Amino acid dipepetide frequency for Brevibacterium celere

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.042AlaAla: 18.042 ± 0.191	0.85AlaCys: 0.85 ± 0.029	7.889AlaAsp: 7.889 ± 0.108	10.031AlaGlu: 10.031 ± 0.104	3.5AlaPhe: 3.5 ± 0.06	11.924AlaGly: 11.924 ± 0.123	2.593AlaHis: 2.593 ± 0.055	5.596AlaIle: 5.596 ± 0.076	3.048AlaLys: 3.048 ± 0.064	12.496AlaLeu: 12.496 ± 0.124	2.561AlaMet: 2.561 ± 0.052	2.245AlaAsn: 2.245 ± 0.053	5.716AlaPro: 5.716 ± 0.085	3.536AlaGln: 3.536 ± 0.071	8.356AlaArg: 8.356 ± 0.123	6.563AlaSer: 6.563 ± 0.088	6.553AlaThr: 6.553 ± 0.075	10.281AlaVal: 10.281 ± 0.11	1.497AlaTrp: 1.497 ± 0.034	2.064AlaTyr: 2.064 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.833CysAla: 0.833 ± 0.028	0.07CysCys: 0.07 ± 0.009	0.366CysAsp: 0.366 ± 0.017	0.374CysGlu: 0.374 ± 0.018	0.228CysPhe: 0.228 ± 0.014	0.73CysGly: 0.73 ± 0.028	0.165CysHis: 0.165 ± 0.011	0.252CysIle: 0.252 ± 0.017	0.078CysLys: 0.078 ± 0.009	0.648CysLeu: 0.648 ± 0.026	0.106CysMet: 0.106 ± 0.01	0.122CysAsn: 0.122 ± 0.009	0.4CysPro: 0.4 ± 0.024	0.13CysGln: 0.13 ± 0.011	0.469CysArg: 0.469 ± 0.021	0.418CysSer: 0.418 ± 0.019	0.424CysThr: 0.424 ± 0.024	0.484CysVal: 0.484 ± 0.022	0.088CysTrp: 0.088 ± 0.009	0.145CysTyr: 0.145 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.179AspAla: 7.179 ± 0.088	0.375AspCys: 0.375 ± 0.019	4.142AspAsp: 4.142 ± 0.072	4.874AspGlu: 4.874 ± 0.07	2.099AspPhe: 2.099 ± 0.047	5.258AspGly: 5.258 ± 0.083	1.564AspHis: 1.564 ± 0.035	2.782AspIle: 2.782 ± 0.052	1.084AspLys: 1.084 ± 0.039	6.624AspLeu: 6.624 ± 0.083	1.026AspMet: 1.026 ± 0.028	1.023AspAsn: 1.023 ± 0.032	4.385AspPro: 4.385 ± 0.066	1.454AspGln: 1.454 ± 0.039	4.696AspArg: 4.696 ± 0.062	3.751AspSer: 3.751 ± 0.062	3.118AspThr: 3.118 ± 0.056	4.98AspVal: 4.98 ± 0.066	0.957AspTrp: 0.957 ± 0.029	1.323AspTyr: 1.323 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.071GluAla: 8.071 ± 0.089	0.345GluCys: 0.345 ± 0.018	3.564GluAsp: 3.564 ± 0.06	3.915GluGlu: 3.915 ± 0.069	2.099GluPhe: 2.099 ± 0.049	4.024GluGly: 4.024 ± 0.07	1.656GluHis: 1.656 ± 0.037	3.269GluIle: 3.269 ± 0.064	1.749GluLys: 1.749 ± 0.045	6.718GluLeu: 6.718 ± 0.087	1.148GluMet: 1.148 ± 0.035	1.416GluAsn: 1.416 ± 0.04	3.057GluPro: 3.057 ± 0.061	2.024GluGln: 2.024 ± 0.048	4.665GluArg: 4.665 ± 0.078	3.805GluSer: 3.805 ± 0.06	3.586GluThr: 3.586 ± 0.055	5.723GluVal: 5.723 ± 0.077	0.83GluTrp: 0.83 ± 0.028	1.252GluTyr: 1.252 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.26PheAla: 4.26 ± 0.069	0.23PheCys: 0.23 ± 0.015	2.575PheAsp: 2.575 ± 0.045	1.664PheGlu: 1.664 ± 0.039	1.163PhePhe: 1.163 ± 0.04	3.528PheGly: 3.528 ± 0.067	0.669PheHis: 0.669 ± 0.025	1.392PheIle: 1.392 ± 0.036	0.542PheLys: 0.542 ± 0.022	2.941PheLeu: 2.941 ± 0.063	0.514PheMet: 0.514 ± 0.025	0.684PheAsn: 0.684 ± 0.026	1.479PhePro: 1.479 ± 0.041	0.685PheGln: 0.685 ± 0.025	1.713PheArg: 1.713 ± 0.042	2.148PheSer: 2.148 ± 0.042	2.191PheThr: 2.191 ± 0.045	2.797PheVal: 2.797 ± 0.057	0.455PheTrp: 0.455 ± 0.021	0.661PheTyr: 0.661 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.859GlyAla: 9.859 ± 0.116	0.637GlyCys: 0.637 ± 0.024	4.896GlyAsp: 4.896 ± 0.07	5.243GlyGlu: 5.243 ± 0.078	3.425GlyPhe: 3.425 ± 0.058	7.447GlyGly: 7.447 ± 0.102	1.98GlyHis: 1.98 ± 0.045	4.995GlyIle: 4.995 ± 0.07	2.112GlyLys: 2.112 ± 0.052	9.245GlyLeu: 9.245 ± 0.092	2.095GlyMet: 2.095 ± 0.044	1.703GlyAsn: 1.703 ± 0.039	4.337GlyPro: 4.337 ± 0.069	2.537GlyGln: 2.537 ± 0.046	6.531GlyArg: 6.531 ± 0.085	5.944GlySer: 5.944 ± 0.074	5.752GlyThr: 5.752 ± 0.075	7.101GlyVal: 7.101 ± 0.089	1.426GlyTrp: 1.426 ± 0.036	2.073GlyTyr: 2.073 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.304HisAla: 2.304 ± 0.048	0.19HisCys: 0.19 ± 0.013	1.394HisAsp: 1.394 ± 0.043	1.314HisGlu: 1.314 ± 0.033	0.667HisPhe: 0.667 ± 0.024	2.059HisGly: 2.059 ± 0.041	0.582HisHis: 0.582 ± 0.024	0.867HisIle: 0.867 ± 0.028	0.329HisLys: 0.329 ± 0.017	2.285HisLeu: 2.285 ± 0.044	0.36HisMet: 0.36 ± 0.017	0.399HisAsn: 0.399 ± 0.019	1.689HisPro: 1.689 ± 0.041	0.579HisGln: 0.579 ± 0.022	1.84HisArg: 1.84 ± 0.04	1.29HisSer: 1.29 ± 0.032	1.108HisThr: 1.108 ± 0.032	1.63HisVal: 1.63 ± 0.041	0.288HisTrp: 0.288 ± 0.016	0.422HisTyr: 0.422 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.047IleAla: 7.047 ± 0.091	0.359IleCys: 0.359 ± 0.017	3.771IleAsp: 3.771 ± 0.059	3.035IleGlu: 3.035 ± 0.053	1.3IlePhe: 1.3 ± 0.035	5.032IleGly: 5.032 ± 0.081	0.92IleHis: 0.92 ± 0.026	2.206IleIle: 2.206 ± 0.053	0.814IleLys: 0.814 ± 0.029	4.034IleLeu: 4.034 ± 0.072	0.809IleMet: 0.809 ± 0.029	1.035IleAsn: 1.035 ± 0.032	2.463IlePro: 2.463 ± 0.047	0.837IleGln: 0.837 ± 0.03	3.048IleArg: 3.048 ± 0.058	2.786IleSer: 2.786 ± 0.05	2.963IleThr: 2.963 ± 0.051	4.764IleVal: 4.764 ± 0.068	0.477IleTrp: 0.477 ± 0.02	0.72IleTyr: 0.72 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.518LysAla: 2.518 ± 0.059	0.118LysCys: 0.118 ± 0.011	1.39LysAsp: 1.39 ± 0.044	1.291LysGlu: 1.291 ± 0.044	0.622LysPhe: 0.622 ± 0.022	1.659LysGly: 1.659 ± 0.042	0.51LysHis: 0.51 ± 0.019	1.012LysIle: 1.012 ± 0.035	0.908LysLys: 0.908 ± 0.04	1.923LysLeu: 1.923 ± 0.048	0.427LysMet: 0.427 ± 0.021	0.62LysAsn: 0.62 ± 0.027	1.238LysPro: 1.238 ± 0.041	0.66LysGln: 0.66 ± 0.028	1.644LysArg: 1.644 ± 0.04	1.406LysSer: 1.406 ± 0.041	1.275LysThr: 1.275 ± 0.039	1.812LysVal: 1.812 ± 0.042	0.294LysTrp: 0.294 ± 0.015	0.538LysTyr: 0.538 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.939LeuAla: 12.939 ± 0.136	0.643LeuCys: 0.643 ± 0.024	6.995LeuAsp: 6.995 ± 0.075	5.421LeuGlu: 5.421 ± 0.085	2.931LeuPhe: 2.931 ± 0.061	9.709LeuGly: 9.709 ± 0.119	1.933LeuHis: 1.933 ± 0.047	4.844LeuIle: 4.844 ± 0.081	1.924LeuLys: 1.924 ± 0.044	9.839LeuLeu: 9.839 ± 0.116	1.775LeuMet: 1.775 ± 0.043	1.851LeuAsn: 1.851 ± 0.049	5.46LeuPro: 5.46 ± 0.066	2.154LeuGln: 2.154 ± 0.049	7.143LeuArg: 7.143 ± 0.087	6.475LeuSer: 6.475 ± 0.077	6.326LeuThr: 6.326 ± 0.082	8.61LeuVal: 8.61 ± 0.101	1.119LeuTrp: 1.119 ± 0.032	1.43LeuTyr: 1.43 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.273MetAla: 2.273 ± 0.047	0.134MetCys: 0.134 ± 0.011	0.929MetAsp: 0.929 ± 0.028	0.842MetGlu: 0.842 ± 0.027	0.59MetPhe: 0.59 ± 0.024	1.501MetGly: 1.501 ± 0.041	0.382MetHis: 0.382 ± 0.019	1.064MetIle: 1.064 ± 0.03	0.533MetLys: 0.533 ± 0.023	1.901MetLeu: 1.901 ± 0.045	0.378MetMet: 0.378 ± 0.02	0.576MetAsn: 0.576 ± 0.022	1.052MetPro: 1.052 ± 0.032	0.465MetGln: 0.465 ± 0.02	1.436MetArg: 1.436 ± 0.03	1.776MetSer: 1.776 ± 0.033	1.748MetThr: 1.748 ± 0.037	1.431MetVal: 1.431 ± 0.04	0.23MetTrp: 0.23 ± 0.016	0.346MetTyr: 0.346 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.286AsnAla: 2.286 ± 0.05	0.14AsnCys: 0.14 ± 0.011	1.139AsnAsp: 1.139 ± 0.034	1.012AsnGlu: 1.012 ± 0.032	0.664AsnPhe: 0.664 ± 0.026	1.831AsnGly: 1.831 ± 0.045	0.445AsnHis: 0.445 ± 0.022	0.886AsnIle: 0.886 ± 0.03	0.372AsnLys: 0.372 ± 0.021	1.972AsnLeu: 1.972 ± 0.042	0.363AsnMet: 0.363 ± 0.019	0.426AsnAsn: 0.426 ± 0.021	1.607AsnPro: 1.607 ± 0.036	0.562AsnGln: 0.562 ± 0.022	1.503AsnArg: 1.503 ± 0.036	1.29AsnSer: 1.29 ± 0.037	1.118AsnThr: 1.118 ± 0.031	1.474AsnVal: 1.474 ± 0.034	0.317AsnTrp: 0.317 ± 0.016	0.418AsnTyr: 0.418 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.874ProAla: 6.874 ± 0.1	0.247ProCys: 0.247 ± 0.016	3.891ProAsp: 3.891 ± 0.055	4.251ProGlu: 4.251 ± 0.063	1.687ProPhe: 1.687 ± 0.037	5.657ProGly: 5.657 ± 0.071	1.138ProHis: 1.138 ± 0.029	2.17ProIle: 2.17 ± 0.045	1.168ProLys: 1.168 ± 0.033	4.517ProLeu: 4.517 ± 0.053	0.954ProMet: 0.954 ± 0.03	1.042ProAsn: 1.042 ± 0.032	2.21ProPro: 2.21 ± 0.044	1.655ProGln: 1.655 ± 0.042	3.455ProArg: 3.455 ± 0.06	2.967ProSer: 2.967 ± 0.059	3.285ProThr: 3.285 ± 0.069	4.667ProVal: 4.667 ± 0.065	0.737ProTrp: 0.737 ± 0.027	1.007ProTyr: 1.007 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.246GlnAla: 3.246 ± 0.059	0.139GlnCys: 0.139 ± 0.011	1.166GlnAsp: 1.166 ± 0.031	1.37GlnGlu: 1.37 ± 0.035	0.787GlnPhe: 0.787 ± 0.026	2.025GlnGly: 2.025 ± 0.047	0.536GlnHis: 0.536 ± 0.02	1.363GlnIle: 1.363 ± 0.038	0.721GlnLys: 0.721 ± 0.031	2.805GlnLeu: 2.805 ± 0.055	0.6GlnMet: 0.6 ± 0.026	0.552GlnAsn: 0.552 ± 0.023	1.402GlnPro: 1.402 ± 0.04	0.915GlnGln: 0.915 ± 0.04	2.099GlnArg: 2.099 ± 0.046	1.593GlnSer: 1.593 ± 0.041	1.442GlnThr: 1.442 ± 0.039	2.302GlnVal: 2.302 ± 0.047	0.441GlnTrp: 0.441 ± 0.019	0.528GlnTyr: 0.528 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.113ArgAla: 8.113 ± 0.111	0.428ArgCys: 0.428 ± 0.02	3.987ArgAsp: 3.987 ± 0.06	4.496ArgGlu: 4.496 ± 0.067	2.479ArgPhe: 2.479 ± 0.05	5.212ArgGly: 5.212 ± 0.072	1.602ArgHis: 1.602 ± 0.038	4.042ArgIle: 4.042 ± 0.067	1.611ArgLys: 1.611 ± 0.042	7.293ArgLeu: 7.293 ± 0.094	1.686ArgMet: 1.686 ± 0.04	1.417ArgAsn: 1.417 ± 0.038	3.73ArgPro: 3.73 ± 0.061	2.042ArgGln: 2.042 ± 0.045	6.499ArgArg: 6.499 ± 0.099	4.686ArgSer: 4.686 ± 0.062	4.644ArgThr: 4.644 ± 0.061	5.041ArgVal: 5.041 ± 0.077	1.027ArgTrp: 1.027 ± 0.027	1.427ArgTyr: 1.427 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	8.316SerAla: 8.316 ± 0.096	0.381SerCys: 0.381 ± 0.019	3.314SerAsp: 3.314 ± 0.058	3.465SerGlu: 3.465 ± 0.063	1.989SerPhe: 1.989 ± 0.043	6.373SerGly: 6.373 ± 0.088	1.23SerHis: 1.23 ± 0.037	2.684SerIle: 2.684 ± 0.049	1.249SerLys: 1.249 ± 0.038	5.926SerLeu: 5.926 ± 0.08	1.377SerMet: 1.377 ± 0.037	1.175SerAsn: 1.175 ± 0.032	3.418SerPro: 3.418 ± 0.064	1.681SerGln: 1.681 ± 0.045	4.526SerArg: 4.526 ± 0.061	3.955SerSer: 3.955 ± 0.073	4.172SerThr: 4.172 ± 0.067	4.715SerVal: 4.715 ± 0.073	0.895SerTrp: 0.895 ± 0.028	1.208SerTyr: 1.208 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.839ThrAla: 7.839 ± 0.091	0.341ThrCys: 0.341 ± 0.019	3.549ThrAsp: 3.549 ± 0.065	3.548ThrGlu: 3.548 ± 0.057	1.858ThrPhe: 1.858 ± 0.04	6.116ThrGly: 6.116 ± 0.073	1.199ThrHis: 1.199 ± 0.033	3.103ThrIle: 3.103 ± 0.059	1.273ThrLys: 1.273 ± 0.041	5.546ThrLeu: 5.546 ± 0.078	1.274ThrMet: 1.274 ± 0.037	1.12ThrAsn: 1.12 ± 0.032	3.686ThrPro: 3.686 ± 0.06	1.365ThrGln: 1.365 ± 0.042	3.664ThrArg: 3.664 ± 0.063	3.824ThrSer: 3.824 ± 0.055	4.0ThrThr: 4.0 ± 0.073	5.602ThrVal: 5.602 ± 0.068	0.864ThrTrp: 0.864 ± 0.025	1.137ThrTyr: 1.137 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.938ValAla: 9.938 ± 0.098	0.651ValCys: 0.651 ± 0.026	5.864ValAsp: 5.864 ± 0.068	5.057ValGlu: 5.057 ± 0.077	2.91ValPhe: 2.91 ± 0.059	6.467ValGly: 6.467 ± 0.084	1.811ValHis: 1.811 ± 0.043	4.488ValIle: 4.488 ± 0.068	1.637ValLys: 1.637 ± 0.044	9.163ValLeu: 9.163 ± 0.094	1.499ValMet: 1.499 ± 0.037	1.686ValAsn: 1.686 ± 0.048	4.631ValPro: 4.631 ± 0.07	1.713ValGln: 1.713 ± 0.037	5.622ValArg: 5.622 ± 0.073	5.156ValSer: 5.156 ± 0.074	5.335ValThr: 5.335 ± 0.078	7.877ValVal: 7.877 ± 0.098	0.972ValTrp: 0.972 ± 0.027	1.349ValTyr: 1.349 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.402TrpAla: 1.402 ± 0.035	0.106TrpCys: 0.106 ± 0.01	0.73TrpAsp: 0.73 ± 0.028	0.665TrpGlu: 0.665 ± 0.026	0.54TrpPhe: 0.54 ± 0.02	0.964TrpGly: 0.964 ± 0.03	0.299TrpHis: 0.299 ± 0.019	0.706TrpIle: 0.706 ± 0.025	0.363TrpLys: 0.363 ± 0.017	1.535TrpLeu: 1.535 ± 0.038	0.347TrpMet: 0.347 ± 0.017	0.375TrpAsn: 0.375 ± 0.018	0.617TrpPro: 0.617 ± 0.024	0.481TrpGln: 0.481 ± 0.023	0.976TrpArg: 0.976 ± 0.03	0.927TrpSer: 0.927 ± 0.031	0.839TrpThr: 0.839 ± 0.028	1.073TrpVal: 1.073 ± 0.037	0.303TrpTrp: 0.303 ± 0.017	0.259TrpTyr: 0.259 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.001TyrAla: 2.001 ± 0.045	0.146TyrCys: 0.146 ± 0.01	1.144TyrAsp: 1.144 ± 0.033	1.049TyrGlu: 1.049 ± 0.03	0.753TyrPhe: 0.753 ± 0.027	1.821TyrGly: 1.821 ± 0.047	0.383TyrHis: 0.383 ± 0.019	0.698TyrIle: 0.698 ± 0.025	0.351TyrLys: 0.351 ± 0.021	2.11TyrLeu: 2.11 ± 0.045	0.289TyrMet: 0.289 ± 0.017	0.356TyrAsn: 0.356 ± 0.018	1.0TyrPro: 1.0 ± 0.03	0.557TyrGln: 0.557 ± 0.023	1.578TyrArg: 1.578 ± 0.043	1.29TyrSer: 1.29 ± 0.033	1.028TyrThr: 1.028 ± 0.031	1.462TyrVal: 1.462 ± 0.039	0.29TyrTrp: 0.29 ± 0.016	0.416TyrTyr: 0.416 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3344 proteins (1135316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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