Human papillomavirus type 60

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 4

Average proteome isoelectric point is 6.3

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|Q80943|VE1_HPV60 Replication protein E1 OS=Human papillomavirus type 60 OX=40540 GN=E1 PE=3 SV=1
MM1 pKa = 7.76IGNQPNVNNLDD12 pKa = 3.59VNLEE16 pKa = 4.03EE17 pKa = 4.96LVLPVSLLADD27 pKa = 3.84EE28 pKa = 4.92EE29 pKa = 4.55LSPDD33 pKa = 3.55GDD35 pKa = 3.97PEE37 pKa = 4.19EE38 pKa = 4.72EE39 pKa = 3.6EE40 pKa = 4.56HH41 pKa = 6.86YY42 pKa = 10.35PYY44 pKa = 10.63TIDD47 pKa = 3.84TCCKK51 pKa = 8.03PCGAGVRR58 pKa = 11.84FTIIATPSAVITLRR72 pKa = 11.84QLLLQEE78 pKa = 4.49VFLTCLRR85 pKa = 11.84CSRR88 pKa = 11.84SLFRR92 pKa = 11.84HH93 pKa = 5.48GRR95 pKa = 11.84SS96 pKa = 3.13

Molecular weight: 10.69 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|Q80945|Q80945_HPV60 E4 protein (Fragment) OS=Human papillomavirus type 60 OX=40540 GN=E4 PE=4 SV=1
MM1 pKa = 6.99NQADD5 pKa = 3.85LTEE8 pKa = 4.93RR9 pKa = 11.84SDD11 pKa = 3.9ALQEE15 pKa = 4.19QILNLYY21 pKa = 8.54EE22 pKa = 4.07QDD24 pKa = 3.78SKK26 pKa = 11.6DD27 pKa = 3.24IQAQIQYY34 pKa = 9.66WDD36 pKa = 4.33LNRR39 pKa = 11.84KK40 pKa = 9.67LYY42 pKa = 7.88VTYY45 pKa = 10.6YY46 pKa = 8.06YY47 pKa = 10.98ARR49 pKa = 11.84KK50 pKa = 9.46EE51 pKa = 4.51GYY53 pKa = 9.26SHH55 pKa = 7.58LGLQPLPALQVSEE68 pKa = 4.66YY69 pKa = 9.85KK70 pKa = 10.6AKK72 pKa = 10.41QAIEE76 pKa = 4.05MGLLLTSLSKK86 pKa = 10.65SQYY89 pKa = 10.88ASEE92 pKa = 4.14LWGLTDD98 pKa = 3.8TSAEE102 pKa = 4.1LLLTPPRR109 pKa = 11.84NTFKK113 pKa = 11.12KK114 pKa = 9.9KK115 pKa = 10.41GYY117 pKa = 7.22TVNVWFDD124 pKa = 3.51NNEE127 pKa = 4.09NNTFPYY133 pKa = 9.95TNWEE137 pKa = 4.08YY138 pKa = 10.6IYY140 pKa = 10.46YY141 pKa = 9.96QDD143 pKa = 6.29DD144 pKa = 3.39IEE146 pKa = 4.3QWHH149 pKa = 5.46RR150 pKa = 11.84TRR152 pKa = 11.84GEE154 pKa = 3.24VDD156 pKa = 3.24YY157 pKa = 11.44NGLYY161 pKa = 8.81FTEE164 pKa = 4.38NNGNRR169 pKa = 11.84AYY171 pKa = 10.72FLLFDD176 pKa = 5.32SDD178 pKa = 3.7AQTYY182 pKa = 9.13SQTGTWTVHH191 pKa = 5.53YY192 pKa = 9.46KK193 pKa = 10.2NQIISAPVTSSSKK206 pKa = 10.39QSSDD210 pKa = 3.93DD211 pKa = 3.7YY212 pKa = 10.91TSKK215 pKa = 10.92AGQQPHH221 pKa = 6.19FFASSSSPTTTDD233 pKa = 2.67GGQTSQEE240 pKa = 4.26GVSSSTTSPSAVRR253 pKa = 11.84LRR255 pKa = 11.84RR256 pKa = 11.84RR257 pKa = 11.84RR258 pKa = 11.84SNEE261 pKa = 3.33QQRR264 pKa = 11.84EE265 pKa = 4.07LSSRR269 pKa = 11.84EE270 pKa = 3.7SPRR273 pKa = 11.84TKK275 pKa = 10.03RR276 pKa = 11.84RR277 pKa = 11.84RR278 pKa = 11.84VPDD281 pKa = 3.31EE282 pKa = 3.91VDD284 pKa = 3.11RR285 pKa = 11.84QSAVGSAPTAEE296 pKa = 4.43EE297 pKa = 3.7VGSRR301 pKa = 11.84HH302 pKa = 6.13RR303 pKa = 11.84SLPRR307 pKa = 11.84SGISRR312 pKa = 11.84LARR315 pKa = 11.84LQGEE319 pKa = 4.22ARR321 pKa = 11.84DD322 pKa = 4.02PPILLIKK329 pKa = 10.6GLANSLKK336 pKa = 9.48CWRR339 pKa = 11.84YY340 pKa = 9.19RR341 pKa = 11.84LKK343 pKa = 10.78KK344 pKa = 6.84YY345 pKa = 8.56TRR347 pKa = 11.84YY348 pKa = 8.59FKK350 pKa = 11.07CMSTVFRR357 pKa = 11.84WVDD360 pKa = 2.63IDD362 pKa = 3.73VPEE365 pKa = 4.26SSRR368 pKa = 11.84HH369 pKa = 4.84KK370 pKa = 10.77LLVVFNDD377 pKa = 3.35TTQRR381 pKa = 11.84DD382 pKa = 3.79VFMKK386 pKa = 10.68LVTLPRR392 pKa = 11.84GCTYY396 pKa = 10.85TFGTLNSLL404 pKa = 3.96

Molecular weight: 46.53 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2492

96

610

356.0

40.38

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.658 ± 0.631

2.167 ± 0.728

6.14 ± 0.338

6.34 ± 0.61

4.735 ± 0.396

5.538 ± 0.829

1.525 ± 0.371

5.778 ± 0.817

5.217 ± 0.699

9.551 ± 0.73

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.886 ± 0.308

4.775 ± 0.393

5.979 ± 1.014

4.735 ± 0.322

5.819 ± 0.493

7.343 ± 0.701

6.541 ± 0.546

5.177 ± 0.54

1.244 ± 0.245

3.852 ± 0.562
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski