Amino acid dipepetide frequency for Thioclava arenosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.321AlaAla: 18.321 ± 0.219
1.11AlaCys: 1.11 ± 0.041
6.612AlaAsp: 6.612 ± 0.1
10.092AlaGlu: 10.092 ± 0.144
4.404AlaPhe: 4.404 ± 0.08
11.305AlaGly: 11.305 ± 0.135
2.433AlaHis: 2.433 ± 0.054
5.978AlaIle: 5.978 ± 0.088
4.106AlaLys: 4.106 ± 0.089
15.535AlaLeu: 15.535 ± 0.17
3.991AlaMet: 3.991 ± 0.078
2.665AlaAsn: 2.665 ± 0.056
7.161AlaPro: 7.161 ± 0.162
4.684AlaGln: 4.684 ± 0.079
10.267AlaArg: 10.267 ± 0.152
5.606AlaSer: 5.606 ± 0.087
5.887AlaThr: 5.887 ± 0.073
8.052AlaVal: 8.052 ± 0.098
1.395AlaTrp: 1.395 ± 0.047
2.48AlaTyr: 2.48 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
1.123CysAla: 1.123 ± 0.041
0.103CysCys: 0.103 ± 0.012
0.586CysAsp: 0.586 ± 0.028
0.429CysGlu: 0.429 ± 0.023
0.314CysPhe: 0.314 ± 0.019
0.865CysGly: 0.865 ± 0.034
0.308CysHis: 0.308 ± 0.022
0.371CysIle: 0.371 ± 0.023
0.216CysLys: 0.216 ± 0.016
0.837CysLeu: 0.837 ± 0.035
0.158CysMet: 0.158 ± 0.015
0.203CysAsn: 0.203 ± 0.016
0.573CysPro: 0.573 ± 0.03
0.214CysGln: 0.214 ± 0.015
0.54CysArg: 0.54 ± 0.024
0.431CysSer: 0.431 ± 0.024
0.453CysThr: 0.453 ± 0.025
0.558CysVal: 0.558 ± 0.032
0.095CysTrp: 0.095 ± 0.011
0.194CysTyr: 0.194 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.62AspAla: 6.62 ± 0.093
0.487AspCys: 0.487 ± 0.024
2.811AspAsp: 2.811 ± 0.099
3.557AspGlu: 3.557 ± 0.093
2.242AspPhe: 2.242 ± 0.048
4.914AspGly: 4.914 ± 0.085
1.219AspHis: 1.219 ± 0.045
2.637AspIle: 2.637 ± 0.06
1.671AspLys: 1.671 ± 0.054
6.458AspLeu: 6.458 ± 0.096
1.524AspMet: 1.524 ± 0.047
1.08AspAsn: 1.08 ± 0.039
3.723AspPro: 3.723 ± 0.075
1.693AspGln: 1.693 ± 0.044
3.781AspArg: 3.781 ± 0.076
1.744AspSer: 1.744 ± 0.052
2.588AspThr: 2.588 ± 0.064
3.567AspVal: 3.567 ± 0.075
1.228AspTrp: 1.228 ± 0.04
1.599AspTyr: 1.599 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
10.386GluAla: 10.386 ± 0.153
0.368GluCys: 0.368 ± 0.021
3.279GluAsp: 3.279 ± 0.075
4.013GluGlu: 4.013 ± 0.079
2.019GluPhe: 2.019 ± 0.056
5.776GluGly: 5.776 ± 0.09
1.118GluHis: 1.118 ± 0.041
4.034GluIle: 4.034 ± 0.064
2.334GluLys: 2.334 ± 0.058
5.729GluLeu: 5.729 ± 0.095
2.045GluMet: 2.045 ± 0.051
1.624GluAsn: 1.624 ± 0.052
2.893GluPro: 2.893 ± 0.083
1.873GluGln: 1.873 ± 0.053
4.659GluArg: 4.659 ± 0.089
2.18GluSer: 2.18 ± 0.051
3.985GluThr: 3.985 ± 0.061
4.699GluVal: 4.699 ± 0.073
0.751GluTrp: 0.751 ± 0.027
1.003GluTyr: 1.003 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
4.739PheAla: 4.739 ± 0.083
0.44PheCys: 0.44 ± 0.02
2.644PheAsp: 2.644 ± 0.056
2.366PheGlu: 2.366 ± 0.053
1.416PhePhe: 1.416 ± 0.053
3.799PheGly: 3.799 ± 0.077
0.732PheHis: 0.732 ± 0.03
1.588PheIle: 1.588 ± 0.043
0.939PheLys: 0.939 ± 0.033
3.496PheLeu: 3.496 ± 0.077
0.845PheMet: 0.845 ± 0.034
0.986PheAsn: 0.986 ± 0.034
1.529PhePro: 1.529 ± 0.04
0.884PheGln: 0.884 ± 0.03
2.204PheArg: 2.204 ± 0.054
2.086PheSer: 2.086 ± 0.05
2.034PheThr: 2.034 ± 0.052
2.576PheVal: 2.576 ± 0.062
0.602PheTrp: 0.602 ± 0.03
0.948PheTyr: 0.948 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
11.216GlyAla: 11.216 ± 0.128
0.867GlyCys: 0.867 ± 0.031
4.499GlyAsp: 4.499 ± 0.092
5.019GlyGlu: 5.019 ± 0.09
3.913GlyPhe: 3.913 ± 0.079
7.43GlyGly: 7.43 ± 0.133
1.882GlyHis: 1.882 ± 0.05
4.341GlyIle: 4.341 ± 0.082
3.268GlyLys: 3.268 ± 0.078
9.944GlyLeu: 9.944 ± 0.123
2.584GlyMet: 2.584 ± 0.054
1.942GlyAsn: 1.942 ± 0.054
3.845GlyPro: 3.845 ± 0.073
3.206GlyGln: 3.206 ± 0.062
6.063GlyArg: 6.063 ± 0.093
4.048GlySer: 4.048 ± 0.081
4.324GlyThr: 4.324 ± 0.071
6.542GlyVal: 6.542 ± 0.088
1.564GlyTrp: 1.564 ± 0.045
2.284GlyTyr: 2.284 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.334HisAla: 2.334 ± 0.062
0.234HisCys: 0.234 ± 0.018
1.217HisAsp: 1.217 ± 0.042
1.151HisGlu: 1.151 ± 0.041
0.78HisPhe: 0.78 ± 0.032
1.854HisGly: 1.854 ± 0.055
0.533HisHis: 0.533 ± 0.026
0.899HisIle: 0.899 ± 0.035
0.469HisLys: 0.469 ± 0.026
2.144HisLeu: 2.144 ± 0.047
0.498HisMet: 0.498 ± 0.027
0.425HisAsn: 0.425 ± 0.02
1.414HisPro: 1.414 ± 0.042
0.577HisGln: 0.577 ± 0.029
1.316HisArg: 1.316 ± 0.041
0.858HisSer: 0.858 ± 0.039
0.654HisThr: 0.654 ± 0.029
1.4HisVal: 1.4 ± 0.037
0.35HisTrp: 0.35 ± 0.019
0.6HisTyr: 0.6 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
7.239IleAla: 7.239 ± 0.1
0.642IleCys: 0.642 ± 0.03
3.384IleAsp: 3.384 ± 0.066
3.89IleGlu: 3.89 ± 0.068
1.722IlePhe: 1.722 ± 0.046
4.922IleGly: 4.922 ± 0.091
0.91IleHis: 0.91 ± 0.032
1.931IleIle: 1.931 ± 0.056
1.38IleLys: 1.38 ± 0.042
4.688IleLeu: 4.688 ± 0.082
0.95IleMet: 0.95 ± 0.034
1.279IleAsn: 1.279 ± 0.048
2.257IlePro: 2.257 ± 0.049
1.042IleGln: 1.042 ± 0.038
3.296IleArg: 3.296 ± 0.067
2.962IleSer: 2.962 ± 0.058
2.713IleThr: 2.713 ± 0.059
3.708IleVal: 3.708 ± 0.081
0.689IleTrp: 0.689 ± 0.034
1.138IleTyr: 1.138 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
4.086LysAla: 4.086 ± 0.083
0.2LysCys: 0.2 ± 0.014
1.599LysAsp: 1.599 ± 0.045
1.611LysGlu: 1.611 ± 0.052
1.013LysPhe: 1.013 ± 0.037
2.888LysGly: 2.888 ± 0.074
0.569LysHis: 0.569 ± 0.028
1.781LysIle: 1.781 ± 0.049
1.279LysLys: 1.279 ± 0.051
3.153LysLeu: 3.153 ± 0.063
0.923LysMet: 0.923 ± 0.036
0.757LysAsn: 0.757 ± 0.033
1.931LysPro: 1.931 ± 0.062
0.815LysGln: 0.815 ± 0.03
2.278LysArg: 2.278 ± 0.056
1.755LysSer: 1.755 ± 0.053
1.877LysThr: 1.877 ± 0.05
2.419LysVal: 2.419 ± 0.057
0.382LysTrp: 0.382 ± 0.025
0.667LysTyr: 0.667 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
14.775LeuAla: 14.775 ± 0.166
0.898LeuCys: 0.898 ± 0.031
5.769LeuAsp: 5.769 ± 0.092
6.074LeuGlu: 6.074 ± 0.102
3.483LeuPhe: 3.483 ± 0.071
9.032LeuGly: 9.032 ± 0.116
1.966LeuHis: 1.966 ± 0.048
5.522LeuIle: 5.522 ± 0.091
3.276LeuLys: 3.276 ± 0.074
9.124LeuLeu: 9.124 ± 0.15
2.823LeuMet: 2.823 ± 0.063
2.424LeuAsn: 2.424 ± 0.061
5.982LeuPro: 5.982 ± 0.092
2.68LeuGln: 2.68 ± 0.063
7.722LeuArg: 7.722 ± 0.117
6.435LeuSer: 6.435 ± 0.1
5.381LeuThr: 5.381 ± 0.084
7.282LeuVal: 7.282 ± 0.102
1.488LeuTrp: 1.488 ± 0.051
1.873LeuTyr: 1.873 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
3.59MetAla: 3.59 ± 0.076
0.163MetCys: 0.163 ± 0.013
1.219MetAsp: 1.219 ± 0.042
1.445MetGlu: 1.445 ± 0.042
0.805MetPhe: 0.805 ± 0.03
2.444MetGly: 2.444 ± 0.063
0.454MetHis: 0.454 ± 0.025
1.554MetIle: 1.554 ± 0.042
1.132MetLys: 1.132 ± 0.037
2.719MetLeu: 2.719 ± 0.062
0.809MetMet: 0.809 ± 0.033
0.82MetAsn: 0.82 ± 0.032
1.558MetPro: 1.558 ± 0.041
0.866MetGln: 0.866 ± 0.03
2.034MetArg: 2.034 ± 0.054
1.627MetSer: 1.627 ± 0.042
1.882MetThr: 1.882 ± 0.047
1.824MetVal: 1.824 ± 0.046
0.208MetTrp: 0.208 ± 0.015
0.285MetTyr: 0.285 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.907AsnAla: 2.907 ± 0.057
0.244AsnCys: 0.244 ± 0.019
1.268AsnAsp: 1.268 ± 0.043
1.172AsnGlu: 1.172 ± 0.043
0.955AsnPhe: 0.955 ± 0.039
2.136AsnGly: 2.136 ± 0.057
0.467AsnHis: 0.467 ± 0.024
1.229AsnIle: 1.229 ± 0.041
0.638AsnLys: 0.638 ± 0.027
2.371AsnLeu: 2.371 ± 0.052
0.645AsnMet: 0.645 ± 0.03
0.54AsnAsn: 0.54 ± 0.027
1.8AsnPro: 1.8 ± 0.047
0.617AsnGln: 0.617 ± 0.031
1.628AsnArg: 1.628 ± 0.04
0.988AsnSer: 0.988 ± 0.038
1.162AsnThr: 1.162 ± 0.037
1.627AsnVal: 1.627 ± 0.048
0.354AsnTrp: 0.354 ± 0.023
0.589AsnTyr: 0.589 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.676ProAla: 6.676 ± 0.129
0.369ProCys: 0.369 ± 0.021
3.413ProAsp: 3.413 ± 0.066
5.365ProGlu: 5.365 ± 0.105
1.97ProPhe: 1.97 ± 0.057
5.096ProGly: 5.096 ± 0.089
1.037ProHis: 1.037 ± 0.038
2.259ProIle: 2.259 ± 0.047
1.739ProLys: 1.739 ± 0.048
4.784ProLeu: 4.784 ± 0.076
1.343ProMet: 1.343 ± 0.039
1.219ProAsn: 1.219 ± 0.038
2.459ProPro: 2.459 ± 0.066
1.678ProGln: 1.678 ± 0.051
3.166ProArg: 3.166 ± 0.073
2.315ProSer: 2.315 ± 0.058
2.289ProThr: 2.289 ± 0.055
4.283ProVal: 4.283 ± 0.076
0.671ProTrp: 0.671 ± 0.03
1.131ProTyr: 1.131 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.006GlnAla: 4.006 ± 0.079
0.186GlnCys: 0.186 ± 0.015
1.435GlnAsp: 1.435 ± 0.045
1.545GlnGlu: 1.545 ± 0.041
1.016GlnPhe: 1.016 ± 0.033
2.679GlnGly: 2.679 ± 0.052
0.513GlnHis: 0.513 ± 0.026
2.052GlnIle: 2.052 ± 0.051
1.043GlnLys: 1.043 ± 0.038
2.776GlnLeu: 2.776 ± 0.059
1.074GlnMet: 1.074 ± 0.038
0.796GlnAsn: 0.796 ± 0.027
1.606GlnPro: 1.606 ± 0.046
0.9GlnGln: 0.9 ± 0.039
2.069GlnArg: 2.069 ± 0.054
1.561GlnSer: 1.561 ± 0.04
1.496GlnThr: 1.496 ± 0.043
2.317GlnVal: 2.317 ± 0.053
0.344GlnTrp: 0.344 ± 0.018
0.501GlnTyr: 0.501 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
9.666ArgAla: 9.666 ± 0.126
0.463ArgCys: 0.463 ± 0.023
4.011ArgAsp: 4.011 ± 0.067
4.21ArgGlu: 4.21 ± 0.079
2.788ArgPhe: 2.788 ± 0.049
4.973ArgGly: 4.973 ± 0.095
1.568ArgHis: 1.568 ± 0.051
3.902ArgIle: 3.902 ± 0.076
2.317ArgLys: 2.317 ± 0.058
7.935ArgLeu: 7.935 ± 0.141
2.017ArgMet: 2.017 ± 0.056
1.606ArgAsn: 1.606 ± 0.045
3.638ArgPro: 3.638 ± 0.071
2.14ArgGln: 2.14 ± 0.044
5.084ArgArg: 5.084 ± 0.098
3.045ArgSer: 3.045 ± 0.074
2.735ArgThr: 2.735 ± 0.059
4.94ArgVal: 4.94 ± 0.096
0.909ArgTrp: 0.909 ± 0.032
1.475ArgTyr: 1.475 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.865SerAla: 5.865 ± 0.091
0.408SerCys: 0.408 ± 0.022
2.951SerAsp: 2.951 ± 0.06
3.061SerGlu: 3.061 ± 0.071
2.111SerPhe: 2.111 ± 0.045
5.228SerGly: 5.228 ± 0.1
0.985SerHis: 0.985 ± 0.036
2.189SerIle: 2.189 ± 0.051
1.407SerLys: 1.407 ± 0.043
4.801SerLeu: 4.801 ± 0.08
1.161SerMet: 1.161 ± 0.039
1.15SerAsn: 1.15 ± 0.04
2.304SerPro: 2.304 ± 0.057
1.363SerGln: 1.363 ± 0.039
2.998SerArg: 2.998 ± 0.066
2.247SerSer: 2.247 ± 0.054
2.184SerThr: 2.184 ± 0.051
3.544SerVal: 3.544 ± 0.064
0.696SerTrp: 0.696 ± 0.028
1.178SerTyr: 1.178 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
5.595ThrAla: 5.595 ± 0.085
0.475ThrCys: 0.475 ± 0.027
2.676ThrAsp: 2.676 ± 0.062
3.231ThrGlu: 3.231 ± 0.07
1.716ThrPhe: 1.716 ± 0.046
5.126ThrGly: 5.126 ± 0.07
1.042ThrHis: 1.042 ± 0.034
2.579ThrIle: 2.579 ± 0.063
1.426ThrLys: 1.426 ± 0.044
5.781ThrLeu: 5.781 ± 0.095
1.103ThrMet: 1.103 ± 0.035
1.118ThrAsn: 1.118 ± 0.044
3.358ThrPro: 3.358 ± 0.064
1.476ThrGln: 1.476 ± 0.043
3.671ThrArg: 3.671 ± 0.075
2.248ThrSer: 2.248 ± 0.054
2.415ThrThr: 2.415 ± 0.059
3.659ThrVal: 3.659 ± 0.067
0.548ThrTrp: 0.548 ± 0.026
1.073ThrTyr: 1.073 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
9.082ValAla: 9.082 ± 0.111
0.554ValCys: 0.554 ± 0.024
3.555ValAsp: 3.555 ± 0.068
4.589ValGlu: 4.589 ± 0.071
2.77ValPhe: 2.77 ± 0.061
5.212ValGly: 5.212 ± 0.083
1.165ValHis: 1.165 ± 0.04
4.302ValIle: 4.302 ± 0.082
2.26ValLys: 2.26 ± 0.055
7.751ValLeu: 7.751 ± 0.111
2.086ValMet: 2.086 ± 0.05
1.765ValAsn: 1.765 ± 0.052
3.481ValPro: 3.481 ± 0.066
1.953ValGln: 1.953 ± 0.046
3.991ValArg: 3.991 ± 0.073
3.921ValSer: 3.921 ± 0.068
4.542ValThr: 4.542 ± 0.079
5.581ValVal: 5.581 ± 0.102
0.903ValTrp: 0.903 ± 0.035
1.412ValTyr: 1.412 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.433TrpAla: 1.433 ± 0.046
0.126TrpCys: 0.126 ± 0.013
0.69TrpAsp: 0.69 ± 0.029
0.679TrpGlu: 0.679 ± 0.028
0.523TrpPhe: 0.523 ± 0.028
1.085TrpGly: 1.085 ± 0.044
0.332TrpHis: 0.332 ± 0.022
0.697TrpIle: 0.697 ± 0.027
0.483TrpLys: 0.483 ± 0.024
1.682TrpLeu: 1.682 ± 0.05
0.404TrpMet: 0.404 ± 0.023
0.359TrpAsn: 0.359 ± 0.02
0.691TrpPro: 0.691 ± 0.029
0.57TrpGln: 0.57 ± 0.027
1.172TrpArg: 1.172 ± 0.043
0.713TrpSer: 0.713 ± 0.032
0.658TrpThr: 0.658 ± 0.031
0.941TrpVal: 0.941 ± 0.034
0.205TrpTrp: 0.205 ± 0.017
0.272TrpTyr: 0.272 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.424TyrAla: 2.424 ± 0.055
0.238TyrCys: 0.238 ± 0.017
1.523TyrAsp: 1.523 ± 0.042
1.269TyrGlu: 1.269 ± 0.041
0.89TyrPhe: 0.89 ± 0.031
2.014TyrGly: 2.014 ± 0.054
0.475TyrHis: 0.475 ± 0.024
0.899TyrIle: 0.899 ± 0.034
0.598TyrLys: 0.598 ± 0.027
2.302TyrLeu: 2.302 ± 0.058
0.456TyrMet: 0.456 ± 0.025
0.58TyrAsn: 0.58 ± 0.027
1.061TyrPro: 1.061 ± 0.04
0.682TyrGln: 0.682 ± 0.03
1.482TyrArg: 1.482 ± 0.046
1.061TyrSer: 1.061 ± 0.038
1.057TyrThr: 1.057 ± 0.039
1.357TyrVal: 1.357 ± 0.038
0.334TyrTrp: 0.334 ± 0.019
0.548TyrTyr: 0.548 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2673 proteins (840682 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski