Amino acid dipepetide frequency for Aminicella lysinilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.435AlaAla: 7.435 ± 0.15
1.227AlaCys: 1.227 ± 0.047
5.155AlaAsp: 5.155 ± 0.101
5.464AlaGlu: 5.464 ± 0.101
3.037AlaPhe: 3.037 ± 0.088
6.637AlaGly: 6.637 ± 0.122
1.106AlaHis: 1.106 ± 0.043
5.819AlaIle: 5.819 ± 0.104
5.262AlaLys: 5.262 ± 0.103
6.704AlaLeu: 6.704 ± 0.116
2.725AlaMet: 2.725 ± 0.078
2.73AlaAsn: 2.73 ± 0.061
2.051AlaPro: 2.051 ± 0.055
1.981AlaGln: 1.981 ± 0.054
3.177AlaArg: 3.177 ± 0.077
4.28AlaSer: 4.28 ± 0.083
4.188AlaThr: 4.188 ± 0.096
6.149AlaVal: 6.149 ± 0.087
0.55AlaTrp: 0.55 ± 0.032
2.745AlaTyr: 2.745 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
1.106CysAla: 1.106 ± 0.041
0.272CysCys: 0.272 ± 0.023
0.925CysAsp: 0.925 ± 0.034
0.844CysGlu: 0.844 ± 0.038
0.523CysPhe: 0.523 ± 0.031
1.591CysGly: 1.591 ± 0.057
0.315CysHis: 0.315 ± 0.021
1.099CysIle: 1.099 ± 0.042
0.952CysLys: 0.952 ± 0.039
1.065CysLeu: 1.065 ± 0.04
0.454CysMet: 0.454 ± 0.024
0.658CysAsn: 0.658 ± 0.035
0.682CysPro: 0.682 ± 0.04
0.342CysGln: 0.342 ± 0.022
0.726CysArg: 0.726 ± 0.035
0.928CysSer: 0.928 ± 0.038
0.752CysThr: 0.752 ± 0.036
1.022CysVal: 1.022 ± 0.04
0.116CysTrp: 0.116 ± 0.013
0.551CysTyr: 0.551 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
4.463AspAla: 4.463 ± 0.095
0.9AspCys: 0.9 ± 0.041
3.922AspAsp: 3.922 ± 0.087
4.901AspGlu: 4.901 ± 0.101
2.779AspPhe: 2.779 ± 0.066
4.604AspGly: 4.604 ± 0.104
1.093AspHis: 1.093 ± 0.046
5.29AspIle: 5.29 ± 0.115
4.683AspLys: 4.683 ± 0.079
5.115AspLeu: 5.115 ± 0.108
2.397AspMet: 2.397 ± 0.066
2.757AspAsn: 2.757 ± 0.067
2.287AspPro: 2.287 ± 0.062
1.481AspGln: 1.481 ± 0.05
2.77AspArg: 2.77 ± 0.069
3.573AspSer: 3.573 ± 0.091
3.29AspThr: 3.29 ± 0.081
4.245AspVal: 4.245 ± 0.079
0.471AspTrp: 0.471 ± 0.024
2.954AspTyr: 2.954 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.434GluAla: 5.434 ± 0.107
0.749GluCys: 0.749 ± 0.033
4.279GluAsp: 4.279 ± 0.083
5.382GluGlu: 5.382 ± 0.113
2.516GluPhe: 2.516 ± 0.066
4.194GluGly: 4.194 ± 0.084
1.153GluHis: 1.153 ± 0.049
5.275GluIle: 5.275 ± 0.094
5.807GluLys: 5.807 ± 0.107
5.944GluLeu: 5.944 ± 0.117
2.339GluMet: 2.339 ± 0.063
3.441GluAsn: 3.441 ± 0.083
1.753GluPro: 1.753 ± 0.055
1.993GluGln: 1.993 ± 0.061
3.009GluArg: 3.009 ± 0.077
3.496GluSer: 3.496 ± 0.095
3.376GluThr: 3.376 ± 0.082
4.0GluVal: 4.0 ± 0.085
0.441GluTrp: 0.441 ± 0.031
2.82GluTyr: 2.82 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.125PheAla: 3.125 ± 0.077
0.694PheCys: 0.694 ± 0.038
2.661PheAsp: 2.661 ± 0.066
2.274PheGlu: 2.274 ± 0.06
1.64PhePhe: 1.64 ± 0.056
3.211PheGly: 3.211 ± 0.073
0.67PheHis: 0.67 ± 0.032
2.904PheIle: 2.904 ± 0.072
2.385PheLys: 2.385 ± 0.06
3.109PheLeu: 3.109 ± 0.079
1.237PheMet: 1.237 ± 0.048
1.757PheAsn: 1.757 ± 0.047
1.222PhePro: 1.222 ± 0.042
0.916PheGln: 0.916 ± 0.041
1.537PheArg: 1.537 ± 0.056
2.54PheSer: 2.54 ± 0.063
2.372PheThr: 2.372 ± 0.072
2.846PheVal: 2.846 ± 0.081
0.336PheTrp: 0.336 ± 0.023
1.439PheTyr: 1.439 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
5.506GlyAla: 5.506 ± 0.103
1.224GlyCys: 1.224 ± 0.055
4.364GlyAsp: 4.364 ± 0.082
4.317GlyGlu: 4.317 ± 0.082
3.161GlyPhe: 3.161 ± 0.078
5.639GlyGly: 5.639 ± 0.124
1.411GlyHis: 1.411 ± 0.051
6.262GlyIle: 6.262 ± 0.096
5.896GlyLys: 5.896 ± 0.111
6.135GlyLeu: 6.135 ± 0.116
2.425GlyMet: 2.425 ± 0.058
3.365GlyAsn: 3.365 ± 0.077
1.554GlyPro: 1.554 ± 0.053
1.983GlyGln: 1.983 ± 0.048
3.511GlyArg: 3.511 ± 0.08
4.468GlySer: 4.468 ± 0.097
4.69GlyThr: 4.69 ± 0.103
5.369GlyVal: 5.369 ± 0.097
0.652GlyTrp: 0.652 ± 0.038
3.26GlyTyr: 3.26 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.001HisAla: 1.001 ± 0.038
0.324HisCys: 0.324 ± 0.02
0.968HisAsp: 0.968 ± 0.037
1.046HisGlu: 1.046 ± 0.043
0.652HisPhe: 0.652 ± 0.03
1.356HisGly: 1.356 ± 0.048
0.377HisHis: 0.377 ± 0.039
1.32HisIle: 1.32 ± 0.044
1.083HisLys: 1.083 ± 0.044
1.249HisLeu: 1.249 ± 0.044
0.548HisMet: 0.548 ± 0.028
0.72HisAsn: 0.72 ± 0.035
0.799HisPro: 0.799 ± 0.036
0.441HisGln: 0.441 ± 0.025
0.737HisArg: 0.737 ± 0.037
0.949HisSer: 0.949 ± 0.038
0.875HisThr: 0.875 ± 0.035
1.066HisVal: 1.066 ± 0.041
0.107HisTrp: 0.107 ± 0.014
0.68HisTyr: 0.68 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.978IleAla: 5.978 ± 0.1
1.347IleCys: 1.347 ± 0.046
5.027IleAsp: 5.027 ± 0.09
4.851IleGlu: 4.851 ± 0.091
2.985IlePhe: 2.985 ± 0.086
5.437IleGly: 5.437 ± 0.105
1.138IleHis: 1.138 ± 0.047
5.822IleIle: 5.822 ± 0.11
5.002IleLys: 5.002 ± 0.089
6.086IleLeu: 6.086 ± 0.118
2.516IleMet: 2.516 ± 0.057
3.395IleAsn: 3.395 ± 0.06
2.77IlePro: 2.77 ± 0.067
1.735IleGln: 1.735 ± 0.052
3.315IleArg: 3.315 ± 0.07
5.137IleSer: 5.137 ± 0.093
4.548IleThr: 4.548 ± 0.094
5.599IleVal: 5.599 ± 0.08
0.544IleTrp: 0.544 ± 0.03
2.682IleTyr: 2.682 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
6.027LysAla: 6.027 ± 0.1
0.836LysCys: 0.836 ± 0.039
4.716LysAsp: 4.716 ± 0.097
5.428LysGlu: 5.428 ± 0.11
2.142LysPhe: 2.142 ± 0.056
4.873LysGly: 4.873 ± 0.084
1.086LysHis: 1.086 ± 0.046
4.974LysIle: 4.974 ± 0.081
5.966LysLys: 5.966 ± 0.118
5.767LysLeu: 5.767 ± 0.091
2.382LysMet: 2.382 ± 0.059
3.548LysAsn: 3.548 ± 0.076
2.223LysPro: 2.223 ± 0.061
1.839LysGln: 1.839 ± 0.052
2.856LysArg: 2.856 ± 0.063
4.147LysSer: 4.147 ± 0.076
4.254LysThr: 4.254 ± 0.101
5.066LysVal: 5.066 ± 0.102
0.551LysTrp: 0.551 ± 0.025
3.376LysTyr: 3.376 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
6.783LeuAla: 6.783 ± 0.111
1.35LeuCys: 1.35 ± 0.043
5.065LeuAsp: 5.065 ± 0.094
5.099LeuGlu: 5.099 ± 0.096
3.244LeuPhe: 3.244 ± 0.078
5.916LeuGly: 5.916 ± 0.094
1.288LeuHis: 1.288 ± 0.051
6.073LeuIle: 6.073 ± 0.121
5.859LeuLys: 5.859 ± 0.101
6.921LeuLeu: 6.921 ± 0.131
2.664LeuMet: 2.664 ± 0.059
3.508LeuAsn: 3.508 ± 0.065
3.057LeuPro: 3.057 ± 0.074
2.171LeuGln: 2.171 ± 0.054
3.587LeuArg: 3.587 ± 0.088
5.773LeuSer: 5.773 ± 0.104
4.854LeuThr: 4.854 ± 0.083
5.466LeuVal: 5.466 ± 0.099
0.651LeuTrp: 0.651 ± 0.032
2.825LeuTyr: 2.825 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
3.006MetAla: 3.006 ± 0.076
0.346MetCys: 0.346 ± 0.022
2.283MetAsp: 2.283 ± 0.053
2.255MetGlu: 2.255 ± 0.063
1.132MetPhe: 1.132 ± 0.045
2.372MetGly: 2.372 ± 0.06
0.508MetHis: 0.508 ± 0.027
2.333MetIle: 2.333 ± 0.063
2.681MetLys: 2.681 ± 0.055
2.629MetLeu: 2.629 ± 0.06
1.043MetMet: 1.043 ± 0.038
1.649MetAsn: 1.649 ± 0.047
1.182MetPro: 1.182 ± 0.042
0.842MetGln: 0.842 ± 0.032
1.298MetArg: 1.298 ± 0.046
2.084MetSer: 2.084 ± 0.057
1.955MetThr: 1.955 ± 0.049
2.076MetVal: 2.076 ± 0.056
0.215MetTrp: 0.215 ± 0.017
0.994MetTyr: 0.994 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.073AsnAla: 3.073 ± 0.078
0.673AsnCys: 0.673 ± 0.029
2.685AsnAsp: 2.685 ± 0.071
2.754AsnGlu: 2.754 ± 0.062
1.576AsnPhe: 1.576 ± 0.046
3.395AsnGly: 3.395 ± 0.081
0.719AsnHis: 0.719 ± 0.03
3.677AsnIle: 3.677 ± 0.079
3.33AsnLys: 3.33 ± 0.078
3.49AsnLeu: 3.49 ± 0.076
1.487AsnMet: 1.487 ± 0.044
2.136AsnAsn: 2.136 ± 0.072
1.604AsnPro: 1.604 ± 0.046
1.169AsnGln: 1.169 ± 0.044
2.045AsnArg: 2.045 ± 0.057
2.63AsnSer: 2.63 ± 0.074
2.408AsnThr: 2.408 ± 0.06
3.016AsnVal: 3.016 ± 0.072
0.414AsnTrp: 0.414 ± 0.025
1.944AsnTyr: 1.944 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
2.546ProAla: 2.546 ± 0.066
0.44ProCys: 0.44 ± 0.028
2.406ProAsp: 2.406 ± 0.056
2.96ProGlu: 2.96 ± 0.072
1.359ProPhe: 1.359 ± 0.041
2.483ProGly: 2.483 ± 0.066
0.463ProHis: 0.463 ± 0.028
2.096ProIle: 2.096 ± 0.056
2.048ProLys: 2.048 ± 0.054
2.58ProLeu: 2.58 ± 0.065
0.955ProMet: 0.955 ± 0.035
1.133ProAsn: 1.133 ± 0.042
0.752ProPro: 0.752 ± 0.033
0.881ProGln: 0.881 ± 0.034
1.019ProArg: 1.019 ± 0.04
1.818ProSer: 1.818 ± 0.052
1.6ProThr: 1.6 ± 0.053
2.816ProVal: 2.816 ± 0.062
0.319ProTrp: 0.319 ± 0.023
1.357ProTyr: 1.357 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.085GlnAla: 2.085 ± 0.06
0.408GlnCys: 0.408 ± 0.023
1.288GlnAsp: 1.288 ± 0.037
1.617GlnGlu: 1.617 ± 0.049
0.936GlnPhe: 0.936 ± 0.033
1.733GlnGly: 1.733 ± 0.055
0.438GlnHis: 0.438 ± 0.027
1.977GlnIle: 1.977 ± 0.045
1.98GlnLys: 1.98 ± 0.057
2.464GlnLeu: 2.464 ± 0.072
0.989GlnMet: 0.989 ± 0.038
1.083GlnAsn: 1.083 ± 0.041
0.714GlnPro: 0.714 ± 0.034
0.864GlnGln: 0.864 ± 0.036
1.222GlnArg: 1.222 ± 0.048
1.433GlnSer: 1.433 ± 0.044
1.374GlnThr: 1.374 ± 0.046
1.897GlnVal: 1.897 ± 0.048
0.257GlnTrp: 0.257 ± 0.02
1.047GlnTyr: 1.047 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.847ArgAla: 2.847 ± 0.072
0.603ArgCys: 0.603 ± 0.03
2.638ArgAsp: 2.638 ± 0.071
3.455ArgGlu: 3.455 ± 0.093
1.637ArgPhe: 1.637 ± 0.047
2.654ArgGly: 2.654 ± 0.068
0.798ArgHis: 0.798 ± 0.035
3.242ArgIle: 3.242 ± 0.073
3.444ArgLys: 3.444 ± 0.067
3.64ArgLeu: 3.64 ± 0.08
1.499ArgMet: 1.499 ± 0.05
2.223ArgAsn: 2.223 ± 0.054
1.338ArgPro: 1.338 ± 0.052
1.415ArgGln: 1.415 ± 0.051
2.366ArgArg: 2.366 ± 0.069
2.26ArgSer: 2.26 ± 0.068
2.256ArgThr: 2.256 ± 0.053
2.789ArgVal: 2.789 ± 0.07
0.376ArgTrp: 0.376 ± 0.025
1.83ArgTyr: 1.83 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
4.54SerAla: 4.54 ± 0.085
0.769SerCys: 0.769 ± 0.035
3.821SerAsp: 3.821 ± 0.08
3.756SerGlu: 3.756 ± 0.082
2.495SerPhe: 2.495 ± 0.067
5.473SerGly: 5.473 ± 0.114
1.026SerHis: 1.026 ± 0.043
4.381SerIle: 4.381 ± 0.092
4.251SerLys: 4.251 ± 0.097
4.91SerLeu: 4.91 ± 0.095
1.928SerMet: 1.928 ± 0.048
2.706SerAsn: 2.706 ± 0.068
1.729SerPro: 1.729 ± 0.058
1.692SerGln: 1.692 ± 0.049
2.789SerArg: 2.789 ± 0.062
4.059SerSer: 4.059 ± 0.119
3.443SerThr: 3.443 ± 0.1
4.245SerVal: 4.245 ± 0.093
0.498SerTrp: 0.498 ± 0.026
2.47SerTyr: 2.47 ± 0.079
0.0SerXaa: 0.0 ± 0.0
Thr
4.723ThrAla: 4.723 ± 0.087
0.75ThrCys: 0.75 ± 0.034
3.747ThrAsp: 3.747 ± 0.076
3.563ThrGlu: 3.563 ± 0.071
2.128ThrPhe: 2.128 ± 0.058
5.219ThrGly: 5.219 ± 0.1
0.827ThrHis: 0.827 ± 0.035
4.221ThrIle: 4.221 ± 0.078
3.443ThrLys: 3.443 ± 0.082
4.672ThrLeu: 4.672 ± 0.081
1.613ThrMet: 1.613 ± 0.049
2.035ThrAsn: 2.035 ± 0.069
2.252ThrPro: 2.252 ± 0.06
1.323ThrGln: 1.323 ± 0.047
2.115ThrArg: 2.115 ± 0.057
3.458ThrSer: 3.458 ± 0.099
3.453ThrThr: 3.453 ± 0.11
4.759ThrVal: 4.759 ± 0.123
0.463ThrTrp: 0.463 ± 0.025
2.189ThrTyr: 2.189 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
5.656ValAla: 5.656 ± 0.107
1.218ValCys: 1.218 ± 0.047
4.531ValAsp: 4.531 ± 0.083
4.369ValGlu: 4.369 ± 0.086
2.918ValPhe: 2.918 ± 0.068
4.609ValGly: 4.609 ± 0.092
1.043ValHis: 1.043 ± 0.041
5.871ValIle: 5.871 ± 0.088
4.72ValLys: 4.72 ± 0.091
5.821ValLeu: 5.821 ± 0.096
2.24ValMet: 2.24 ± 0.058
3.073ValAsn: 3.073 ± 0.078
2.575ValPro: 2.575 ± 0.068
1.524ValGln: 1.524 ± 0.044
3.048ValArg: 3.048 ± 0.07
4.751ValSer: 4.751 ± 0.102
4.549ValThr: 4.549 ± 0.093
5.085ValVal: 5.085 ± 0.097
0.501ValTrp: 0.501 ± 0.027
2.494ValTyr: 2.494 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.027
0.153TrpCys: 0.153 ± 0.015
0.481TrpAsp: 0.481 ± 0.025
0.426TrpGlu: 0.426 ± 0.024
0.368TrpPhe: 0.368 ± 0.027
0.56TrpGly: 0.56 ± 0.033
0.154TrpHis: 0.154 ± 0.017
0.558TrpIle: 0.558 ± 0.032
0.566TrpLys: 0.566 ± 0.035
0.747TrpLeu: 0.747 ± 0.036
0.273TrpMet: 0.273 ± 0.021
0.457TrpAsn: 0.457 ± 0.029
0.239TrpPro: 0.239 ± 0.019
0.301TrpGln: 0.301 ± 0.023
0.312TrpArg: 0.312 ± 0.02
0.503TrpSer: 0.503 ± 0.028
0.379TrpThr: 0.379 ± 0.028
0.468TrpVal: 0.468 ± 0.028
0.071TrpTrp: 0.071 ± 0.011
0.362TrpTyr: 0.362 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.562TyrAla: 2.562 ± 0.065
0.64TyrCys: 0.64 ± 0.031
3.012TyrAsp: 3.012 ± 0.085
2.641TyrGlu: 2.641 ± 0.06
1.647TyrPhe: 1.647 ± 0.057
3.235TyrGly: 3.235 ± 0.082
0.686TyrHis: 0.686 ± 0.035
2.719TyrIle: 2.719 ± 0.063
2.7TyrLys: 2.7 ± 0.065
3.103TyrLeu: 3.103 ± 0.075
1.164TyrMet: 1.164 ± 0.038
1.851TyrAsn: 1.851 ± 0.05
1.248TyrPro: 1.248 ± 0.04
0.913TyrGln: 0.913 ± 0.038
1.871TyrArg: 1.871 ± 0.049
2.693TyrSer: 2.693 ± 0.067
2.341TyrThr: 2.341 ± 0.082
2.617TyrVal: 2.617 ± 0.06
0.377TyrTrp: 0.377 ± 0.022
2.081TyrTyr: 2.081 ± 0.073
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2119 proteins (673308 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski