Human papillomavirus 116

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 9

Average proteome isoelectric point is 6.35

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|C7B7D8|C7B7D8_9PAPI Major capsid protein L1 OS=Human papillomavirus 116 OX=915428 GN=L1 PE=3 SV=1
MM1 pKa = 6.73MRR3 pKa = 11.84IRR5 pKa = 11.84RR6 pKa = 11.84KK7 pKa = 9.63RR8 pKa = 11.84ASPTDD13 pKa = 3.26LHH15 pKa = 6.82RR16 pKa = 11.84SCALGGDD23 pKa = 4.38CFPDD27 pKa = 3.63VEE29 pKa = 4.79NKK31 pKa = 10.71LSGNTLADD39 pKa = 3.31ILLKK43 pKa = 10.95AFGSILYY50 pKa = 9.92LGNLGIGTGKK60 pKa = 10.75GGGGQYY66 pKa = 10.87GYY68 pKa = 9.03TPFGGTRR75 pKa = 11.84PSISRR80 pKa = 11.84APVRR84 pKa = 11.84PAIPVDD90 pKa = 3.62TVVPGEE96 pKa = 4.18VLPVTPLDD104 pKa = 3.69PAIVPLTDD112 pKa = 4.11GLPEE116 pKa = 3.95PAVIDD121 pKa = 3.77VPGAGPGLPTEE132 pKa = 4.75TIDD135 pKa = 3.72VTTEE139 pKa = 3.56LDD141 pKa = 3.63LVSEE145 pKa = 4.36VTGVGEE151 pKa = 4.54HH152 pKa = 7.02PSVTYY157 pKa = 8.35DD158 pKa = 3.47TNNVAQIDD166 pKa = 4.35VQVQPPPPKK175 pKa = 10.18RR176 pKa = 11.84ILLDD180 pKa = 3.32TSITDD185 pKa = 3.27TEE187 pKa = 4.61LAVQTHH193 pKa = 6.81ASHH196 pKa = 7.32VDD198 pKa = 2.78EE199 pKa = 5.45HH200 pKa = 7.92YY201 pKa = 11.37NVFVDD206 pKa = 3.93AQFHH210 pKa = 6.37GEE212 pKa = 4.12HH213 pKa = 6.47IGAFEE218 pKa = 4.27PEE220 pKa = 4.47SIEE223 pKa = 3.85LQEE226 pKa = 3.94INLRR230 pKa = 11.84QEE232 pKa = 3.99FEE234 pKa = 3.89IDD236 pKa = 3.25EE237 pKa = 4.84GPLRR241 pKa = 11.84STPLSSRR248 pKa = 11.84AISRR252 pKa = 11.84ARR254 pKa = 11.84DD255 pKa = 3.24LYY257 pKa = 10.83NRR259 pKa = 11.84YY260 pKa = 8.37VQQVPTTQLASVSTPRR276 pKa = 11.84VTFEE280 pKa = 3.97FEE282 pKa = 3.88NPAFEE287 pKa = 5.61AEE289 pKa = 4.1IADD292 pKa = 3.68VFNRR296 pKa = 11.84EE297 pKa = 4.04VQEE300 pKa = 4.95LATQGQDD307 pKa = 2.95EE308 pKa = 5.19AGTDD312 pKa = 4.63LIRR315 pKa = 11.84LSDD318 pKa = 3.31IRR320 pKa = 11.84YY321 pKa = 8.73GEE323 pKa = 4.4SPAGTVRR330 pKa = 11.84VSRR333 pKa = 11.84LGQRR337 pKa = 11.84EE338 pKa = 4.1GMIMRR343 pKa = 11.84SGLQVGQRR351 pKa = 11.84VHH353 pKa = 7.1FYY355 pKa = 11.11YY356 pKa = 10.66DD357 pKa = 3.39ISPIPKK363 pKa = 9.48EE364 pKa = 4.18AIEE367 pKa = 4.04LRR369 pKa = 11.84TFGEE373 pKa = 4.34YY374 pKa = 8.98SHH376 pKa = 7.3EE377 pKa = 4.13YY378 pKa = 9.53TVVDD382 pKa = 4.66DD383 pKa = 4.6LASSSFINPFEE394 pKa = 4.11QPVDD398 pKa = 3.56GSLEE402 pKa = 3.94FSDD405 pKa = 4.65AALIDD410 pKa = 3.96SVEE413 pKa = 4.03EE414 pKa = 4.33DD415 pKa = 3.65FSGTHH420 pKa = 7.6LILTSANAADD430 pKa = 4.77SIDD433 pKa = 3.73IPVIPPGIGVRR444 pKa = 11.84VFVDD448 pKa = 4.99DD449 pKa = 3.83YY450 pKa = 12.01AKK452 pKa = 10.64GLSVLHH458 pKa = 5.91PTIIDD463 pKa = 3.3NGAIYY468 pKa = 8.15PTDD471 pKa = 3.22ISSNILPLTPSFSIDD486 pKa = 3.39VNYY489 pKa = 10.76SDD491 pKa = 5.76YY492 pKa = 11.17NIHH495 pKa = 6.93PANIRR500 pKa = 11.84RR501 pKa = 11.84KK502 pKa = 8.5RR503 pKa = 11.84KK504 pKa = 9.36HH505 pKa = 6.09SSSLYY510 pKa = 9.47FF511 pKa = 3.99

Molecular weight: 55.66 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|C7B7D6|C7B7D6_9PAPI Putative E4 protein OS=Human papillomavirus 116 OX=915428 PE=4 SV=1
MM1 pKa = 6.92NQSDD5 pKa = 3.78LTEE8 pKa = 4.6RR9 pKa = 11.84LDD11 pKa = 4.06ALQTALMNIYY21 pKa = 10.27EE22 pKa = 4.51EE23 pKa = 5.02APTDD27 pKa = 3.64LPSQIRR33 pKa = 11.84HH34 pKa = 5.92FDD36 pKa = 3.78LLRR39 pKa = 11.84KK40 pKa = 9.8QSVLEE45 pKa = 3.91YY46 pKa = 9.14YY47 pKa = 9.93VRR49 pKa = 11.84KK50 pKa = 9.92EE51 pKa = 4.05GYY53 pKa = 6.85TQLGLYY59 pKa = 9.24HH60 pKa = 7.25IPTLKK65 pKa = 10.07VSEE68 pKa = 4.27YY69 pKa = 9.71HH70 pKa = 6.11AKK72 pKa = 10.11EE73 pKa = 4.22AIKK76 pKa = 9.97MGIVLRR82 pKa = 11.84SLQKK86 pKa = 10.46SPYY89 pKa = 10.13ADD91 pKa = 4.26EE92 pKa = 4.3EE93 pKa = 4.33WSLQDD98 pKa = 3.76VNADD102 pKa = 3.99FFNSPPRR109 pKa = 11.84NCFKK113 pKa = 10.91KK114 pKa = 10.11GGYY117 pKa = 9.23DD118 pKa = 3.31VEE120 pKa = 4.3VWFDD124 pKa = 3.96HH125 pKa = 6.75NPLNTFPYY133 pKa = 9.99TNWTWIYY140 pKa = 10.45YY141 pKa = 9.84QDD143 pKa = 5.8DD144 pKa = 3.78EE145 pKa = 4.96EE146 pKa = 4.48NWHH149 pKa = 6.0KK150 pKa = 11.03VQGEE154 pKa = 4.02TDD156 pKa = 3.79YY157 pKa = 11.87NGLFYY162 pKa = 10.93RR163 pKa = 11.84EE164 pKa = 3.67TDD166 pKa = 3.28GTVVYY171 pKa = 9.83FLLFEE176 pKa = 4.73SDD178 pKa = 2.89AARR181 pKa = 11.84YY182 pKa = 6.31GTKK185 pKa = 10.36NEE187 pKa = 3.55WTVNVKK193 pKa = 10.34NEE195 pKa = 4.31QISLPANSNGRR206 pKa = 11.84RR207 pKa = 11.84SSSGTPTHH215 pKa = 6.0STTNSVAEE223 pKa = 4.37PGPSRR228 pKa = 11.84STEE231 pKa = 3.86EE232 pKa = 3.6ADD234 pKa = 4.58GRR236 pKa = 11.84RR237 pKa = 11.84TPQAQTQSVGASKK250 pKa = 10.66KK251 pKa = 8.38PSSVGRR257 pKa = 11.84RR258 pKa = 11.84RR259 pKa = 11.84RR260 pKa = 11.84RR261 pKa = 11.84KK262 pKa = 9.24QGKK265 pKa = 5.35QTPSKK270 pKa = 10.3RR271 pKa = 11.84RR272 pKa = 11.84RR273 pKa = 11.84TGGGSGDD280 pKa = 3.73EE281 pKa = 4.32ADD283 pKa = 3.96SGGISAEE290 pKa = 4.19EE291 pKa = 4.12VGSSHH296 pKa = 7.33RR297 pKa = 11.84SVARR301 pKa = 11.84SGLSRR306 pKa = 11.84LEE308 pKa = 3.96RR309 pKa = 11.84LQKK312 pKa = 9.91EE313 pKa = 3.89ARR315 pKa = 11.84DD316 pKa = 3.74PYY318 pKa = 10.26IILVRR323 pKa = 11.84GPQNTLKK330 pKa = 10.01CWRR333 pKa = 11.84YY334 pKa = 10.03RR335 pKa = 11.84IQTKK339 pKa = 10.85ANFPFLYY346 pKa = 10.13ISTVWKK352 pKa = 9.67WVTKK356 pKa = 10.4DD357 pKa = 3.4AVGHH361 pKa = 5.7EE362 pKa = 4.25GRR364 pKa = 11.84VLIAFLSKK372 pKa = 10.58EE373 pKa = 4.15SRR375 pKa = 11.84DD376 pKa = 3.48LFANSVHH383 pKa = 6.02FPKK386 pKa = 9.95NTTHH390 pKa = 7.24SYY392 pKa = 11.32GSLDD396 pKa = 3.38ALL398 pKa = 4.28

Molecular weight: 45.38 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2396

98

602

342.3

38.71

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.676 ± 0.27

2.337 ± 1.016

6.553 ± 0.294

6.386 ± 0.687

4.382 ± 0.539

5.676 ± 0.838

2.295 ± 0.194

4.967 ± 0.692

5.05 ± 0.761

9.641 ± 0.831

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.461 ± 0.27

5.092 ± 0.469

6.01 ± 1.006

4.007 ± 0.421

6.052 ± 0.807

7.095 ± 0.7

6.177 ± 0.617

6.344 ± 0.513

1.252 ± 0.321

3.548 ± 0.391
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski