Amino acid dipepetide frequency for Raphidocelis subcapitata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	59.695AlaAla: 59.695 ± 0.35	2.26AlaCys: 2.26 ± 0.027	7.018AlaAsp: 7.018 ± 0.038	9.108AlaGlu: 9.108 ± 0.083	3.466AlaPhe: 3.466 ± 0.027	19.38AlaGly: 19.38 ± 0.079	2.555AlaHis: 2.555 ± 0.023	2.767AlaIle: 2.767 ± 0.023	3.478AlaLys: 3.478 ± 0.036	16.076AlaLeu: 16.076 ± 0.088	2.255AlaMet: 2.255 ± 0.018	2.101AlaAsn: 2.101 ± 0.023	14.798AlaPro: 14.798 ± 0.094	5.506AlaGln: 5.506 ± 0.04	13.072AlaArg: 13.072 ± 0.071	10.256AlaSer: 10.256 ± 0.05	5.856AlaThr: 5.856 ± 0.033	9.936AlaVal: 9.936 ± 0.051	2.037AlaTrp: 2.037 ± 0.022	1.962AlaTyr: 1.962 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	2.054CysAla: 2.054 ± 0.022	0.466CysCys: 0.466 ± 0.014	0.685CysAsp: 0.685 ± 0.01	0.625CysGlu: 0.625 ± 0.011	0.416CysPhe: 0.416 ± 0.008	1.757CysGly: 1.757 ± 0.021	0.245CysHis: 0.245 ± 0.005	0.375CysIle: 0.375 ± 0.008	0.367CysLys: 0.367 ± 0.009	1.199CysLeu: 1.199 ± 0.017	0.234CysMet: 0.234 ± 0.006	0.314CysAsn: 0.314 ± 0.008	1.016CysPro: 1.016 ± 0.022	0.364CysGln: 0.364 ± 0.008	1.021CysArg: 1.021 ± 0.013	1.109CysSer: 1.109 ± 0.017	0.633CysThr: 0.633 ± 0.012	0.922CysVal: 0.922 ± 0.013	0.246CysTrp: 0.246 ± 0.006	0.253CysTyr: 0.253 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	8.799AspAla: 8.799 ± 0.046	0.719AspCys: 0.719 ± 0.012	2.984AspAsp: 2.984 ± 0.029	2.99AspGlu: 2.99 ± 0.027	1.167AspPhe: 1.167 ± 0.015	5.922AspGly: 5.922 ± 0.032	0.613AspHis: 0.613 ± 0.009	1.022AspIle: 1.022 ± 0.013	1.107AspLys: 1.107 ± 0.019	3.641AspLeu: 3.641 ± 0.024	0.691AspMet: 0.691 ± 0.009	0.668AspAsn: 0.668 ± 0.011	2.789AspPro: 2.789 ± 0.023	1.002AspGln: 1.002 ± 0.013	2.278AspArg: 2.278 ± 0.023	2.473AspSer: 2.473 ± 0.023	1.524AspThr: 1.524 ± 0.015	2.747AspVal: 2.747 ± 0.02	0.729AspTrp: 0.729 ± 0.011	0.892AspTyr: 0.892 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	10.68GluAla: 10.68 ± 0.08	0.567GluCys: 0.567 ± 0.009	2.502GluAsp: 2.502 ± 0.025	4.819GluGlu: 4.819 ± 0.06	1.171GluPhe: 1.171 ± 0.015	5.527GluGly: 5.527 ± 0.038	0.809GluHis: 0.809 ± 0.011	1.039GluIle: 1.039 ± 0.012	1.193GluLys: 1.193 ± 0.019	5.199GluLeu: 5.199 ± 0.034	0.837GluMet: 0.837 ± 0.013	0.559GluAsn: 0.559 ± 0.01	2.995GluPro: 2.995 ± 0.027	2.472GluGln: 2.472 ± 0.028	4.298GluArg: 4.298 ± 0.035	2.092GluSer: 2.092 ± 0.02	1.433GluThr: 1.433 ± 0.014	3.141GluVal: 3.141 ± 0.025	0.788GluTrp: 0.788 ± 0.012	0.758GluTyr: 0.758 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.991PheAla: 2.991 ± 0.025	0.423PheCys: 0.423 ± 0.008	1.518PheAsp: 1.518 ± 0.016	1.463PheGlu: 1.463 ± 0.016	0.824PhePhe: 0.824 ± 0.013	2.483PheGly: 2.483 ± 0.025	0.422PheHis: 0.422 ± 0.009	0.591PheIle: 0.591 ± 0.01	0.792PheLys: 0.792 ± 0.012	1.987PheLeu: 1.987 ± 0.019	0.461PheMet: 0.461 ± 0.008	0.617PheAsn: 0.617 ± 0.01	1.087PhePro: 1.087 ± 0.013	0.648PheGln: 0.648 ± 0.009	1.268PheArg: 1.268 ± 0.013	1.605PheSer: 1.605 ± 0.016	1.08PheThr: 1.08 ± 0.012	1.735PheVal: 1.735 ± 0.018	0.367PheTrp: 0.367 ± 0.007	0.536PheTyr: 0.536 ± 0.009	0.0PheXaa: 0.0 ± 0.0
Gly	20.63GlyAla: 20.63 ± 0.084	1.535GlyCys: 1.535 ± 0.018	5.357GlyAsp: 5.357 ± 0.032	5.173GlyGlu: 5.173 ± 0.034	2.262GlyPhe: 2.262 ± 0.021	28.54GlyGly: 28.54 ± 0.189	1.639GlyHis: 1.639 ± 0.021	1.697GlyIle: 1.697 ± 0.018	2.331GlyLys: 2.331 ± 0.023	7.445GlyLeu: 7.445 ± 0.041	1.428GlyMet: 1.428 ± 0.019	1.413GlyAsn: 1.413 ± 0.017	6.258GlyPro: 6.258 ± 0.038	2.889GlyGln: 2.889 ± 0.025	7.466GlyArg: 7.466 ± 0.044	8.39GlySer: 8.39 ± 0.053	3.381GlyThr: 3.381 ± 0.029	5.379GlyVal: 5.379 ± 0.031	1.419GlyTrp: 1.419 ± 0.016	1.49GlyTyr: 1.49 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.748HisAla: 2.748 ± 0.025	0.304HisCys: 0.304 ± 0.007	0.736HisAsp: 0.736 ± 0.01	0.805HisGlu: 0.805 ± 0.01	0.477HisPhe: 0.477 ± 0.008	1.654HisGly: 1.654 ± 0.018	0.643HisHis: 0.643 ± 0.014	0.459HisIle: 0.459 ± 0.008	0.432HisLys: 0.432 ± 0.008	1.731HisLeu: 1.731 ± 0.018	0.333HisMet: 0.333 ± 0.007	0.331HisAsn: 0.331 ± 0.007	1.306HisPro: 1.306 ± 0.014	0.777HisGln: 0.777 ± 0.014	1.202HisArg: 1.202 ± 0.013	1.021HisSer: 1.021 ± 0.013	0.706HisThr: 0.706 ± 0.009	1.076HisVal: 1.076 ± 0.013	0.269HisTrp: 0.269 ± 0.006	0.381HisTyr: 0.381 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.805IleAla: 2.805 ± 0.022	0.364IleCys: 0.364 ± 0.007	1.219IleAsp: 1.219 ± 0.015	1.213IleGlu: 1.213 ± 0.014	0.564IlePhe: 0.564 ± 0.009	1.687IleGly: 1.687 ± 0.018	0.386IleHis: 0.386 ± 0.007	0.652IleIle: 0.652 ± 0.011	0.849IleLys: 0.849 ± 0.013	1.472IleLeu: 1.472 ± 0.017	0.394IleMet: 0.394 ± 0.008	0.61IleAsn: 0.61 ± 0.01	1.0IlePro: 1.0 ± 0.013	0.594IleGln: 0.594 ± 0.011	1.162IleArg: 1.162 ± 0.013	1.337IleSer: 1.337 ± 0.016	1.151IleThr: 1.151 ± 0.016	1.434IleVal: 1.434 ± 0.018	0.29IleTrp: 0.29 ± 0.006	0.439IleTyr: 0.439 ± 0.009	0.0IleXaa: 0.0 ± 0.0
Lys	3.606LysAla: 3.606 ± 0.04	0.295LysCys: 0.295 ± 0.007	1.042LysAsp: 1.042 ± 0.018	1.373LysGlu: 1.373 ± 0.02	0.576LysPhe: 0.576 ± 0.009	2.075LysGly: 2.075 ± 0.023	0.445LysHis: 0.445 ± 0.009	0.62LysIle: 0.62 ± 0.012	1.291LysLys: 1.291 ± 0.025	2.23LysLeu: 2.23 ± 0.025	0.446LysMet: 0.446 ± 0.009	0.459LysAsn: 0.459 ± 0.008	1.615LysPro: 1.615 ± 0.02	1.116LysGln: 1.116 ± 0.016	2.054LysArg: 2.054 ± 0.022	1.16LysSer: 1.16 ± 0.017	0.996LysThr: 0.996 ± 0.014	1.47LysVal: 1.47 ± 0.02	0.341LysTrp: 0.341 ± 0.007	0.506LysTyr: 0.506 ± 0.009	0.0LysXaa: 0.0 ± 0.0
Leu	14.615LeuAla: 14.615 ± 0.081	1.275LeuCys: 1.275 ± 0.016	4.183LeuAsp: 4.183 ± 0.025	5.118LeuGlu: 5.118 ± 0.033	2.178LeuPhe: 2.178 ± 0.02	7.209LeuGly: 7.209 ± 0.032	1.835LeuHis: 1.835 ± 0.02	1.784LeuIle: 1.784 ± 0.019	2.218LeuLys: 2.218 ± 0.023	10.996LeuLeu: 10.996 ± 0.073	1.544LeuMet: 1.544 ± 0.016	1.457LeuAsn: 1.457 ± 0.016	6.977LeuPro: 6.977 ± 0.043	4.371LeuGln: 4.371 ± 0.034	7.816LeuArg: 7.816 ± 0.044	5.765LeuSer: 5.765 ± 0.035	3.473LeuThr: 3.473 ± 0.027	5.316LeuVal: 5.316 ± 0.033	1.156LeuTrp: 1.156 ± 0.015	1.418LeuTyr: 1.418 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	2.505MetAla: 2.505 ± 0.018	0.201MetCys: 0.201 ± 0.006	0.704MetAsp: 0.704 ± 0.01	0.847MetGlu: 0.847 ± 0.01	0.38MetPhe: 0.38 ± 0.007	1.336MetGly: 1.336 ± 0.016	0.311MetHis: 0.311 ± 0.007	0.323MetIle: 0.323 ± 0.007	0.352MetLys: 0.352 ± 0.008	1.623MetLeu: 1.623 ± 0.018	0.348MetMet: 0.348 ± 0.007	0.248MetAsn: 0.248 ± 0.006	1.009MetPro: 1.009 ± 0.012	0.798MetGln: 0.798 ± 0.014	1.264MetArg: 1.264 ± 0.014	0.858MetSer: 0.858 ± 0.013	0.578MetThr: 0.578 ± 0.009	0.882MetVal: 0.882 ± 0.013	0.185MetTrp: 0.185 ± 0.005	0.253MetTyr: 0.253 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.141AsnAla: 2.141 ± 0.022	0.277AsnCys: 0.277 ± 0.007	0.664AsnAsp: 0.664 ± 0.01	0.699AsnGlu: 0.699 ± 0.01	0.492AsnPhe: 0.492 ± 0.007	1.747AsnGly: 1.747 ± 0.021	0.26AsnHis: 0.26 ± 0.005	0.532AsnIle: 0.532 ± 0.009	0.543AsnLys: 0.543 ± 0.01	1.331AsnLeu: 1.331 ± 0.016	0.321AsnMet: 0.321 ± 0.007	0.406AsnAsn: 0.406 ± 0.009	1.07AsnPro: 1.07 ± 0.015	0.422AsnGln: 0.422 ± 0.008	0.832AsnArg: 0.832 ± 0.012	0.931AsnSer: 0.931 ± 0.013	0.782AsnThr: 0.782 ± 0.012	1.039AsnVal: 1.039 ± 0.014	0.244AsnTrp: 0.244 ± 0.006	0.376AsnTyr: 0.376 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	14.194ProAla: 14.194 ± 0.088	0.938ProCys: 0.938 ± 0.017	2.888ProAsp: 2.888 ± 0.02	3.51ProGlu: 3.51 ± 0.023	1.492ProPhe: 1.492 ± 0.016	7.396ProGly: 7.396 ± 0.043	1.294ProHis: 1.294 ± 0.013	1.087ProIle: 1.087 ± 0.012	1.509ProLys: 1.509 ± 0.02	6.3ProLeu: 6.3 ± 0.041	0.851ProMet: 0.851 ± 0.013	0.981ProAsn: 0.981 ± 0.014	10.725ProPro: 10.725 ± 0.093	3.558ProGln: 3.558 ± 0.042	5.482ProArg: 5.482 ± 0.035	4.964ProSer: 4.964 ± 0.033	2.426ProThr: 2.426 ± 0.018	3.261ProVal: 3.261 ± 0.028	0.999ProTrp: 0.999 ± 0.019	0.913ProTyr: 0.913 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	5.162GlnAla: 5.162 ± 0.044	0.369GlnCys: 0.369 ± 0.008	1.102GlnAsp: 1.102 ± 0.013	2.171GlnGlu: 2.171 ± 0.028	0.63GlnPhe: 0.63 ± 0.01	2.549GlnGly: 2.549 ± 0.021	1.131GlnHis: 1.131 ± 0.018	0.753GlnIle: 0.753 ± 0.011	0.796GlnLys: 0.796 ± 0.013	4.637GlnLeu: 4.637 ± 0.036	0.6GlnMet: 0.6 ± 0.011	0.41GlnAsn: 0.41 ± 0.009	3.959GlnPro: 3.959 ± 0.046	10.698GlnGln: 10.698 ± 0.188	3.814GlnArg: 3.814 ± 0.032	1.57GlnSer: 1.57 ± 0.016	0.996GlnThr: 0.996 ± 0.011	1.68GlnVal: 1.68 ± 0.017	0.604GlnTrp: 0.604 ± 0.017	0.547GlnTyr: 0.547 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	12.587ArgAla: 12.587 ± 0.066	1.126ArgCys: 1.126 ± 0.016	3.124ArgAsp: 3.124 ± 0.024	3.868ArgGlu: 3.868 ± 0.03	1.623ArgPhe: 1.623 ± 0.016	7.69ArgGly: 7.69 ± 0.047	1.54ArgHis: 1.54 ± 0.016	1.518ArgIle: 1.518 ± 0.014	1.626ArgLys: 1.626 ± 0.017	7.585ArgLeu: 7.585 ± 0.048	1.16ArgMet: 1.16 ± 0.013	0.937ArgAsn: 0.937 ± 0.013	5.07ArgPro: 5.07 ± 0.034	3.108ArgGln: 3.108 ± 0.027	8.437ArgArg: 8.437 ± 0.055	4.195ArgSer: 4.195 ± 0.035	2.417ArgThr: 2.417 ± 0.02	4.169ArgVal: 4.169 ± 0.027	1.02ArgTrp: 1.02 ± 0.014	1.11ArgTyr: 1.11 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	9.21SerAla: 9.21 ± 0.046	0.949SerCys: 0.949 ± 0.014	3.064SerAsp: 3.064 ± 0.026	2.887SerGlu: 2.887 ± 0.024	1.611SerPhe: 1.611 ± 0.016	8.637SerGly: 8.637 ± 0.054	0.967SerHis: 0.967 ± 0.012	1.342SerIle: 1.342 ± 0.017	1.548SerLys: 1.548 ± 0.018	5.07SerLeu: 5.07 ± 0.034	0.945SerMet: 0.945 ± 0.013	1.08SerAsn: 1.08 ± 0.014	4.772SerPro: 4.772 ± 0.044	1.715SerGln: 1.715 ± 0.018	3.853SerArg: 3.853 ± 0.029	6.004SerSer: 6.004 ± 0.052	2.396SerThr: 2.396 ± 0.02	3.173SerVal: 3.173 ± 0.025	0.818SerTrp: 0.818 ± 0.011	0.986SerTyr: 0.986 ± 0.014	0.0SerXaa: 0.0 ± 0.0
Thr	5.979ThrAla: 5.979 ± 0.036	0.745ThrCys: 0.745 ± 0.02	1.488ThrAsp: 1.488 ± 0.019	1.446ThrGlu: 1.446 ± 0.014	1.046ThrPhe: 1.046 ± 0.013	3.353ThrGly: 3.353 ± 0.028	0.644ThrHis: 0.644 ± 0.011	0.961ThrIle: 0.961 ± 0.014	0.944ThrLys: 0.944 ± 0.014	3.507ThrLeu: 3.507 ± 0.029	0.556ThrMet: 0.556 ± 0.01	0.751ThrAsn: 0.751 ± 0.012	3.072ThrPro: 3.072 ± 0.027	1.118ThrGln: 1.118 ± 0.015	2.236ThrArg: 2.236 ± 0.018	2.213ThrSer: 2.213 ± 0.019	1.757ThrThr: 1.757 ± 0.024	2.365ThrVal: 2.365 ± 0.026	0.499ThrTrp: 0.499 ± 0.009	0.727ThrTyr: 0.727 ± 0.011	0.0ThrXaa: 0.0 ± 0.0
Val	9.364ValAla: 9.364 ± 0.042	0.938ValCys: 0.938 ± 0.013	2.818ValAsp: 2.818 ± 0.021	3.173ValGlu: 3.173 ± 0.027	1.676ValPhe: 1.676 ± 0.019	4.329ValGly: 4.329 ± 0.029	1.04ValHis: 1.04 ± 0.014	1.401ValIle: 1.401 ± 0.015	1.565ValLys: 1.565 ± 0.022	5.831ValLeu: 5.831 ± 0.036	1.035ValMet: 1.035 ± 0.013	1.085ValAsn: 1.085 ± 0.014	3.73ValPro: 3.73 ± 0.026	1.859ValGln: 1.859 ± 0.018	3.915ValArg: 3.915 ± 0.025	3.287ValSer: 3.287 ± 0.023	2.533ValThr: 2.533 ± 0.024	4.402ValVal: 4.402 ± 0.032	0.834ValTrp: 0.834 ± 0.012	1.094ValTyr: 1.094 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	1.843TrpAla: 1.843 ± 0.026	0.208TrpCys: 0.208 ± 0.006	0.774TrpAsp: 0.774 ± 0.014	0.74TrpGlu: 0.74 ± 0.011	0.332TrpPhe: 0.332 ± 0.008	1.29TrpGly: 1.29 ± 0.015	0.296TrpHis: 0.296 ± 0.006	0.252TrpIle: 0.252 ± 0.006	0.266TrpLys: 0.266 ± 0.006	1.47TrpLeu: 1.47 ± 0.017	0.251TrpMet: 0.251 ± 0.006	0.259TrpAsn: 0.259 ± 0.007	0.786TrpPro: 0.786 ± 0.011	0.675TrpGln: 0.675 ± 0.011	1.42TrpArg: 1.42 ± 0.018	0.744TrpSer: 0.744 ± 0.011	0.517TrpThr: 0.517 ± 0.01	0.726TrpVal: 0.726 ± 0.011	0.271TrpTrp: 0.271 ± 0.006	0.24TrpTyr: 0.24 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.973TyrAla: 1.973 ± 0.02	0.344TyrCys: 0.344 ± 0.008	0.887TyrAsp: 0.887 ± 0.013	0.853TyrGlu: 0.853 ± 0.012	0.511TyrPhe: 0.511 ± 0.01	1.561TyrGly: 1.561 ± 0.023	0.313TyrHis: 0.313 ± 0.008	0.447TyrIle: 0.447 ± 0.008	0.509TyrLys: 0.509 ± 0.011	1.376TyrLeu: 1.376 ± 0.015	0.316TyrMet: 0.316 ± 0.007	0.422TyrAsn: 0.422 ± 0.008	0.736TyrPro: 0.736 ± 0.012	0.486TyrGln: 0.486 ± 0.009	1.02TyrArg: 1.02 ± 0.014	1.054TyrSer: 1.054 ± 0.015	0.771TyrThr: 0.771 ± 0.013	1.053TyrVal: 1.053 ± 0.013	0.247TyrTrp: 0.247 ± 0.006	0.482TyrTyr: 0.482 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13347 proteins (7490027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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