Amino acid dipepetide frequency for Desulfurivibrio alkaliphilus (strain DSM 19089 / UNIQEM U267 / AHT2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.199AlaAla: 15.199 ± 0.203	1.247AlaCys: 1.247 ± 0.044	5.807AlaAsp: 5.807 ± 0.082	7.824AlaGlu: 7.824 ± 0.109	3.133AlaPhe: 3.133 ± 0.059	10.275AlaGly: 10.275 ± 0.129	1.88AlaHis: 1.88 ± 0.042	4.877AlaIle: 4.877 ± 0.076	3.517AlaLys: 3.517 ± 0.066	11.283AlaLeu: 11.283 ± 0.125	2.788AlaMet: 2.788 ± 0.061	2.579AlaAsn: 2.579 ± 0.061	4.501AlaPro: 4.501 ± 0.088	3.267AlaGln: 3.267 ± 0.056	7.288AlaArg: 7.288 ± 0.098	4.273AlaSer: 4.273 ± 0.078	5.032AlaThr: 5.032 ± 0.082	7.66AlaVal: 7.66 ± 0.101	1.185AlaTrp: 1.185 ± 0.04	2.141AlaTyr: 2.141 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.965CysAla: 0.965 ± 0.038	0.231CysCys: 0.231 ± 0.016	0.497CysAsp: 0.497 ± 0.024	0.536CysGlu: 0.536 ± 0.026	0.413CysPhe: 0.413 ± 0.022	1.233CysGly: 1.233 ± 0.044	0.746CysHis: 0.746 ± 0.073	0.439CysIle: 0.439 ± 0.024	0.347CysLys: 0.347 ± 0.021	1.28CysLeu: 1.28 ± 0.049	0.193CysMet: 0.193 ± 0.015	0.373CysAsn: 0.373 ± 0.021	0.787CysPro: 0.787 ± 0.035	0.436CysGln: 0.436 ± 0.025	1.207CysArg: 1.207 ± 0.039	0.636CysSer: 0.636 ± 0.027	0.513CysThr: 0.513 ± 0.027	0.6CysVal: 0.6 ± 0.026	0.143CysTrp: 0.143 ± 0.013	0.288CysTyr: 0.288 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.687AspAla: 3.687 ± 0.076	0.679AspCys: 0.679 ± 0.034	2.932AspAsp: 2.932 ± 0.072	3.664AspGlu: 3.664 ± 0.066	2.639AspPhe: 2.639 ± 0.047	4.076AspGly: 4.076 ± 0.094	1.415AspHis: 1.415 ± 0.042	2.807AspIle: 2.807 ± 0.06	1.826AspLys: 1.826 ± 0.05	6.06AspLeu: 6.06 ± 0.091	0.899AspMet: 0.899 ± 0.033	1.686AspAsn: 1.686 ± 0.046	3.349AspPro: 3.349 ± 0.068	2.415AspGln: 2.415 ± 0.052	3.782AspArg: 3.782 ± 0.075	2.335AspSer: 2.335 ± 0.056	2.117AspThr: 2.117 ± 0.05	2.401AspVal: 2.401 ± 0.062	0.73AspTrp: 0.73 ± 0.029	1.881AspTyr: 1.881 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.968GluAla: 6.968 ± 0.101	0.498GluCys: 0.498 ± 0.024	2.812GluAsp: 2.812 ± 0.063	5.617GluGlu: 5.617 ± 0.105	2.145GluPhe: 2.145 ± 0.046	4.122GluGly: 4.122 ± 0.07	1.439GluHis: 1.439 ± 0.043	4.678GluIle: 4.678 ± 0.08	3.37GluLys: 3.37 ± 0.074	8.776GluLeu: 8.776 ± 0.125	1.823GluMet: 1.823 ± 0.05	2.029GluAsn: 2.029 ± 0.051	3.073GluPro: 3.073 ± 0.068	3.881GluGln: 3.881 ± 0.076	4.328GluArg: 4.328 ± 0.078	2.815GluSer: 2.815 ± 0.053	2.98GluThr: 2.98 ± 0.062	5.223GluVal: 5.223 ± 0.082	0.548GluTrp: 0.548 ± 0.028	1.488GluTyr: 1.488 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.724PheAla: 3.724 ± 0.07	0.571PheCys: 0.571 ± 0.029	2.075PheAsp: 2.075 ± 0.046	1.786PheGlu: 1.786 ± 0.046	1.846PhePhe: 1.846 ± 0.052	2.847PheGly: 2.847 ± 0.068	0.822PheHis: 0.822 ± 0.028	1.876PheIle: 1.876 ± 0.047	1.278PheLys: 1.278 ± 0.044	3.828PheLeu: 3.828 ± 0.074	0.855PheMet: 0.855 ± 0.034	1.319PheAsn: 1.319 ± 0.038	1.698PhePro: 1.698 ± 0.046	1.247PheGln: 1.247 ± 0.039	2.3PheArg: 2.3 ± 0.059	2.422PheSer: 2.422 ± 0.052	2.239PheThr: 2.239 ± 0.054	2.296PheVal: 2.296 ± 0.051	0.52PheTrp: 0.52 ± 0.023	1.194PheTyr: 1.194 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.841GlyAla: 6.841 ± 0.113	1.193GlyCys: 1.193 ± 0.042	3.807GlyAsp: 3.807 ± 0.069	5.66GlyGlu: 5.66 ± 0.084	2.975GlyPhe: 2.975 ± 0.061	6.629GlyGly: 6.629 ± 0.109	1.912GlyHis: 1.912 ± 0.056	4.276GlyIle: 4.276 ± 0.077	3.641GlyLys: 3.641 ± 0.077	8.637GlyLeu: 8.637 ± 0.106	2.072GlyMet: 2.072 ± 0.053	2.266GlyAsn: 2.266 ± 0.052	3.211GlyPro: 3.211 ± 0.067	3.156GlyGln: 3.156 ± 0.061	6.544GlyArg: 6.544 ± 0.094	4.183GlySer: 4.183 ± 0.084	3.599GlyThr: 3.599 ± 0.066	5.6GlyVal: 5.6 ± 0.092	1.017GlyTrp: 1.017 ± 0.038	2.43GlyTyr: 2.43 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.569HisAla: 1.569 ± 0.047	0.375HisCys: 0.375 ± 0.021	1.41HisAsp: 1.41 ± 0.046	1.257HisGlu: 1.257 ± 0.04	0.973HisPhe: 0.973 ± 0.032	2.106HisGly: 2.106 ± 0.052	0.791HisHis: 0.791 ± 0.032	0.945HisIle: 0.945 ± 0.034	0.631HisLys: 0.631 ± 0.028	2.713HisLeu: 2.713 ± 0.055	0.29HisMet: 0.29 ± 0.019	0.77HisAsn: 0.77 ± 0.032	1.483HisPro: 1.483 ± 0.04	1.163HisGln: 1.163 ± 0.044	2.001HisArg: 2.001 ± 0.055	1.034HisSer: 1.034 ± 0.033	0.98HisThr: 0.98 ± 0.035	1.058HisVal: 1.058 ± 0.036	0.325HisTrp: 0.325 ± 0.023	0.818HisTyr: 0.818 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.772IleAla: 4.772 ± 0.095	0.64IleCys: 0.64 ± 0.028	3.072IleAsp: 3.072 ± 0.058	3.059IleGlu: 3.059 ± 0.06	2.107IlePhe: 2.107 ± 0.059	4.078IleGly: 4.078 ± 0.075	1.145IleHis: 1.145 ± 0.033	3.189IleIle: 3.189 ± 0.077	2.231IleLys: 2.231 ± 0.052	4.797IleLeu: 4.797 ± 0.093	1.327IleMet: 1.327 ± 0.036	2.097IleAsn: 2.097 ± 0.054	2.495IlePro: 2.495 ± 0.053	1.45IleGln: 1.45 ± 0.041	3.453IleArg: 3.453 ± 0.069	3.264IleSer: 3.264 ± 0.056	2.95IleThr: 2.95 ± 0.063	2.906IleVal: 2.906 ± 0.061	0.491IleTrp: 0.491 ± 0.023	1.44IleTyr: 1.44 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	3.568LysAla: 3.568 ± 0.076	0.33LysCys: 0.33 ± 0.021	1.649LysAsp: 1.649 ± 0.044	2.813LysGlu: 2.813 ± 0.06	1.063LysPhe: 1.063 ± 0.041	2.557LysGly: 2.557 ± 0.056	0.653LysHis: 0.653 ± 0.027	2.504LysIle: 2.504 ± 0.058	2.274LysLys: 2.274 ± 0.058	3.781LysLeu: 3.781 ± 0.072	1.096LysMet: 1.096 ± 0.036	1.311LysAsn: 1.311 ± 0.039	1.83LysPro: 1.83 ± 0.045	1.42LysGln: 1.42 ± 0.037	2.319LysArg: 2.319 ± 0.059	1.851LysSer: 1.851 ± 0.052	1.939LysThr: 1.939 ± 0.049	2.706LysVal: 2.706 ± 0.062	0.315LysTrp: 0.315 ± 0.02	0.863LysTyr: 0.863 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	15.358LeuAla: 15.358 ± 0.173	1.149LeuCys: 1.149 ± 0.042	5.765LeuAsp: 5.765 ± 0.087	7.642LeuGlu: 7.642 ± 0.113	3.905LeuPhe: 3.905 ± 0.08	8.151LeuGly: 8.151 ± 0.103	2.33LeuHis: 2.33 ± 0.056	4.924LeuIle: 4.924 ± 0.086	3.996LeuLys: 3.996 ± 0.069	14.951LeuLeu: 14.951 ± 0.231	2.032LeuMet: 2.032 ± 0.05	3.31LeuAsn: 3.31 ± 0.064	6.581LeuPro: 6.581 ± 0.1	4.719LeuGln: 4.719 ± 0.087	7.3LeuArg: 7.3 ± 0.11	5.761LeuSer: 5.761 ± 0.076	5.645LeuThr: 5.645 ± 0.084	8.016LeuVal: 8.016 ± 0.1	1.109LeuTrp: 1.109 ± 0.038	2.598LeuTyr: 2.598 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.866MetAla: 2.866 ± 0.062	0.17MetCys: 0.17 ± 0.016	1.093MetAsp: 1.093 ± 0.036	1.493MetGlu: 1.493 ± 0.051	0.639MetPhe: 0.639 ± 0.03	1.727MetGly: 1.727 ± 0.047	0.381MetHis: 0.381 ± 0.021	1.24MetIle: 1.24 ± 0.04	1.024MetLys: 1.024 ± 0.038	2.495MetLeu: 2.495 ± 0.048	0.567MetMet: 0.567 ± 0.024	0.767MetAsn: 0.767 ± 0.029	1.207MetPro: 1.207 ± 0.044	0.875MetGln: 0.875 ± 0.034	1.297MetArg: 1.297 ± 0.045	1.227MetSer: 1.227 ± 0.035	1.249MetThr: 1.249 ± 0.038	1.886MetVal: 1.886 ± 0.044	0.133MetTrp: 0.133 ± 0.012	0.373MetTyr: 0.373 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.309AsnAla: 2.309 ± 0.06	0.443AsnCys: 0.443 ± 0.025	1.419AsnAsp: 1.419 ± 0.042	1.545AsnGlu: 1.545 ± 0.045	1.318AsnPhe: 1.318 ± 0.039	2.037AsnGly: 2.037 ± 0.058	0.785AsnHis: 0.785 ± 0.029	1.841AsnIle: 1.841 ± 0.051	0.972AsnLys: 0.972 ± 0.036	3.698AsnLeu: 3.698 ± 0.07	0.667AsnMet: 0.667 ± 0.028	0.969AsnAsn: 0.969 ± 0.035	2.021AsnPro: 2.021 ± 0.052	1.314AsnGln: 1.314 ± 0.042	2.418AsnArg: 2.418 ± 0.055	1.486AsnSer: 1.486 ± 0.044	1.302AsnThr: 1.302 ± 0.042	1.59AsnVal: 1.59 ± 0.05	0.438AsnTrp: 0.438 ± 0.023	0.941AsnTyr: 0.941 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.647ProAla: 6.647 ± 0.12	0.488ProCys: 0.488 ± 0.022	3.241ProAsp: 3.241 ± 0.065	4.894ProGlu: 4.894 ± 0.078	1.851ProPhe: 1.851 ± 0.046	4.869ProGly: 4.869 ± 0.079	1.113ProHis: 1.113 ± 0.039	1.755ProIle: 1.755 ± 0.046	1.423ProLys: 1.423 ± 0.043	5.314ProLeu: 5.314 ± 0.091	1.03ProMet: 1.03 ± 0.034	1.124ProAsn: 1.124 ± 0.033	3.445ProPro: 3.445 ± 0.085	1.817ProGln: 1.817 ± 0.045	2.965ProArg: 2.965 ± 0.056	2.14ProSer: 2.14 ± 0.053	2.186ProThr: 2.186 ± 0.042	4.091ProVal: 4.091 ± 0.069	0.708ProTrp: 0.708 ± 0.029	1.283ProTyr: 1.283 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	5.229GlnAla: 5.229 ± 0.079	0.388GlnCys: 0.388 ± 0.027	1.772GlnAsp: 1.772 ± 0.049	3.137GlnGlu: 3.137 ± 0.068	1.013GlnPhe: 1.013 ± 0.034	3.166GlnGly: 3.166 ± 0.068	0.88GlnHis: 0.88 ± 0.03	1.87GlnIle: 1.87 ± 0.041	1.356GlnLys: 1.356 ± 0.04	4.627GlnLeu: 4.627 ± 0.083	0.883GlnMet: 0.883 ± 0.03	0.996GlnAsn: 0.996 ± 0.034	2.266GlnPro: 2.266 ± 0.055	2.674GlnGln: 2.674 ± 0.073	3.397GlnArg: 3.397 ± 0.065	1.716GlnSer: 1.716 ± 0.042	1.758GlnThr: 1.758 ± 0.044	3.21GlnVal: 3.21 ± 0.057	0.561GlnTrp: 0.561 ± 0.027	0.818GlnTyr: 0.818 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.773ArgAla: 5.773 ± 0.086	0.814ArgCys: 0.814 ± 0.031	3.591ArgAsp: 3.591 ± 0.077	5.661ArgGlu: 5.661 ± 0.089	2.762ArgPhe: 2.762 ± 0.055	4.452ArgGly: 4.452 ± 0.064	2.034ArgHis: 2.034 ± 0.05	3.552ArgIle: 3.552 ± 0.069	2.575ArgLys: 2.575 ± 0.064	9.462ArgLeu: 9.462 ± 0.132	1.487ArgMet: 1.487 ± 0.046	1.987ArgAsn: 1.987 ± 0.044	3.61ArgPro: 3.61 ± 0.071	4.44ArgGln: 4.44 ± 0.092	7.058ArgArg: 7.058 ± 0.127	3.064ArgSer: 3.064 ± 0.067	2.586ArgThr: 2.586 ± 0.052	4.685ArgVal: 4.685 ± 0.07	0.835ArgTrp: 0.835 ± 0.035	2.125ArgTyr: 2.125 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	4.45SerAla: 4.45 ± 0.063	0.728SerCys: 0.728 ± 0.034	2.328SerAsp: 2.328 ± 0.056	2.776SerGlu: 2.776 ± 0.048	2.145SerPhe: 2.145 ± 0.045	4.798SerGly: 4.798 ± 0.085	1.165SerHis: 1.165 ± 0.032	2.191SerIle: 2.191 ± 0.05	1.57SerLys: 1.57 ± 0.047	5.757SerLeu: 5.757 ± 0.089	1.119SerMet: 1.119 ± 0.035	1.255SerAsn: 1.255 ± 0.036	2.811SerPro: 2.811 ± 0.06	1.898SerGln: 1.898 ± 0.048	4.108SerArg: 4.108 ± 0.072	2.825SerSer: 2.825 ± 0.068	2.177SerThr: 2.177 ± 0.057	2.743SerVal: 2.743 ± 0.068	0.692SerTrp: 0.692 ± 0.031	1.412SerTyr: 1.412 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.356ThrAla: 5.356 ± 0.083	0.588ThrCys: 0.588 ± 0.032	2.321ThrAsp: 2.321 ± 0.058	2.418ThrGlu: 2.418 ± 0.049	1.732ThrPhe: 1.732 ± 0.045	4.682ThrGly: 4.682 ± 0.08	0.847ThrHis: 0.847 ± 0.03	2.768ThrIle: 2.768 ± 0.067	1.315ThrLys: 1.315 ± 0.046	5.409ThrLeu: 5.409 ± 0.088	1.249ThrMet: 1.249 ± 0.034	1.271ThrAsn: 1.271 ± 0.039	2.895ThrPro: 2.895 ± 0.056	1.139ThrGln: 1.139 ± 0.032	2.702ThrArg: 2.702 ± 0.056	2.222ThrSer: 2.222 ± 0.051	2.664ThrThr: 2.664 ± 0.063	3.686ThrVal: 3.686 ± 0.072	0.51ThrTrp: 0.51 ± 0.027	1.192ThrTyr: 1.192 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.589ValAla: 7.589 ± 0.108	0.829ValCys: 0.829 ± 0.038	3.735ValAsp: 3.735 ± 0.072	4.776ValGlu: 4.776 ± 0.076	2.514ValPhe: 2.514 ± 0.057	4.968ValGly: 4.968 ± 0.078	1.301ValHis: 1.301 ± 0.034	3.758ValIle: 3.758 ± 0.071	2.509ValLys: 2.509 ± 0.056	7.398ValLeu: 7.398 ± 0.109	1.698ValMet: 1.698 ± 0.054	2.203ValAsn: 2.203 ± 0.051	3.077ValPro: 3.077 ± 0.066	2.142ValGln: 2.142 ± 0.049	4.455ValArg: 4.455 ± 0.073	3.664ValSer: 3.664 ± 0.073	3.482ValThr: 3.482 ± 0.071	5.477ValVal: 5.477 ± 0.098	0.594ValTrp: 0.594 ± 0.025	1.737ValTyr: 1.737 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.789TrpAla: 0.789 ± 0.029	0.122TrpCys: 0.122 ± 0.011	0.519TrpAsp: 0.519 ± 0.025	0.676TrpGlu: 0.676 ± 0.03	0.416TrpPhe: 0.416 ± 0.023	0.808TrpGly: 0.808 ± 0.029	0.309TrpHis: 0.309 ± 0.021	0.444TrpIle: 0.444 ± 0.026	0.313TrpLys: 0.313 ± 0.019	1.659TrpLeu: 1.659 ± 0.051	0.242TrpMet: 0.242 ± 0.014	0.351TrpAsn: 0.351 ± 0.02	0.676TrpPro: 0.676 ± 0.031	0.859TrpGln: 0.859 ± 0.035	1.07TrpArg: 1.07 ± 0.042	0.635TrpSer: 0.635 ± 0.025	0.357TrpThr: 0.357 ± 0.021	0.673TrpVal: 0.673 ± 0.029	0.208TrpTrp: 0.208 ± 0.016	0.297TrpTyr: 0.297 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.095TyrAla: 2.095 ± 0.051	0.38TyrCys: 0.38 ± 0.021	1.537TyrAsp: 1.537 ± 0.048	1.378TyrGlu: 1.378 ± 0.039	1.155TyrPhe: 1.155 ± 0.039	2.068TyrGly: 2.068 ± 0.053	0.744TyrHis: 0.744 ± 0.028	1.027TyrIle: 1.027 ± 0.036	0.677TyrLys: 0.677 ± 0.026	3.318TyrLeu: 3.318 ± 0.069	0.394TyrMet: 0.394 ± 0.024	0.848TyrAsn: 0.848 ± 0.036	1.37TyrPro: 1.37 ± 0.041	1.408TyrGln: 1.408 ± 0.039	2.563TyrArg: 2.563 ± 0.061	1.392TyrSer: 1.392 ± 0.034	1.208TyrThr: 1.208 ± 0.04	1.399TyrVal: 1.399 ± 0.041	0.359TyrTrp: 0.359 ± 0.022	0.823TyrTyr: 0.823 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2595 proteins (903674 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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