Amino acid dipepetide frequency for Lake Sarah-associated circular virus-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.996AlaAla: 4.996 ± 2.084
2.498AlaCys: 2.498 ± 0.826
1.665AlaAsp: 1.665 ± 1.35
3.331AlaGlu: 3.331 ± 2.82
4.163AlaPhe: 4.163 ± 1.098
4.996AlaGly: 4.996 ± 2.479
2.498AlaHis: 2.498 ± 2.115
4.996AlaIle: 4.996 ± 2.105
4.163AlaLys: 4.163 ± 1.873
9.159AlaLeu: 9.159 ± 1.644
3.331AlaMet: 3.331 ± 1.342
4.163AlaAsn: 4.163 ± 1.098
3.331AlaPro: 3.331 ± 0.955
1.665AlaGln: 1.665 ± 0.834
2.498AlaArg: 2.498 ± 1.246
8.326AlaSer: 8.326 ± 3.858
6.661AlaThr: 6.661 ± 0.951
4.996AlaVal: 4.996 ± 2.084
0.0AlaTrp: 0.0 ± 0.0
2.498AlaTyr: 2.498 ± 1.753
0.0AlaXaa: 0.0 ± 0.0
Cys
1.665CysAla: 1.665 ± 0.477
0.0CysCys: 0.0 ± 0.0
2.498CysAsp: 2.498 ± 1.012
1.665CysGlu: 1.665 ± 1.169
0.833CysPhe: 0.833 ± 0.675
1.665CysGly: 1.665 ± 1.169
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.833CysLys: 0.833 ± 0.584
4.163CysLeu: 4.163 ± 1.908
0.0CysMet: 0.0 ± 0.0
0.833CysAsn: 0.833 ± 0.584
1.665CysPro: 1.665 ± 0.671
0.0CysGln: 0.0 ± 0.0
2.498CysArg: 2.498 ± 0.281
0.833CysSer: 0.833 ± 0.675
1.665CysThr: 1.665 ± 0.834
0.833CysVal: 0.833 ± 0.584
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.163AspAla: 4.163 ± 1.652
0.0AspCys: 0.0 ± 0.0
2.498AspAsp: 2.498 ± 2.024
4.163AspGlu: 4.163 ± 1.439
2.498AspPhe: 2.498 ± 1.012
4.163AspGly: 4.163 ± 0.342
0.833AspHis: 0.833 ± 0.675
3.331AspIle: 3.331 ± 2.699
0.833AspLys: 0.833 ± 0.705
3.331AspLeu: 3.331 ± 0.955
2.498AspMet: 2.498 ± 1.389
0.833AspAsn: 0.833 ± 0.584
3.331AspPro: 3.331 ± 1.551
1.665AspGln: 1.665 ± 1.35
2.498AspArg: 2.498 ± 2.024
0.833AspSer: 0.833 ± 0.675
3.331AspThr: 3.331 ± 0.955
4.163AspVal: 4.163 ± 1.432
0.833AspTrp: 0.833 ± 0.675
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
4.996GluAla: 4.996 ± 2.686
0.0GluCys: 0.0 ± 0.0
1.665GluAsp: 1.665 ± 1.35
1.665GluGlu: 1.665 ± 1.35
0.833GluPhe: 0.833 ± 0.675
1.665GluGly: 1.665 ± 1.169
5.828GluHis: 5.828 ± 2.993
0.833GluIle: 0.833 ± 0.675
2.498GluLys: 2.498 ± 1.389
2.498GluLeu: 2.498 ± 1.246
1.665GluMet: 1.665 ± 1.41
1.665GluAsn: 1.665 ± 1.169
1.665GluPro: 1.665 ± 0.671
0.833GluGln: 0.833 ± 0.705
4.163GluArg: 4.163 ± 1.098
4.996GluSer: 4.996 ± 1.67
0.833GluThr: 0.833 ± 0.675
4.996GluVal: 4.996 ± 0.562
0.0GluTrp: 0.0 ± 0.0
2.498GluTyr: 2.498 ± 1.042
0.0GluXaa: 0.0 ± 0.0
Phe
2.498PheAla: 2.498 ± 1.343
0.0PheCys: 0.0 ± 0.0
2.498PheAsp: 2.498 ± 2.024
0.833PheGlu: 0.833 ± 0.675
0.833PhePhe: 0.833 ± 0.675
6.661PheGly: 6.661 ± 0.405
4.163PheHis: 4.163 ± 2.313
1.665PheIle: 1.665 ± 0.834
5.828PheLys: 5.828 ± 3.416
3.331PheLeu: 3.331 ± 1.667
0.833PheMet: 0.833 ± 0.705
4.163PheAsn: 4.163 ± 2.921
3.331PhePro: 3.331 ± 1.955
1.665PheGln: 1.665 ± 0.477
2.498PheArg: 2.498 ± 1.012
4.996PheSer: 4.996 ± 0.545
4.163PheThr: 4.163 ± 1.217
0.833PheVal: 0.833 ± 0.584
0.0PheTrp: 0.0 ± 0.0
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
7.494GlyAla: 7.494 ± 1.0
0.0GlyCys: 0.0 ± 0.0
3.331GlyAsp: 3.331 ± 2.039
0.833GlyGlu: 0.833 ± 0.584
2.498GlyPhe: 2.498 ± 0.281
4.996GlyGly: 4.996 ± 2.479
0.833GlyHis: 0.833 ± 0.705
5.828GlyIle: 5.828 ± 0.97
3.331GlyLys: 3.331 ± 0.961
8.326GlyLeu: 8.326 ± 2.801
1.665GlyMet: 1.665 ± 0.477
1.665GlyAsn: 1.665 ± 0.671
4.163GlyPro: 4.163 ± 1.217
4.163GlyGln: 4.163 ± 1.908
1.665GlyArg: 1.665 ± 0.477
4.996GlySer: 4.996 ± 2.479
6.661GlyThr: 6.661 ± 1.645
8.326GlyVal: 8.326 ± 4.794
0.0GlyTrp: 0.0 ± 0.0
3.331GlyTyr: 3.331 ± 2.337
0.0GlyXaa: 0.0 ± 0.0
His
4.163HisAla: 4.163 ± 1.662
2.498HisCys: 2.498 ± 1.012
1.665HisAsp: 1.665 ± 1.35
4.996HisGlu: 4.996 ± 0.999
0.0HisPhe: 0.0 ± 0.0
1.665HisGly: 1.665 ± 0.834
3.331HisHis: 3.331 ± 2.039
3.331HisIle: 3.331 ± 0.787
1.665HisLys: 1.665 ± 1.41
4.163HisLeu: 4.163 ± 3.374
0.833HisMet: 0.833 ± 0.705
0.0HisAsn: 0.0 ± 0.0
2.498HisPro: 2.498 ± 2.024
1.665HisGln: 1.665 ± 0.834
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
1.665HisThr: 1.665 ± 0.834
0.833HisVal: 0.833 ± 0.675
0.0HisTrp: 0.0 ± 0.0
1.665HisTyr: 1.665 ± 0.834
0.0HisXaa: 0.0 ± 0.0
Ile
4.163IleAla: 4.163 ± 0.342
0.0IleCys: 0.0 ± 0.0
2.498IleAsp: 2.498 ± 1.012
4.996IleGlu: 4.996 ± 0.999
0.833IlePhe: 0.833 ± 0.584
1.665IleGly: 1.665 ± 1.169
1.665IleHis: 1.665 ± 1.35
4.996IleIle: 4.996 ± 1.432
3.331IleLys: 3.331 ± 1.653
1.665IleLeu: 1.665 ± 0.834
1.665IleMet: 1.665 ± 1.169
2.498IleAsn: 2.498 ± 0.281
4.163IlePro: 4.163 ± 0.342
1.665IleGln: 1.665 ± 1.169
2.498IleArg: 2.498 ± 0.281
1.665IleSer: 1.665 ± 0.834
5.828IleThr: 5.828 ± 2.108
4.996IleVal: 4.996 ± 2.98
0.833IleTrp: 0.833 ± 0.584
2.498IleTyr: 2.498 ± 1.012
0.0IleXaa: 0.0 ± 0.0
Lys
1.665LysAla: 1.665 ± 0.477
0.833LysCys: 0.833 ± 0.584
2.498LysAsp: 2.498 ± 0.281
0.833LysGlu: 0.833 ± 0.705
4.163LysPhe: 4.163 ± 2.179
2.498LysGly: 2.498 ± 1.246
1.665LysHis: 1.665 ± 1.35
3.331LysIle: 3.331 ± 0.382
2.498LysLys: 2.498 ± 2.115
4.163LysLeu: 4.163 ± 1.873
1.665LysMet: 1.665 ± 1.41
0.833LysAsn: 0.833 ± 0.705
0.833LysPro: 0.833 ± 0.705
0.833LysGln: 0.833 ± 0.705
4.996LysArg: 4.996 ± 1.549
5.828LysSer: 5.828 ± 2.316
2.498LysThr: 2.498 ± 1.343
2.498LysVal: 2.498 ± 1.389
0.0LysTrp: 0.0 ± 0.0
1.665LysTyr: 1.665 ± 1.41
0.0LysXaa: 0.0 ± 0.0
Leu
4.996LeuAla: 4.996 ± 2.012
4.163LeuCys: 4.163 ± 1.217
4.163LeuAsp: 4.163 ± 0.342
2.498LeuGlu: 2.498 ± 2.024
4.996LeuPhe: 4.996 ± 1.549
5.828LeuGly: 5.828 ± 3.055
1.665LeuHis: 1.665 ± 0.834
4.996LeuIle: 4.996 ± 0.545
3.331LeuLys: 3.331 ± 2.039
5.828LeuLeu: 5.828 ± 0.781
0.0LeuMet: 0.0 ± 0.0
5.828LeuAsn: 5.828 ± 0.329
8.326LeuPro: 8.326 ± 1.403
0.833LeuGln: 0.833 ± 0.675
2.498LeuArg: 2.498 ± 1.246
4.996LeuSer: 4.996 ± 2.084
4.996LeuThr: 4.996 ± 0.545
4.163LeuVal: 4.163 ± 1.873
1.665LeuTrp: 1.665 ± 1.169
2.498LeuTyr: 2.498 ± 1.012
0.0LeuXaa: 0.0 ± 0.0
Met
1.665MetAla: 1.665 ± 0.671
0.833MetCys: 0.833 ± 0.705
0.0MetAsp: 0.0 ± 0.0
1.665MetGlu: 1.665 ± 1.41
1.665MetPhe: 1.665 ± 0.671
2.498MetGly: 2.498 ± 1.389
0.0MetHis: 0.0 ± 0.0
0.833MetIle: 0.833 ± 0.584
0.0MetLys: 0.0 ± 0.0
2.498MetLeu: 2.498 ± 2.115
0.833MetMet: 0.833 ± 0.598
0.833MetAsn: 0.833 ± 0.584
1.665MetPro: 1.665 ± 0.477
0.833MetGln: 0.833 ± 0.705
1.665MetArg: 1.665 ± 1.41
3.331MetSer: 3.331 ± 0.382
0.0MetThr: 0.0 ± 0.0
1.665MetVal: 1.665 ± 0.671
0.0MetTrp: 0.0 ± 0.0
0.833MetTyr: 0.833 ± 0.705
0.0MetXaa: 0.0 ± 0.0
Asn
1.665AsnAla: 1.665 ± 0.671
0.833AsnCys: 0.833 ± 0.584
1.665AsnAsp: 1.665 ± 0.671
1.665AsnGlu: 1.665 ± 1.41
2.498AsnPhe: 2.498 ± 0.826
4.163AsnGly: 4.163 ± 1.908
0.833AsnHis: 0.833 ± 0.705
2.498AsnIle: 2.498 ± 0.826
1.665AsnLys: 1.665 ± 0.834
3.331AsnLeu: 3.331 ± 1.551
1.665AsnMet: 1.665 ± 0.546
2.498AsnAsn: 2.498 ± 1.753
1.665AsnPro: 1.665 ± 1.169
1.665AsnGln: 1.665 ± 1.169
0.833AsnArg: 0.833 ± 0.675
3.331AsnSer: 3.331 ± 2.337
1.665AsnThr: 1.665 ± 1.35
3.331AsnVal: 3.331 ± 0.382
0.833AsnTrp: 0.833 ± 0.584
1.665AsnTyr: 1.665 ± 0.671
0.0AsnXaa: 0.0 ± 0.0
Pro
4.996ProAla: 4.996 ± 1.432
0.833ProCys: 0.833 ± 0.584
4.996ProAsp: 4.996 ± 2.025
1.665ProGlu: 1.665 ± 0.671
7.494ProPhe: 7.494 ± 0.265
3.331ProGly: 3.331 ± 0.787
0.833ProHis: 0.833 ± 0.675
1.665ProIle: 1.665 ± 1.35
1.665ProLys: 1.665 ± 0.834
5.828ProLeu: 5.828 ± 0.781
0.0ProMet: 0.0 ± 0.0
1.665ProAsn: 1.665 ± 1.169
1.665ProPro: 1.665 ± 0.477
2.498ProGln: 2.498 ± 1.753
1.665ProArg: 1.665 ± 1.35
2.498ProSer: 2.498 ± 1.042
8.326ProThr: 8.326 ± 0.684
4.163ProVal: 4.163 ± 1.217
0.833ProTrp: 0.833 ± 0.584
0.833ProTyr: 0.833 ± 0.675
0.0ProXaa: 0.0 ± 0.0
Gln
4.996GlnAla: 4.996 ± 0.999
0.0GlnCys: 0.0 ± 0.0
0.833GlnAsp: 0.833 ± 0.584
0.833GlnGlu: 0.833 ± 0.705
3.331GlnPhe: 3.331 ± 0.787
2.498GlnGly: 2.498 ± 1.753
1.665GlnHis: 1.665 ± 1.169
0.0GlnIle: 0.0 ± 0.0
1.665GlnLys: 1.665 ± 1.41
0.833GlnLeu: 0.833 ± 0.675
0.833GlnMet: 0.833 ± 0.705
0.0GlnAsn: 0.0 ± 0.0
0.833GlnPro: 0.833 ± 0.675
1.665GlnGln: 1.665 ± 0.671
1.665GlnArg: 1.665 ± 1.169
4.996GlnSer: 4.996 ± 2.084
2.498GlnThr: 2.498 ± 0.281
0.833GlnVal: 0.833 ± 0.584
0.833GlnTrp: 0.833 ± 0.675
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.661ArgAla: 6.661 ± 2.02
0.833ArgCys: 0.833 ± 0.675
1.665ArgAsp: 1.665 ± 0.477
4.996ArgGlu: 4.996 ± 2.366
3.331ArgPhe: 3.331 ± 1.653
2.498ArgGly: 2.498 ± 1.389
0.833ArgHis: 0.833 ± 0.675
3.331ArgIle: 3.331 ± 0.787
0.833ArgLys: 0.833 ± 0.675
3.331ArgLeu: 3.331 ± 0.787
0.833ArgMet: 0.833 ± 0.705
3.331ArgAsn: 3.331 ± 1.342
3.331ArgPro: 3.331 ± 1.653
0.833ArgGln: 0.833 ± 0.705
3.331ArgArg: 3.331 ± 1.653
3.331ArgSer: 3.331 ± 1.667
3.331ArgThr: 3.331 ± 0.787
1.665ArgVal: 1.665 ± 1.169
0.0ArgTrp: 0.0 ± 0.0
1.665ArgTyr: 1.665 ± 0.671
0.0ArgXaa: 0.0 ± 0.0
Ser
5.828SerAla: 5.828 ± 2.108
4.163SerCys: 4.163 ± 1.908
4.163SerAsp: 4.163 ± 0.946
1.665SerGlu: 1.665 ± 0.834
1.665SerPhe: 1.665 ± 1.35
10.824SerGly: 10.824 ± 3.633
1.665SerHis: 1.665 ± 0.834
3.331SerIle: 3.331 ± 0.955
2.498SerLys: 2.498 ± 1.246
4.996SerLeu: 4.996 ± 2.663
1.665SerMet: 1.665 ± 1.169
4.163SerAsn: 4.163 ± 0.342
3.331SerPro: 3.331 ± 0.955
0.0SerGln: 0.0 ± 0.0
2.498SerArg: 2.498 ± 1.246
4.996SerSer: 4.996 ± 0.982
5.828SerThr: 5.828 ± 2.576
11.657SerVal: 11.657 ± 1.921
0.833SerTrp: 0.833 ± 0.584
1.665SerTyr: 1.665 ± 0.834
0.0SerXaa: 0.0 ± 0.0
Thr
4.996ThrAla: 4.996 ± 0.982
2.498ThrCys: 2.498 ± 1.389
1.665ThrAsp: 1.665 ± 1.35
2.498ThrGlu: 2.498 ± 1.012
3.331ThrPhe: 3.331 ± 1.349
5.828ThrGly: 5.828 ± 2.16
1.665ThrHis: 1.665 ± 1.35
2.498ThrIle: 2.498 ± 1.753
0.833ThrLys: 0.833 ± 0.705
6.661ThrLeu: 6.661 ± 0.951
0.0ThrMet: 0.0 ± 0.0
1.665ThrAsn: 1.665 ± 0.477
4.996ThrPro: 4.996 ± 0.999
5.828ThrGln: 5.828 ± 1.417
6.661ThrArg: 6.661 ± 2.36
7.494ThrSer: 7.494 ± 2.108
5.828ThrThr: 5.828 ± 0.781
4.163ThrVal: 4.163 ± 1.652
2.498ThrTrp: 2.498 ± 1.012
4.163ThrTyr: 4.163 ± 1.439
0.0ThrXaa: 0.0 ± 0.0
Val
5.828ValAla: 5.828 ± 2.576
0.0ValCys: 0.0 ± 0.0
3.331ValAsp: 3.331 ± 0.382
4.163ValGlu: 4.163 ± 1.662
2.498ValPhe: 2.498 ± 2.024
5.828ValGly: 5.828 ± 0.329
4.996ValHis: 4.996 ± 2.025
5.828ValIle: 5.828 ± 3.055
4.996ValLys: 4.996 ± 1.653
3.331ValLeu: 3.331 ± 1.551
2.498ValMet: 2.498 ± 2.115
4.163ValAsn: 4.163 ± 1.908
4.996ValPro: 4.996 ± 0.545
2.498ValGln: 2.498 ± 0.281
1.665ValArg: 1.665 ± 0.477
4.996ValSer: 4.996 ± 0.982
4.996ValThr: 4.996 ± 0.999
3.331ValVal: 3.331 ± 0.955
0.0ValTrp: 0.0 ± 0.0
0.833ValTyr: 0.833 ± 0.705
0.0ValXaa: 0.0 ± 0.0
Trp
1.665TrpAla: 1.665 ± 0.477
0.833TrpCys: 0.833 ± 0.584
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
2.498TrpSer: 2.498 ± 1.012
3.331TrpThr: 3.331 ± 0.955
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
2.498TrpTyr: 2.498 ± 1.753
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.833TyrAla: 0.833 ± 0.705
0.833TyrCys: 0.833 ± 0.584
2.498TyrAsp: 2.498 ± 0.826
0.833TyrGlu: 0.833 ± 0.675
3.331TyrPhe: 3.331 ± 0.961
0.833TyrGly: 0.833 ± 0.584
1.665TyrHis: 1.665 ± 0.834
0.833TyrIle: 0.833 ± 0.584
3.331TyrLys: 3.331 ± 1.667
0.833TyrLeu: 0.833 ± 0.584
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
1.665TyrPro: 1.665 ± 1.169
0.0TyrGln: 0.0 ± 0.0
4.163TyrArg: 4.163 ± 1.873
2.498TyrSer: 2.498 ± 1.753
1.665TyrThr: 1.665 ± 0.834
3.331TyrVal: 3.331 ± 0.955
1.665TyrTrp: 1.665 ± 0.477
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski