Amino acid dipepetide frequency for Streptomyces sp. Ag109_G2-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.781AlaAla: 24.781 ± 0.194	1.152AlaCys: 1.152 ± 0.02	8.438AlaAsp: 8.438 ± 0.071	9.172AlaGlu: 9.172 ± 0.114	3.696AlaPhe: 3.696 ± 0.048	15.076AlaGly: 15.076 ± 0.113	2.992AlaHis: 2.992 ± 0.039	3.1AlaIle: 3.1 ± 0.04	2.859AlaLys: 2.859 ± 0.055	15.539AlaLeu: 15.539 ± 0.186	2.501AlaMet: 2.501 ± 0.033	1.872AlaAsn: 1.872 ± 0.032	8.502AlaPro: 8.502 ± 0.104	4.001AlaGln: 4.001 ± 0.051	10.767AlaArg: 10.767 ± 0.086	5.908AlaSer: 5.908 ± 0.066	6.887AlaThr: 6.887 ± 0.064	12.721AlaVal: 12.721 ± 0.092	1.981AlaTrp: 1.981 ± 0.033	2.815AlaTyr: 2.815 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.219CysAla: 1.219 ± 0.024	0.098CysCys: 0.098 ± 0.007	0.475CysAsp: 0.475 ± 0.015	0.41CysGlu: 0.41 ± 0.014	0.239CysPhe: 0.239 ± 0.011	1.01CysGly: 1.01 ± 0.022	0.181CysHis: 0.181 ± 0.009	0.16CysIle: 0.16 ± 0.008	0.128CysLys: 0.128 ± 0.008	0.778CysLeu: 0.778 ± 0.023	0.129CysMet: 0.129 ± 0.007	0.134CysAsn: 0.134 ± 0.008	0.533CysPro: 0.533 ± 0.017	0.164CysGln: 0.164 ± 0.01	0.624CysArg: 0.624 ± 0.017	0.44CysSer: 0.44 ± 0.013	0.541CysThr: 0.541 ± 0.015	0.648CysVal: 0.648 ± 0.016	0.129CysTrp: 0.129 ± 0.008	0.141CysTyr: 0.141 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.502AspAla: 7.502 ± 0.081	0.462AspCys: 0.462 ± 0.015	2.874AspAsp: 2.874 ± 0.037	3.509AspGlu: 3.509 ± 0.049	1.466AspPhe: 1.466 ± 0.025	6.287AspGly: 6.287 ± 0.071	1.354AspHis: 1.354 ± 0.025	1.613AspIle: 1.613 ± 0.03	1.105AspLys: 1.105 ± 0.029	5.866AspLeu: 5.866 ± 0.054	0.753AspMet: 0.753 ± 0.016	0.863AspAsn: 0.863 ± 0.025	4.644AspPro: 4.644 ± 0.045	1.429AspGln: 1.429 ± 0.029	4.713AspArg: 4.713 ± 0.05	2.345AspSer: 2.345 ± 0.031	3.006AspThr: 3.006 ± 0.039	4.214AspVal: 4.214 ± 0.045	1.021AspTrp: 1.021 ± 0.022	1.059AspTyr: 1.059 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	8.042GluAla: 8.042 ± 0.092	0.379GluCys: 0.379 ± 0.012	2.863GluAsp: 2.863 ± 0.041	3.655GluGlu: 3.655 ± 0.049	1.488GluPhe: 1.488 ± 0.028	4.596GluGly: 4.596 ± 0.054	1.47GluHis: 1.47 ± 0.022	2.101GluIle: 2.101 ± 0.034	1.269GluLys: 1.269 ± 0.03	6.905GluLeu: 6.905 ± 0.069	0.844GluMet: 0.844 ± 0.023	1.009GluAsn: 1.009 ± 0.023	3.427GluPro: 3.427 ± 0.046	2.11GluGln: 2.11 ± 0.029	5.383GluArg: 5.383 ± 0.057	2.375GluSer: 2.375 ± 0.033	2.709GluThr: 2.709 ± 0.04	4.461GluVal: 4.461 ± 0.049	0.754GluTrp: 0.754 ± 0.019	1.112GluTyr: 1.112 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.048	0.274PheCys: 0.274 ± 0.012	1.859PheAsp: 1.859 ± 0.027	1.429PheGlu: 1.429 ± 0.027	0.835PhePhe: 0.835 ± 0.022	2.971PheGly: 2.971 ± 0.038	0.594PheHis: 0.594 ± 0.016	0.662PheIle: 0.662 ± 0.016	0.501PheLys: 0.501 ± 0.015	2.512PheLeu: 2.512 ± 0.035	0.388PheMet: 0.388 ± 0.015	0.533PheAsn: 0.533 ± 0.016	1.448PhePro: 1.448 ± 0.023	0.642PheGln: 0.642 ± 0.017	1.785PheArg: 1.785 ± 0.024	1.422PheSer: 1.422 ± 0.027	1.95PheThr: 1.95 ± 0.027	2.073PheVal: 2.073 ± 0.032	0.407PheTrp: 0.407 ± 0.013	0.558PheTyr: 0.558 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.321GlyAla: 12.321 ± 0.103	0.89GlyCys: 0.89 ± 0.02	4.842GlyAsp: 4.842 ± 0.048	5.282GlyGlu: 5.282 ± 0.051	2.879GlyPhe: 2.879 ± 0.042	9.56GlyGly: 9.56 ± 0.104	2.473GlyHis: 2.473 ± 0.035	3.439GlyIle: 3.439 ± 0.041	2.377GlyLys: 2.377 ± 0.045	9.879GlyLeu: 9.879 ± 0.074	2.006GlyMet: 2.006 ± 0.033	1.704GlyAsn: 1.704 ± 0.028	6.171GlyPro: 6.171 ± 0.069	2.738GlyGln: 2.738 ± 0.04	8.44GlyArg: 8.44 ± 0.078	5.458GlySer: 5.458 ± 0.061	6.302GlyThr: 6.302 ± 0.067	7.462GlyVal: 7.462 ± 0.073	1.739GlyTrp: 1.739 ± 0.029	2.253GlyTyr: 2.253 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.775HisAla: 2.775 ± 0.041	0.207HisCys: 0.207 ± 0.008	1.251HisAsp: 1.251 ± 0.024	1.192HisGlu: 1.192 ± 0.021	0.583HisPhe: 0.583 ± 0.018	2.39HisGly: 2.39 ± 0.032	0.698HisHis: 0.698 ± 0.019	0.594HisIle: 0.594 ± 0.016	0.34HisLys: 0.34 ± 0.012	2.396HisLeu: 2.396 ± 0.039	0.341HisMet: 0.341 ± 0.011	0.33HisAsn: 0.33 ± 0.012	2.025HisPro: 2.025 ± 0.031	0.638HisGln: 0.638 ± 0.016	2.1HisArg: 2.1 ± 0.032	1.003HisSer: 1.003 ± 0.021	1.361HisThr: 1.361 ± 0.026	1.668HisVal: 1.668 ± 0.029	0.386HisTrp: 0.386 ± 0.014	0.462HisTyr: 0.462 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.519IleAla: 4.519 ± 0.044	0.281IleCys: 0.281 ± 0.012	1.959IleAsp: 1.959 ± 0.031	1.876IleGlu: 1.876 ± 0.034	0.596IlePhe: 0.596 ± 0.016	3.329IleGly: 3.329 ± 0.046	0.582IleHis: 0.582 ± 0.017	0.735IleIle: 0.735 ± 0.021	0.707IleLys: 0.707 ± 0.019	2.172IleLeu: 2.172 ± 0.035	0.394IleMet: 0.394 ± 0.014	0.621IleAsn: 0.621 ± 0.019	1.688IlePro: 1.688 ± 0.032	0.646IleGln: 0.646 ± 0.019	2.159IleArg: 2.159 ± 0.03	1.594IleSer: 1.594 ± 0.029	2.07IleThr: 2.07 ± 0.033	2.369IleVal: 2.369 ± 0.044	0.35IleTrp: 0.35 ± 0.013	0.467IleTyr: 0.467 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	2.966LysAla: 2.966 ± 0.056	0.112LysCys: 0.112 ± 0.008	1.277LysAsp: 1.277 ± 0.028	1.141LysGlu: 1.141 ± 0.025	0.432LysPhe: 0.432 ± 0.015	1.77LysGly: 1.77 ± 0.035	0.399LysHis: 0.399 ± 0.014	0.833LysIle: 0.833 ± 0.02	0.77LysLys: 0.77 ± 0.031	1.918LysLeu: 1.918 ± 0.037	0.36LysMet: 0.36 ± 0.012	0.517LysAsn: 0.517 ± 0.02	1.381LysPro: 1.381 ± 0.034	0.657LysGln: 0.657 ± 0.018	1.347LysArg: 1.347 ± 0.026	1.064LysSer: 1.064 ± 0.027	1.276LysThr: 1.276 ± 0.029	1.77LysVal: 1.77 ± 0.035	0.246LysTrp: 0.246 ± 0.011	0.42LysTyr: 0.42 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.07LeuAla: 16.07 ± 0.128	0.9LeuCys: 0.9 ± 0.022	6.41LeuAsp: 6.41 ± 0.061	4.983LeuGlu: 4.983 ± 0.054	2.568LeuPhe: 2.568 ± 0.041	9.634LeuGly: 9.634 ± 0.077	2.338LeuHis: 2.338 ± 0.039	2.993LeuIle: 2.993 ± 0.043	1.913LeuLys: 1.913 ± 0.031	11.569LeuLeu: 11.569 ± 0.117	1.59LeuMet: 1.59 ± 0.026	1.562LeuAsn: 1.562 ± 0.028	6.812LeuPro: 6.812 ± 0.061	2.105LeuGln: 2.105 ± 0.034	8.777LeuArg: 8.777 ± 0.089	5.143LeuSer: 5.143 ± 0.051	6.849LeuThr: 6.849 ± 0.082	8.779LeuVal: 8.779 ± 0.069	1.352LeuTrp: 1.352 ± 0.027	1.839LeuTyr: 1.839 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.253MetAla: 2.253 ± 0.032	0.131MetCys: 0.131 ± 0.008	0.929MetAsp: 0.929 ± 0.021	0.747MetGlu: 0.747 ± 0.023	0.417MetPhe: 0.417 ± 0.015	1.275MetGly: 1.275 ± 0.025	0.332MetHis: 0.332 ± 0.012	0.613MetIle: 0.613 ± 0.018	0.406MetLys: 0.406 ± 0.012	1.64MetLeu: 1.64 ± 0.029	0.271MetMet: 0.271 ± 0.011	0.44MetAsn: 0.44 ± 0.011	1.133MetPro: 1.133 ± 0.024	0.418MetGln: 0.418 ± 0.013	1.362MetArg: 1.362 ± 0.023	1.271MetSer: 1.271 ± 0.028	1.453MetThr: 1.453 ± 0.029	1.209MetVal: 1.209 ± 0.024	0.207MetTrp: 0.207 ± 0.01	0.308MetTyr: 0.308 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.125AsnAla: 2.125 ± 0.034	0.151AsnCys: 0.151 ± 0.008	0.843AsnAsp: 0.843 ± 0.02	0.781AsnGlu: 0.781 ± 0.021	0.465AsnPhe: 0.465 ± 0.015	1.838AsnGly: 1.838 ± 0.035	0.385AsnHis: 0.385 ± 0.014	0.582AsnIle: 0.582 ± 0.015	0.392AsnLys: 0.392 ± 0.015	1.6AsnLeu: 1.6 ± 0.029	0.285AsnMet: 0.285 ± 0.011	0.382AsnAsn: 0.382 ± 0.015	1.35AsnPro: 1.35 ± 0.025	0.51AsnGln: 0.51 ± 0.017	1.193AsnArg: 1.193 ± 0.026	0.844AsnSer: 0.844 ± 0.02	1.067AsnThr: 1.067 ± 0.025	1.249AsnVal: 1.249 ± 0.025	0.285AsnTrp: 0.285 ± 0.012	0.343AsnTyr: 0.343 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	10.821ProAla: 10.821 ± 0.107	0.355ProCys: 0.355 ± 0.014	4.391ProAsp: 4.391 ± 0.047	4.515ProGlu: 4.515 ± 0.05	1.552ProPhe: 1.552 ± 0.026	7.713ProGly: 7.713 ± 0.091	1.464ProHis: 1.464 ± 0.027	1.113ProIle: 1.113 ± 0.026	1.185ProLys: 1.185 ± 0.028	5.701ProLeu: 5.701 ± 0.059	1.015ProMet: 1.015 ± 0.022	0.855ProAsn: 0.855 ± 0.021	3.932ProPro: 3.932 ± 0.074	2.04ProGln: 2.04 ± 0.04	4.191ProArg: 4.191 ± 0.052	3.279ProSer: 3.279 ± 0.046	3.045ProThr: 3.045 ± 0.05	5.78ProVal: 5.78 ± 0.046	0.955ProTrp: 0.955 ± 0.022	1.429ProTyr: 1.429 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.943GlnAla: 3.943 ± 0.052	0.192GlnCys: 0.192 ± 0.009	1.415GlnAsp: 1.415 ± 0.026	1.44GlnGlu: 1.44 ± 0.028	0.628GlnPhe: 0.628 ± 0.017	2.383GlnGly: 2.383 ± 0.035	0.638GlnHis: 0.638 ± 0.017	0.977GlnIle: 0.977 ± 0.023	0.592GlnLys: 0.592 ± 0.018	2.912GlnLeu: 2.912 ± 0.038	0.458GlnMet: 0.458 ± 0.014	0.476GlnAsn: 0.476 ± 0.017	1.767GlnPro: 1.767 ± 0.037	1.21GlnGln: 1.21 ± 0.032	2.272GlnArg: 2.272 ± 0.032	1.204GlnSer: 1.204 ± 0.025	1.313GlnThr: 1.313 ± 0.029	2.264GlnVal: 2.264 ± 0.037	0.479GlnTrp: 0.479 ± 0.016	0.585GlnTyr: 0.585 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.391ArgAla: 10.391 ± 0.081	0.621ArgCys: 0.621 ± 0.019	3.986ArgAsp: 3.986 ± 0.05	4.886ArgGlu: 4.886 ± 0.057	2.307ArgPhe: 2.307 ± 0.033	6.057ArgGly: 6.057 ± 0.06	2.075ArgHis: 2.075 ± 0.037	3.225ArgIle: 3.225 ± 0.041	1.574ArgLys: 1.574 ± 0.032	8.931ArgLeu: 8.931 ± 0.076	1.714ArgMet: 1.714 ± 0.03	1.268ArgAsn: 1.268 ± 0.022	5.451ArgPro: 5.451 ± 0.059	2.164ArgGln: 2.164 ± 0.03	7.853ArgArg: 7.853 ± 0.08	3.919ArgSer: 3.919 ± 0.04	5.438ArgThr: 5.438 ± 0.064	5.679ArgVal: 5.679 ± 0.055	1.356ArgTrp: 1.356 ± 0.027	1.764ArgTyr: 1.764 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.822SerAla: 6.822 ± 0.062	0.455SerCys: 0.455 ± 0.017	2.363SerAsp: 2.363 ± 0.035	2.255SerGlu: 2.255 ± 0.031	1.483SerPhe: 1.483 ± 0.027	5.873SerGly: 5.873 ± 0.058	0.965SerHis: 0.965 ± 0.022	1.249SerIle: 1.249 ± 0.025	0.95SerLys: 0.95 ± 0.023	4.758SerLeu: 4.758 ± 0.055	1.016SerMet: 1.016 ± 0.024	0.829SerAsn: 0.829 ± 0.023	3.352SerPro: 3.352 ± 0.045	1.221SerGln: 1.221 ± 0.026	3.616SerArg: 3.616 ± 0.041	2.68SerSer: 2.68 ± 0.043	2.792SerThr: 2.792 ± 0.04	4.133SerVal: 4.133 ± 0.045	0.899SerTrp: 0.899 ± 0.018	1.156SerTyr: 1.156 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	9.356ThrAla: 9.356 ± 0.11	0.423ThrCys: 0.423 ± 0.013	3.215ThrAsp: 3.215 ± 0.041	3.005ThrGlu: 3.005 ± 0.037	1.457ThrPhe: 1.457 ± 0.025	6.948ThrGly: 6.948 ± 0.064	1.141ThrHis: 1.141 ± 0.023	1.479ThrIle: 1.479 ± 0.028	1.076ThrLys: 1.076 ± 0.027	5.678ThrLeu: 5.678 ± 0.071	0.853ThrMet: 0.853 ± 0.021	0.9ThrAsn: 0.9 ± 0.022	4.366ThrPro: 4.366 ± 0.056	1.213ThrGln: 1.213 ± 0.027	3.804ThrArg: 3.804 ± 0.047	2.859ThrSer: 2.859 ± 0.042	3.627ThrThr: 3.627 ± 0.048	5.651ThrVal: 5.651 ± 0.06	0.859ThrTrp: 0.859 ± 0.021	1.272ThrTyr: 1.272 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.49ValAla: 10.49 ± 0.066	0.776ValCys: 0.776 ± 0.019	4.537ValAsp: 4.537 ± 0.052	4.58ValGlu: 4.58 ± 0.053	2.398ValPhe: 2.398 ± 0.035	6.145ValGly: 6.145 ± 0.06	1.913ValHis: 1.913 ± 0.036	2.685ValIle: 2.685 ± 0.037	1.741ValLys: 1.741 ± 0.035	9.586ValLeu: 9.586 ± 0.083	1.382ValMet: 1.382 ± 0.025	1.596ValAsn: 1.596 ± 0.028	5.458ValPro: 5.458 ± 0.053	2.015ValGln: 2.015 ± 0.032	7.157ValArg: 7.157 ± 0.068	4.223ValSer: 4.223 ± 0.051	5.303ValThr: 5.303 ± 0.054	7.535ValVal: 7.535 ± 0.078	1.144ValTrp: 1.144 ± 0.024	1.582ValTyr: 1.582 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.734TrpAla: 1.734 ± 0.03	0.159TrpCys: 0.159 ± 0.007	0.813TrpAsp: 0.813 ± 0.021	0.78TrpGlu: 0.78 ± 0.02	0.476TrpPhe: 0.476 ± 0.014	1.084TrpGly: 1.084 ± 0.022	0.37TrpHis: 0.37 ± 0.014	0.539TrpIle: 0.539 ± 0.017	0.382TrpLys: 0.382 ± 0.016	1.793TrpLeu: 1.793 ± 0.032	0.276TrpMet: 0.276 ± 0.012	0.41TrpAsn: 0.41 ± 0.013	0.829TrpPro: 0.829 ± 0.021	0.615TrpGln: 0.615 ± 0.016	1.316TrpArg: 1.316 ± 0.026	0.934TrpSer: 0.934 ± 0.024	1.078TrpThr: 1.078 ± 0.021	0.995TrpVal: 0.995 ± 0.021	0.347TrpTrp: 0.347 ± 0.014	0.347TrpTyr: 0.347 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.884TyrAla: 2.884 ± 0.037	0.163TyrCys: 0.163 ± 0.008	1.346TyrAsp: 1.346 ± 0.03	1.314TyrGlu: 1.314 ± 0.025	0.617TyrPhe: 0.617 ± 0.018	2.275TyrGly: 2.275 ± 0.038	0.375TyrHis: 0.375 ± 0.011	0.421TyrIle: 0.421 ± 0.015	0.39TyrLys: 0.39 ± 0.015	2.055TyrLeu: 2.055 ± 0.033	0.24TyrMet: 0.24 ± 0.011	0.368TyrAsn: 0.368 ± 0.016	1.063TyrPro: 1.063 ± 0.024	0.613TyrGln: 0.613 ± 0.018	1.8TyrArg: 1.8 ± 0.033	0.904TyrSer: 0.904 ± 0.022	1.115TyrThr: 1.115 ± 0.023	1.587TyrVal: 1.587 ± 0.029	0.383TyrTrp: 0.383 ± 0.014	0.41TyrTyr: 0.41 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7108 proteins (2357120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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