Amino acid dipepetide frequency for Staphylococcus virus IPLA5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.903AlaAla: 1.903 ± 0.456
0.381AlaCys: 0.381 ± 0.192
2.741AlaAsp: 2.741 ± 0.499
3.502AlaGlu: 3.502 ± 0.507
2.512AlaPhe: 2.512 ± 0.55
3.273AlaGly: 3.273 ± 0.608
0.99AlaHis: 0.99 ± 0.241
5.786AlaIle: 5.786 ± 0.707
5.177AlaLys: 5.177 ± 0.825
4.72AlaLeu: 4.72 ± 0.689
1.523AlaMet: 1.523 ± 0.322
3.959AlaAsn: 3.959 ± 0.557
1.218AlaPro: 1.218 ± 0.273
3.045AlaGln: 3.045 ± 0.484
1.827AlaArg: 1.827 ± 0.395
3.578AlaSer: 3.578 ± 0.779
2.588AlaThr: 2.588 ± 0.421
3.273AlaVal: 3.273 ± 0.597
0.685AlaTrp: 0.685 ± 0.208
1.979AlaTyr: 1.979 ± 0.394
0.0AlaXaa: 0.0 ± 0.0
Cys
0.228CysAla: 0.228 ± 0.133
0.0CysCys: 0.0 ± 0.0
0.152CysAsp: 0.152 ± 0.113
0.076CysGlu: 0.076 ± 0.074
0.0CysPhe: 0.0 ± 0.0
0.533CysGly: 0.533 ± 0.179
0.076CysHis: 0.076 ± 0.087
0.457CysIle: 0.457 ± 0.158
0.609CysLys: 0.609 ± 0.202
0.457CysLeu: 0.457 ± 0.194
0.228CysMet: 0.228 ± 0.126
0.457CysAsn: 0.457 ± 0.156
0.152CysPro: 0.152 ± 0.096
0.0CysGln: 0.0 ± 0.0
0.228CysArg: 0.228 ± 0.128
0.305CysSer: 0.305 ± 0.209
0.228CysThr: 0.228 ± 0.119
0.381CysVal: 0.381 ± 0.178
0.076CysTrp: 0.076 ± 0.088
0.381CysTyr: 0.381 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
3.426AspAla: 3.426 ± 0.682
0.381AspCys: 0.381 ± 0.213
4.796AspAsp: 4.796 ± 0.578
5.405AspGlu: 5.405 ± 0.674
2.664AspPhe: 2.664 ± 0.429
4.872AspGly: 4.872 ± 0.55
0.457AspHis: 0.457 ± 0.222
4.948AspIle: 4.948 ± 0.714
5.253AspLys: 5.253 ± 0.585
5.633AspLeu: 5.633 ± 0.721
1.218AspMet: 1.218 ± 0.32
5.024AspAsn: 5.024 ± 0.738
1.218AspPro: 1.218 ± 0.303
0.99AspGln: 0.99 ± 0.376
1.979AspArg: 1.979 ± 0.388
3.578AspSer: 3.578 ± 0.474
4.187AspThr: 4.187 ± 0.621
3.806AspVal: 3.806 ± 0.57
0.685AspTrp: 0.685 ± 0.211
2.969AspTyr: 2.969 ± 0.46
0.0AspXaa: 0.0 ± 0.0
Glu
3.502GluAla: 3.502 ± 0.809
0.457GluCys: 0.457 ± 0.223
3.654GluAsp: 3.654 ± 0.557
5.1GluGlu: 5.1 ± 0.742
2.512GluPhe: 2.512 ± 0.482
2.588GluGly: 2.588 ± 0.431
1.446GluHis: 1.446 ± 0.343
4.415GluIle: 4.415 ± 0.521
6.166GluLys: 6.166 ± 0.804
7.537GluLeu: 7.537 ± 1.111
2.36GluMet: 2.36 ± 0.414
4.644GluAsn: 4.644 ± 0.633
1.523GluPro: 1.523 ± 0.36
4.263GluGln: 4.263 ± 0.59
3.959GluArg: 3.959 ± 0.672
3.654GluSer: 3.654 ± 0.564
3.426GluThr: 3.426 ± 0.516
4.644GluVal: 4.644 ± 0.51
1.218GluTrp: 1.218 ± 0.35
3.959GluTyr: 3.959 ± 0.501
0.0GluXaa: 0.0 ± 0.0
Phe
2.055PheAla: 2.055 ± 0.368
0.076PheCys: 0.076 ± 0.088
2.588PheAsp: 2.588 ± 0.391
1.827PheGlu: 1.827 ± 0.531
1.294PhePhe: 1.294 ± 0.393
2.741PheGly: 2.741 ± 0.67
0.609PheHis: 0.609 ± 0.234
2.893PheIle: 2.893 ± 0.504
3.197PheLys: 3.197 ± 0.477
2.284PheLeu: 2.284 ± 0.338
1.751PheMet: 1.751 ± 0.316
3.121PheAsn: 3.121 ± 0.388
0.685PhePro: 0.685 ± 0.238
1.142PheGln: 1.142 ± 0.297
1.37PheArg: 1.37 ± 0.35
1.903PheSer: 1.903 ± 0.376
2.36PheThr: 2.36 ± 0.392
2.436PheVal: 2.436 ± 0.324
0.381PheTrp: 0.381 ± 0.202
2.208PheTyr: 2.208 ± 0.48
0.0PheXaa: 0.0 ± 0.0
Gly
3.959GlyAla: 3.959 ± 0.631
0.609GlyCys: 0.609 ± 0.2
2.969GlyAsp: 2.969 ± 0.599
2.969GlyGlu: 2.969 ± 0.608
2.512GlyPhe: 2.512 ± 0.46
3.426GlyGly: 3.426 ± 0.716
1.37GlyHis: 1.37 ± 0.356
5.1GlyIle: 5.1 ± 0.906
5.557GlyLys: 5.557 ± 0.566
4.187GlyLeu: 4.187 ± 0.591
1.599GlyMet: 1.599 ± 0.33
3.959GlyAsn: 3.959 ± 0.723
0.837GlyPro: 0.837 ± 0.226
3.502GlyGln: 3.502 ± 0.386
2.36GlyArg: 2.36 ± 0.286
3.121GlySer: 3.121 ± 0.744
4.491GlyThr: 4.491 ± 0.551
4.415GlyVal: 4.415 ± 0.622
1.37GlyTrp: 1.37 ± 0.439
3.121GlyTyr: 3.121 ± 0.417
0.0GlyXaa: 0.0 ± 0.0
His
0.761HisAla: 0.761 ± 0.281
0.076HisCys: 0.076 ± 0.074
1.066HisAsp: 1.066 ± 0.245
0.837HisGlu: 0.837 ± 0.217
0.533HisPhe: 0.533 ± 0.225
1.066HisGly: 1.066 ± 0.22
0.609HisHis: 0.609 ± 0.266
1.599HisIle: 1.599 ± 0.345
1.599HisLys: 1.599 ± 0.36
1.37HisLeu: 1.37 ± 0.317
0.152HisMet: 0.152 ± 0.1
1.142HisAsn: 1.142 ± 0.295
0.609HisPro: 0.609 ± 0.229
0.533HisGln: 0.533 ± 0.21
0.533HisArg: 0.533 ± 0.233
1.142HisSer: 1.142 ± 0.28
1.37HisThr: 1.37 ± 0.328
1.294HisVal: 1.294 ± 0.342
0.076HisTrp: 0.076 ± 0.066
0.761HisTyr: 0.761 ± 0.224
0.0HisXaa: 0.0 ± 0.0
Ile
5.1IleAla: 5.1 ± 0.817
0.305IleCys: 0.305 ± 0.181
5.405IleAsp: 5.405 ± 0.667
6.928IleGlu: 6.928 ± 0.831
1.675IlePhe: 1.675 ± 0.423
5.1IleGly: 5.1 ± 0.657
1.066IleHis: 1.066 ± 0.262
4.796IleIle: 4.796 ± 0.668
7.613IleLys: 7.613 ± 0.865
4.187IleLeu: 4.187 ± 0.656
1.523IleMet: 1.523 ± 0.355
4.796IleAsn: 4.796 ± 0.553
2.436IlePro: 2.436 ± 0.306
2.817IleGln: 2.817 ± 0.42
2.741IleArg: 2.741 ± 0.414
4.796IleSer: 4.796 ± 0.768
5.253IleThr: 5.253 ± 0.542
3.045IleVal: 3.045 ± 0.485
0.99IleTrp: 0.99 ± 0.326
2.664IleTyr: 2.664 ± 0.452
0.0IleXaa: 0.0 ± 0.0
Lys
5.329LysAla: 5.329 ± 0.507
0.228LysCys: 0.228 ± 0.126
6.471LysAsp: 6.471 ± 0.584
7.689LysGlu: 7.689 ± 1.016
3.654LysPhe: 3.654 ± 0.481
6.014LysGly: 6.014 ± 0.667
1.827LysHis: 1.827 ± 0.294
5.862LysIle: 5.862 ± 0.715
7.08LysLys: 7.08 ± 0.902
7.156LysLeu: 7.156 ± 0.796
2.436LysMet: 2.436 ± 0.446
5.1LysAsn: 5.1 ± 0.624
2.969LysPro: 2.969 ± 0.56
4.644LysGln: 4.644 ± 0.528
4.568LysArg: 4.568 ± 0.672
5.253LysSer: 5.253 ± 0.863
6.166LysThr: 6.166 ± 0.813
5.481LysVal: 5.481 ± 0.757
1.218LysTrp: 1.218 ± 0.308
3.35LysTyr: 3.35 ± 0.517
0.0LysXaa: 0.0 ± 0.0
Leu
3.959LeuAla: 3.959 ± 0.598
0.228LeuCys: 0.228 ± 0.171
5.024LeuAsp: 5.024 ± 0.513
6.09LeuGlu: 6.09 ± 0.719
2.893LeuPhe: 2.893 ± 0.472
4.644LeuGly: 4.644 ± 0.754
1.066LeuHis: 1.066 ± 0.277
5.481LeuIle: 5.481 ± 0.643
7.232LeuLys: 7.232 ± 0.798
6.242LeuLeu: 6.242 ± 0.953
1.827LeuMet: 1.827 ± 0.406
5.862LeuAsn: 5.862 ± 0.489
2.055LeuPro: 2.055 ± 0.34
3.35LeuGln: 3.35 ± 0.555
3.73LeuArg: 3.73 ± 0.61
4.72LeuSer: 4.72 ± 0.583
4.339LeuThr: 4.339 ± 0.467
3.806LeuVal: 3.806 ± 0.458
0.914LeuTrp: 0.914 ± 0.297
2.741LeuTyr: 2.741 ± 0.543
0.0LeuXaa: 0.0 ± 0.0
Met
1.827MetAla: 1.827 ± 0.504
0.152MetCys: 0.152 ± 0.116
1.294MetAsp: 1.294 ± 0.302
1.751MetGlu: 1.751 ± 0.358
0.914MetPhe: 0.914 ± 0.329
0.761MetGly: 0.761 ± 0.226
0.152MetHis: 0.152 ± 0.096
1.142MetIle: 1.142 ± 0.277
3.045MetLys: 3.045 ± 0.376
2.208MetLeu: 2.208 ± 0.391
0.761MetMet: 0.761 ± 0.289
1.599MetAsn: 1.599 ± 0.313
1.142MetPro: 1.142 ± 0.212
0.99MetGln: 0.99 ± 0.264
0.99MetArg: 0.99 ± 0.236
2.512MetSer: 2.512 ± 0.461
2.208MetThr: 2.208 ± 0.421
0.99MetVal: 0.99 ± 0.226
0.533MetTrp: 0.533 ± 0.217
1.294MetTyr: 1.294 ± 0.331
0.0MetXaa: 0.0 ± 0.0
Asn
3.806AsnAla: 3.806 ± 0.611
0.533AsnCys: 0.533 ± 0.33
3.654AsnAsp: 3.654 ± 0.531
4.415AsnGlu: 4.415 ± 0.635
2.512AsnPhe: 2.512 ± 0.353
4.568AsnGly: 4.568 ± 0.818
1.066AsnHis: 1.066 ± 0.337
5.177AsnIle: 5.177 ± 0.816
7.613AsnLys: 7.613 ± 0.73
4.187AsnLeu: 4.187 ± 0.594
1.599AsnMet: 1.599 ± 0.39
5.405AsnAsn: 5.405 ± 0.914
2.436AsnPro: 2.436 ± 0.422
2.588AsnGln: 2.588 ± 0.42
3.35AsnArg: 3.35 ± 0.563
4.111AsnSer: 4.111 ± 0.506
4.187AsnThr: 4.187 ± 0.761
3.959AsnVal: 3.959 ± 0.765
0.609AsnTrp: 0.609 ± 0.194
2.741AsnTyr: 2.741 ± 0.551
0.0AsnXaa: 0.0 ± 0.0
Pro
1.294ProAla: 1.294 ± 0.258
0.152ProCys: 0.152 ± 0.115
1.446ProAsp: 1.446 ± 0.364
1.827ProGlu: 1.827 ± 0.375
1.294ProPhe: 1.294 ± 0.439
1.37ProGly: 1.37 ± 0.305
0.685ProHis: 0.685 ± 0.197
2.664ProIle: 2.664 ± 0.54
3.35ProLys: 3.35 ± 0.615
1.142ProLeu: 1.142 ± 0.267
0.685ProMet: 0.685 ± 0.241
1.523ProAsn: 1.523 ± 0.498
0.99ProPro: 0.99 ± 0.241
0.99ProGln: 0.99 ± 0.247
1.218ProArg: 1.218 ± 0.296
2.208ProSer: 2.208 ± 0.414
1.294ProThr: 1.294 ± 0.351
1.751ProVal: 1.751 ± 0.346
0.152ProTrp: 0.152 ± 0.091
1.218ProTyr: 1.218 ± 0.268
0.0ProXaa: 0.0 ± 0.0
Gln
2.741GlnAla: 2.741 ± 0.445
0.152GlnCys: 0.152 ± 0.094
2.664GlnAsp: 2.664 ± 0.492
2.741GlnGlu: 2.741 ± 0.515
1.294GlnPhe: 1.294 ± 0.248
2.284GlnGly: 2.284 ± 0.347
0.533GlnHis: 0.533 ± 0.194
3.35GlnIle: 3.35 ± 0.396
3.35GlnLys: 3.35 ± 0.508
3.121GlnLeu: 3.121 ± 0.472
1.066GlnMet: 1.066 ± 0.27
2.969GlnAsn: 2.969 ± 0.476
1.218GlnPro: 1.218 ± 0.297
2.208GlnGln: 2.208 ± 0.499
1.979GlnArg: 1.979 ± 0.352
2.817GlnSer: 2.817 ± 0.414
3.121GlnThr: 3.121 ± 0.594
1.903GlnVal: 1.903 ± 0.418
0.609GlnTrp: 0.609 ± 0.218
1.827GlnTyr: 1.827 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
2.055ArgAla: 2.055 ± 0.537
0.228ArgCys: 0.228 ± 0.125
3.273ArgAsp: 3.273 ± 0.529
3.121ArgGlu: 3.121 ± 0.502
1.523ArgPhe: 1.523 ± 0.292
2.36ArgGly: 2.36 ± 0.452
0.837ArgHis: 0.837 ± 0.182
3.045ArgIle: 3.045 ± 0.464
3.578ArgLys: 3.578 ± 0.607
3.959ArgLeu: 3.959 ± 0.456
1.294ArgMet: 1.294 ± 0.316
2.817ArgAsn: 2.817 ± 0.349
0.837ArgPro: 0.837 ± 0.244
1.142ArgGln: 1.142 ± 0.272
1.979ArgArg: 1.979 ± 0.419
2.741ArgSer: 2.741 ± 0.453
1.827ArgThr: 1.827 ± 0.441
3.045ArgVal: 3.045 ± 0.424
0.761ArgTrp: 0.761 ± 0.21
2.817ArgTyr: 2.817 ± 0.479
0.0ArgXaa: 0.0 ± 0.0
Ser
3.197SerAla: 3.197 ± 0.736
0.152SerCys: 0.152 ± 0.115
4.035SerAsp: 4.035 ± 0.595
3.959SerGlu: 3.959 ± 0.591
2.36SerPhe: 2.36 ± 0.45
4.644SerGly: 4.644 ± 0.666
0.761SerHis: 0.761 ± 0.265
3.35SerIle: 3.35 ± 0.503
5.633SerLys: 5.633 ± 0.647
5.633SerLeu: 5.633 ± 0.682
2.208SerMet: 2.208 ± 0.373
5.557SerAsn: 5.557 ± 0.848
1.142SerPro: 1.142 ± 0.234
2.741SerGln: 2.741 ± 0.562
2.817SerArg: 2.817 ± 0.564
3.273SerSer: 3.273 ± 0.464
3.426SerThr: 3.426 ± 0.449
3.654SerVal: 3.654 ± 0.579
1.066SerTrp: 1.066 ± 0.254
2.512SerTyr: 2.512 ± 0.408
0.0SerXaa: 0.0 ± 0.0
Thr
3.35ThrAla: 3.35 ± 0.544
0.228ThrCys: 0.228 ± 0.141
4.263ThrAsp: 4.263 ± 0.614
3.502ThrGlu: 3.502 ± 0.549
3.197ThrPhe: 3.197 ± 0.562
3.882ThrGly: 3.882 ± 0.44
1.218ThrHis: 1.218 ± 0.266
5.024ThrIle: 5.024 ± 0.466
6.775ThrLys: 6.775 ± 0.954
3.959ThrLeu: 3.959 ± 0.529
1.218ThrMet: 1.218 ± 0.247
3.806ThrAsn: 3.806 ± 0.615
2.512ThrPro: 2.512 ± 0.454
2.893ThrGln: 2.893 ± 0.333
1.827ThrArg: 1.827 ± 0.41
4.035ThrSer: 4.035 ± 0.53
4.796ThrThr: 4.796 ± 0.843
4.111ThrVal: 4.111 ± 0.762
0.457ThrTrp: 0.457 ± 0.172
2.208ThrTyr: 2.208 ± 0.486
0.0ThrXaa: 0.0 ± 0.0
Val
3.502ValAla: 3.502 ± 0.7
0.152ValCys: 0.152 ± 0.105
4.415ValAsp: 4.415 ± 0.558
4.796ValGlu: 4.796 ± 0.715
1.446ValPhe: 1.446 ± 0.375
3.502ValGly: 3.502 ± 0.486
0.914ValHis: 0.914 ± 0.218
4.035ValIle: 4.035 ± 0.593
4.872ValLys: 4.872 ± 0.536
4.263ValLeu: 4.263 ± 0.709
1.066ValMet: 1.066 ± 0.206
3.121ValAsn: 3.121 ± 0.382
2.208ValPro: 2.208 ± 0.532
1.827ValGln: 1.827 ± 0.421
3.502ValArg: 3.502 ± 0.418
5.1ValSer: 5.1 ± 0.672
3.73ValThr: 3.73 ± 0.486
4.339ValVal: 4.339 ± 0.555
0.609ValTrp: 0.609 ± 0.315
2.284ValTyr: 2.284 ± 0.537
0.0ValXaa: 0.0 ± 0.0
Trp
0.685TrpAla: 0.685 ± 0.245
0.152TrpCys: 0.152 ± 0.1
0.457TrpAsp: 0.457 ± 0.191
1.218TrpGlu: 1.218 ± 0.297
0.381TrpPhe: 0.381 ± 0.167
0.837TrpGly: 0.837 ± 0.296
0.533TrpHis: 0.533 ± 0.25
0.914TrpIle: 0.914 ± 0.256
0.914TrpLys: 0.914 ± 0.272
0.685TrpLeu: 0.685 ± 0.22
0.0TrpMet: 0.0 ± 0.0
1.066TrpAsn: 1.066 ± 0.308
0.152TrpPro: 0.152 ± 0.086
0.457TrpGln: 0.457 ± 0.163
0.533TrpArg: 0.533 ± 0.172
0.837TrpSer: 0.837 ± 0.241
1.751TrpThr: 1.751 ± 0.284
0.99TrpVal: 0.99 ± 0.277
0.0TrpTrp: 0.0 ± 0.0
0.457TrpTyr: 0.457 ± 0.162
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.979TyrAla: 1.979 ± 0.452
0.381TyrCys: 0.381 ± 0.192
3.121TyrAsp: 3.121 ± 0.428
3.273TyrGlu: 3.273 ± 0.631
1.751TyrPhe: 1.751 ± 0.34
2.969TyrGly: 2.969 ± 0.472
0.914TyrHis: 0.914 ± 0.285
3.197TyrIle: 3.197 ± 0.532
3.882TyrLys: 3.882 ± 0.509
3.273TyrLeu: 3.273 ± 0.491
1.675TyrMet: 1.675 ± 0.37
2.588TyrAsn: 2.588 ± 0.327
0.914TyrPro: 0.914 ± 0.256
1.827TyrGln: 1.827 ± 0.349
1.751TyrArg: 1.751 ± 0.39
2.436TyrSer: 2.436 ± 0.407
2.512TyrThr: 2.512 ± 0.43
2.436TyrVal: 2.436 ± 0.42
0.609TyrTrp: 0.609 ± 0.196
1.599TyrTyr: 1.599 ± 0.328
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (13137 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski