Amino acid dipepetide frequency for Erwinia phage pEp_SNUABM_08

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.832AlaAla: 11.832 ± 1.674
0.41AlaCys: 0.41 ± 0.167
6.351AlaAsp: 6.351 ± 0.833
6.556AlaGlu: 6.556 ± 0.672
3.073AlaPhe: 3.073 ± 0.512
7.632AlaGly: 7.632 ± 0.624
1.383AlaHis: 1.383 ± 0.299
5.327AlaIle: 5.327 ± 0.619
5.02AlaLys: 5.02 ± 0.819
7.683AlaLeu: 7.683 ± 0.817
4.098AlaMet: 4.098 ± 0.602
5.02AlaAsn: 5.02 ± 0.6
4.456AlaPro: 4.456 ± 0.459
3.995AlaGln: 3.995 ± 0.736
4.917AlaArg: 4.917 ± 0.538
4.456AlaSer: 4.456 ± 0.549
5.173AlaThr: 5.173 ± 0.708
6.505AlaVal: 6.505 ± 0.559
1.434AlaTrp: 1.434 ± 0.276
3.176AlaTyr: 3.176 ± 0.401
0.0AlaXaa: 0.0 ± 0.0
Cys
0.768CysAla: 0.768 ± 0.192
0.307CysCys: 0.307 ± 0.141
0.768CysAsp: 0.768 ± 0.22
0.615CysGlu: 0.615 ± 0.181
0.359CysPhe: 0.359 ± 0.133
0.82CysGly: 0.82 ± 0.208
0.256CysHis: 0.256 ± 0.114
0.359CysIle: 0.359 ± 0.139
0.359CysLys: 0.359 ± 0.164
0.359CysLeu: 0.359 ± 0.126
0.359CysMet: 0.359 ± 0.11
0.307CysAsn: 0.307 ± 0.136
0.461CysPro: 0.461 ± 0.14
0.359CysGln: 0.359 ± 0.16
0.82CysArg: 0.82 ± 0.195
0.512CysSer: 0.512 ± 0.189
0.359CysThr: 0.359 ± 0.122
0.461CysVal: 0.461 ± 0.172
0.0CysTrp: 0.0 ± 0.0
0.307CysTyr: 0.307 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
6.147AspAla: 6.147 ± 0.714
0.768AspCys: 0.768 ± 0.203
5.429AspAsp: 5.429 ± 0.735
4.354AspGlu: 4.354 ± 0.499
2.612AspPhe: 2.612 ± 0.46
5.583AspGly: 5.583 ± 0.722
1.332AspHis: 1.332 ± 0.276
3.125AspIle: 3.125 ± 0.432
3.227AspLys: 3.227 ± 0.335
5.942AspLeu: 5.942 ± 0.544
2.049AspMet: 2.049 ± 0.303
2.868AspAsn: 2.868 ± 0.393
3.688AspPro: 3.688 ± 0.481
3.073AspGln: 3.073 ± 0.432
4.098AspArg: 4.098 ± 0.536
3.227AspSer: 3.227 ± 0.471
3.586AspThr: 3.586 ± 0.367
4.149AspVal: 4.149 ± 0.431
1.434AspTrp: 1.434 ± 0.238
2.049AspTyr: 2.049 ± 0.36
0.0AspXaa: 0.0 ± 0.0
Glu
5.071GluAla: 5.071 ± 0.589
0.666GluCys: 0.666 ± 0.191
3.995GluAsp: 3.995 ± 0.638
4.405GluGlu: 4.405 ± 0.63
2.356GluPhe: 2.356 ± 0.366
3.688GluGly: 3.688 ± 0.417
1.024GluHis: 1.024 ± 0.265
3.739GluIle: 3.739 ± 0.462
3.432GluLys: 3.432 ± 0.419
4.559GluLeu: 4.559 ± 0.476
1.793GluMet: 1.793 ± 0.297
2.92GluAsn: 2.92 ± 0.43
2.407GluPro: 2.407 ± 0.373
2.612GluGln: 2.612 ± 0.469
2.612GluArg: 2.612 ± 0.386
3.483GluSer: 3.483 ± 0.451
4.149GluThr: 4.149 ± 0.548
3.586GluVal: 3.586 ± 0.492
1.485GluTrp: 1.485 ± 0.257
2.305GluTyr: 2.305 ± 0.314
0.0GluXaa: 0.0 ± 0.0
Phe
3.381PheAla: 3.381 ± 0.335
0.41PheCys: 0.41 ± 0.189
3.842PheAsp: 3.842 ± 0.401
2.151PheGlu: 2.151 ± 0.325
1.332PhePhe: 1.332 ± 0.272
3.176PheGly: 3.176 ± 0.352
0.563PheHis: 0.563 ± 0.203
1.946PheIle: 1.946 ± 0.402
1.742PheLys: 1.742 ± 0.268
1.998PheLeu: 1.998 ± 0.296
1.127PheMet: 1.127 ± 0.265
2.1PheAsn: 2.1 ± 0.29
1.485PhePro: 1.485 ± 0.29
1.537PheGln: 1.537 ± 0.295
2.407PheArg: 2.407 ± 0.392
2.356PheSer: 2.356 ± 0.363
2.203PheThr: 2.203 ± 0.406
2.305PheVal: 2.305 ± 0.386
0.461PheTrp: 0.461 ± 0.146
1.434PheTyr: 1.434 ± 0.226
0.0PheXaa: 0.0 ± 0.0
Gly
7.12GlyAla: 7.12 ± 0.701
0.82GlyCys: 0.82 ± 0.221
4.251GlyAsp: 4.251 ± 0.47
4.508GlyGlu: 4.508 ± 0.5
2.92GlyPhe: 2.92 ± 0.466
6.403GlyGly: 6.403 ± 0.909
1.076GlyHis: 1.076 ± 0.292
3.586GlyIle: 3.586 ± 0.409
3.995GlyLys: 3.995 ± 0.484
5.02GlyLeu: 5.02 ± 0.476
2.151GlyMet: 2.151 ± 0.395
2.561GlyAsn: 2.561 ± 0.381
1.998GlyPro: 1.998 ± 0.308
3.432GlyGln: 3.432 ± 0.407
4.712GlyArg: 4.712 ± 0.613
3.739GlySer: 3.739 ± 0.46
4.559GlyThr: 4.559 ± 0.553
5.532GlyVal: 5.532 ± 0.534
1.639GlyTrp: 1.639 ± 0.283
2.868GlyTyr: 2.868 ± 0.447
0.0GlyXaa: 0.0 ± 0.0
His
1.076HisAla: 1.076 ± 0.225
0.102HisCys: 0.102 ± 0.067
1.178HisAsp: 1.178 ± 0.249
0.922HisGlu: 0.922 ± 0.204
0.973HisPhe: 0.973 ± 0.261
1.588HisGly: 1.588 ± 0.318
0.205HisHis: 0.205 ± 0.098
1.229HisIle: 1.229 ± 0.232
1.024HisLys: 1.024 ± 0.214
1.178HisLeu: 1.178 ± 0.277
0.41HisMet: 0.41 ± 0.108
0.563HisAsn: 0.563 ± 0.172
0.82HisPro: 0.82 ± 0.224
0.563HisGln: 0.563 ± 0.176
1.127HisArg: 1.127 ± 0.276
0.512HisSer: 0.512 ± 0.149
1.281HisThr: 1.281 ± 0.261
0.768HisVal: 0.768 ± 0.224
0.563HisTrp: 0.563 ± 0.169
0.615HisTyr: 0.615 ± 0.207
0.0HisXaa: 0.0 ± 0.0
Ile
5.122IleAla: 5.122 ± 0.57
0.461IleCys: 0.461 ± 0.167
3.586IleAsp: 3.586 ± 0.436
3.329IleGlu: 3.329 ± 0.393
1.485IlePhe: 1.485 ± 0.279
3.073IleGly: 3.073 ± 0.299
1.127IleHis: 1.127 ± 0.242
2.305IleIle: 2.305 ± 0.424
3.227IleLys: 3.227 ± 0.415
3.073IleLeu: 3.073 ± 0.325
1.588IleMet: 1.588 ± 0.238
2.612IleAsn: 2.612 ± 0.494
2.203IlePro: 2.203 ± 0.243
2.254IleGln: 2.254 ± 0.384
3.688IleArg: 3.688 ± 0.383
2.92IleSer: 2.92 ± 0.456
3.227IleThr: 3.227 ± 0.515
4.098IleVal: 4.098 ± 0.415
0.512IleTrp: 0.512 ± 0.143
1.537IleTyr: 1.537 ± 0.273
0.0IleXaa: 0.0 ± 0.0
Lys
5.225LysAla: 5.225 ± 0.658
0.41LysCys: 0.41 ± 0.158
3.176LysAsp: 3.176 ± 0.399
4.2LysGlu: 4.2 ± 0.571
1.998LysPhe: 1.998 ± 0.345
3.381LysGly: 3.381 ± 0.466
0.973LysHis: 0.973 ± 0.214
2.049LysIle: 2.049 ± 0.308
3.227LysLys: 3.227 ± 0.501
4.251LysLeu: 4.251 ± 0.543
1.434LysMet: 1.434 ± 0.251
2.817LysAsn: 2.817 ± 0.455
2.305LysPro: 2.305 ± 0.351
2.049LysGln: 2.049 ± 0.343
3.381LysArg: 3.381 ± 0.495
2.561LysSer: 2.561 ± 0.417
3.381LysThr: 3.381 ± 0.434
3.176LysVal: 3.176 ± 0.366
1.178LysTrp: 1.178 ± 0.271
1.639LysTyr: 1.639 ± 0.3
0.0LysXaa: 0.0 ± 0.0
Leu
8.656LeuAla: 8.656 ± 0.837
0.666LeuCys: 0.666 ± 0.19
5.071LeuAsp: 5.071 ± 0.536
4.047LeuGlu: 4.047 ± 0.442
2.305LeuPhe: 2.305 ± 0.331
5.02LeuGly: 5.02 ± 0.464
1.076LeuHis: 1.076 ± 0.256
4.61LeuIle: 4.61 ± 0.568
4.303LeuLys: 4.303 ± 0.601
4.712LeuLeu: 4.712 ± 0.602
2.715LeuMet: 2.715 ± 0.348
3.688LeuAsn: 3.688 ± 0.429
3.893LeuPro: 3.893 ± 0.507
3.637LeuGln: 3.637 ± 0.748
3.842LeuArg: 3.842 ± 0.542
4.712LeuSer: 4.712 ± 0.474
5.583LeuThr: 5.583 ± 0.582
4.866LeuVal: 4.866 ± 0.406
0.922LeuTrp: 0.922 ± 0.248
2.356LeuTyr: 2.356 ± 0.388
0.0LeuXaa: 0.0 ± 0.0
Met
4.712MetAla: 4.712 ± 0.412
0.307MetCys: 0.307 ± 0.123
1.844MetAsp: 1.844 ± 0.301
1.383MetGlu: 1.383 ± 0.285
1.127MetPhe: 1.127 ± 0.258
1.69MetGly: 1.69 ± 0.377
0.922MetHis: 0.922 ± 0.26
1.383MetIle: 1.383 ± 0.306
1.742MetLys: 1.742 ± 0.351
2.1MetLeu: 2.1 ± 0.287
0.82MetMet: 0.82 ± 0.207
1.485MetAsn: 1.485 ± 0.312
1.793MetPro: 1.793 ± 0.29
1.281MetGln: 1.281 ± 0.294
2.151MetArg: 2.151 ± 0.377
1.793MetSer: 1.793 ± 0.265
2.254MetThr: 2.254 ± 0.365
2.049MetVal: 2.049 ± 0.289
0.359MetTrp: 0.359 ± 0.124
0.512MetTyr: 0.512 ± 0.148
0.0MetXaa: 0.0 ± 0.0
Asn
5.122AsnAla: 5.122 ± 0.587
0.154AsnCys: 0.154 ± 0.09
2.151AsnAsp: 2.151 ± 0.333
1.998AsnGlu: 1.998 ± 0.314
1.588AsnPhe: 1.588 ± 0.313
5.071AsnGly: 5.071 ± 0.454
0.666AsnHis: 0.666 ± 0.179
1.793AsnIle: 1.793 ± 0.303
1.639AsnLys: 1.639 ± 0.263
3.944AsnLeu: 3.944 ± 0.609
1.024AsnMet: 1.024 ± 0.26
2.356AsnAsn: 2.356 ± 0.528
2.612AsnPro: 2.612 ± 0.438
1.588AsnGln: 1.588 ± 0.367
1.895AsnArg: 1.895 ± 0.263
1.895AsnSer: 1.895 ± 0.313
3.534AsnThr: 3.534 ± 0.486
2.254AsnVal: 2.254 ± 0.373
0.922AsnTrp: 0.922 ± 0.275
1.588AsnTyr: 1.588 ± 0.325
0.0AsnXaa: 0.0 ± 0.0
Pro
4.712ProAla: 4.712 ± 0.772
0.563ProCys: 0.563 ± 0.169
4.303ProAsp: 4.303 ± 0.675
2.766ProGlu: 2.766 ± 0.403
1.793ProPhe: 1.793 ± 0.315
3.125ProGly: 3.125 ± 0.504
0.82ProHis: 0.82 ± 0.248
1.946ProIle: 1.946 ± 0.36
2.151ProLys: 2.151 ± 0.403
3.227ProLeu: 3.227 ± 0.481
1.485ProMet: 1.485 ± 0.347
2.151ProAsn: 2.151 ± 0.299
1.639ProPro: 1.639 ± 0.397
1.588ProGln: 1.588 ± 0.327
1.69ProArg: 1.69 ± 0.314
2.612ProSer: 2.612 ± 0.32
2.561ProThr: 2.561 ± 0.425
3.381ProVal: 3.381 ± 0.471
1.024ProTrp: 1.024 ± 0.239
1.946ProTyr: 1.946 ± 0.38
0.0ProXaa: 0.0 ± 0.0
Gln
4.2GlnAla: 4.2 ± 0.776
0.359GlnCys: 0.359 ± 0.124
2.459GlnAsp: 2.459 ± 0.299
2.305GlnGlu: 2.305 ± 0.312
1.537GlnPhe: 1.537 ± 0.257
1.998GlnGly: 1.998 ± 0.337
0.41GlnHis: 0.41 ± 0.198
2.407GlnIle: 2.407 ± 0.322
2.459GlnLys: 2.459 ± 0.402
3.688GlnLeu: 3.688 ± 0.528
1.946GlnMet: 1.946 ± 0.346
1.127GlnAsn: 1.127 ± 0.213
2.51GlnPro: 2.51 ± 0.398
2.817GlnGln: 2.817 ± 0.639
2.817GlnArg: 2.817 ± 0.379
2.049GlnSer: 2.049 ± 0.505
2.92GlnThr: 2.92 ± 0.491
3.227GlnVal: 3.227 ± 0.387
1.024GlnTrp: 1.024 ± 0.217
1.383GlnTyr: 1.383 ± 0.231
0.0GlnXaa: 0.0 ± 0.0
Arg
4.866ArgAla: 4.866 ± 0.569
0.41ArgCys: 0.41 ± 0.157
3.79ArgAsp: 3.79 ± 0.563
3.534ArgGlu: 3.534 ± 0.608
2.407ArgPhe: 2.407 ± 0.347
3.586ArgGly: 3.586 ± 0.467
1.024ArgHis: 1.024 ± 0.288
3.534ArgIle: 3.534 ± 0.463
3.278ArgLys: 3.278 ± 0.558
5.737ArgLeu: 5.737 ± 0.559
1.639ArgMet: 1.639 ± 0.314
2.561ArgAsn: 2.561 ± 0.386
2.1ArgPro: 2.1 ± 0.318
3.432ArgGln: 3.432 ± 0.485
4.149ArgArg: 4.149 ± 0.481
2.817ArgSer: 2.817 ± 0.363
2.868ArgThr: 2.868 ± 0.46
4.098ArgVal: 4.098 ± 0.488
0.615ArgTrp: 0.615 ± 0.156
1.537ArgTyr: 1.537 ± 0.306
0.0ArgXaa: 0.0 ± 0.0
Ser
3.688SerAla: 3.688 ± 0.461
0.461SerCys: 0.461 ± 0.179
3.995SerAsp: 3.995 ± 0.507
3.073SerGlu: 3.073 ± 0.423
2.305SerPhe: 2.305 ± 0.322
4.047SerGly: 4.047 ± 0.479
0.768SerHis: 0.768 ± 0.196
2.92SerIle: 2.92 ± 0.487
2.92SerLys: 2.92 ± 0.361
4.149SerLeu: 4.149 ± 0.36
1.895SerMet: 1.895 ± 0.289
1.998SerAsn: 1.998 ± 0.438
2.1SerPro: 2.1 ± 0.478
2.254SerGln: 2.254 ± 0.418
3.176SerArg: 3.176 ± 0.427
3.278SerSer: 3.278 ± 0.612
3.176SerThr: 3.176 ± 0.492
3.842SerVal: 3.842 ± 0.453
1.024SerTrp: 1.024 ± 0.236
1.69SerTyr: 1.69 ± 0.308
0.0SerXaa: 0.0 ± 0.0
Thr
5.737ThrAla: 5.737 ± 0.891
0.512ThrCys: 0.512 ± 0.211
4.098ThrAsp: 4.098 ± 0.363
3.125ThrGlu: 3.125 ± 0.466
2.356ThrPhe: 2.356 ± 0.312
5.071ThrGly: 5.071 ± 0.506
1.281ThrHis: 1.281 ± 0.313
3.227ThrIle: 3.227 ± 0.474
3.125ThrLys: 3.125 ± 0.418
5.173ThrLeu: 5.173 ± 0.725
2.049ThrMet: 2.049 ± 0.34
2.971ThrAsn: 2.971 ± 0.451
3.176ThrPro: 3.176 ± 0.481
1.998ThrGln: 1.998 ± 0.339
3.688ThrArg: 3.688 ± 0.56
3.586ThrSer: 3.586 ± 0.493
4.815ThrThr: 4.815 ± 0.708
4.764ThrVal: 4.764 ± 0.565
1.024ThrTrp: 1.024 ± 0.269
1.69ThrTyr: 1.69 ± 0.288
0.0ThrXaa: 0.0 ± 0.0
Val
6.198ValAla: 6.198 ± 0.611
0.717ValCys: 0.717 ± 0.183
5.02ValAsp: 5.02 ± 0.521
4.303ValGlu: 4.303 ± 0.444
2.561ValPhe: 2.561 ± 0.367
4.866ValGly: 4.866 ± 0.502
0.973ValHis: 0.973 ± 0.199
3.125ValIle: 3.125 ± 0.447
3.995ValLys: 3.995 ± 0.457
5.634ValLeu: 5.634 ± 0.544
1.383ValMet: 1.383 ± 0.255
2.203ValAsn: 2.203 ± 0.433
3.022ValPro: 3.022 ± 0.463
2.561ValGln: 2.561 ± 0.313
3.893ValArg: 3.893 ± 0.484
4.047ValSer: 4.047 ± 0.576
4.303ValThr: 4.303 ± 0.589
3.637ValVal: 3.637 ± 0.467
1.485ValTrp: 1.485 ± 0.253
2.049ValTyr: 2.049 ± 0.255
0.0ValXaa: 0.0 ± 0.0
Trp
1.485TrpAla: 1.485 ± 0.285
0.154TrpCys: 0.154 ± 0.074
0.922TrpAsp: 0.922 ± 0.225
1.178TrpGlu: 1.178 ± 0.231
1.127TrpPhe: 1.127 ± 0.218
0.871TrpGly: 0.871 ± 0.176
0.256TrpHis: 0.256 ± 0.116
1.127TrpIle: 1.127 ± 0.312
0.973TrpLys: 0.973 ± 0.237
1.383TrpLeu: 1.383 ± 0.284
0.461TrpMet: 0.461 ± 0.159
0.615TrpAsn: 0.615 ± 0.161
1.024TrpPro: 1.024 ± 0.222
1.229TrpGln: 1.229 ± 0.288
0.871TrpArg: 0.871 ± 0.238
0.922TrpSer: 0.922 ± 0.242
1.178TrpThr: 1.178 ± 0.273
1.178TrpVal: 1.178 ± 0.265
0.359TrpTrp: 0.359 ± 0.124
0.563TrpTyr: 0.563 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.381TyrAla: 3.381 ± 0.481
0.256TyrCys: 0.256 ± 0.105
2.51TyrAsp: 2.51 ± 0.333
1.537TyrGlu: 1.537 ± 0.274
1.742TyrPhe: 1.742 ± 0.3
2.203TyrGly: 2.203 ± 0.351
0.563TyrHis: 0.563 ± 0.179
1.69TyrIle: 1.69 ± 0.269
1.024TyrLys: 1.024 ± 0.213
2.868TyrLeu: 2.868 ± 0.47
1.229TyrMet: 1.229 ± 0.228
0.871TyrAsn: 0.871 ± 0.242
1.793TyrPro: 1.793 ± 0.309
1.383TyrGln: 1.383 ± 0.244
2.049TyrArg: 2.049 ± 0.267
1.281TyrSer: 1.281 ± 0.323
2.356TyrThr: 2.356 ± 0.355
2.1TyrVal: 2.1 ± 0.384
0.41TyrTrp: 0.41 ± 0.134
1.178TyrTyr: 1.178 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (19524 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski