Amino acid dipepetide frequency for Fusobacterium varium ATCC 27725

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.486AlaAla: 4.486 ± 0.095	0.594AlaCys: 0.594 ± 0.028	2.919AlaAsp: 2.919 ± 0.063	4.138AlaGlu: 4.138 ± 0.079	2.605AlaPhe: 2.605 ± 0.069	4.971AlaGly: 4.971 ± 0.113	0.81AlaHis: 0.81 ± 0.026	5.082AlaIle: 5.082 ± 0.082	4.545AlaLys: 4.545 ± 0.081	5.721AlaLeu: 5.721 ± 0.095	1.68AlaMet: 1.68 ± 0.048	2.286AlaAsn: 2.286 ± 0.057	1.613AlaPro: 1.613 ± 0.048	1.485AlaGln: 1.485 ± 0.051	1.779AlaArg: 1.779 ± 0.049	3.134AlaSer: 3.134 ± 0.072	2.896AlaThr: 2.896 ± 0.087	4.813AlaVal: 4.813 ± 0.091	0.308AlaTrp: 0.308 ± 0.022	2.09AlaTyr: 2.09 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.433CysAla: 0.433 ± 0.022	0.142CysCys: 0.142 ± 0.013	0.466CysAsp: 0.466 ± 0.023	0.614CysGlu: 0.614 ± 0.025	0.465CysPhe: 0.465 ± 0.025	0.958CysGly: 0.958 ± 0.036	0.166CysHis: 0.166 ± 0.013	0.83CysIle: 0.83 ± 0.036	0.68CysLys: 0.68 ± 0.027	0.697CysLeu: 0.697 ± 0.028	0.239CysMet: 0.239 ± 0.017	0.465CysAsn: 0.465 ± 0.023	0.392CysPro: 0.392 ± 0.027	0.218CysGln: 0.218 ± 0.016	0.308CysArg: 0.308 ± 0.02	0.631CysSer: 0.631 ± 0.03	0.478CysThr: 0.478 ± 0.025	0.526CysVal: 0.526 ± 0.027	0.071CysTrp: 0.071 ± 0.009	0.302CysTyr: 0.302 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	2.304AspAla: 2.304 ± 0.06	0.432AspCys: 0.432 ± 0.02	2.203AspAsp: 2.203 ± 0.052	4.33AspGlu: 4.33 ± 0.079	2.78AspPhe: 2.78 ± 0.061	3.568AspGly: 3.568 ± 0.077	0.479AspHis: 0.479 ± 0.022	6.059AspIle: 6.059 ± 0.105	4.914AspLys: 4.914 ± 0.088	4.011AspLeu: 4.011 ± 0.067	1.602AspMet: 1.602 ± 0.041	2.799AspAsn: 2.799 ± 0.061	1.298AspPro: 1.298 ± 0.035	0.713AspGln: 0.713 ± 0.028	1.896AspArg: 1.896 ± 0.05	2.882AspSer: 2.882 ± 0.061	2.511AspThr: 2.511 ± 0.049	2.929AspVal: 2.929 ± 0.058	0.378AspTrp: 0.378 ± 0.019	2.453AspTyr: 2.453 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.408GluAla: 4.408 ± 0.08	0.519GluCys: 0.519 ± 0.026	3.799GluAsp: 3.799 ± 0.068	7.316GluGlu: 7.316 ± 0.129	3.284GluPhe: 3.284 ± 0.065	4.135GluGly: 4.135 ± 0.079	0.894GluHis: 0.894 ± 0.031	8.452GluIle: 8.452 ± 0.123	10.279GluLys: 10.279 ± 0.176	7.018GluLeu: 7.018 ± 0.099	2.17GluMet: 2.17 ± 0.056	6.143GluAsn: 6.143 ± 0.092	1.241GluPro: 1.241 ± 0.031	1.511GluGln: 1.511 ± 0.043	2.956GluArg: 2.956 ± 0.062	3.195GluSer: 3.195 ± 0.065	3.358GluThr: 3.358 ± 0.067	4.665GluVal: 4.665 ± 0.08	0.534GluTrp: 0.534 ± 0.023	3.527GluTyr: 3.527 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.381PheAla: 2.381 ± 0.052	0.437PheCys: 0.437 ± 0.021	2.474PheAsp: 2.474 ± 0.052	2.995PheGlu: 2.995 ± 0.062	2.666PhePhe: 2.666 ± 0.073	3.232PheGly: 3.232 ± 0.063	0.604PheHis: 0.604 ± 0.026	4.72PheIle: 4.72 ± 0.109	3.872PheLys: 3.872 ± 0.074	4.787PheLeu: 4.787 ± 0.093	1.315PheMet: 1.315 ± 0.042	2.577PheAsn: 2.577 ± 0.055	1.371PhePro: 1.371 ± 0.042	1.075PheGln: 1.075 ± 0.035	1.437PheArg: 1.437 ± 0.037	3.701PheSer: 3.701 ± 0.076	2.465PheThr: 2.465 ± 0.057	2.543PheVal: 2.543 ± 0.059	0.343PheTrp: 0.343 ± 0.021	2.099PheTyr: 2.099 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.982GlyAla: 4.982 ± 0.118	0.727GlyCys: 0.727 ± 0.036	3.443GlyAsp: 3.443 ± 0.064	4.954GlyGlu: 4.954 ± 0.083	3.096GlyPhe: 3.096 ± 0.065	5.089GlyGly: 5.089 ± 0.134	0.977GlyHis: 0.977 ± 0.036	8.343GlyIle: 8.343 ± 0.143	6.865GlyLys: 6.865 ± 0.1	5.511GlyLeu: 5.511 ± 0.088	2.159GlyMet: 2.159 ± 0.048	4.085GlyAsn: 4.085 ± 0.122	1.097GlyPro: 1.097 ± 0.04	1.322GlyGln: 1.322 ± 0.044	2.329GlyArg: 2.329 ± 0.059	3.854GlySer: 3.854 ± 0.102	4.699GlyThr: 4.699 ± 0.227	5.201GlyVal: 5.201 ± 0.121	0.499GlyTrp: 0.499 ± 0.03	3.112GlyTyr: 3.112 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.617HisAla: 0.617 ± 0.025	0.133HisCys: 0.133 ± 0.012	0.536HisAsp: 0.536 ± 0.027	0.82HisGlu: 0.82 ± 0.031	0.584HisPhe: 0.584 ± 0.027	1.009HisGly: 1.009 ± 0.035	0.271HisHis: 0.271 ± 0.017	1.205HisIle: 1.205 ± 0.033	0.95HisLys: 0.95 ± 0.034	1.142HisLeu: 1.142 ± 0.04	0.336HisMet: 0.336 ± 0.016	0.68HisAsn: 0.68 ± 0.029	0.524HisPro: 0.524 ± 0.025	0.317HisGln: 0.317 ± 0.017	0.477HisArg: 0.477 ± 0.02	0.855HisSer: 0.855 ± 0.028	0.683HisThr: 0.683 ± 0.03	0.599HisVal: 0.599 ± 0.03	0.078HisTrp: 0.078 ± 0.011	0.506HisTyr: 0.506 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.998IleAla: 5.998 ± 0.095	1.01IleCys: 1.01 ± 0.038	5.228IleAsp: 5.228 ± 0.084	7.78IleGlu: 7.78 ± 0.119	5.104IlePhe: 5.104 ± 0.091	7.002IleGly: 7.002 ± 0.117	1.102IleHis: 1.102 ± 0.033	9.163IleIle: 9.163 ± 0.134	8.878IleLys: 8.878 ± 0.135	9.622IleLeu: 9.622 ± 0.157	2.387IleMet: 2.387 ± 0.046	5.568IleAsn: 5.568 ± 0.099	3.43IlePro: 3.43 ± 0.063	1.959IleGln: 1.959 ± 0.044	2.739IleArg: 2.739 ± 0.065	6.457IleSer: 6.457 ± 0.095	5.358IleThr: 5.358 ± 0.096	6.006IleVal: 6.006 ± 0.089	0.519IleTrp: 0.519 ± 0.022	3.884IleTyr: 3.884 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	4.869LysAla: 4.869 ± 0.086	0.651LysCys: 0.651 ± 0.03	5.532LysAsp: 5.532 ± 0.079	9.702LysGlu: 9.702 ± 0.145	3.659LysPhe: 3.659 ± 0.062	5.46LysGly: 5.46 ± 0.084	0.873LysHis: 0.873 ± 0.036	9.716LysIle: 9.716 ± 0.132	10.28LysLys: 10.28 ± 0.135	7.494LysLeu: 7.494 ± 0.106	2.859LysMet: 2.859 ± 0.054	7.214LysAsn: 7.214 ± 0.099	1.849LysPro: 1.849 ± 0.043	1.636LysGln: 1.636 ± 0.046	3.214LysArg: 3.214 ± 0.073	4.522LysSer: 4.522 ± 0.07	4.353LysThr: 4.353 ± 0.061	5.7LysVal: 5.7 ± 0.083	0.615LysTrp: 0.615 ± 0.03	4.672LysTyr: 4.672 ± 0.078	0.0LysXaa: 0.0 ± 0.0
Leu	5.24LeuAla: 5.24 ± 0.092	0.842LeuCys: 0.842 ± 0.032	4.713LeuAsp: 4.713 ± 0.077	7.341LeuGlu: 7.341 ± 0.107	4.058LeuPhe: 4.058 ± 0.081	6.836LeuGly: 6.836 ± 0.104	1.008LeuHis: 1.008 ± 0.031	7.519LeuIle: 7.519 ± 0.117	9.404LeuLys: 9.404 ± 0.12	7.692LeuLeu: 7.692 ± 0.122	2.363LeuMet: 2.363 ± 0.052	5.527LeuAsn: 5.527 ± 0.098	2.707LeuPro: 2.707 ± 0.057	1.815LeuGln: 1.815 ± 0.048	2.858LeuArg: 2.858 ± 0.057	5.969LeuSer: 5.969 ± 0.074	4.545LeuThr: 4.545 ± 0.074	5.102LeuVal: 5.102 ± 0.082	0.544LeuTrp: 0.544 ± 0.026	3.124LeuTyr: 3.124 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.812MetAla: 1.812 ± 0.044	0.208MetCys: 0.208 ± 0.014	1.227MetAsp: 1.227 ± 0.032	2.271MetGlu: 2.271 ± 0.051	1.084MetPhe: 1.084 ± 0.034	2.141MetGly: 2.141 ± 0.052	0.3MetHis: 0.3 ± 0.017	2.498MetIle: 2.498 ± 0.06	3.182MetLys: 3.182 ± 0.055	2.275MetLeu: 2.275 ± 0.051	0.76MetMet: 0.76 ± 0.032	1.599MetAsn: 1.599 ± 0.039	0.781MetPro: 0.781 ± 0.033	0.53MetGln: 0.53 ± 0.023	0.924MetArg: 0.924 ± 0.034	1.531MetSer: 1.531 ± 0.04	1.409MetThr: 1.409 ± 0.044	1.631MetVal: 1.631 ± 0.043	0.146MetTrp: 0.146 ± 0.012	0.894MetTyr: 0.894 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.66AsnAla: 2.66 ± 0.073	0.513AsnCys: 0.513 ± 0.024	2.616AsnAsp: 2.616 ± 0.053	4.011AsnGlu: 4.011 ± 0.073	3.032AsnPhe: 3.032 ± 0.059	4.632AsnGly: 4.632 ± 0.124	0.734AsnHis: 0.734 ± 0.03	7.038AsnIle: 7.038 ± 0.124	5.253AsnLys: 5.253 ± 0.092	5.366AsnLeu: 5.366 ± 0.079	1.607AsnMet: 1.607 ± 0.041	3.799AsnAsn: 3.799 ± 0.101	2.04AsnPro: 2.04 ± 0.051	1.176AsnGln: 1.176 ± 0.039	2.082AsnArg: 2.082 ± 0.048	3.717AsnSer: 3.717 ± 0.097	2.848AsnThr: 2.848 ± 0.079	3.134AsnVal: 3.134 ± 0.072	0.45AsnTrp: 0.45 ± 0.018	2.618AsnTyr: 2.618 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.661ProAla: 1.661 ± 0.05	0.256ProCys: 0.256 ± 0.016	1.365ProAsp: 1.365 ± 0.034	2.522ProGlu: 2.522 ± 0.063	1.389ProPhe: 1.389 ± 0.043	1.703ProGly: 1.703 ± 0.055	0.503ProHis: 0.503 ± 0.024	2.447ProIle: 2.447 ± 0.048	2.048ProLys: 2.048 ± 0.046	2.62ProLeu: 2.62 ± 0.069	0.74ProMet: 0.74 ± 0.03	1.32ProAsn: 1.32 ± 0.04	0.546ProPro: 0.546 ± 0.025	0.656ProGln: 0.656 ± 0.024	0.816ProArg: 0.816 ± 0.029	1.518ProSer: 1.518 ± 0.044	1.391ProThr: 1.391 ± 0.049	2.309ProVal: 2.309 ± 0.051	0.225ProTrp: 0.225 ± 0.015	1.197ProTyr: 1.197 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.239GlnAla: 1.239 ± 0.04	0.198GlnCys: 0.198 ± 0.015	0.957GlnAsp: 0.957 ± 0.034	1.733GlnGlu: 1.733 ± 0.047	0.83GlnPhe: 0.83 ± 0.032	1.518GlnGly: 1.518 ± 0.043	0.268GlnHis: 0.268 ± 0.018	1.87GlnIle: 1.87 ± 0.044	1.954GlnLys: 1.954 ± 0.051	1.849GlnLeu: 1.849 ± 0.048	0.589GlnMet: 0.589 ± 0.025	1.302GlnAsn: 1.302 ± 0.048	0.481GlnPro: 0.481 ± 0.022	0.528GlnGln: 0.528 ± 0.028	0.736GlnArg: 0.736 ± 0.031	1.096GlnSer: 1.096 ± 0.034	0.958GlnThr: 0.958 ± 0.031	1.219GlnVal: 1.219 ± 0.035	0.208GlnTrp: 0.208 ± 0.014	0.926GlnTyr: 0.926 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.928ArgAla: 1.928 ± 0.05	0.313ArgCys: 0.313 ± 0.017	1.863ArgAsp: 1.863 ± 0.051	3.398ArgGlu: 3.398 ± 0.069	1.425ArgPhe: 1.425 ± 0.04	2.161ArgGly: 2.161 ± 0.049	0.393ArgHis: 0.393 ± 0.021	3.21ArgIle: 3.21 ± 0.068	3.38ArgLys: 3.38 ± 0.06	2.578ArgLeu: 2.578 ± 0.06	0.978ArgMet: 0.978 ± 0.035	1.96ArgAsn: 1.96 ± 0.046	0.735ArgPro: 0.735 ± 0.033	0.665ArgGln: 0.665 ± 0.028	1.262ArgArg: 1.262 ± 0.04	1.32ArgSer: 1.32 ± 0.039	1.54ArgThr: 1.54 ± 0.037	2.117ArgVal: 2.117 ± 0.051	0.238ArgTrp: 0.238 ± 0.015	1.455ArgTyr: 1.455 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.149SerAla: 3.149 ± 0.067	0.587SerCys: 0.587 ± 0.032	2.759SerAsp: 2.759 ± 0.063	3.901SerGlu: 3.901 ± 0.057	3.21SerPhe: 3.21 ± 0.073	4.771SerGly: 4.771 ± 0.123	0.865SerHis: 0.865 ± 0.03	5.597SerIle: 5.597 ± 0.082	5.072SerLys: 5.072 ± 0.08	5.637SerLeu: 5.637 ± 0.084	1.468SerMet: 1.468 ± 0.043	3.191SerAsn: 3.191 ± 0.075	1.676SerPro: 1.676 ± 0.041	1.391SerGln: 1.391 ± 0.037	1.941SerArg: 1.941 ± 0.049	4.021SerSer: 4.021 ± 0.092	3.039SerThr: 3.039 ± 0.069	3.527SerVal: 3.527 ± 0.085	0.417SerTrp: 0.417 ± 0.024	2.511SerTyr: 2.511 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.589ThrAla: 3.589 ± 0.091	0.392ThrCys: 0.392 ± 0.024	2.522ThrAsp: 2.522 ± 0.053	3.391ThrGlu: 3.391 ± 0.064	2.328ThrPhe: 2.328 ± 0.054	5.015ThrGly: 5.015 ± 0.158	0.687ThrHis: 0.687 ± 0.028	4.935ThrIle: 4.935 ± 0.116	3.621ThrLys: 3.621 ± 0.069	4.938ThrLeu: 4.938 ± 0.086	1.19ThrMet: 1.19 ± 0.04	2.472ThrAsn: 2.472 ± 0.075	1.952ThrPro: 1.952 ± 0.043	1.072ThrGln: 1.072 ± 0.032	1.531ThrArg: 1.531 ± 0.039	3.031ThrSer: 3.031 ± 0.085	2.732ThrThr: 2.732 ± 0.088	3.607ThrVal: 3.607 ± 0.097	0.31ThrTrp: 0.31 ± 0.02	1.881ThrTyr: 1.881 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	3.837ValAla: 3.837 ± 0.082	0.626ValCys: 0.626 ± 0.032	3.265ValAsp: 3.265 ± 0.065	4.77ValGlu: 4.77 ± 0.086	2.958ValPhe: 2.958 ± 0.064	4.447ValGly: 4.447 ± 0.136	0.723ValHis: 0.723 ± 0.031	6.068ValIle: 6.068 ± 0.085	5.477ValLys: 5.477 ± 0.078	5.719ValLeu: 5.719 ± 0.088	1.625ValMet: 1.625 ± 0.043	3.206ValAsn: 3.206 ± 0.079	2.048ValPro: 2.048 ± 0.054	1.277ValGln: 1.277 ± 0.037	1.906ValArg: 1.906 ± 0.052	3.925ValSer: 3.925 ± 0.065	3.522ValThr: 3.522 ± 0.081	4.378ValVal: 4.378 ± 0.081	0.391ValTrp: 0.391 ± 0.02	2.396ValTyr: 2.396 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.354TrpAla: 0.354 ± 0.02	0.075TrpCys: 0.075 ± 0.01	0.358TrpAsp: 0.358 ± 0.019	0.549TrpGlu: 0.549 ± 0.026	0.28TrpPhe: 0.28 ± 0.017	0.536TrpGly: 0.536 ± 0.026	0.092TrpHis: 0.092 ± 0.01	0.593TrpIle: 0.593 ± 0.029	0.589TrpLys: 0.589 ± 0.024	0.677TrpLeu: 0.677 ± 0.031	0.153TrpMet: 0.153 ± 0.013	0.506TrpAsn: 0.506 ± 0.028	0.14TrpPro: 0.14 ± 0.014	0.176TrpGln: 0.176 ± 0.015	0.216TrpArg: 0.216 ± 0.017	0.34TrpSer: 0.34 ± 0.021	0.28TrpThr: 0.28 ± 0.02	0.4TrpVal: 0.4 ± 0.021	0.072TrpTrp: 0.072 ± 0.01	0.243TrpTyr: 0.243 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.008TyrAla: 2.008 ± 0.057	0.426TyrCys: 0.426 ± 0.024	2.297TyrAsp: 2.297 ± 0.054	2.869TyrGlu: 2.869 ± 0.067	2.255TyrPhe: 2.255 ± 0.053	3.158TyrGly: 3.158 ± 0.082	0.573TyrHis: 0.573 ± 0.025	3.85TyrIle: 3.85 ± 0.075	3.629TyrLys: 3.629 ± 0.074	3.855TyrLeu: 3.855 ± 0.065	0.982TyrMet: 0.982 ± 0.03	2.628TyrAsn: 2.628 ± 0.053	1.313TyrPro: 1.313 ± 0.043	0.938TyrGln: 0.938 ± 0.04	1.509TyrArg: 1.509 ± 0.046	3.03TyrSer: 3.03 ± 0.058	2.132TyrThr: 2.132 ± 0.055	2.157TyrVal: 2.157 ± 0.047	0.283TyrTrp: 0.283 ± 0.017	1.836TyrTyr: 1.836 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3007 proteins (949191 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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