Amino acid dipepetide frequency for Tissierellia bacterium KA00581

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.857AlaAla: 1.857 ± 0.098
0.674AlaCys: 0.674 ± 0.042
2.251AlaAsp: 2.251 ± 0.071
2.089AlaGlu: 2.089 ± 0.071
2.55AlaPhe: 2.55 ± 0.084
2.78AlaGly: 2.78 ± 0.092
0.529AlaHis: 0.529 ± 0.032
5.345AlaIle: 5.345 ± 0.126
5.071AlaLys: 5.071 ± 0.117
4.865AlaLeu: 4.865 ± 0.115
1.235AlaMet: 1.235 ± 0.056
2.622AlaAsn: 2.622 ± 0.081
1.026AlaPro: 1.026 ± 0.053
1.172AlaGln: 1.172 ± 0.057
1.6AlaArg: 1.6 ± 0.067
2.909AlaSer: 2.909 ± 0.088
2.517AlaThr: 2.517 ± 0.081
3.221AlaVal: 3.221 ± 0.096
0.293AlaTrp: 0.293 ± 0.025
1.722AlaTyr: 1.722 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.554CysAla: 0.554 ± 0.032
0.152CysCys: 0.152 ± 0.021
0.765CysAsp: 0.765 ± 0.043
0.668CysGlu: 0.668 ± 0.038
0.607CysPhe: 0.607 ± 0.038
0.898CysGly: 0.898 ± 0.047
0.164CysHis: 0.164 ± 0.017
1.13CysIle: 1.13 ± 0.05
1.193CysLys: 1.193 ± 0.059
0.807CysLeu: 0.807 ± 0.042
0.293CysMet: 0.293 ± 0.026
0.643CysAsn: 0.643 ± 0.036
0.367CysPro: 0.367 ± 0.03
0.207CysGln: 0.207 ± 0.023
0.295CysArg: 0.295 ± 0.026
0.763CysSer: 0.763 ± 0.041
0.4CysThr: 0.4 ± 0.028
0.626CysVal: 0.626 ± 0.037
0.055CysTrp: 0.055 ± 0.01
0.424CysTyr: 0.424 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
2.515AspAla: 2.515 ± 0.087
0.721AspCys: 0.721 ± 0.036
3.642AspAsp: 3.642 ± 0.117
5.497AspGlu: 5.497 ± 0.135
4.011AspPhe: 4.011 ± 0.113
3.269AspGly: 3.269 ± 0.117
0.506AspHis: 0.506 ± 0.035
6.469AspIle: 6.469 ± 0.124
6.686AspLys: 6.686 ± 0.14
5.495AspLeu: 5.495 ± 0.104
1.433AspMet: 1.433 ± 0.06
3.257AspAsn: 3.257 ± 0.106
1.18AspPro: 1.18 ± 0.049
0.738AspGln: 0.738 ± 0.037
1.735AspArg: 1.735 ± 0.063
3.246AspSer: 3.246 ± 0.093
2.458AspThr: 2.458 ± 0.075
3.939AspVal: 3.939 ± 0.095
0.306AspTrp: 0.306 ± 0.027
2.727AspTyr: 2.727 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
2.675GluAla: 2.675 ± 0.079
0.525GluCys: 0.525 ± 0.034
4.152GluAsp: 4.152 ± 0.107
5.337GluGlu: 5.337 ± 0.148
3.4GluPhe: 3.4 ± 0.09
2.978GluGly: 2.978 ± 0.087
0.803GluHis: 0.803 ± 0.043
7.94GluIle: 7.94 ± 0.171
10.646GluLys: 10.646 ± 0.203
5.777GluLeu: 5.777 ± 0.125
1.701GluMet: 1.701 ± 0.07
7.434GluAsn: 7.434 ± 0.157
1.134GluPro: 1.134 ± 0.053
1.903GluGln: 1.903 ± 0.067
2.125GluArg: 2.125 ± 0.089
3.208GluSer: 3.208 ± 0.091
2.81GluThr: 2.81 ± 0.084
4.367GluVal: 4.367 ± 0.103
0.261GluTrp: 0.261 ± 0.026
2.995GluTyr: 2.995 ± 0.087
0.0GluXaa: 0.0 ± 0.0
Phe
2.375PheAla: 2.375 ± 0.074
0.66PheCys: 0.66 ± 0.037
3.44PheAsp: 3.44 ± 0.084
3.807PheGlu: 3.807 ± 0.109
3.092PhePhe: 3.092 ± 0.112
2.983PheGly: 2.983 ± 0.095
0.542PheHis: 0.542 ± 0.034
5.352PheIle: 5.352 ± 0.148
5.436PheLys: 5.436 ± 0.114
5.702PheLeu: 5.702 ± 0.149
1.29PheMet: 1.29 ± 0.059
3.157PheAsn: 3.157 ± 0.097
1.227PhePro: 1.227 ± 0.056
0.921PheGln: 0.921 ± 0.047
1.463PheArg: 1.463 ± 0.062
4.399PheSer: 4.399 ± 0.117
2.624PheThr: 2.624 ± 0.089
3.533PheVal: 3.533 ± 0.098
0.327PheTrp: 0.327 ± 0.023
2.375PheTyr: 2.375 ± 0.091
0.0PheXaa: 0.0 ± 0.0
Gly
3.155GlyAla: 3.155 ± 0.098
0.721GlyCys: 0.721 ± 0.038
2.637GlyAsp: 2.637 ± 0.081
3.181GlyGlu: 3.181 ± 0.075
3.143GlyPhe: 3.143 ± 0.071
3.292GlyGly: 3.292 ± 0.098
0.78GlyHis: 0.78 ± 0.039
5.265GlyIle: 5.265 ± 0.146
5.942GlyLys: 5.942 ± 0.129
4.519GlyLeu: 4.519 ± 0.11
1.355GlyMet: 1.355 ± 0.062
2.989GlyAsn: 2.989 ± 0.084
0.879GlyPro: 0.879 ± 0.055
1.26GlyGln: 1.26 ± 0.052
1.832GlyArg: 1.832 ± 0.06
3.261GlySer: 3.261 ± 0.093
2.81GlyThr: 2.81 ± 0.086
3.722GlyVal: 3.722 ± 0.107
0.365GlyTrp: 0.365 ± 0.03
2.675GlyTyr: 2.675 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
0.571HisAla: 0.571 ± 0.036
0.15HisCys: 0.15 ± 0.018
0.544HisAsp: 0.544 ± 0.037
0.672HisGlu: 0.672 ± 0.043
0.696HisPhe: 0.696 ± 0.038
0.727HisGly: 0.727 ± 0.047
0.253HisHis: 0.253 ± 0.023
1.172HisIle: 1.172 ± 0.048
0.955HisLys: 0.955 ± 0.042
1.104HisLeu: 1.104 ± 0.052
0.238HisMet: 0.238 ± 0.021
0.698HisAsn: 0.698 ± 0.04
0.472HisPro: 0.472 ± 0.031
0.28HisGln: 0.28 ± 0.026
0.459HisArg: 0.459 ± 0.032
0.778HisSer: 0.778 ± 0.045
0.634HisThr: 0.634 ± 0.031
0.622HisVal: 0.622 ± 0.037
0.072HisTrp: 0.072 ± 0.013
0.523HisTyr: 0.523 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
4.892IleAla: 4.892 ± 0.116
1.271IleCys: 1.271 ± 0.055
6.372IleAsp: 6.372 ± 0.119
7.23IleGlu: 7.23 ± 0.124
5.959IlePhe: 5.959 ± 0.155
5.124IleGly: 5.124 ± 0.117
1.077IleHis: 1.077 ± 0.054
8.657IleIle: 8.657 ± 0.192
9.97IleLys: 9.97 ± 0.167
10.554IleLeu: 10.554 ± 0.186
2.0IleMet: 2.0 ± 0.069
5.851IleAsn: 5.851 ± 0.145
2.753IlePro: 2.753 ± 0.085
1.918IleGln: 1.918 ± 0.06
2.801IleArg: 2.801 ± 0.079
8.012IleSer: 8.012 ± 0.158
4.909IleThr: 4.909 ± 0.099
6.121IleVal: 6.121 ± 0.145
0.371IleTrp: 0.371 ± 0.033
3.851IleTyr: 3.851 ± 0.1
0.0IleXaa: 0.0 ± 0.0
Lys
4.692LysAla: 4.692 ± 0.135
0.719LysCys: 0.719 ± 0.045
8.085LysAsp: 8.085 ± 0.185
11.34LysGlu: 11.34 ± 0.217
4.892LysPhe: 4.892 ± 0.117
4.633LysGly: 4.633 ± 0.107
1.121LysHis: 1.121 ± 0.046
11.123LysIle: 11.123 ± 0.169
12.689LysLys: 12.689 ± 0.248
9.152LysLeu: 9.152 ± 0.167
2.774LysMet: 2.774 ± 0.083
9.867LysAsn: 9.867 ± 0.189
2.026LysPro: 2.026 ± 0.079
2.453LysGln: 2.453 ± 0.084
3.56LysArg: 3.56 ± 0.096
5.971LysSer: 5.971 ± 0.124
5.147LysThr: 5.147 ± 0.129
6.167LysVal: 6.167 ± 0.139
0.607LysTrp: 0.607 ± 0.042
4.717LysTyr: 4.717 ± 0.116
0.0LysXaa: 0.0 ± 0.0
Leu
4.344LeuAla: 4.344 ± 0.127
0.98LeuCys: 0.98 ± 0.046
5.841LeuAsp: 5.841 ± 0.105
6.732LeuGlu: 6.732 ± 0.146
4.717LeuPhe: 4.717 ± 0.133
4.842LeuGly: 4.842 ± 0.131
1.016LeuHis: 1.016 ± 0.047
8.425LeuIle: 8.425 ± 0.178
11.471LeuLys: 11.471 ± 0.196
7.792LeuLeu: 7.792 ± 0.148
2.0LeuMet: 2.0 ± 0.067
6.18LeuAsn: 6.18 ± 0.118
2.508LeuPro: 2.508 ± 0.069
2.177LeuGln: 2.177 ± 0.079
2.696LeuArg: 2.696 ± 0.079
7.122LeuSer: 7.122 ± 0.132
4.861LeuThr: 4.861 ± 0.106
5.215LeuVal: 5.215 ± 0.113
0.455LeuTrp: 0.455 ± 0.031
3.216LeuTyr: 3.216 ± 0.093
0.0LeuXaa: 0.0 ± 0.0
Met
1.366MetAla: 1.366 ± 0.061
0.247MetCys: 0.247 ± 0.02
1.45MetAsp: 1.45 ± 0.054
1.64MetGlu: 1.64 ± 0.063
1.062MetPhe: 1.062 ± 0.054
1.343MetGly: 1.343 ± 0.066
0.278MetHis: 0.278 ± 0.025
2.142MetIle: 2.142 ± 0.072
2.799MetLys: 2.799 ± 0.077
2.201MetLeu: 2.201 ± 0.08
0.5MetMet: 0.5 ± 0.037
1.57MetAsn: 1.57 ± 0.049
0.71MetPro: 0.71 ± 0.037
0.719MetGln: 0.719 ± 0.039
0.66MetArg: 0.66 ± 0.038
1.33MetSer: 1.33 ± 0.052
0.885MetThr: 0.885 ± 0.047
1.338MetVal: 1.338 ± 0.056
0.118MetTrp: 0.118 ± 0.018
0.875MetTyr: 0.875 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
2.81AsnAla: 2.81 ± 0.09
0.736AsnCys: 0.736 ± 0.037
3.227AsnAsp: 3.227 ± 0.079
4.835AsnGlu: 4.835 ± 0.112
3.906AsnPhe: 3.906 ± 0.081
3.583AsnGly: 3.583 ± 0.101
0.757AsnHis: 0.757 ± 0.04
7.485AsnIle: 7.485 ± 0.128
7.255AsnLys: 7.255 ± 0.151
6.909AsnLeu: 6.909 ± 0.148
1.551AsnMet: 1.551 ± 0.066
4.14AsnAsn: 4.14 ± 0.126
2.08AsnPro: 2.08 ± 0.079
1.277AsnGln: 1.277 ± 0.055
2.057AsnArg: 2.057 ± 0.068
4.043AsnSer: 4.043 ± 0.092
2.911AsnThr: 2.911 ± 0.086
3.944AsnVal: 3.944 ± 0.087
0.47AsnTrp: 0.47 ± 0.033
2.753AsnTyr: 2.753 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
1.098ProAla: 1.098 ± 0.061
0.285ProCys: 0.285 ± 0.028
1.284ProAsp: 1.284 ± 0.058
1.492ProGlu: 1.492 ± 0.067
1.328ProPhe: 1.328 ± 0.043
1.107ProGly: 1.107 ± 0.058
0.363ProHis: 0.363 ± 0.025
2.361ProIle: 2.361 ± 0.07
2.548ProLys: 2.548 ± 0.084
1.99ProLeu: 1.99 ± 0.075
0.529ProMet: 0.529 ± 0.034
1.513ProAsn: 1.513 ± 0.075
0.417ProPro: 0.417 ± 0.035
0.696ProGln: 0.696 ± 0.035
0.666ProArg: 0.666 ± 0.038
1.473ProSer: 1.473 ± 0.059
1.465ProThr: 1.465 ± 0.07
1.68ProVal: 1.68 ± 0.067
0.171ProTrp: 0.171 ± 0.02
1.098ProTyr: 1.098 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.26GlnAla: 1.26 ± 0.06
0.154GlnCys: 0.154 ± 0.018
1.117GlnAsp: 1.117 ± 0.044
1.699GlnGlu: 1.699 ± 0.076
0.873GlnPhe: 0.873 ± 0.041
1.172GlnGly: 1.172 ± 0.05
0.236GlnHis: 0.236 ± 0.024
2.213GlnIle: 2.213 ± 0.063
2.628GlnLys: 2.628 ± 0.084
1.768GlnLeu: 1.768 ± 0.065
0.594GlnMet: 0.594 ± 0.037
1.45GlnAsn: 1.45 ± 0.051
0.367GlnPro: 0.367 ± 0.029
0.59GlnGln: 0.59 ± 0.04
1.079GlnArg: 1.079 ± 0.056
1.343GlnSer: 1.343 ± 0.06
1.18GlnThr: 1.18 ± 0.048
1.18GlnVal: 1.18 ± 0.052
0.177GlnTrp: 0.177 ± 0.02
0.786GlnTyr: 0.786 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
1.653ArgAla: 1.653 ± 0.067
0.373ArgCys: 0.373 ± 0.031
1.703ArgAsp: 1.703 ± 0.061
2.475ArgGlu: 2.475 ± 0.081
1.494ArgPhe: 1.494 ± 0.066
1.72ArgGly: 1.72 ± 0.064
0.424ArgHis: 0.424 ± 0.029
2.835ArgIle: 2.835 ± 0.078
3.406ArgLys: 3.406 ± 0.098
2.888ArgLeu: 2.888 ± 0.086
0.782ArgMet: 0.782 ± 0.044
1.905ArgAsn: 1.905 ± 0.063
0.797ArgPro: 0.797 ± 0.044
0.778ArgGln: 0.778 ± 0.044
1.168ArgArg: 1.168 ± 0.061
1.524ArgSer: 1.524 ± 0.059
1.309ArgThr: 1.309 ± 0.051
1.969ArgVal: 1.969 ± 0.084
0.19ArgTrp: 0.19 ± 0.02
1.421ArgTyr: 1.421 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
2.814SerAla: 2.814 ± 0.089
0.734SerCys: 0.734 ± 0.04
3.37SerAsp: 3.37 ± 0.088
3.497SerGlu: 3.497 ± 0.091
4.093SerPhe: 4.093 ± 0.104
3.861SerGly: 3.861 ± 0.112
0.82SerHis: 0.82 ± 0.042
6.745SerIle: 6.745 ± 0.14
7.116SerLys: 7.116 ± 0.131
6.298SerLeu: 6.298 ± 0.124
1.57SerMet: 1.57 ± 0.067
4.066SerAsn: 4.066 ± 0.114
1.246SerPro: 1.246 ± 0.049
1.433SerGln: 1.433 ± 0.059
1.775SerArg: 1.775 ± 0.059
4.367SerSer: 4.367 ± 0.118
2.873SerThr: 2.873 ± 0.091
3.931SerVal: 3.931 ± 0.11
0.39SerTrp: 0.39 ± 0.029
2.854SerTyr: 2.854 ± 0.076
0.0SerXaa: 0.0 ± 0.0
Thr
2.418ThrAla: 2.418 ± 0.085
0.466ThrCys: 0.466 ± 0.03
2.78ThrAsp: 2.78 ± 0.083
2.751ThrGlu: 2.751 ± 0.095
2.746ThrPhe: 2.746 ± 0.093
3.039ThrGly: 3.039 ± 0.093
0.723ThrHis: 0.723 ± 0.044
4.728ThrIle: 4.728 ± 0.111
4.749ThrLys: 4.749 ± 0.124
4.565ThrLeu: 4.565 ± 0.114
1.008ThrMet: 1.008 ± 0.049
2.886ThrAsn: 2.886 ± 0.087
1.56ThrPro: 1.56 ± 0.074
1.107ThrGln: 1.107 ± 0.049
1.421ThrArg: 1.421 ± 0.057
2.867ThrSer: 2.867 ± 0.084
2.7ThrThr: 2.7 ± 0.087
3.294ThrVal: 3.294 ± 0.095
0.236ThrTrp: 0.236 ± 0.021
1.699ThrTyr: 1.699 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
3.17ValAla: 3.17 ± 0.092
0.892ValCys: 0.892 ± 0.043
4.205ValAsp: 4.205 ± 0.101
4.163ValGlu: 4.163 ± 0.097
3.313ValPhe: 3.313 ± 0.085
3.762ValGly: 3.762 ± 0.101
0.67ValHis: 0.67 ± 0.041
5.603ValIle: 5.603 ± 0.131
6.136ValLys: 6.136 ± 0.132
5.925ValLeu: 5.925 ± 0.118
1.362ValMet: 1.362 ± 0.055
3.581ValAsn: 3.581 ± 0.086
1.667ValPro: 1.667 ± 0.07
1.199ValGln: 1.199 ± 0.054
1.806ValArg: 1.806 ± 0.064
4.266ValSer: 4.266 ± 0.086
2.985ValThr: 2.985 ± 0.089
4.519ValVal: 4.519 ± 0.115
0.339ValTrp: 0.339 ± 0.023
2.443ValTyr: 2.443 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.301TrpAla: 0.301 ± 0.026
0.051TrpCys: 0.051 ± 0.013
0.356TrpAsp: 0.356 ± 0.03
0.291TrpGlu: 0.291 ± 0.026
0.322TrpPhe: 0.322 ± 0.031
0.329TrpGly: 0.329 ± 0.026
0.082TrpHis: 0.082 ± 0.015
0.546TrpIle: 0.546 ± 0.03
0.527TrpLys: 0.527 ± 0.029
0.457TrpLeu: 0.457 ± 0.032
0.135TrpMet: 0.135 ± 0.019
0.367TrpAsn: 0.367 ± 0.028
0.105TrpPro: 0.105 ± 0.014
0.152TrpGln: 0.152 ± 0.018
0.213TrpArg: 0.213 ± 0.021
0.356TrpSer: 0.356 ± 0.027
0.253TrpThr: 0.253 ± 0.027
0.276TrpVal: 0.276 ± 0.023
0.099TrpTrp: 0.099 ± 0.021
0.335TrpTyr: 0.335 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.808TyrAla: 1.808 ± 0.069
0.504TyrCys: 0.504 ± 0.03
2.607TyrAsp: 2.607 ± 0.083
2.778TyrGlu: 2.778 ± 0.07
2.498TyrPhe: 2.498 ± 0.085
2.34TyrGly: 2.34 ± 0.072
0.476TyrHis: 0.476 ± 0.027
4.159TyrIle: 4.159 ± 0.108
4.513TyrLys: 4.513 ± 0.118
3.821TyrLeu: 3.821 ± 0.11
0.879TyrMet: 0.879 ± 0.046
2.553TyrAsn: 2.553 ± 0.076
1.041TyrPro: 1.041 ± 0.046
0.887TyrGln: 0.887 ± 0.044
1.402TyrArg: 1.402 ± 0.057
2.616TyrSer: 2.616 ± 0.084
2.011TyrThr: 2.011 ± 0.074
2.344TyrVal: 2.344 ± 0.074
0.253TyrTrp: 0.253 ± 0.021
1.684TyrTyr: 1.684 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1550 proteins (474432 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski