Amino acid dipepetide frequency for Simkania negevensis (strain ATCC VR-1471 / Z)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.268AlaAla: 5.268 ± 0.101	0.788AlaCys: 0.788 ± 0.032	2.782AlaAsp: 2.782 ± 0.07	4.164AlaGlu: 4.164 ± 0.075	3.736AlaPhe: 3.736 ± 0.079	4.117AlaGly: 4.117 ± 0.121	1.631AlaHis: 1.631 ± 0.047	5.225AlaIle: 5.225 ± 0.094	4.711AlaLys: 4.711 ± 0.095	8.617AlaLeu: 8.617 ± 0.112	1.636AlaMet: 1.636 ± 0.051	2.438AlaAsn: 2.438 ± 0.068	2.48AlaPro: 2.48 ± 0.066	2.656AlaGln: 2.656 ± 0.061	2.77AlaArg: 2.77 ± 0.064	4.318AlaSer: 4.318 ± 0.09	3.698AlaThr: 3.698 ± 0.09	4.022AlaVal: 4.022 ± 0.081	0.756AlaTrp: 0.756 ± 0.029	2.277AlaTyr: 2.277 ± 0.053	0.005AlaXaa: 0.005 ± 0.003
Cys	0.729CysAla: 0.729 ± 0.035	0.166CysCys: 0.166 ± 0.016	0.592CysAsp: 0.592 ± 0.03	0.705CysGlu: 0.705 ± 0.033	0.765CysPhe: 0.765 ± 0.034	0.751CysGly: 0.751 ± 0.032	0.386CysHis: 0.386 ± 0.022	0.707CysIle: 0.707 ± 0.027	0.533CysLys: 0.533 ± 0.029	1.286CysLeu: 1.286 ± 0.046	0.268CysMet: 0.268 ± 0.019	0.371CysAsn: 0.371 ± 0.021	0.57CysPro: 0.57 ± 0.03	0.487CysGln: 0.487 ± 0.023	0.485CysArg: 0.485 ± 0.028	0.755CysSer: 0.755 ± 0.031	0.485CysThr: 0.485 ± 0.027	0.616CysVal: 0.616 ± 0.03	0.137CysTrp: 0.137 ± 0.014	0.431CysTyr: 0.431 ± 0.021	0.001CysXaa: 0.001 ± 0.001
Asp	3.067AspAla: 3.067 ± 0.06	0.507AspCys: 0.507 ± 0.028	2.059AspAsp: 2.059 ± 0.056	3.607AspGlu: 3.607 ± 0.075	2.984AspPhe: 2.984 ± 0.068	2.837AspGly: 2.837 ± 0.069	1.407AspHis: 1.407 ± 0.042	2.949AspIle: 2.949 ± 0.065	2.735AspLys: 2.735 ± 0.054	5.814AspLeu: 5.814 ± 0.086	0.924AspMet: 0.924 ± 0.042	1.441AspAsn: 1.441 ± 0.044	2.865AspPro: 2.865 ± 0.065	2.267AspGln: 2.267 ± 0.059	2.383AspArg: 2.383 ± 0.051	2.736AspSer: 2.736 ± 0.063	2.128AspThr: 2.128 ± 0.054	2.946AspVal: 2.946 ± 0.067	0.716AspTrp: 0.716 ± 0.031	1.846AspTyr: 1.846 ± 0.052	0.004AspXaa: 0.004 ± 0.002
Glu	4.995GluAla: 4.995 ± 0.099	0.601GluCys: 0.601 ± 0.029	3.168GluAsp: 3.168 ± 0.076	6.362GluGlu: 6.362 ± 0.13	2.731GluPhe: 2.731 ± 0.064	4.344GluGly: 4.344 ± 0.081	1.378GluHis: 1.378 ± 0.046	5.299GluIle: 5.299 ± 0.102	7.028GluLys: 7.028 ± 0.11	6.582GluLeu: 6.582 ± 0.107	1.933GluMet: 1.933 ± 0.048	3.268GluAsn: 3.268 ± 0.076	1.903GluPro: 1.903 ± 0.057	2.569GluGln: 2.569 ± 0.057	3.335GluArg: 3.335 ± 0.08	3.783GluSer: 3.783 ± 0.077	3.922GluThr: 3.922 ± 0.075	4.375GluVal: 4.375 ± 0.077	0.832GluTrp: 0.832 ± 0.033	1.91GluTyr: 1.91 ± 0.054	0.003GluXaa: 0.003 ± 0.002
Phe	3.541PheAla: 3.541 ± 0.078	0.757PheCys: 0.757 ± 0.028	2.867PheAsp: 2.867 ± 0.065	3.408PheGlu: 3.408 ± 0.067	3.613PhePhe: 3.613 ± 0.104	3.353PheGly: 3.353 ± 0.08	1.407PheHis: 1.407 ± 0.048	3.306PheIle: 3.306 ± 0.081	2.621PheLys: 2.621 ± 0.059	6.041PheLeu: 6.041 ± 0.121	1.08PheMet: 1.08 ± 0.035	1.91PheAsn: 1.91 ± 0.059	2.466PhePro: 2.466 ± 0.058	2.17PheGln: 2.17 ± 0.053	2.03PheArg: 2.03 ± 0.057	4.445PheSer: 4.445 ± 0.1	2.612PheThr: 2.612 ± 0.069	2.934PheVal: 2.934 ± 0.068	0.69PheTrp: 0.69 ± 0.026	1.966PheTyr: 1.966 ± 0.058	0.001PheXaa: 0.001 ± 0.001
Gly	4.406GlyAla: 4.406 ± 0.111	0.836GlyCys: 0.836 ± 0.032	2.924GlyAsp: 2.924 ± 0.071	3.788GlyGlu: 3.788 ± 0.07	3.374GlyPhe: 3.374 ± 0.083	4.497GlyGly: 4.497 ± 0.177	1.454GlyHis: 1.454 ± 0.043	4.893GlyIle: 4.893 ± 0.093	4.795GlyLys: 4.795 ± 0.077	6.262GlyLeu: 6.262 ± 0.11	1.831GlyMet: 1.831 ± 0.047	2.554GlyAsn: 2.554 ± 0.133	1.987GlyPro: 1.987 ± 0.06	1.977GlyGln: 1.977 ± 0.045	2.638GlyArg: 2.638 ± 0.059	3.994GlySer: 3.994 ± 0.134	3.902GlyThr: 3.902 ± 0.216	4.235GlyVal: 4.235 ± 0.105	0.908GlyTrp: 0.908 ± 0.043	2.355GlyTyr: 2.355 ± 0.061	0.003GlyXaa: 0.003 ± 0.002
His	1.574HisAla: 1.574 ± 0.048	0.279HisCys: 0.279 ± 0.02	1.123HisAsp: 1.123 ± 0.039	1.709HisGlu: 1.709 ± 0.05	1.68HisPhe: 1.68 ± 0.048	1.398HisGly: 1.398 ± 0.05	0.876HisHis: 0.876 ± 0.04	1.546HisIle: 1.546 ± 0.047	1.118HisLys: 1.118 ± 0.039	3.229HisLeu: 3.229 ± 0.068	0.499HisMet: 0.499 ± 0.025	0.805HisAsn: 0.805 ± 0.033	1.636HisPro: 1.636 ± 0.051	1.143HisGln: 1.143 ± 0.038	1.176HisArg: 1.176 ± 0.04	1.474HisSer: 1.474 ± 0.046	1.136HisThr: 1.136 ± 0.043	1.459HisVal: 1.459 ± 0.042	0.346HisTrp: 0.346 ± 0.023	1.009HisTyr: 1.009 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.328IleAla: 5.328 ± 0.099	0.816IleCys: 0.816 ± 0.033	4.088IleAsp: 4.088 ± 0.073	5.197IleGlu: 5.197 ± 0.085	3.546IlePhe: 3.546 ± 0.077	4.914IleGly: 4.914 ± 0.103	1.842IleHis: 1.842 ± 0.043	3.817IleIle: 3.817 ± 0.096	3.559IleLys: 3.559 ± 0.078	6.952IleLeu: 6.952 ± 0.121	1.225IleMet: 1.225 ± 0.044	2.474IleAsn: 2.474 ± 0.063	3.589IlePro: 3.589 ± 0.085	3.012IleGln: 3.012 ± 0.07	3.032IleArg: 3.032 ± 0.071	4.741IleSer: 4.741 ± 0.086	3.364IleThr: 3.364 ± 0.074	4.057IleVal: 4.057 ± 0.076	0.787IleTrp: 0.787 ± 0.035	2.216IleTyr: 2.216 ± 0.054	0.001IleXaa: 0.001 ± 0.001
Lys	4.512LysAla: 4.512 ± 0.081	0.599LysCys: 0.599 ± 0.026	3.309LysAsp: 3.309 ± 0.074	6.022LysGlu: 6.022 ± 0.114	2.231LysPhe: 2.231 ± 0.056	4.516LysGly: 4.516 ± 0.078	1.558LysHis: 1.558 ± 0.048	4.777LysIle: 4.777 ± 0.082	6.529LysLys: 6.529 ± 0.117	6.333LysLeu: 6.333 ± 0.107	1.827LysMet: 1.827 ± 0.047	3.126LysAsn: 3.126 ± 0.071	2.518LysPro: 2.518 ± 0.061	2.797LysGln: 2.797 ± 0.055	3.675LysArg: 3.675 ± 0.078	3.878LysSer: 3.878 ± 0.075	3.984LysThr: 3.984 ± 0.07	4.087LysVal: 4.087 ± 0.073	0.903LysTrp: 0.903 ± 0.041	1.695LysTyr: 1.695 ± 0.042	0.005LysXaa: 0.005 ± 0.002
Leu	7.51LeuAla: 7.51 ± 0.112	1.318LeuCys: 1.318 ± 0.047	5.215LeuAsp: 5.215 ± 0.088	7.384LeuGlu: 7.384 ± 0.127	5.899LeuPhe: 5.899 ± 0.123	6.509LeuGly: 6.509 ± 0.094	2.471LeuHis: 2.471 ± 0.066	7.462LeuIle: 7.462 ± 0.131	7.926LeuLys: 7.926 ± 0.117	11.052LeuLeu: 11.052 ± 0.165	2.409LeuMet: 2.409 ± 0.053	4.209LeuAsn: 4.209 ± 0.086	4.899LeuPro: 4.899 ± 0.088	4.188LeuGln: 4.188 ± 0.085	4.572LeuArg: 4.572 ± 0.088	8.529LeuSer: 8.529 ± 0.113	6.094LeuThr: 6.094 ± 0.13	5.566LeuVal: 5.566 ± 0.098	1.032LeuTrp: 1.032 ± 0.034	3.282LeuTyr: 3.282 ± 0.071	0.005LeuXaa: 0.005 ± 0.003
Met	1.646MetAla: 1.646 ± 0.051	0.176MetCys: 0.176 ± 0.015	1.012MetAsp: 1.012 ± 0.035	1.383MetGlu: 1.383 ± 0.044	0.78MetPhe: 0.78 ± 0.026	1.732MetGly: 1.732 ± 0.053	0.626MetHis: 0.626 ± 0.028	1.767MetIle: 1.767 ± 0.051	2.017MetLys: 2.017 ± 0.047	2.065MetLeu: 2.065 ± 0.051	0.62MetMet: 0.62 ± 0.029	0.97MetAsn: 0.97 ± 0.037	0.875MetPro: 0.875 ± 0.035	1.068MetGln: 1.068 ± 0.039	1.303MetArg: 1.303 ± 0.046	1.645MetSer: 1.645 ± 0.049	1.515MetThr: 1.515 ± 0.047	1.193MetVal: 1.193 ± 0.043	0.225MetTrp: 0.225 ± 0.014	0.462MetTyr: 0.462 ± 0.023	0.001MetXaa: 0.001 ± 0.001
Asn	2.596AsnAla: 2.596 ± 0.072	0.455AsnCys: 0.455 ± 0.026	1.641AsnAsp: 1.641 ± 0.044	2.421AsnGlu: 2.421 ± 0.061	2.094AsnPhe: 2.094 ± 0.05	2.499AsnGly: 2.499 ± 0.101	1.144AsnHis: 1.144 ± 0.041	2.543AsnIle: 2.543 ± 0.063	1.987AsnLys: 1.987 ± 0.05	4.462AsnLeu: 4.462 ± 0.093	0.827AsnMet: 0.827 ± 0.031	1.338AsnAsn: 1.338 ± 0.054	2.403AsnPro: 2.403 ± 0.054	1.919AsnGln: 1.919 ± 0.052	1.938AsnArg: 1.938 ± 0.05	2.29AsnSer: 2.29 ± 0.083	1.968AsnThr: 1.968 ± 0.08	2.246AsnVal: 2.246 ± 0.06	0.697AsnTrp: 0.697 ± 0.032	1.478AsnTyr: 1.478 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.325ProAla: 2.325 ± 0.054	0.465ProCys: 0.465 ± 0.025	2.087ProAsp: 2.087 ± 0.059	3.395ProGlu: 3.395 ± 0.078	2.51ProPhe: 2.51 ± 0.055	2.173ProGly: 2.173 ± 0.064	1.25ProHis: 1.25 ± 0.041	3.126ProIle: 3.126 ± 0.068	3.068ProLys: 3.068 ± 0.077	4.831ProLeu: 4.831 ± 0.085	0.869ProMet: 0.869 ± 0.034	1.821ProAsn: 1.821 ± 0.048	2.153ProPro: 2.153 ± 0.077	1.64ProGln: 1.64 ± 0.045	1.551ProArg: 1.551 ± 0.044	3.198ProSer: 3.198 ± 0.065	2.47ProThr: 2.47 ± 0.067	2.436ProVal: 2.436 ± 0.048	0.487ProTrp: 0.487 ± 0.024	1.734ProTyr: 1.734 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	3.195GlnAla: 3.195 ± 0.07	0.311GlnCys: 0.311 ± 0.02	1.967GlnAsp: 1.967 ± 0.057	3.204GlnGlu: 3.204 ± 0.073	1.821GlnPhe: 1.821 ± 0.054	2.511GlnGly: 2.511 ± 0.083	0.819GlnHis: 0.819 ± 0.034	2.872GlnIle: 2.872 ± 0.06	3.432GlnLys: 3.432 ± 0.083	3.804GlnLeu: 3.804 ± 0.067	1.026GlnMet: 1.026 ± 0.038	1.934GlnAsn: 1.934 ± 0.052	1.229GlnPro: 1.229 ± 0.043	1.612GlnGln: 1.612 ± 0.055	1.5GlnArg: 1.5 ± 0.047	2.404GlnSer: 2.404 ± 0.053	2.411GlnThr: 2.411 ± 0.067	2.658GlnVal: 2.658 ± 0.061	0.454GlnTrp: 0.454 ± 0.025	1.112GlnTyr: 1.112 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.767ArgAla: 2.767 ± 0.054	0.487ArgCys: 0.487 ± 0.025	2.233ArgAsp: 2.233 ± 0.06	3.438ArgGlu: 3.438 ± 0.085	2.642ArgPhe: 2.642 ± 0.056	2.442ArgGly: 2.442 ± 0.063	1.025ArgHis: 1.025 ± 0.034	3.1ArgIle: 3.1 ± 0.077	3.278ArgLys: 3.278 ± 0.066	4.891ArgLeu: 4.891 ± 0.1	1.112ArgMet: 1.112 ± 0.031	1.722ArgAsn: 1.722 ± 0.048	1.583ArgPro: 1.583 ± 0.049	1.752ArgGln: 1.752 ± 0.045	2.177ArgArg: 2.177 ± 0.057	2.758ArgSer: 2.758 ± 0.058	1.993ArgThr: 1.993 ± 0.056	2.548ArgVal: 2.548 ± 0.061	0.551ArgTrp: 0.551 ± 0.027	1.703ArgTyr: 1.703 ± 0.05	0.003ArgXaa: 0.003 ± 0.002
Ser	3.898SerAla: 3.898 ± 0.082	0.816SerCys: 0.816 ± 0.037	3.125SerAsp: 3.125 ± 0.062	4.102SerGlu: 4.102 ± 0.083	4.003SerPhe: 4.003 ± 0.082	4.245SerGly: 4.245 ± 0.172	1.856SerHis: 1.856 ± 0.044	4.316SerIle: 4.316 ± 0.082	4.174SerLys: 4.174 ± 0.083	7.728SerLeu: 7.728 ± 0.11	1.586SerMet: 1.586 ± 0.044	2.393SerAsn: 2.393 ± 0.066	3.252SerPro: 3.252 ± 0.073	2.736SerGln: 2.736 ± 0.058	2.88SerArg: 2.88 ± 0.057	5.253SerSer: 5.253 ± 0.112	3.363SerThr: 3.363 ± 0.083	3.563SerVal: 3.563 ± 0.064	0.949SerTrp: 0.949 ± 0.043	2.582SerTyr: 2.582 ± 0.069	0.003SerXaa: 0.003 ± 0.002
Thr	3.602ThrAla: 3.602 ± 0.103	0.607ThrCys: 0.607 ± 0.029	2.388ThrAsp: 2.388 ± 0.057	2.984ThrGlu: 2.984 ± 0.069	3.115ThrPhe: 3.115 ± 0.069	3.62ThrGly: 3.62 ± 0.168	1.512ThrHis: 1.512 ± 0.05	3.686ThrIle: 3.686 ± 0.08	2.916ThrLys: 2.916 ± 0.067	6.745ThrLeu: 6.745 ± 0.133	1.058ThrMet: 1.058 ± 0.036	1.954ThrAsn: 1.954 ± 0.075	2.988ThrPro: 2.988 ± 0.077	1.998ThrGln: 1.998 ± 0.065	1.996ThrArg: 1.996 ± 0.055	3.68ThrSer: 3.68 ± 0.108	3.029ThrThr: 3.029 ± 0.099	3.17ThrVal: 3.17 ± 0.088	0.655ThrTrp: 0.655 ± 0.034	2.096ThrTyr: 2.096 ± 0.086	0.004ThrXaa: 0.004 ± 0.002
Val	4.125ValAla: 4.125 ± 0.081	0.716ValCys: 0.716 ± 0.027	3.051ValAsp: 3.051 ± 0.057	3.885ValGlu: 3.885 ± 0.076	2.982ValPhe: 2.982 ± 0.074	4.125ValGly: 4.125 ± 0.091	1.273ValHis: 1.273 ± 0.043	4.31ValIle: 4.31 ± 0.09	3.786ValLys: 3.786 ± 0.08	5.783ValLeu: 5.783 ± 0.101	1.408ValMet: 1.408 ± 0.048	2.227ValAsn: 2.227 ± 0.073	2.386ValPro: 2.386 ± 0.053	2.176ValGln: 2.176 ± 0.05	2.534ValArg: 2.534 ± 0.061	4.102ValSer: 4.102 ± 0.077	3.355ValThr: 3.355 ± 0.104	3.737ValVal: 3.737 ± 0.077	0.599ValTrp: 0.599 ± 0.029	1.782ValTyr: 1.782 ± 0.044	0.003ValXaa: 0.003 ± 0.002
Trp	0.727TrpAla: 0.727 ± 0.033	0.143TrpCys: 0.143 ± 0.013	0.669TrpAsp: 0.669 ± 0.034	0.952TrpGlu: 0.952 ± 0.037	0.556TrpPhe: 0.556 ± 0.029	0.986TrpGly: 0.986 ± 0.038	0.308TrpHis: 0.308 ± 0.019	1.016TrpIle: 1.016 ± 0.039	1.019TrpLys: 1.019 ± 0.044	1.098TrpLeu: 1.098 ± 0.039	0.355TrpMet: 0.355 ± 0.022	0.718TrpAsn: 0.718 ± 0.03	0.306TrpPro: 0.306 ± 0.021	0.47TrpGln: 0.47 ± 0.021	0.562TrpArg: 0.562 ± 0.031	0.62TrpSer: 0.62 ± 0.03	0.63TrpThr: 0.63 ± 0.031	0.726TrpVal: 0.726 ± 0.027	0.221TrpTrp: 0.221 ± 0.018	0.322TrpTyr: 0.322 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.277TyrAla: 2.277 ± 0.056	0.384TyrCys: 0.384 ± 0.022	1.92TyrAsp: 1.92 ± 0.089	2.208TyrGlu: 2.208 ± 0.056	2.157TyrPhe: 2.157 ± 0.065	2.045TyrGly: 2.045 ± 0.046	0.991TyrHis: 0.991 ± 0.034	1.84TyrIle: 1.84 ± 0.048	1.641TyrLys: 1.641 ± 0.05	3.95TyrLeu: 3.95 ± 0.078	0.585TyrMet: 0.585 ± 0.025	1.269TyrAsn: 1.269 ± 0.048	1.504TyrPro: 1.504 ± 0.048	1.64TyrGln: 1.64 ± 0.049	1.662TyrArg: 1.662 ± 0.052	2.218TyrSer: 2.218 ± 0.07	1.74TyrThr: 1.74 ± 0.056	1.767TyrVal: 1.767 ± 0.052	0.458TyrTrp: 0.458 ± 0.026	1.347TyrTyr: 1.347 ± 0.043	0.005TyrXaa: 0.005 ± 0.003
Xaa	0.006XaaAla: 0.006 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.003XaaGlu: 0.003 ± 0.002	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.006XaaLys: 0.006 ± 0.004	0.008XaaLeu: 0.008 ± 0.003	0.001XaaMet: 0.001 ± 0.001	0.003XaaAsn: 0.003 ± 0.002	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.003XaaSer: 0.003 ± 0.002	0.004XaaThr: 0.004 ± 0.002	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.004XaaTyr: 0.004 ± 0.002	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 2516 proteins (795211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---