: 3.212 ± 0.051	12.31AlaGly: 12.31 ± 0.106	2.69AlaHis: 2.69 ± 0.05	3.874AlaIle: 3.874 ± 0.069	2.288AlaLys: 2.288 ± 0.044	12.967AlaLeu: 12.967 ± 0.118	2.702AlaMet: 2.702 ± 0.046	2.022AlaAsn: 2.022 ± 0.042	5.635AlaPro: 5.635 ± 0.079	3.595AlaGln: 3.595 ± 0.057	9.257AlaArg: 9.257 ± 0.099	5.788AlaSer: 5.788 ± 0.066	6.859AlaThr: 6.859 ± 0.069	11.112AlaVal: 11.112 ± 0.107	1.601AlaTrp: 1.601 ± 0.037	2.041AlaTyr: 2.041 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.999CysAla: 0.999 ± 0.027	0.11CysCys: 0.11 ± 0.01	0.484CysAsp: 0.484 ± 0.019	0.459CysGlu: 0.459 ± 0.021	0.23CysPhe: 0.23 ± 0.012	1.024CysGly: 1.024 ± 0.033	0.227CysHis: 0.227 ± 0.013	0.197CysIle: 0.197 ± 0.012	0.12CysLys: 0.12 ± 0.012	0.798CysLeu: 0.798 ± 0.024	0.13CysMet: 0.13 ± 0.01	0.12CysAsn: 0.12 ± 0.01	0.551CysPro: 0.551 ± 0.023	0.168CysGln: 0.168 ± 0.012	0.669CysArg: 0.669 ± 0.023	0.532CysSer: 0.532 ± 0.023	0.54CysThr: 0.54 ± 0.02	0.659CysVal: 0.659 ± 0.022	0.14CysTrp: 0.14 ± 0.011	0.176CysTyr: 0.176 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.537AspAla: 6.537 ± 0.086	0.397AspCys: 0.397 ± 0.019	3.392AspAsp: 3.392 ± 0.049	4.605AspGlu: 4.605 ± 0.071	1.535AspPhe: 1.535 ± 0.037	5.432AspGly: 5.432 ± 0.069	1.41AspHis: 1.41 ± 0.034	2.041AspIle: 2.041 ± 0.047	1.067AspLys: 1.067 ± 0.032	5.802AspLeu: 5.802 ± 0.077	0.922AspMet: 0.922 ± 0.027	1.109AspAsn: 1.109 ± 0.029	4.416AspPro: 4.416 ± 0.067	1.495AspGln: 1.495 ± 0.032	4.854AspArg: 4.854 ± 0.07	3.211AspSer: 3.211 ± 0.05	3.451AspThr: 3.451 ± 0.054	4.991AspVal: 4.991 ± 0.072	0.806AspTrp: 0.806 ± 0.027	1.191AspTyr: 1.191 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.079GluAla: 7.079 ± 0.088	0.421GluCys: 0.421 ± 0.018	2.934GluAsp: 2.934 ± 0.053	3.732GluGlu: 3.732 ± 0.064	1.821GluPhe: 1.821 ± 0.035	4.23GluGly: 4.23 ± 0.057	2.326GluHis: 2.326 ± 0.044	2.596GluIle: 2.596 ± 0.048	1.266GluLys: 1.266 ± 0.037	7.692GluLeu: 7.692 ± 0.097	1.208GluMet: 1.208 ± 0.029	1.211GluAsn: 1.211 ± 0.04	3.616GluPro: 3.616 ± 0.059	3.601GluGln: 3.601 ± 0.062	5.821GluArg: 5.821 ± 0.084	3.455GluSer: 3.455 ± 0.055	3.267GluThr: 3.267 ± 0.059	5.262GluVal: 5.262 ± 0.073	0.917GluTrp: 0.917 ± 0.028	1.143GluTyr: 1.143 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.616PheAla: 3.616 ± 0.053	0.276PheCys: 0.276 ± 0.014	2.055PheAsp: 2.055 ± 0.046	1.477PheGlu: 1.477 ± 0.039	0.879PhePhe: 0.879 ± 0.03	3.335PheGly: 3.335 ± 0.059	0.693PheHis: 0.693 ± 0.027	0.771PheIle: 0.771 ± 0.025	0.401PheLys: 0.401 ± 0.02	2.642PheLeu: 2.642 ± 0.049	0.399PheMet: 0.399 ± 0.017	0.545PheAsn: 0.545 ± 0.02	1.337PhePro: 1.337 ± 0.032	0.608PheGln: 0.608 ± 0.021	1.895PheArg: 1.895 ± 0.035	1.54PheSer: 1.54 ± 0.033	1.959PheThr: 1.959 ± 0.038	2.364PheVal: 2.364 ± 0.045	0.408PheTrp: 0.408 ± 0.02	0.584PheTyr: 0.584 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.874GlyAla: 9.874 ± 0.113	0.886GlyCys: 0.886 ± 0.027	4.919GlyAsp: 4.919 ± 0.068	5.7GlyGlu: 5.7 ± 0.067	2.92GlyPhe: 2.92 ± 0.043	8.263GlyGly: 8.263 ± 0.106	2.348GlyHis: 2.348 ± 0.043	3.902GlyIle: 3.902 ± 0.057	2.242GlyLys: 2.242 ± 0.05	8.901GlyLeu: 8.901 ± 0.089	2.392GlyMet: 2.392 ± 0.05	2.002GlyAsn: 2.002 ± 0.041	4.439GlyPro: 4.439 ± 0.056	2.892GlyGln: 2.892 ± 0.053	7.152GlyArg: 7.152 ± 0.079	5.805GlySer: 5.805 ± 0.081	5.97GlyThr: 5.97 ± 0.072	7.578GlyVal: 7.578 ± 0.088	1.688GlyTrp: 1.688 ± 0.037	2.216GlyTyr: 2.216 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.816HisAla: 2.816 ± 0.048	0.251HisCys: 0.251 ± 0.013	1.462HisAsp: 1.462 ± 0.032	1.477HisGlu: 1.477 ± 0.036	0.659HisPhe: 0.659 ± 0.019	2.66HisGly: 2.66 ± 0.046	0.816HisHis: 0.816 ± 0.026	0.729HisIle: 0.729 ± 0.021	0.325HisLys: 0.325 ± 0.015	2.421HisLeu: 2.421 ± 0.049	0.389HisMet: 0.389 ± 0.019	0.486HisAsn: 0.486 ± 0.02	1.879HisPro: 1.879 ± 0.036	0.689HisGln: 0.689 ± 0.023	2.394HisArg: 2.394 ± 0.051	1.365HisSer: 1.365 ± 0.034	1.441HisThr: 1.441 ± 0.036	1.91HisVal: 1.91 ± 0.038	0.388HisTrp: 0.388 ± 0.018	0.55HisTyr: 0.55 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.014IleAla: 5.014 ± 0.065	0.303IleCys: 0.303 ± 0.014	2.49IleAsp: 2.49 ± 0.044	2.364IleGlu: 2.364 ± 0.048	0.758IlePhe: 0.758 ± 0.029	3.904IleGly: 3.904 ± 0.056	0.682IleHis: 0.682 ± 0.021	0.964IleIle: 0.964 ± 0.03	0.662IleLys: 0.662 ± 0.025	2.592IleLeu: 2.592 ± 0.044	0.534IleMet: 0.534 ± 0.018	0.844IleAsn: 0.844 ± 0.028	1.984IlePro: 1.984 ± 0.039	0.708IleGln: 0.708 ± 0.025	2.432IleArg: 2.432 ± 0.045	1.883IleSer: 1.883 ± 0.036	2.731IleThr: 2.731 ± 0.051	3.039IleVal: 3.039 ± 0.046	0.322IleTrp: 0.322 ± 0.017	0.587IleTyr: 0.587 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	2.183LysAla: 2.183 ± 0.051	0.106LysCys: 0.106 ± 0.009	0.926LysAsp: 0.926 ± 0.029	0.926LysGlu: 0.926 ± 0.025	0.462LysPhe: 0.462 ± 0.017	1.329LysGly: 1.329 ± 0.037	0.463LysHis: 0.463 ± 0.019	0.739LysIle: 0.739 ± 0.026	0.579LysLys: 0.579 ± 0.025	2.032LysLeu: 2.032 ± 0.043	0.367LysMet: 0.367 ± 0.018	0.415LysAsn: 0.415 ± 0.02	1.26LysPro: 1.26 ± 0.035	0.852LysGln: 0.852 ± 0.028	1.504LysArg: 1.504 ± 0.034	1.083LysSer: 1.083 ± 0.033	1.088LysThr: 1.088 ± 0.034	1.602LysVal: 1.602 ± 0.043	0.219LysTrp: 0.219 ± 0.013	0.364LysTyr: 0.364 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.963LeuAla: 13.963 ± 0.144	0.864LeuCys: 0.864 ± 0.026	6.77LeuAsp: 6.77 ± 0.09	5.262LeuGlu: 5.262 ± 0.078	2.705LeuPhe: 2.705 ± 0.059	9.456LeuGly: 9.456 ± 0.103	2.551LeuHis: 2.551 ± 0.051	3.312LeuIle: 3.312 ± 0.054	1.425LeuLys: 1.425 ± 0.037	11.037LeuLeu: 11.037 ± 0.118	1.573LeuMet: 1.573 ± 0.034	1.771LeuAsn: 1.771 ± 0.036	6.149LeuPro: 6.149 ± 0.075	2.784LeuGln: 2.784 ± 0.053	8.699LeuArg: 8.699 ± 0.092	5.847LeuSer: 5.847 ± 0.069	5.906LeuThr: 5.906 ± 0.067	9.066LeuVal: 9.066 ± 0.1	1.269LeuTrp: 1.269 ± 0.033	1.697LeuTyr: 1.697 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.423MetAla: 2.423 ± 0.036	0.159MetCys: 0.159 ± 0.011	0.911MetAsp: 0.911 ± 0.026	0.756MetGlu: 0.756 ± 0.021	0.52MetPhe: 0.52 ± 0.02	1.412MetGly: 1.412 ± 0.034	0.455MetHis: 0.455 ± 0.017	0.723MetIle: 0.723 ± 0.023	0.348MetLys: 0.348 ± 0.017	2.175MetLeu: 2.175 ± 0.044	0.339MetMet: 0.339 ± 0.017	0.463MetAsn: 0.463 ± 0.019	1.279MetPro: 1.279 ± 0.032	0.578MetGln: 0.578 ± 0.019	1.619MetArg: 1.619 ± 0.035	1.61MetSer: 1.61 ± 0.033	1.58MetThr: 1.58 ± 0.034	1.579MetVal: 1.579 ± 0.037	0.246MetTrp: 0.246 ± 0.016	0.291MetTyr: 0.291 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.34AsnAla: 2.34 ± 0.04	0.173AsnCys: 0.173 ± 0.012	0.962AsnAsp: 0.962 ± 0.028	1.004AsnGlu: 1.004 ± 0.026	0.511AsnPhe: 0.511 ± 0.019	1.852AsnGly: 1.852 ± 0.041	0.452AsnHis: 0.452 ± 0.019	0.706AsnIle: 0.706 ± 0.024	0.429AsnLys: 0.429 ± 0.017	1.863AsnLeu: 1.863 ± 0.042	0.351AsnMet: 0.351 ± 0.016	0.472AsnAsn: 0.472 ± 0.021	1.53AsnPro: 1.53 ± 0.036	0.546AsnGln: 0.546 ± 0.022	1.57AsnArg: 1.57 ± 0.037	1.027AsnSer: 1.027 ± 0.026	1.202AsnThr: 1.202 ± 0.033	1.51AsnVal: 1.51 ± 0.035	0.301AsnTrp: 0.301 ± 0.016	0.414AsnTyr: 0.414 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.011ProAla: 7.011 ± 0.075	0.345ProCys: 0.345 ± 0.017	4.177ProAsp: 4.177 ± 0.064	4.856ProGlu: 4.856 ± 0.061	1.465ProPhe: 1.465 ± 0.033	5.832ProGly: 5.832 ± 0.079	1.41ProHis: 1.41 ± 0.038	1.691ProIle: 1.691 ± 0.036	1.071ProLys: 1.071 ± 0.029	4.923ProLeu: 4.923 ± 0.067	1.07ProMet: 1.07 ± 0.028	1.064ProAsn: 1.064 ± 0.029	3.336ProPro: 3.336 ± 0.069	1.995ProGln: 1.995 ± 0.052	3.661ProArg: 3.661 ± 0.06	3.272ProSer: 3.272 ± 0.061	3.058ProThr: 3.058 ± 0.049	5.072ProVal: 5.072 ± 0.067	0.886ProTrp: 0.886 ± 0.027	1.144ProTyr: 1.144 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.189GlnAla: 4.189 ± 0.062	0.224GlnCys: 0.224 ± 0.013	1.476GlnAsp: 1.476 ± 0.034	1.8GlnGlu: 1.8 ± 0.04	0.761GlnPhe: 0.761 ± 0.022	2.352GlnGly: 2.352 ± 0.043	0.935GlnHis: 0.935 ± 0.027	1.03GlnIle: 1.03 ± 0.03	0.468GlnLys: 0.468 ± 0.022	3.368GlnLeu: 3.368 ± 0.05	0.527GlnMet: 0.527 ± 0.018	0.53GlnAsn: 0.53 ± 0.021	2.036GlnPro: 2.036 ± 0.064	1.89GlnGln: 1.89 ± 0.05	3.383GlnArg: 3.383 ± 0.056	1.403GlnSer: 1.403 ± 0.038	1.321GlnThr: 1.321 ± 0.033	2.641GlnVal: 2.641 ± 0.045	0.554GlnTrp: 0.554 ± 0.021	0.644GlnTyr: 0.644 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	9.148ArgAla: 9.148 ± 0.094	0.693ArgCys: 0.693 ± 0.022	4.215ArgAsp: 4.215 ± 0.052	5.078ArgGlu: 5.078 ± 0.072	2.402ArgPhe: 2.402 ± 0.044	5.806ArgGly: 5.806 ± 0.072	2.153ArgHis: 2.153 ± 0.041	3.531ArgIle: 3.531 ± 0.052	1.785ArgLys: 1.785 ± 0.045	8.216ArgLeu: 8.216 ± 0.097	2.108ArgMet: 2.108 ± 0.037	1.703ArgAsn: 1.703 ± 0.044	4.358ArgPro: 4.358 ± 0.066	2.754ArgGln: 2.754 ± 0.049	7.846ArgArg: 7.846 ± 0.108	4.985ArgSer: 4.985 ± 0.064	5.036ArgThr: 5.036 ± 0.072	6.057ArgVal: 6.057 ± 0.073	1.397ArgTrp: 1.397 ± 0.034	1.848ArgTyr: 1.848 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.094SerAla: 7.094 ± 0.078	0.457SerCys: 0.457 ± 0.02	3.067SerAsp: 3.067 ± 0.051	3.604SerGlu: 3.604 ± 0.057	1.613SerPhe: 1.613 ± 0.036	6.623SerGly: 6.623 ± 0.081	1.06SerHis: 1.06 ± 0.03	1.834SerIle: 1.834 ± 0.037	1.089SerLys: 1.089 ± 0.032	4.972SerLeu: 4.972 ± 0.067	1.335SerMet: 1.335 ± 0.027	1.046SerAsn: 1.046 ± 0.032	3.199SerPro: 3.199 ± 0.052	1.475SerGln: 1.475 ± 0.033	4.3SerArg: 4.3 ± 0.061	3.537SerSer: 3.537 ± 0.052	3.712SerThr: 3.712 ± 0.06	4.656SerVal: 4.656 ± 0.064	0.963SerTrp: 0.963 ± 0.031	1.115SerTyr: 1.115 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	7.821ThrAla: 7.821 ± 0.08	0.462ThrCys: 0.462 ± 0.021	3.662ThrAsp: 3.662 ± 0.057	4.074ThrGlu: 4.074 ± 0.067	1.626ThrPhe: 1.626 ± 0.035	6.357ThrGly: 6.357 ± 0.069	1.281ThrHis: 1.281 ± 0.031	2.048ThrIle: 2.048 ± 0.047	1.081ThrLys: 1.081 ± 0.031	5.462ThrLeu: 5.462 ± 0.068	1.172ThrMet: 1.172 ± 0.031	1.024ThrAsn: 1.024 ± 0.028	3.607ThrPro: 3.607 ± 0.053	1.407ThrGln: 1.407 ± 0.035	4.052ThrArg: 4.052 ± 0.06	3.42ThrSer: 3.42 ± 0.053	3.854ThrThr: 3.854 ± 0.065	5.884ThrVal: 5.884 ± 0.066	0.836ThrTrp: 0.836 ± 0.031	1.109ThrTyr: 1.109 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.385ValAla: 10.385 ± 0.106	0.766ValCys: 0.766 ± 0.028	5.357ValAsp: 5.357 ± 0.068	5.116ValGlu: 5.116 ± 0.064	2.5ValPhe: 2.5 ± 0.051	6.885ValGly: 6.885 ± 0.082	2.312ValHis: 2.312 ± 0.043	2.989ValIle: 2.989 ± 0.058	1.248ValLys: 1.248 ± 0.032	10.274ValLeu: 10.274 ± 0.117	1.337ValMet: 1.337 ± 0.029	1.681ValAsn: 1.681 ± 0.034	4.855ValPro: 4.855 ± 0.066	2.287ValGln: 2.287 ± 0.039	6.869ValArg: 6.869 ± 0.081	4.887ValSer: 4.887 ± 0.068	5.338ValThr: 5.338 ± 0.072	8.276ValVal: 8.276 ± 0.096	1.062ValTrp: 1.062 ± 0.024	1.434ValTyr: 1.434 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.438TrpAla: 1.438 ± 0.03	0.155TrpCys: 0.155 ± 0.011	0.698TrpAsp: 0.698 ± 0.021	0.681TrpGlu: 0.681 ± 0.025	0.552TrpPhe: 0.552 ± 0.021	0.988TrpGly: 0.988 ± 0.028	0.4TrpHis: 0.4 ± 0.016	0.596TrpIle: 0.596 ± 0.02	0.285TrpLys: 0.285 ± 0.015	1.867TrpLeu: 1.867 ± 0.039	0.386TrpMet: 0.386 ± 0.019	0.338TrpAsn: 0.338 ± 0.017	0.804TrpPro: 0.804 ± 0.027	0.66TrpGln: 0.66 ± 0.022	1.269TrpArg: 1.269 ± 0.032	1.003TrpSer: 1.003 ± 0.029	0.805TrpThr: 0.805 ± 0.023	1.082TrpVal: 1.082 ± 0.033	0.377TrpTrp: 0.377 ± 0.017	0.289TrpTyr: 0.289 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.192TyrAla: 2.192 ± 0.035	0.189TyrCys: 0.189 ± 0.01	1.156TyrAsp: 1.156 ± 0.031	1.103TyrGlu: 1.103 ± 0.031	0.652TyrPhe: 0.652 ± 0.024	2.038TyrGly: 2.038 ± 0.049	0.442TyrHis: 0.442 ± 0.02	0.525TyrIle: 0.525 ± 0.021	0.317TyrLys: 0.317 ± 0.017	2.101TyrLeu: 2.101 ± 0.046	0.225TyrMet: 0.225 ± 0.014	0.367TyrAsn: 0.367 ± 0.018	1.071TyrPro: 1.071 ± 0.026	0.549TyrGln: 0.549 ± 0.021	1.875TyrArg: 1.875 ± 0.043	1.1TyrSer: 1.1 ± 0.03	1.118TyrThr: 1.118 ± 0.03	1.52TyrVal: 1.52 ± 0.038	0.296TyrTrp: 0.296 ± 0.015	0.449TyrTyr: 0.449 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4304 proteins (1331474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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