Amino acid dipepetide frequency for Paenibacillus rigui

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.595AlaAla: 9.595 ± 0.128
0.726AlaCys: 0.726 ± 0.019
4.29AlaAsp: 4.29 ± 0.057
5.42AlaGlu: 5.42 ± 0.066
3.355AlaPhe: 3.355 ± 0.046
6.852AlaGly: 6.852 ± 0.079
1.485AlaHis: 1.485 ± 0.028
5.178AlaIle: 5.178 ± 0.056
4.379AlaLys: 4.379 ± 0.053
8.378AlaLeu: 8.378 ± 0.075
2.336AlaMet: 2.336 ± 0.036
2.668AlaAsn: 2.668 ± 0.042
2.996AlaPro: 2.996 ± 0.055
3.124AlaGln: 3.124 ± 0.044
3.505AlaArg: 3.505 ± 0.05
5.511AlaSer: 5.511 ± 0.063
3.665AlaThr: 3.665 ± 0.052
6.533AlaVal: 6.533 ± 0.073
1.054AlaTrp: 1.054 ± 0.024
2.875AlaTyr: 2.875 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.532CysAla: 0.532 ± 0.015
0.125CysCys: 0.125 ± 0.008
0.359CysAsp: 0.359 ± 0.014
0.424CysGlu: 0.424 ± 0.015
0.335CysPhe: 0.335 ± 0.013
0.702CysGly: 0.702 ± 0.021
0.202CysHis: 0.202 ± 0.01
0.547CysIle: 0.547 ± 0.017
0.346CysLys: 0.346 ± 0.014
0.778CysLeu: 0.778 ± 0.022
0.211CysMet: 0.211 ± 0.011
0.238CysAsn: 0.238 ± 0.012
0.355CysPro: 0.355 ± 0.014
0.214CysGln: 0.214 ± 0.011
0.446CysArg: 0.446 ± 0.017
0.583CysSer: 0.583 ± 0.017
0.446CysThr: 0.446 ± 0.015
0.451CysVal: 0.451 ± 0.018
0.099CysTrp: 0.099 ± 0.008
0.28CysTyr: 0.28 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.134AspAla: 4.134 ± 0.045
0.37AspCys: 0.37 ± 0.013
2.272AspAsp: 2.272 ± 0.037
3.364AspGlu: 3.364 ± 0.051
2.095AspPhe: 2.095 ± 0.031
4.012AspGly: 4.012 ± 0.055
1.118AspHis: 1.118 ± 0.028
3.246AspIle: 3.246 ± 0.049
2.811AspLys: 2.811 ± 0.044
4.694AspLeu: 4.694 ± 0.048
1.333AspMet: 1.333 ± 0.028
1.8AspAsn: 1.8 ± 0.035
2.43AspPro: 2.43 ± 0.037
1.961AspGln: 1.961 ± 0.035
2.721AspArg: 2.721 ± 0.039
2.775AspSer: 2.775 ± 0.037
2.656AspThr: 2.656 ± 0.038
3.459AspVal: 3.459 ± 0.045
0.831AspTrp: 0.831 ± 0.02
2.061AspTyr: 2.061 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.228GluAla: 6.228 ± 0.064
0.394GluCys: 0.394 ± 0.015
2.849GluAsp: 2.849 ± 0.042
4.955GluGlu: 4.955 ± 0.067
1.972GluPhe: 1.972 ± 0.035
4.288GluGly: 4.288 ± 0.054
1.601GluHis: 1.601 ± 0.033
3.795GluIle: 3.795 ± 0.049
3.704GluLys: 3.704 ± 0.054
7.198GluLeu: 7.198 ± 0.074
1.825GluMet: 1.825 ± 0.03
2.075GluAsn: 2.075 ± 0.033
2.405GluPro: 2.405 ± 0.033
3.995GluGln: 3.995 ± 0.052
3.826GluArg: 3.826 ± 0.052
3.38GluSer: 3.38 ± 0.042
3.163GluThr: 3.163 ± 0.038
4.2GluVal: 4.2 ± 0.049
0.922GluTrp: 0.922 ± 0.025
1.791GluTyr: 1.791 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.112PheAla: 3.112 ± 0.042
0.352PheCys: 0.352 ± 0.013
2.222PheAsp: 2.222 ± 0.035
2.337PheGlu: 2.337 ± 0.035
1.722PhePhe: 1.722 ± 0.039
3.049PheGly: 3.049 ± 0.044
0.973PheHis: 0.973 ± 0.024
2.92PheIle: 2.92 ± 0.042
1.955PheLys: 1.955 ± 0.033
3.811PheLeu: 3.811 ± 0.047
1.097PheMet: 1.097 ± 0.024
1.506PheAsn: 1.506 ± 0.026
1.625PhePro: 1.625 ± 0.03
1.643PheGln: 1.643 ± 0.025
1.999PheArg: 1.999 ± 0.034
2.735PheSer: 2.735 ± 0.038
2.574PheThr: 2.574 ± 0.038
2.918PheVal: 2.918 ± 0.044
0.523PheTrp: 0.523 ± 0.016
1.488PheTyr: 1.488 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
5.686GlyAla: 5.686 ± 0.067
0.732GlyCys: 0.732 ± 0.02
3.334GlyAsp: 3.334 ± 0.046
4.209GlyGlu: 4.209 ± 0.048
3.153GlyPhe: 3.153 ± 0.039
5.499GlyGly: 5.499 ± 0.074
1.579GlyHis: 1.579 ± 0.027
5.428GlyIle: 5.428 ± 0.061
4.595GlyLys: 4.595 ± 0.052
7.233GlyLeu: 7.233 ± 0.067
2.286GlyMet: 2.286 ± 0.034
2.696GlyAsn: 2.696 ± 0.052
2.044GlyPro: 2.044 ± 0.033
2.9GlyGln: 2.9 ± 0.046
3.475GlyArg: 3.475 ± 0.042
5.057GlySer: 5.057 ± 0.06
4.881GlyThr: 4.881 ± 0.072
5.123GlyVal: 5.123 ± 0.055
1.151GlyTrp: 1.151 ± 0.03
2.841GlyTyr: 2.841 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
1.683HisAla: 1.683 ± 0.031
0.21HisCys: 0.21 ± 0.01
1.029HisAsp: 1.029 ± 0.026
1.304HisGlu: 1.304 ± 0.031
1.076HisPhe: 1.076 ± 0.025
1.56HisGly: 1.56 ± 0.027
0.679HisHis: 0.679 ± 0.026
1.454HisIle: 1.454 ± 0.029
0.936HisLys: 0.936 ± 0.022
2.217HisLeu: 2.217 ± 0.04
0.642HisMet: 0.642 ± 0.018
0.742HisAsn: 0.742 ± 0.021
1.306HisPro: 1.306 ± 0.031
0.921HisGln: 0.921 ± 0.022
1.128HisArg: 1.128 ± 0.023
1.222HisSer: 1.222 ± 0.025
1.137HisThr: 1.137 ± 0.024
1.47HisVal: 1.47 ± 0.026
0.393HisTrp: 0.393 ± 0.015
0.922HisTyr: 0.922 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.593IleAla: 5.593 ± 0.065
0.571IleCys: 0.571 ± 0.018
3.559IleAsp: 3.559 ± 0.044
4.068IleGlu: 4.068 ± 0.059
2.199IlePhe: 2.199 ± 0.04
5.176IleGly: 5.176 ± 0.06
1.594IleHis: 1.594 ± 0.027
3.873IleIle: 3.873 ± 0.052
2.819IleLys: 2.819 ± 0.039
5.425IleLeu: 5.425 ± 0.064
1.498IleMet: 1.498 ± 0.028
2.227IleAsn: 2.227 ± 0.035
3.104IlePro: 3.104 ± 0.043
2.816IleGln: 2.816 ± 0.038
3.74IleArg: 3.74 ± 0.045
4.356IleSer: 4.356 ± 0.055
3.745IleThr: 3.745 ± 0.052
5.026IleVal: 5.026 ± 0.055
0.681IleTrp: 0.681 ± 0.021
2.035IleTyr: 2.035 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.427LysAla: 4.427 ± 0.058
0.25LysCys: 0.25 ± 0.012
3.0LysAsp: 3.0 ± 0.048
4.262LysGlu: 4.262 ± 0.051
1.568LysPhe: 1.568 ± 0.028
3.668LysGly: 3.668 ± 0.046
1.19LysHis: 1.19 ± 0.027
3.014LysIle: 3.014 ± 0.042
3.327LysLys: 3.327 ± 0.053
5.565LysLeu: 5.565 ± 0.057
1.627LysMet: 1.627 ± 0.03
2.019LysAsn: 2.019 ± 0.036
2.496LysPro: 2.496 ± 0.041
2.852LysGln: 2.852 ± 0.037
2.67LysArg: 2.67 ± 0.041
2.978LysSer: 2.978 ± 0.034
2.758LysThr: 2.758 ± 0.039
3.811LysVal: 3.811 ± 0.052
0.686LysTrp: 0.686 ± 0.019
1.768LysTyr: 1.768 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
8.028LeuAla: 8.028 ± 0.076
0.865LeuCys: 0.865 ± 0.024
5.019LeuAsp: 5.019 ± 0.05
6.26LeuGlu: 6.26 ± 0.073
4.518LeuPhe: 4.518 ± 0.058
6.703LeuGly: 6.703 ± 0.077
2.315LeuHis: 2.315 ± 0.039
6.148LeuIle: 6.148 ± 0.069
5.43LeuLys: 5.43 ± 0.057
11.179LeuLeu: 11.179 ± 0.12
2.636LeuMet: 2.636 ± 0.036
3.92LeuAsn: 3.92 ± 0.05
4.7LeuPro: 4.7 ± 0.055
4.605LeuGln: 4.605 ± 0.057
4.89LeuArg: 4.89 ± 0.063
7.097LeuSer: 7.097 ± 0.065
5.864LeuThr: 5.864 ± 0.051
6.34LeuVal: 6.34 ± 0.058
1.118LeuTrp: 1.118 ± 0.028
3.299LeuTyr: 3.299 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.197MetAla: 2.197 ± 0.039
0.169MetCys: 0.169 ± 0.01
1.531MetAsp: 1.531 ± 0.033
1.917MetGlu: 1.917 ± 0.035
0.998MetPhe: 0.998 ± 0.023
1.747MetGly: 1.747 ± 0.035
0.495MetHis: 0.495 ± 0.017
1.836MetIle: 1.836 ± 0.032
2.022MetLys: 2.022 ± 0.035
2.925MetLeu: 2.925 ± 0.047
0.878MetMet: 0.878 ± 0.025
1.509MetAsn: 1.509 ± 0.034
1.112MetPro: 1.112 ± 0.028
1.085MetGln: 1.085 ± 0.022
1.283MetArg: 1.283 ± 0.027
1.752MetSer: 1.752 ± 0.027
1.667MetThr: 1.667 ± 0.031
1.766MetVal: 1.766 ± 0.03
0.244MetTrp: 0.244 ± 0.011
0.787MetTyr: 0.787 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.833AsnAla: 2.833 ± 0.049
0.224AsnCys: 0.224 ± 0.011
1.864AsnAsp: 1.864 ± 0.035
2.407AsnGlu: 2.407 ± 0.033
1.315AsnPhe: 1.315 ± 0.026
3.443AsnGly: 3.443 ± 0.063
0.857AsnHis: 0.857 ± 0.022
2.236AsnIle: 2.236 ± 0.037
2.142AsnLys: 2.142 ± 0.039
3.161AsnLeu: 3.161 ± 0.038
0.954AsnMet: 0.954 ± 0.022
1.576AsnAsn: 1.576 ± 0.039
2.083AsnPro: 2.083 ± 0.036
1.639AsnGln: 1.639 ± 0.031
2.088AsnArg: 2.088 ± 0.033
2.033AsnSer: 2.033 ± 0.04
2.041AsnThr: 2.041 ± 0.035
2.604AsnVal: 2.604 ± 0.04
0.513AsnTrp: 0.513 ± 0.017
1.351AsnTyr: 1.351 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
3.671ProAla: 3.671 ± 0.052
0.25ProCys: 0.25 ± 0.011
2.575ProAsp: 2.575 ± 0.037
3.236ProGlu: 3.236 ± 0.048
1.908ProPhe: 1.908 ± 0.033
3.069ProGly: 3.069 ± 0.045
0.984ProHis: 0.984 ± 0.026
2.457ProIle: 2.457 ± 0.034
1.944ProLys: 1.944 ± 0.03
4.147ProLeu: 4.147 ± 0.047
1.122ProMet: 1.122 ± 0.024
1.668ProAsn: 1.668 ± 0.031
1.305ProPro: 1.305 ± 0.024
1.621ProGln: 1.621 ± 0.031
1.425ProArg: 1.425 ± 0.031
2.789ProSer: 2.789 ± 0.043
2.068ProThr: 2.068 ± 0.039
3.43ProVal: 3.43 ± 0.038
0.56ProTrp: 0.56 ± 0.017
1.636ProTyr: 1.636 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.951GlnAla: 3.951 ± 0.054
0.235GlnCys: 0.235 ± 0.012
1.842GlnAsp: 1.842 ± 0.037
2.831GlnGlu: 2.831 ± 0.049
1.724GlnPhe: 1.724 ± 0.029
2.955GlnGly: 2.955 ± 0.042
0.905GlnHis: 0.905 ± 0.021
2.51GlnIle: 2.51 ± 0.036
2.098GlnLys: 2.098 ± 0.036
4.928GlnLeu: 4.928 ± 0.05
1.27GlnMet: 1.27 ± 0.027
1.342GlnAsn: 1.342 ± 0.03
1.803GlnPro: 1.803 ± 0.032
2.356GlnGln: 2.356 ± 0.044
2.039GlnArg: 2.039 ± 0.035
2.531GlnSer: 2.531 ± 0.041
2.217GlnThr: 2.217 ± 0.032
3.047GlnVal: 3.047 ± 0.038
0.665GlnTrp: 0.665 ± 0.02
1.414GlnTyr: 1.414 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
3.305ArgAla: 3.305 ± 0.048
0.378ArgCys: 0.378 ± 0.015
2.244ArgAsp: 2.244 ± 0.043
3.461ArgGlu: 3.461 ± 0.052
2.256ArgPhe: 2.256 ± 0.037
2.929ArgGly: 2.929 ± 0.037
1.068ArgHis: 1.068 ± 0.027
3.598ArgIle: 3.598 ± 0.05
2.99ArgLys: 2.99 ± 0.044
5.441ArgLeu: 5.441 ± 0.074
1.665ArgMet: 1.665 ± 0.03
1.951ArgAsn: 1.951 ± 0.036
1.721ArgPro: 1.721 ± 0.029
2.111ArgGln: 2.111 ± 0.035
2.604ArgArg: 2.604 ± 0.049
3.145ArgSer: 3.145 ± 0.047
2.709ArgThr: 2.709 ± 0.036
3.103ArgVal: 3.103 ± 0.04
0.812ArgTrp: 0.812 ± 0.026
1.866ArgTyr: 1.866 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
4.964SerAla: 4.964 ± 0.066
0.451SerCys: 0.451 ± 0.015
3.072SerAsp: 3.072 ± 0.041
3.635SerGlu: 3.635 ± 0.04
3.015SerPhe: 3.015 ± 0.042
5.448SerGly: 5.448 ± 0.073
1.285SerHis: 1.285 ± 0.028
4.299SerIle: 4.299 ± 0.056
3.3SerLys: 3.3 ± 0.045
6.435SerLeu: 6.435 ± 0.068
1.863SerMet: 1.863 ± 0.028
2.353SerAsn: 2.353 ± 0.04
2.588SerPro: 2.588 ± 0.035
2.234SerGln: 2.234 ± 0.039
3.119SerArg: 3.119 ± 0.04
4.58SerSer: 4.58 ± 0.065
3.416SerThr: 3.416 ± 0.049
4.717SerVal: 4.717 ± 0.052
0.873SerTrp: 0.873 ± 0.023
2.345SerTyr: 2.345 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
5.022ThrAla: 5.022 ± 0.066
0.351ThrCys: 0.351 ± 0.013
2.956ThrAsp: 2.956 ± 0.037
3.202ThrGlu: 3.202 ± 0.04
2.394ThrPhe: 2.394 ± 0.039
4.771ThrGly: 4.771 ± 0.07
1.035ThrHis: 1.035 ± 0.025
3.749ThrIle: 3.749 ± 0.049
2.558ThrLys: 2.558 ± 0.037
5.497ThrLeu: 5.497 ± 0.053
1.386ThrMet: 1.386 ± 0.026
2.075ThrAsn: 2.075 ± 0.037
2.643ThrPro: 2.643 ± 0.036
1.757ThrGln: 1.757 ± 0.029
2.316ThrArg: 2.316 ± 0.033
3.44ThrSer: 3.44 ± 0.044
3.014ThrThr: 3.014 ± 0.05
4.683ThrVal: 4.683 ± 0.064
0.679ThrTrp: 0.679 ± 0.021
1.981ThrTyr: 1.981 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.257ValAla: 5.257 ± 0.061
0.605ValCys: 0.605 ± 0.017
3.515ValAsp: 3.515 ± 0.044
4.391ValGlu: 4.391 ± 0.054
2.812ValPhe: 2.812 ± 0.04
4.485ValGly: 4.485 ± 0.054
1.555ValHis: 1.555 ± 0.026
4.769ValIle: 4.769 ± 0.058
4.037ValLys: 4.037 ± 0.054
7.16ValLeu: 7.16 ± 0.066
1.941ValMet: 1.941 ± 0.033
2.82ValAsn: 2.82 ± 0.045
3.201ValPro: 3.201 ± 0.042
3.027ValGln: 3.027 ± 0.038
3.433ValArg: 3.433 ± 0.042
4.867ValSer: 4.867 ± 0.055
4.734ValThr: 4.734 ± 0.061
4.993ValVal: 4.993 ± 0.055
0.915ValTrp: 0.915 ± 0.022
2.501ValTyr: 2.501 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.906TrpAla: 0.906 ± 0.023
0.114TrpCys: 0.114 ± 0.008
0.71TrpAsp: 0.71 ± 0.017
0.746TrpGlu: 0.746 ± 0.02
0.596TrpPhe: 0.596 ± 0.017
0.907TrpGly: 0.907 ± 0.027
0.301TrpHis: 0.301 ± 0.014
0.954TrpIle: 0.954 ± 0.023
0.81TrpLys: 0.81 ± 0.021
1.476TrpLeu: 1.476 ± 0.028
0.443TrpMet: 0.443 ± 0.014
0.72TrpAsn: 0.72 ± 0.02
0.36TrpPro: 0.36 ± 0.015
0.518TrpGln: 0.518 ± 0.018
0.621TrpArg: 0.621 ± 0.017
0.907TrpSer: 0.907 ± 0.027
0.75TrpThr: 0.75 ± 0.023
0.927TrpVal: 0.927 ± 0.021
0.194TrpTrp: 0.194 ± 0.009
0.44TrpTyr: 0.44 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.8TyrAla: 2.8 ± 0.032
0.3TyrCys: 0.3 ± 0.013
1.899TyrAsp: 1.899 ± 0.048
2.136TyrGlu: 2.136 ± 0.034
1.549TyrPhe: 1.549 ± 0.027
2.64TyrGly: 2.64 ± 0.036
0.813TyrHis: 0.813 ± 0.02
2.097TyrIle: 2.097 ± 0.031
1.735TyrLys: 1.735 ± 0.031
3.284TyrLeu: 3.284 ± 0.044
0.907TyrMet: 0.907 ± 0.019
1.462TyrAsn: 1.462 ± 0.029
1.588TyrPro: 1.588 ± 0.029
1.282TyrGln: 1.282 ± 0.025
2.028TyrArg: 2.028 ± 0.037
2.256TyrSer: 2.256 ± 0.036
2.005TyrThr: 2.005 ± 0.034
2.414TyrVal: 2.414 ± 0.033
0.488TyrTrp: 0.488 ± 0.018
1.454TyrTyr: 1.454 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6159 proteins (2066054 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski