human papillomavirus 86

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 3

Average proteome isoelectric point is 6.52

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|Q91AX6|Q91AX6_9PAPI Protein E6 OS=human papillomavirus 86 OX=171370 GN=E6 PE=3 SV=1
MM1 pKa = 7.54HH2 pKa = 7.11GQTPTIKK9 pKa = 10.6DD10 pKa = 3.14IVLCEE15 pKa = 3.95IPDD18 pKa = 3.88VVNLHH23 pKa = 6.93CDD25 pKa = 3.4EE26 pKa = 4.45QLLDD30 pKa = 3.78SSEE33 pKa = 4.49EE34 pKa = 4.0EE35 pKa = 4.46DD36 pKa = 5.9NRR38 pKa = 11.84DD39 pKa = 3.3CDD41 pKa = 4.0QPAEE45 pKa = 4.17PAQLAYY51 pKa = 10.12RR52 pKa = 11.84VLTEE56 pKa = 4.4CGLCRR61 pKa = 11.84RR62 pKa = 11.84PLKK65 pKa = 10.78LVVRR69 pKa = 11.84CGAEE73 pKa = 4.4DD74 pKa = 4.03LRR76 pKa = 11.84QLQQLMVDD84 pKa = 4.51AVALVCPGCAA94 pKa = 3.55

Molecular weight: 10.42 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q91AX3|Q91AX3_9PAPI Regulatory protein E2 OS=human papillomavirus 86 OX=171370 GN=E2 PE=3 SV=1
MM1 pKa = 7.77WEE3 pKa = 3.91AQLFTMHH10 pKa = 6.42ATLYY14 pKa = 9.28PVLRR18 pKa = 11.84EE19 pKa = 3.75EE20 pKa = 5.15CRR22 pKa = 11.84YY23 pKa = 9.67PLLKK27 pKa = 10.39LLHH30 pKa = 6.32SRR32 pKa = 11.84CTPPPRR38 pKa = 11.84PPPPPPRR45 pKa = 11.84KK46 pKa = 9.19PPRR49 pKa = 11.84CRR51 pKa = 11.84RR52 pKa = 11.84RR53 pKa = 11.84LLSDD57 pKa = 3.32SGSEE61 pKa = 3.71ATAYY65 pKa = 10.4SSPTLQEE72 pKa = 4.03TSEE75 pKa = 4.4HH76 pKa = 5.8SWTVASQGHH85 pKa = 7.06KK86 pKa = 9.08ITLTSHH92 pKa = 6.41SGRR95 pKa = 11.84GTTVTVTVHH104 pKa = 7.27LSFTT108 pKa = 3.79

Molecular weight: 12.16 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2359

94

652

337.0

37.54

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.359 ± 0.425

2.543 ± 0.77

5.85 ± 0.456

5.341 ± 0.666

3.561 ± 0.451

6.867 ± 0.357

2.755 ± 0.54

3.646 ± 0.579

4.663 ± 0.763

8.436 ± 0.645

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.95 ± 0.316

3.052 ± 0.525

6.825 ± 1.138

4.705 ± 0.62

5.68 ± 0.256

8.181 ± 0.984

7.334 ± 0.848

7.037 ± 0.414

1.653 ± 0.387

3.561 ± 0.415
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski