Amino acid dipepetide frequency for Staphylococcus virus IPLA7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.309AlaAla: 2.309 ± 0.407
0.231AlaCys: 0.231 ± 0.15
2.616AlaAsp: 2.616 ± 0.508
3.463AlaGlu: 3.463 ± 0.648
2.386AlaPhe: 2.386 ± 0.65
3.617AlaGly: 3.617 ± 0.58
1.385AlaHis: 1.385 ± 0.395
5.464AlaIle: 5.464 ± 0.702
5.848AlaLys: 5.848 ± 0.806
5.31AlaLeu: 5.31 ± 0.833
1.924AlaMet: 1.924 ± 0.395
3.925AlaAsn: 3.925 ± 0.511
1.231AlaPro: 1.231 ± 0.301
2.309AlaGln: 2.309 ± 0.447
1.616AlaArg: 1.616 ± 0.326
3.925AlaSer: 3.925 ± 0.797
2.693AlaThr: 2.693 ± 0.448
2.539AlaVal: 2.539 ± 0.59
0.693AlaTrp: 0.693 ± 0.237
2.001AlaTyr: 2.001 ± 0.401
0.0AlaXaa: 0.0 ± 0.0
Cys
0.385CysAla: 0.385 ± 0.15
0.0CysCys: 0.0 ± 0.0
0.308CysAsp: 0.308 ± 0.155
0.231CysGlu: 0.231 ± 0.131
0.154CysPhe: 0.154 ± 0.095
0.539CysGly: 0.539 ± 0.176
0.077CysHis: 0.077 ± 0.074
0.308CysIle: 0.308 ± 0.154
0.462CysLys: 0.462 ± 0.198
0.385CysLeu: 0.385 ± 0.188
0.0CysMet: 0.0 ± 0.0
0.923CysAsn: 0.923 ± 0.233
0.308CysPro: 0.308 ± 0.171
0.077CysGln: 0.077 ± 0.082
0.154CysArg: 0.154 ± 0.106
0.385CysSer: 0.385 ± 0.199
0.077CysThr: 0.077 ± 0.095
0.385CysVal: 0.385 ± 0.171
0.077CysTrp: 0.077 ± 0.072
0.385CysTyr: 0.385 ± 0.199
0.0CysXaa: 0.0 ± 0.0
Asp
3.386AspAla: 3.386 ± 0.625
0.231AspCys: 0.231 ± 0.145
4.463AspAsp: 4.463 ± 0.681
6.079AspGlu: 6.079 ± 0.697
2.539AspPhe: 2.539 ± 0.431
4.309AspGly: 4.309 ± 0.504
1.0AspHis: 1.0 ± 0.294
5.156AspIle: 5.156 ± 0.621
5.925AspLys: 5.925 ± 0.547
6.079AspLeu: 6.079 ± 0.764
1.385AspMet: 1.385 ± 0.359
4.386AspAsn: 4.386 ± 0.682
1.231AspPro: 1.231 ± 0.278
0.923AspGln: 0.923 ± 0.297
2.232AspArg: 2.232 ± 0.455
3.078AspSer: 3.078 ± 0.414
4.232AspThr: 4.232 ± 0.576
3.54AspVal: 3.54 ± 0.491
0.77AspTrp: 0.77 ± 0.23
3.386AspTyr: 3.386 ± 0.584
0.0AspXaa: 0.0 ± 0.0
Glu
3.309GluAla: 3.309 ± 0.674
0.462GluCys: 0.462 ± 0.22
3.232GluAsp: 3.232 ± 0.52
5.925GluGlu: 5.925 ± 0.968
2.693GluPhe: 2.693 ± 0.451
2.001GluGly: 2.001 ± 0.425
1.385GluHis: 1.385 ± 0.257
5.233GluIle: 5.233 ± 0.605
4.848GluLys: 4.848 ± 0.641
7.234GluLeu: 7.234 ± 0.862
2.539GluMet: 2.539 ± 0.508
4.386GluAsn: 4.386 ± 0.565
1.77GluPro: 1.77 ± 0.416
3.925GluGln: 3.925 ± 0.536
4.54GluArg: 4.54 ± 0.713
4.002GluSer: 4.002 ± 0.661
4.386GluThr: 4.386 ± 0.632
5.848GluVal: 5.848 ± 0.781
1.462GluTrp: 1.462 ± 0.356
4.155GluTyr: 4.155 ± 0.525
0.0GluXaa: 0.0 ± 0.0
Phe
1.693PheAla: 1.693 ± 0.349
0.077PheCys: 0.077 ± 0.082
2.924PheAsp: 2.924 ± 0.431
2.693PheGlu: 2.693 ± 0.583
1.539PhePhe: 1.539 ± 0.385
2.309PheGly: 2.309 ± 0.595
0.693PheHis: 0.693 ± 0.225
3.155PheIle: 3.155 ± 0.507
3.155PheLys: 3.155 ± 0.4
1.924PheLeu: 1.924 ± 0.404
1.462PheMet: 1.462 ± 0.344
3.155PheAsn: 3.155 ± 0.401
0.616PhePro: 0.616 ± 0.22
1.308PheGln: 1.308 ± 0.365
1.693PheArg: 1.693 ± 0.414
1.847PheSer: 1.847 ± 0.363
2.155PheThr: 2.155 ± 0.414
2.232PheVal: 2.232 ± 0.365
0.308PheTrp: 0.308 ± 0.172
2.155PheTyr: 2.155 ± 0.463
0.0PheXaa: 0.0 ± 0.0
Gly
4.078GlyAla: 4.078 ± 0.743
0.616GlyCys: 0.616 ± 0.197
3.001GlyAsp: 3.001 ± 0.639
3.694GlyGlu: 3.694 ± 0.73
2.155GlyPhe: 2.155 ± 0.439
3.771GlyGly: 3.771 ± 0.628
1.385GlyHis: 1.385 ± 0.473
4.848GlyIle: 4.848 ± 0.756
4.771GlyLys: 4.771 ± 0.626
4.078GlyLeu: 4.078 ± 0.578
1.847GlyMet: 1.847 ± 0.404
3.848GlyAsn: 3.848 ± 0.811
0.539GlyPro: 0.539 ± 0.197
3.309GlyGln: 3.309 ± 0.553
2.77GlyArg: 2.77 ± 0.401
2.847GlySer: 2.847 ± 0.89
4.155GlyThr: 4.155 ± 0.555
4.463GlyVal: 4.463 ± 0.55
0.693GlyTrp: 0.693 ± 0.291
3.309GlyTyr: 3.309 ± 0.619
0.0GlyXaa: 0.0 ± 0.0
His
1.539HisAla: 1.539 ± 0.372
0.077HisCys: 0.077 ± 0.079
1.0HisAsp: 1.0 ± 0.324
1.077HisGlu: 1.077 ± 0.255
0.693HisPhe: 0.693 ± 0.214
1.077HisGly: 1.077 ± 0.252
0.616HisHis: 0.616 ± 0.274
0.77HisIle: 0.77 ± 0.288
1.308HisLys: 1.308 ± 0.306
1.308HisLeu: 1.308 ± 0.304
0.231HisMet: 0.231 ± 0.112
1.231HisAsn: 1.231 ± 0.285
0.616HisPro: 0.616 ± 0.196
0.539HisGln: 0.539 ± 0.226
0.77HisArg: 0.77 ± 0.255
1.462HisSer: 1.462 ± 0.261
1.616HisThr: 1.616 ± 0.402
0.77HisVal: 0.77 ± 0.227
0.077HisTrp: 0.077 ± 0.071
0.923HisTyr: 0.923 ± 0.2
0.0HisXaa: 0.0 ± 0.0
Ile
5.464IleAla: 5.464 ± 0.677
0.231IleCys: 0.231 ± 0.135
5.618IleAsp: 5.618 ± 0.764
7.003IleGlu: 7.003 ± 0.807
2.078IlePhe: 2.078 ± 0.451
5.233IleGly: 5.233 ± 0.69
0.77IleHis: 0.77 ± 0.25
3.771IleIle: 3.771 ± 0.673
8.542IleLys: 8.542 ± 0.829
4.155IleLeu: 4.155 ± 0.638
1.539IleMet: 1.539 ± 0.407
4.54IleAsn: 4.54 ± 0.491
2.616IlePro: 2.616 ± 0.363
2.001IleGln: 2.001 ± 0.362
2.001IleArg: 2.001 ± 0.31
5.31IleSer: 5.31 ± 0.791
5.156IleThr: 5.156 ± 0.613
3.617IleVal: 3.617 ± 0.675
1.077IleTrp: 1.077 ± 0.313
2.616IleTyr: 2.616 ± 0.53
0.0IleXaa: 0.0 ± 0.0
Lys
4.694LysAla: 4.694 ± 0.671
0.385LysCys: 0.385 ± 0.277
6.387LysAsp: 6.387 ± 0.681
7.311LysGlu: 7.311 ± 0.971
3.309LysPhe: 3.309 ± 0.448
5.31LysGly: 5.31 ± 0.591
1.462LysHis: 1.462 ± 0.299
5.541LysIle: 5.541 ± 0.838
7.003LysLys: 7.003 ± 0.927
7.849LysLeu: 7.849 ± 0.888
2.155LysMet: 2.155 ± 0.387
5.848LysAsn: 5.848 ± 0.813
3.001LysPro: 3.001 ± 0.706
4.848LysGln: 4.848 ± 0.475
4.386LysArg: 4.386 ± 0.698
5.079LysSer: 5.079 ± 0.691
6.464LysThr: 6.464 ± 0.811
5.387LysVal: 5.387 ± 0.638
1.077LysTrp: 1.077 ± 0.278
4.309LysTyr: 4.309 ± 0.649
0.0LysXaa: 0.0 ± 0.0
Leu
4.078LeuAla: 4.078 ± 0.638
0.231LeuCys: 0.231 ± 0.195
5.694LeuAsp: 5.694 ± 0.54
5.771LeuGlu: 5.771 ± 0.684
3.078LeuPhe: 3.078 ± 0.493
4.463LeuGly: 4.463 ± 0.695
1.462LeuHis: 1.462 ± 0.379
5.618LeuIle: 5.618 ± 0.699
7.157LeuLys: 7.157 ± 0.881
4.309LeuLeu: 4.309 ± 0.555
1.616LeuMet: 1.616 ± 0.332
5.233LeuAsn: 5.233 ± 0.526
2.386LeuPro: 2.386 ± 0.386
3.925LeuGln: 3.925 ± 0.709
3.386LeuArg: 3.386 ± 0.546
4.463LeuSer: 4.463 ± 0.572
3.848LeuThr: 3.848 ± 0.523
3.54LeuVal: 3.54 ± 0.425
1.462LeuTrp: 1.462 ± 0.283
2.77LeuTyr: 2.77 ± 0.552
0.0LeuXaa: 0.0 ± 0.0
Met
1.847MetAla: 1.847 ± 0.499
0.154MetCys: 0.154 ± 0.118
1.154MetAsp: 1.154 ± 0.284
1.539MetGlu: 1.539 ± 0.319
1.0MetPhe: 1.0 ± 0.31
0.846MetGly: 0.846 ± 0.268
0.231MetHis: 0.231 ± 0.121
1.847MetIle: 1.847 ± 0.338
3.078MetLys: 3.078 ± 0.417
2.309MetLeu: 2.309 ± 0.583
0.616MetMet: 0.616 ± 0.246
1.77MetAsn: 1.77 ± 0.388
1.0MetPro: 1.0 ± 0.259
0.846MetGln: 0.846 ± 0.254
0.923MetArg: 0.923 ± 0.246
1.616MetSer: 1.616 ± 0.347
1.924MetThr: 1.924 ± 0.367
1.077MetVal: 1.077 ± 0.257
0.462MetTrp: 0.462 ± 0.216
1.231MetTyr: 1.231 ± 0.388
0.0MetXaa: 0.0 ± 0.0
Asn
3.232AsnAla: 3.232 ± 0.591
0.846AsnCys: 0.846 ± 0.424
5.233AsnAsp: 5.233 ± 0.656
4.463AsnGlu: 4.463 ± 0.633
2.386AsnPhe: 2.386 ± 0.374
5.233AsnGly: 5.233 ± 0.762
1.077AsnHis: 1.077 ± 0.286
4.848AsnIle: 4.848 ± 0.761
6.541AsnLys: 6.541 ± 0.873
4.155AsnLeu: 4.155 ± 0.631
0.923AsnMet: 0.923 ± 0.306
5.464AsnAsn: 5.464 ± 0.864
2.847AsnPro: 2.847 ± 0.478
2.924AsnGln: 2.924 ± 0.594
3.54AsnArg: 3.54 ± 0.608
3.617AsnSer: 3.617 ± 0.417
4.002AsnThr: 4.002 ± 0.768
3.925AsnVal: 3.925 ± 0.598
0.616AsnTrp: 0.616 ± 0.229
2.462AsnTyr: 2.462 ± 0.501
0.0AsnXaa: 0.0 ± 0.0
Pro
1.308ProAla: 1.308 ± 0.316
0.077ProCys: 0.077 ± 0.072
1.924ProAsp: 1.924 ± 0.422
1.77ProGlu: 1.77 ± 0.316
1.616ProPhe: 1.616 ± 0.469
1.231ProGly: 1.231 ± 0.397
0.539ProHis: 0.539 ± 0.176
2.77ProIle: 2.77 ± 0.552
3.54ProLys: 3.54 ± 0.605
1.154ProLeu: 1.154 ± 0.255
0.693ProMet: 0.693 ± 0.236
1.77ProAsn: 1.77 ± 0.395
1.0ProPro: 1.0 ± 0.373
0.77ProGln: 0.77 ± 0.206
1.385ProArg: 1.385 ± 0.342
2.078ProSer: 2.078 ± 0.579
1.231ProThr: 1.231 ± 0.356
1.77ProVal: 1.77 ± 0.391
0.231ProTrp: 0.231 ± 0.109
1.231ProTyr: 1.231 ± 0.331
0.0ProXaa: 0.0 ± 0.0
Gln
2.924GlnAla: 2.924 ± 0.587
0.308GlnCys: 0.308 ± 0.133
2.232GlnAsp: 2.232 ± 0.413
2.77GlnGlu: 2.77 ± 0.526
1.0GlnPhe: 1.0 ± 0.219
2.309GlnGly: 2.309 ± 0.387
0.693GlnHis: 0.693 ± 0.262
3.155GlnIle: 3.155 ± 0.45
4.002GlnLys: 4.002 ± 0.581
2.924GlnLeu: 2.924 ± 0.436
1.154GlnMet: 1.154 ± 0.286
3.386GlnAsn: 3.386 ± 0.501
1.308GlnPro: 1.308 ± 0.277
2.386GlnGln: 2.386 ± 0.521
1.847GlnArg: 1.847 ± 0.31
2.078GlnSer: 2.078 ± 0.436
2.616GlnThr: 2.616 ± 0.518
1.924GlnVal: 1.924 ± 0.443
0.539GlnTrp: 0.539 ± 0.2
1.77GlnTyr: 1.77 ± 0.398
0.0GlnXaa: 0.0 ± 0.0
Arg
1.924ArgAla: 1.924 ± 0.527
0.231ArgCys: 0.231 ± 0.114
2.847ArgAsp: 2.847 ± 0.514
3.309ArgGlu: 3.309 ± 0.544
1.616ArgPhe: 1.616 ± 0.316
2.309ArgGly: 2.309 ± 0.427
0.846ArgHis: 0.846 ± 0.242
2.539ArgIle: 2.539 ± 0.45
4.309ArgLys: 4.309 ± 0.759
3.694ArgLeu: 3.694 ± 0.486
1.693ArgMet: 1.693 ± 0.381
3.001ArgAsn: 3.001 ± 0.45
1.231ArgPro: 1.231 ± 0.339
1.77ArgGln: 1.77 ± 0.426
2.462ArgArg: 2.462 ± 0.554
2.693ArgSer: 2.693 ± 0.481
1.847ArgThr: 1.847 ± 0.364
2.77ArgVal: 2.77 ± 0.491
1.077ArgTrp: 1.077 ± 0.259
2.847ArgTyr: 2.847 ± 0.53
0.0ArgXaa: 0.0 ± 0.0
Ser
3.078SerAla: 3.078 ± 0.692
0.231SerCys: 0.231 ± 0.135
3.848SerAsp: 3.848 ± 0.627
3.617SerGlu: 3.617 ± 0.498
2.155SerPhe: 2.155 ± 0.443
4.848SerGly: 4.848 ± 0.85
1.0SerHis: 1.0 ± 0.352
4.078SerIle: 4.078 ± 0.633
5.233SerLys: 5.233 ± 0.617
4.694SerLeu: 4.694 ± 0.636
1.616SerMet: 1.616 ± 0.312
4.309SerAsn: 4.309 ± 0.76
1.308SerPro: 1.308 ± 0.301
2.77SerGln: 2.77 ± 0.56
2.924SerArg: 2.924 ± 0.533
2.847SerSer: 2.847 ± 0.51
3.54SerThr: 3.54 ± 0.65
3.848SerVal: 3.848 ± 0.486
1.154SerTrp: 1.154 ± 0.322
1.924SerTyr: 1.924 ± 0.431
0.0SerXaa: 0.0 ± 0.0
Thr
3.386ThrAla: 3.386 ± 0.562
0.231ThrCys: 0.231 ± 0.125
3.54ThrAsp: 3.54 ± 0.438
3.232ThrGlu: 3.232 ± 0.567
2.847ThrPhe: 2.847 ± 0.504
3.54ThrGly: 3.54 ± 0.59
1.077ThrHis: 1.077 ± 0.258
6.002ThrIle: 6.002 ± 0.563
6.464ThrLys: 6.464 ± 0.954
4.617ThrLeu: 4.617 ± 0.465
1.077ThrMet: 1.077 ± 0.255
3.694ThrAsn: 3.694 ± 0.661
2.232ThrPro: 2.232 ± 0.473
2.77ThrGln: 2.77 ± 0.373
2.386ThrArg: 2.386 ± 0.507
3.617ThrSer: 3.617 ± 0.552
4.309ThrThr: 4.309 ± 0.622
4.002ThrVal: 4.002 ± 0.749
0.616ThrTrp: 0.616 ± 0.194
1.77ThrTyr: 1.77 ± 0.402
0.0ThrXaa: 0.0 ± 0.0
Val
3.694ValAla: 3.694 ± 0.794
0.385ValCys: 0.385 ± 0.253
4.617ValAsp: 4.617 ± 0.564
4.848ValGlu: 4.848 ± 0.636
1.924ValPhe: 1.924 ± 0.496
3.463ValGly: 3.463 ± 0.472
0.77ValHis: 0.77 ± 0.278
3.694ValIle: 3.694 ± 0.643
5.31ValLys: 5.31 ± 0.654
4.232ValLeu: 4.232 ± 0.708
1.462ValMet: 1.462 ± 0.304
3.463ValAsn: 3.463 ± 0.4
1.616ValPro: 1.616 ± 0.267
1.693ValGln: 1.693 ± 0.417
3.232ValArg: 3.232 ± 0.425
4.848ValSer: 4.848 ± 0.509
3.617ValThr: 3.617 ± 0.528
4.617ValVal: 4.617 ± 0.481
0.462ValTrp: 0.462 ± 0.238
2.386ValTyr: 2.386 ± 0.593
0.0ValXaa: 0.0 ± 0.0
Trp
0.846TrpAla: 0.846 ± 0.242
0.154TrpCys: 0.154 ± 0.098
0.462TrpAsp: 0.462 ± 0.234
1.308TrpGlu: 1.308 ± 0.376
0.385TrpPhe: 0.385 ± 0.187
0.77TrpGly: 0.77 ± 0.266
0.231TrpHis: 0.231 ± 0.122
1.0TrpIle: 1.0 ± 0.27
1.154TrpLys: 1.154 ± 0.29
1.077TrpLeu: 1.077 ± 0.345
0.077TrpMet: 0.077 ± 0.086
0.77TrpAsn: 0.77 ± 0.294
0.154TrpPro: 0.154 ± 0.098
0.308TrpGln: 0.308 ± 0.144
0.616TrpArg: 0.616 ± 0.175
0.616TrpSer: 0.616 ± 0.222
1.539TrpThr: 1.539 ± 0.337
1.539TrpVal: 1.539 ± 0.416
0.231TrpTrp: 0.231 ± 0.176
0.539TrpTyr: 0.539 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.309TyrAla: 2.309 ± 0.501
0.462TyrCys: 0.462 ± 0.185
3.232TyrAsp: 3.232 ± 0.52
3.232TyrGlu: 3.232 ± 0.659
1.539TyrPhe: 1.539 ± 0.473
3.001TyrGly: 3.001 ± 0.644
1.0TyrHis: 1.0 ± 0.286
3.54TyrIle: 3.54 ± 0.442
3.155TyrLys: 3.155 ± 0.502
3.001TyrLeu: 3.001 ± 0.522
1.385TyrMet: 1.385 ± 0.341
3.232TyrAsn: 3.232 ± 0.489
1.077TyrPro: 1.077 ± 0.335
1.924TyrGln: 1.924 ± 0.382
2.155TyrArg: 2.155 ± 0.453
2.616TyrSer: 2.616 ± 0.493
2.001TyrThr: 2.001 ± 0.353
2.616TyrVal: 2.616 ± 0.375
0.693TyrTrp: 0.693 ± 0.283
1.693TyrTyr: 1.693 ± 0.346
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (12996 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski