Amino acid dipepetide frequency for Streptococcus phage Javan214

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.82AlaAla: 2.82 ± 0.947
0.161AlaCys: 0.161 ± 0.121
4.914AlaAsp: 4.914 ± 0.7
4.35AlaGlu: 4.35 ± 0.556
2.82AlaPhe: 2.82 ± 0.444
4.109AlaGly: 4.109 ± 0.71
0.725AlaHis: 0.725 ± 0.203
5.236AlaIle: 5.236 ± 0.814
5.398AlaLys: 5.398 ± 0.677
5.639AlaLeu: 5.639 ± 0.791
2.981AlaMet: 2.981 ± 0.656
3.464AlaAsn: 3.464 ± 0.708
1.933AlaPro: 1.933 ± 0.426
2.497AlaGln: 2.497 ± 0.632
2.659AlaArg: 2.659 ± 0.568
3.786AlaSer: 3.786 ± 0.635
4.27AlaThr: 4.27 ± 0.76
4.511AlaVal: 4.511 ± 0.82
1.128AlaTrp: 1.128 ± 0.283
2.578AlaTyr: 2.578 ± 0.486
0.0AlaXaa: 0.0 ± 0.0
Cys
0.161CysAla: 0.161 ± 0.109
0.0CysCys: 0.0 ± 0.0
0.564CysAsp: 0.564 ± 0.219
0.725CysGlu: 0.725 ± 0.283
0.322CysPhe: 0.322 ± 0.157
0.403CysGly: 0.403 ± 0.172
0.161CysHis: 0.161 ± 0.116
0.564CysIle: 0.564 ± 0.239
0.886CysLys: 0.886 ± 0.302
0.403CysLeu: 0.403 ± 0.209
0.242CysMet: 0.242 ± 0.211
0.322CysAsn: 0.322 ± 0.151
0.242CysPro: 0.242 ± 0.14
0.242CysGln: 0.242 ± 0.142
0.483CysArg: 0.483 ± 0.199
0.403CysSer: 0.403 ± 0.195
0.403CysThr: 0.403 ± 0.195
0.161CysVal: 0.161 ± 0.121
0.0CysTrp: 0.0 ± 0.0
0.242CysTyr: 0.242 ± 0.162
0.0CysXaa: 0.0 ± 0.0
Asp
3.867AspAla: 3.867 ± 0.778
0.403AspCys: 0.403 ± 0.209
4.995AspAsp: 4.995 ± 0.762
5.881AspGlu: 5.881 ± 0.915
3.867AspPhe: 3.867 ± 0.453
6.284AspGly: 6.284 ± 0.758
0.644AspHis: 0.644 ± 0.216
3.867AspIle: 3.867 ± 0.687
5.881AspLys: 5.881 ± 0.628
5.398AspLeu: 5.398 ± 0.532
2.014AspMet: 2.014 ± 0.367
3.947AspAsn: 3.947 ± 0.512
1.208AspPro: 1.208 ± 0.264
1.531AspGln: 1.531 ± 0.356
2.256AspArg: 2.256 ± 0.519
4.189AspSer: 4.189 ± 0.511
3.061AspThr: 3.061 ± 0.469
3.706AspVal: 3.706 ± 0.572
1.208AspTrp: 1.208 ± 0.277
3.947AspTyr: 3.947 ± 0.712
0.0AspXaa: 0.0 ± 0.0
Glu
4.834GluAla: 4.834 ± 0.753
0.967GluCys: 0.967 ± 0.303
5.478GluAsp: 5.478 ± 0.775
6.848GluGlu: 6.848 ± 1.073
3.786GluPhe: 3.786 ± 0.726
3.061GluGly: 3.061 ± 0.445
0.725GluHis: 0.725 ± 0.232
4.914GluIle: 4.914 ± 0.765
7.089GluLys: 7.089 ± 0.951
8.056GluLeu: 8.056 ± 1.069
3.384GluMet: 3.384 ± 0.698
4.189GluAsn: 4.189 ± 0.581
2.014GluPro: 2.014 ± 0.475
2.336GluGln: 2.336 ± 0.514
2.82GluArg: 2.82 ± 0.56
3.786GluSer: 3.786 ± 0.549
4.35GluThr: 4.35 ± 0.736
6.123GluVal: 6.123 ± 0.78
0.967GluTrp: 0.967 ± 0.305
2.659GluTyr: 2.659 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
3.545PheAla: 3.545 ± 0.547
0.242PheCys: 0.242 ± 0.107
2.739PheAsp: 2.739 ± 0.59
4.109PheGlu: 4.109 ± 0.759
1.772PhePhe: 1.772 ± 0.409
2.497PheGly: 2.497 ± 0.371
0.242PheHis: 0.242 ± 0.142
1.933PheIle: 1.933 ± 0.387
4.914PheLys: 4.914 ± 0.736
2.981PheLeu: 2.981 ± 0.657
1.128PheMet: 1.128 ± 0.326
2.417PheAsn: 2.417 ± 0.411
0.806PhePro: 0.806 ± 0.294
1.37PheGln: 1.37 ± 0.346
1.772PheArg: 1.772 ± 0.441
2.9PheSer: 2.9 ± 0.449
3.303PheThr: 3.303 ± 0.663
2.256PheVal: 2.256 ± 0.484
0.725PheTrp: 0.725 ± 0.302
1.692PheTyr: 1.692 ± 0.422
0.0PheXaa: 0.0 ± 0.0
Gly
3.545GlyAla: 3.545 ± 0.531
0.322GlyCys: 0.322 ± 0.157
3.384GlyAsp: 3.384 ± 0.481
4.35GlyGlu: 4.35 ± 0.658
2.336GlyPhe: 2.336 ± 0.491
4.914GlyGly: 4.914 ± 0.624
0.967GlyHis: 0.967 ± 0.329
3.464GlyIle: 3.464 ± 0.484
5.8GlyLys: 5.8 ± 0.639
6.445GlyLeu: 6.445 ± 0.971
1.611GlyMet: 1.611 ± 0.312
3.303GlyAsn: 3.303 ± 0.496
0.483GlyPro: 0.483 ± 0.166
2.014GlyGln: 2.014 ± 0.465
3.545GlyArg: 3.545 ± 0.498
5.398GlySer: 5.398 ± 0.792
4.27GlyThr: 4.27 ± 0.828
3.706GlyVal: 3.706 ± 0.659
0.967GlyTrp: 0.967 ± 0.235
2.659GlyTyr: 2.659 ± 0.352
0.0GlyXaa: 0.0 ± 0.0
His
0.967HisAla: 0.967 ± 0.24
0.081HisCys: 0.081 ± 0.081
0.483HisAsp: 0.483 ± 0.212
0.725HisGlu: 0.725 ± 0.291
0.403HisPhe: 0.403 ± 0.188
0.806HisGly: 0.806 ± 0.312
0.242HisHis: 0.242 ± 0.129
0.644HisIle: 0.644 ± 0.254
0.322HisLys: 0.322 ± 0.187
1.047HisLeu: 1.047 ± 0.253
0.403HisMet: 0.403 ± 0.213
0.806HisAsn: 0.806 ± 0.263
0.725HisPro: 0.725 ± 0.312
0.644HisGln: 0.644 ± 0.251
0.564HisArg: 0.564 ± 0.216
1.289HisSer: 1.289 ± 0.318
0.644HisThr: 0.644 ± 0.229
0.725HisVal: 0.725 ± 0.194
0.0HisTrp: 0.0 ± 0.0
0.242HisTyr: 0.242 ± 0.14
0.0HisXaa: 0.0 ± 0.0
Ile
3.947IleAla: 3.947 ± 0.605
0.725IleCys: 0.725 ± 0.292
4.431IleAsp: 4.431 ± 0.506
6.203IleGlu: 6.203 ± 0.943
2.095IlePhe: 2.095 ± 0.474
2.981IleGly: 2.981 ± 0.423
0.725IleHis: 0.725 ± 0.213
3.222IleIle: 3.222 ± 0.478
5.8IleLys: 5.8 ± 0.812
4.511IleLeu: 4.511 ± 0.786
1.128IleMet: 1.128 ± 0.338
5.236IleAsn: 5.236 ± 0.742
1.611IlePro: 1.611 ± 0.312
1.692IleGln: 1.692 ± 0.369
2.9IleArg: 2.9 ± 0.611
4.431IleSer: 4.431 ± 0.557
4.109IleThr: 4.109 ± 0.509
2.82IleVal: 2.82 ± 0.448
0.806IleTrp: 0.806 ± 0.298
2.095IleTyr: 2.095 ± 0.542
0.0IleXaa: 0.0 ± 0.0
Lys
7.331LysAla: 7.331 ± 0.945
0.242LysCys: 0.242 ± 0.148
5.156LysAsp: 5.156 ± 0.673
8.62LysGlu: 8.62 ± 0.914
3.384LysPhe: 3.384 ± 0.787
4.592LysGly: 4.592 ± 0.535
0.725LysHis: 0.725 ± 0.225
5.639LysIle: 5.639 ± 0.786
6.928LysLys: 6.928 ± 0.92
6.687LysLeu: 6.687 ± 0.863
1.933LysMet: 1.933 ± 0.422
6.606LysAsn: 6.606 ± 0.62
1.611LysPro: 1.611 ± 0.426
4.189LysGln: 4.189 ± 0.513
2.9LysArg: 2.9 ± 0.548
3.867LysSer: 3.867 ± 0.563
5.961LysThr: 5.961 ± 0.713
5.72LysVal: 5.72 ± 0.791
0.806LysTrp: 0.806 ± 0.293
4.109LysTyr: 4.109 ± 0.613
0.0LysXaa: 0.0 ± 0.0
Leu
5.881LeuAla: 5.881 ± 0.818
0.725LeuCys: 0.725 ± 0.323
6.203LeuAsp: 6.203 ± 0.831
6.203LeuGlu: 6.203 ± 0.875
2.981LeuPhe: 2.981 ± 0.419
5.075LeuGly: 5.075 ± 0.602
1.208LeuHis: 1.208 ± 0.336
5.236LeuIle: 5.236 ± 0.58
8.942LeuLys: 8.942 ± 0.996
6.123LeuLeu: 6.123 ± 0.608
1.611LeuMet: 1.611 ± 0.439
5.075LeuAsn: 5.075 ± 0.676
2.659LeuPro: 2.659 ± 0.516
2.659LeuGln: 2.659 ± 0.349
3.061LeuArg: 3.061 ± 0.589
5.398LeuSer: 5.398 ± 0.576
5.075LeuThr: 5.075 ± 0.686
5.075LeuVal: 5.075 ± 0.861
0.564LeuTrp: 0.564 ± 0.181
2.014LeuTyr: 2.014 ± 0.475
0.0LeuXaa: 0.0 ± 0.0
Met
2.417MetAla: 2.417 ± 0.474
0.081MetCys: 0.081 ± 0.081
1.611MetAsp: 1.611 ± 0.311
2.095MetGlu: 2.095 ± 0.454
1.208MetPhe: 1.208 ± 0.303
1.289MetGly: 1.289 ± 0.299
0.403MetHis: 0.403 ± 0.157
2.095MetIle: 2.095 ± 0.431
1.692MetLys: 1.692 ± 0.324
2.256MetLeu: 2.256 ± 0.395
0.644MetMet: 0.644 ± 0.208
1.611MetAsn: 1.611 ± 0.432
0.644MetPro: 0.644 ± 0.243
1.128MetGln: 1.128 ± 0.302
0.967MetArg: 0.967 ± 0.369
1.37MetSer: 1.37 ± 0.336
2.175MetThr: 2.175 ± 0.357
1.611MetVal: 1.611 ± 0.353
0.403MetTrp: 0.403 ± 0.178
1.208MetTyr: 1.208 ± 0.273
0.0MetXaa: 0.0 ± 0.0
Asn
3.786AsnAla: 3.786 ± 0.691
0.322AsnCys: 0.322 ± 0.152
3.947AsnAsp: 3.947 ± 0.71
3.625AsnGlu: 3.625 ± 0.426
3.222AsnPhe: 3.222 ± 0.423
5.236AsnGly: 5.236 ± 0.67
0.644AsnHis: 0.644 ± 0.283
2.659AsnIle: 2.659 ± 0.448
4.914AsnLys: 4.914 ± 0.521
4.511AsnLeu: 4.511 ± 0.498
1.37AsnMet: 1.37 ± 0.321
3.222AsnAsn: 3.222 ± 0.598
2.336AsnPro: 2.336 ± 0.358
2.578AsnGln: 2.578 ± 0.579
1.692AsnArg: 1.692 ± 0.424
4.27AsnSer: 4.27 ± 0.492
4.27AsnThr: 4.27 ± 0.599
2.82AsnVal: 2.82 ± 0.603
0.967AsnTrp: 0.967 ± 0.269
2.82AsnTyr: 2.82 ± 0.523
0.0AsnXaa: 0.0 ± 0.0
Pro
1.772ProAla: 1.772 ± 0.314
0.242ProCys: 0.242 ± 0.13
1.933ProAsp: 1.933 ± 0.353
2.175ProGlu: 2.175 ± 0.418
1.047ProPhe: 1.047 ± 0.266
1.047ProGly: 1.047 ± 0.268
0.242ProHis: 0.242 ± 0.138
2.095ProIle: 2.095 ± 0.409
2.095ProLys: 2.095 ± 0.393
2.175ProLeu: 2.175 ± 0.311
0.806ProMet: 0.806 ± 0.311
1.289ProAsn: 1.289 ± 0.351
0.564ProPro: 0.564 ± 0.27
0.564ProGln: 0.564 ± 0.184
1.128ProArg: 1.128 ± 0.292
1.289ProSer: 1.289 ± 0.291
1.289ProThr: 1.289 ± 0.298
2.095ProVal: 2.095 ± 0.396
0.081ProTrp: 0.081 ± 0.081
1.128ProTyr: 1.128 ± 0.248
0.0ProXaa: 0.0 ± 0.0
Gln
2.739GlnAla: 2.739 ± 0.595
0.081GlnCys: 0.081 ± 0.079
1.853GlnAsp: 1.853 ± 0.316
3.061GlnGlu: 3.061 ± 0.407
1.37GlnPhe: 1.37 ± 0.326
1.772GlnGly: 1.772 ± 0.406
0.403GlnHis: 0.403 ± 0.152
2.014GlnIle: 2.014 ± 0.362
3.303GlnLys: 3.303 ± 0.546
2.497GlnLeu: 2.497 ± 0.609
1.45GlnMet: 1.45 ± 0.368
1.531GlnAsn: 1.531 ± 0.358
1.208GlnPro: 1.208 ± 0.33
1.611GlnGln: 1.611 ± 0.457
1.611GlnArg: 1.611 ± 0.395
1.531GlnSer: 1.531 ± 0.341
2.336GlnThr: 2.336 ± 0.516
2.578GlnVal: 2.578 ± 0.375
0.564GlnTrp: 0.564 ± 0.181
2.256GlnTyr: 2.256 ± 0.398
0.0GlnXaa: 0.0 ± 0.0
Arg
2.497ArgAla: 2.497 ± 0.347
0.483ArgCys: 0.483 ± 0.18
2.014ArgAsp: 2.014 ± 0.525
2.9ArgGlu: 2.9 ± 0.527
1.37ArgPhe: 1.37 ± 0.357
2.578ArgGly: 2.578 ± 0.433
0.483ArgHis: 0.483 ± 0.188
2.659ArgIle: 2.659 ± 0.512
4.109ArgLys: 4.109 ± 0.638
2.9ArgLeu: 2.9 ± 0.42
1.128ArgMet: 1.128 ± 0.456
2.739ArgAsn: 2.739 ± 0.387
0.806ArgPro: 0.806 ± 0.263
1.37ArgGln: 1.37 ± 0.306
1.692ArgArg: 1.692 ± 0.327
1.531ArgSer: 1.531 ± 0.348
2.014ArgThr: 2.014 ± 0.482
2.497ArgVal: 2.497 ± 0.452
0.725ArgTrp: 0.725 ± 0.213
1.692ArgTyr: 1.692 ± 0.373
0.0ArgXaa: 0.0 ± 0.0
Ser
2.981SerAla: 2.981 ± 0.725
0.242SerCys: 0.242 ± 0.139
5.72SerAsp: 5.72 ± 0.807
4.028SerGlu: 4.028 ± 0.576
2.739SerPhe: 2.739 ± 0.552
4.27SerGly: 4.27 ± 0.679
0.806SerHis: 0.806 ± 0.284
3.464SerIle: 3.464 ± 0.496
4.914SerLys: 4.914 ± 0.516
4.753SerLeu: 4.753 ± 0.589
1.772SerMet: 1.772 ± 0.365
4.028SerAsn: 4.028 ± 0.491
1.531SerPro: 1.531 ± 0.305
2.014SerGln: 2.014 ± 0.476
2.095SerArg: 2.095 ± 0.414
5.156SerSer: 5.156 ± 0.611
3.947SerThr: 3.947 ± 0.587
4.028SerVal: 4.028 ± 0.588
1.208SerTrp: 1.208 ± 0.345
2.578SerTyr: 2.578 ± 0.52
0.0SerXaa: 0.0 ± 0.0
Thr
5.156ThrAla: 5.156 ± 0.949
0.806ThrCys: 0.806 ± 0.277
4.028ThrAsp: 4.028 ± 0.504
3.625ThrGlu: 3.625 ± 0.511
3.303ThrPhe: 3.303 ± 0.667
4.995ThrGly: 4.995 ± 0.7
0.564ThrHis: 0.564 ± 0.216
4.35ThrIle: 4.35 ± 0.671
5.639ThrLys: 5.639 ± 0.62
4.592ThrLeu: 4.592 ± 0.588
0.806ThrMet: 0.806 ± 0.222
3.061ThrAsn: 3.061 ± 0.637
2.095ThrPro: 2.095 ± 0.451
2.9ThrGln: 2.9 ± 0.435
1.933ThrArg: 1.933 ± 0.418
4.431ThrSer: 4.431 ± 0.669
5.156ThrThr: 5.156 ± 0.996
5.075ThrVal: 5.075 ± 0.758
1.047ThrTrp: 1.047 ± 0.32
2.256ThrTyr: 2.256 ± 0.332
0.0ThrXaa: 0.0 ± 0.0
Val
4.673ValAla: 4.673 ± 0.598
0.322ValCys: 0.322 ± 0.187
4.592ValAsp: 4.592 ± 0.636
4.592ValGlu: 4.592 ± 0.747
2.9ValPhe: 2.9 ± 0.527
4.753ValGly: 4.753 ± 0.658
0.967ValHis: 0.967 ± 0.288
3.867ValIle: 3.867 ± 0.588
5.156ValLys: 5.156 ± 0.768
5.398ValLeu: 5.398 ± 0.605
1.128ValMet: 1.128 ± 0.262
2.981ValAsn: 2.981 ± 0.509
1.531ValPro: 1.531 ± 0.293
2.175ValGln: 2.175 ± 0.368
1.933ValArg: 1.933 ± 0.452
3.867ValSer: 3.867 ± 0.582
5.236ValThr: 5.236 ± 0.743
4.189ValVal: 4.189 ± 0.588
0.644ValTrp: 0.644 ± 0.238
2.417ValTyr: 2.417 ± 0.433
0.0ValXaa: 0.0 ± 0.0
Trp
1.047TrpAla: 1.047 ± 0.288
0.322TrpCys: 0.322 ± 0.195
0.403TrpAsp: 0.403 ± 0.171
1.531TrpGlu: 1.531 ± 0.384
0.483TrpPhe: 0.483 ± 0.24
0.725TrpGly: 0.725 ± 0.215
0.161TrpHis: 0.161 ± 0.104
0.725TrpIle: 0.725 ± 0.307
0.806TrpLys: 0.806 ± 0.224
1.531TrpLeu: 1.531 ± 0.321
0.242TrpMet: 0.242 ± 0.142
0.967TrpAsn: 0.967 ± 0.295
0.0TrpPro: 0.0 ± 0.0
0.725TrpGln: 0.725 ± 0.26
0.725TrpArg: 0.725 ± 0.255
0.725TrpSer: 0.725 ± 0.252
0.967TrpThr: 0.967 ± 0.33
0.886TrpVal: 0.886 ± 0.25
0.0TrpTrp: 0.0 ± 0.0
0.806TrpTyr: 0.806 ± 0.328
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.014TyrAla: 2.014 ± 0.315
0.161TyrCys: 0.161 ± 0.133
3.706TyrAsp: 3.706 ± 0.613
2.739TyrGlu: 2.739 ± 0.397
1.933TyrPhe: 1.933 ± 0.419
2.095TyrGly: 2.095 ± 0.481
0.725TyrHis: 0.725 ± 0.268
2.82TyrIle: 2.82 ± 0.648
2.417TyrLys: 2.417 ± 0.514
3.867TyrLeu: 3.867 ± 0.873
1.047TyrMet: 1.047 ± 0.279
2.417TyrAsn: 2.417 ± 0.521
1.047TyrPro: 1.047 ± 0.269
1.531TyrGln: 1.531 ± 0.312
1.45TyrArg: 1.45 ± 0.312
2.659TyrSer: 2.659 ± 0.444
3.061TyrThr: 3.061 ± 0.586
2.739TyrVal: 2.739 ± 0.441
0.967TyrTrp: 0.967 ± 0.377
2.014TyrTyr: 2.014 ± 0.42
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (12414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski