Amino acid dipepetide frequency for Limnohabitans sp. 63ED37-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.47AlaAla: 14.47 ± 0.15
1.325AlaCys: 1.325 ± 0.04
5.917AlaAsp: 5.917 ± 0.097
6.13AlaGlu: 6.13 ± 0.093
3.841AlaPhe: 3.841 ± 0.069
9.11AlaGly: 9.11 ± 0.147
2.741AlaHis: 2.741 ± 0.063
4.833AlaIle: 4.833 ± 0.084
4.672AlaLys: 4.672 ± 0.082
14.159AlaLeu: 14.159 ± 0.192
3.82AlaMet: 3.82 ± 0.064
3.101AlaAsn: 3.101 ± 0.1
5.454AlaPro: 5.454 ± 0.088
6.978AlaGln: 6.978 ± 0.105
6.566AlaArg: 6.566 ± 0.098
6.728AlaSer: 6.728 ± 0.121
5.709AlaThr: 5.709 ± 0.15
8.366AlaVal: 8.366 ± 0.093
2.037AlaTrp: 2.037 ± 0.053
2.383AlaTyr: 2.383 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.113CysAla: 1.113 ± 0.033
0.12CysCys: 0.12 ± 0.012
0.519CysAsp: 0.519 ± 0.02
0.508CysGlu: 0.508 ± 0.018
0.298CysPhe: 0.298 ± 0.017
0.967CysGly: 0.967 ± 0.038
0.271CysHis: 0.271 ± 0.016
0.427CysIle: 0.427 ± 0.019
0.263CysLys: 0.263 ± 0.016
0.86CysLeu: 0.86 ± 0.034
0.254CysMet: 0.254 ± 0.016
0.276CysAsn: 0.276 ± 0.015
0.502CysPro: 0.502 ± 0.026
0.349CysGln: 0.349 ± 0.018
0.457CysArg: 0.457 ± 0.023
0.535CysSer: 0.535 ± 0.024
0.555CysThr: 0.555 ± 0.027
0.73CysVal: 0.73 ± 0.031
0.133CysTrp: 0.133 ± 0.013
0.177CysTyr: 0.177 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.213AspAla: 6.213 ± 0.092
0.406AspCys: 0.406 ± 0.021
2.283AspAsp: 2.283 ± 0.049
2.883AspGlu: 2.883 ± 0.069
2.093AspPhe: 2.093 ± 0.052
4.039AspGly: 4.039 ± 0.102
1.148AspHis: 1.148 ± 0.036
2.466AspIle: 2.466 ± 0.056
2.085AspLys: 2.085 ± 0.044
5.417AspLeu: 5.417 ± 0.078
1.54AspMet: 1.54 ± 0.041
1.369AspAsn: 1.369 ± 0.053
2.702AspPro: 2.702 ± 0.053
1.892AspGln: 1.892 ± 0.045
2.76AspArg: 2.76 ± 0.064
2.34AspSer: 2.34 ± 0.075
2.747AspThr: 2.747 ± 0.113
4.099AspVal: 4.099 ± 0.059
0.989AspTrp: 0.989 ± 0.033
1.283AspTyr: 1.283 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.166GluAla: 6.166 ± 0.097
0.381GluCys: 0.381 ± 0.02
2.231GluAsp: 2.231 ± 0.052
2.402GluGlu: 2.402 ± 0.059
1.746GluPhe: 1.746 ± 0.044
3.7GluGly: 3.7 ± 0.067
1.37GluHis: 1.37 ± 0.039
2.597GluIle: 2.597 ± 0.052
2.256GluLys: 2.256 ± 0.059
5.328GluLeu: 5.328 ± 0.095
1.348GluMet: 1.348 ± 0.036
1.361GluAsn: 1.361 ± 0.032
2.283GluPro: 2.283 ± 0.051
2.501GluGln: 2.501 ± 0.055
3.931GluArg: 3.931 ± 0.084
2.491GluSer: 2.491 ± 0.045
2.513GluThr: 2.513 ± 0.057
4.036GluVal: 4.036 ± 0.069
0.757GluTrp: 0.757 ± 0.026
0.937GluTyr: 0.937 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.955PheAla: 3.955 ± 0.064
0.423PheCys: 0.423 ± 0.021
2.409PheAsp: 2.409 ± 0.054
2.151PheGlu: 2.151 ± 0.047
1.431PhePhe: 1.431 ± 0.04
3.251PheGly: 3.251 ± 0.073
0.722PheHis: 0.722 ± 0.025
1.546PheIle: 1.546 ± 0.042
1.621PheLys: 1.621 ± 0.041
2.932PheLeu: 2.932 ± 0.07
1.027PheMet: 1.027 ± 0.032
1.265PheAsn: 1.265 ± 0.035
1.46PhePro: 1.46 ± 0.041
1.127PheGln: 1.127 ± 0.033
1.58PheArg: 1.58 ± 0.04
2.211PheSer: 2.211 ± 0.048
2.048PheThr: 2.048 ± 0.083
2.732PheVal: 2.732 ± 0.06
0.589PheTrp: 0.589 ± 0.023
0.865PheTyr: 0.865 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.073GlyAla: 8.073 ± 0.127
0.886GlyCys: 0.886 ± 0.031
3.756GlyAsp: 3.756 ± 0.076
4.007GlyGlu: 4.007 ± 0.067
3.293GlyPhe: 3.293 ± 0.06
6.65GlyGly: 6.65 ± 0.14
2.096GlyHis: 2.096 ± 0.042
3.857GlyIle: 3.857 ± 0.07
3.367GlyLys: 3.367 ± 0.067
9.336GlyLeu: 9.336 ± 0.116
2.547GlyMet: 2.547 ± 0.06
2.278GlyAsn: 2.278 ± 0.114
3.113GlyPro: 3.113 ± 0.063
4.531GlyGln: 4.531 ± 0.072
4.658GlyArg: 4.658 ± 0.088
4.583GlySer: 4.583 ± 0.123
4.515GlyThr: 4.515 ± 0.2
6.624GlyVal: 6.624 ± 0.087
1.475GlyTrp: 1.475 ± 0.047
2.16GlyTyr: 2.16 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.758HisAla: 2.758 ± 0.064
0.299HisCys: 0.299 ± 0.019
1.182HisAsp: 1.182 ± 0.034
1.101HisGlu: 1.101 ± 0.031
0.908HisPhe: 0.908 ± 0.03
2.077HisGly: 2.077 ± 0.049
0.669HisHis: 0.669 ± 0.028
1.154HisIle: 1.154 ± 0.036
0.739HisLys: 0.739 ± 0.028
2.488HisLeu: 2.488 ± 0.053
0.645HisMet: 0.645 ± 0.024
0.651HisAsn: 0.651 ± 0.023
1.462HisPro: 1.462 ± 0.042
0.962HisGln: 0.962 ± 0.035
1.383HisArg: 1.383 ± 0.041
1.136HisSer: 1.136 ± 0.031
1.291HisThr: 1.291 ± 0.036
1.583HisVal: 1.583 ± 0.04
0.462HisTrp: 0.462 ± 0.018
0.607HisTyr: 0.607 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.3IleAla: 5.3 ± 0.079
0.44IleCys: 0.44 ± 0.022
2.969IleAsp: 2.969 ± 0.058
3.155IleGlu: 3.155 ± 0.059
1.35IlePhe: 1.35 ± 0.038
3.905IleGly: 3.905 ± 0.072
0.949IleHis: 0.949 ± 0.03
1.66IleIle: 1.66 ± 0.043
1.843IleLys: 1.843 ± 0.048
3.398IleLeu: 3.398 ± 0.072
0.957IleMet: 0.957 ± 0.033
1.711IleAsn: 1.711 ± 0.054
2.064IlePro: 2.064 ± 0.049
1.723IleGln: 1.723 ± 0.042
2.467IleArg: 2.467 ± 0.054
2.638IleSer: 2.638 ± 0.065
2.874IleThr: 2.874 ± 0.105
3.193IleVal: 3.193 ± 0.059
0.555IleTrp: 0.555 ± 0.021
0.985IleTyr: 0.985 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.968LysAla: 4.968 ± 0.074
0.19LysCys: 0.19 ± 0.015
2.101LysAsp: 2.101 ± 0.048
1.728LysGlu: 1.728 ± 0.048
1.17LysPhe: 1.17 ± 0.038
2.923LysGly: 2.923 ± 0.055
0.838LysHis: 0.838 ± 0.027
1.844LysIle: 1.844 ± 0.049
1.881LysLys: 1.881 ± 0.06
3.982LysLeu: 3.982 ± 0.066
1.073LysMet: 1.073 ± 0.036
1.29LysAsn: 1.29 ± 0.037
2.389LysPro: 2.389 ± 0.059
1.477LysGln: 1.477 ± 0.045
2.244LysArg: 2.244 ± 0.051
2.227LysSer: 2.227 ± 0.047
2.502LysThr: 2.502 ± 0.07
2.991LysVal: 2.991 ± 0.058
0.427LysTrp: 0.427 ± 0.019
0.737LysTyr: 0.737 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
13.527LeuAla: 13.527 ± 0.136
1.051LeuCys: 1.051 ± 0.035
5.404LeuAsp: 5.404 ± 0.082
4.585LeuGlu: 4.585 ± 0.089
3.311LeuPhe: 3.311 ± 0.072
8.708LeuGly: 8.708 ± 0.118
2.393LeuHis: 2.393 ± 0.065
4.46LeuIle: 4.46 ± 0.074
4.353LeuLys: 4.353 ± 0.062
10.497LeuLeu: 10.497 ± 0.162
3.061LeuMet: 3.061 ± 0.066
3.408LeuAsn: 3.408 ± 0.069
6.031LeuPro: 6.031 ± 0.109
5.324LeuGln: 5.324 ± 0.09
6.283LeuArg: 6.283 ± 0.104
7.031LeuSer: 7.031 ± 0.116
5.673LeuThr: 5.673 ± 0.122
7.604LeuVal: 7.604 ± 0.106
1.556LeuTrp: 1.556 ± 0.047
1.964LeuTyr: 1.964 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
3.66MetAla: 3.66 ± 0.077
0.202MetCys: 0.202 ± 0.014
1.375MetAsp: 1.375 ± 0.037
1.082MetGlu: 1.082 ± 0.031
0.79MetPhe: 0.79 ± 0.033
2.57MetGly: 2.57 ± 0.054
0.64MetHis: 0.64 ± 0.026
1.087MetIle: 1.087 ± 0.034
1.271MetLys: 1.271 ± 0.033
2.86MetLeu: 2.86 ± 0.058
0.731MetMet: 0.731 ± 0.031
1.122MetAsn: 1.122 ± 0.036
1.635MetPro: 1.635 ± 0.045
1.371MetGln: 1.371 ± 0.041
1.744MetArg: 1.744 ± 0.044
1.901MetSer: 1.901 ± 0.045
1.832MetThr: 1.832 ± 0.046
2.086MetVal: 2.086 ± 0.05
0.255MetTrp: 0.255 ± 0.017
0.415MetTyr: 0.415 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.653AsnAla: 3.653 ± 0.096
0.26AsnCys: 0.26 ± 0.017
1.512AsnAsp: 1.512 ± 0.061
1.344AsnGlu: 1.344 ± 0.037
1.115AsnPhe: 1.115 ± 0.032
2.502AsnGly: 2.502 ± 0.121
0.599AsnHis: 0.599 ± 0.025
1.428AsnIle: 1.428 ± 0.05
1.152AsnLys: 1.152 ± 0.037
2.99AsnLeu: 2.99 ± 0.061
0.795AsnMet: 0.795 ± 0.03
1.006AsnAsn: 1.006 ± 0.056
2.08AsnPro: 2.08 ± 0.051
1.149AsnGln: 1.149 ± 0.036
1.555AsnArg: 1.555 ± 0.042
1.381AsnSer: 1.381 ± 0.055
1.936AsnThr: 1.936 ± 0.085
2.142AsnVal: 2.142 ± 0.07
0.493AsnTrp: 0.493 ± 0.023
0.687AsnTyr: 0.687 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
6.17ProAla: 6.17 ± 0.102
0.37ProCys: 0.37 ± 0.021
2.874ProAsp: 2.874 ± 0.062
3.545ProGlu: 3.545 ± 0.069
1.82ProPhe: 1.82 ± 0.049
4.383ProGly: 4.383 ± 0.074
1.208ProHis: 1.208 ± 0.038
1.917ProIle: 1.917 ± 0.049
1.836ProLys: 1.836 ± 0.05
5.006ProLeu: 5.006 ± 0.086
1.551ProMet: 1.551 ± 0.045
1.441ProAsn: 1.441 ± 0.042
2.187ProPro: 2.187 ± 0.063
2.348ProGln: 2.348 ± 0.052
2.352ProArg: 2.352 ± 0.057
2.943ProSer: 2.943 ± 0.061
2.847ProThr: 2.847 ± 0.069
4.308ProVal: 4.308 ± 0.072
0.823ProTrp: 0.823 ± 0.03
1.136ProTyr: 1.136 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
7.075GlnAla: 7.075 ± 0.118
0.337GlnCys: 0.337 ± 0.017
2.066GlnAsp: 2.066 ± 0.054
1.87GlnGlu: 1.87 ± 0.049
1.434GlnPhe: 1.434 ± 0.044
3.92GlnGly: 3.92 ± 0.073
1.213GlnHis: 1.213 ± 0.038
2.188GlnIle: 2.188 ± 0.076
1.691GlnLys: 1.691 ± 0.047
4.859GlnLeu: 4.859 ± 0.087
1.226GlnMet: 1.226 ± 0.033
1.253GlnAsn: 1.253 ± 0.037
2.293GlnPro: 2.293 ± 0.05
2.197GlnGln: 2.197 ± 0.056
3.339GlnArg: 3.339 ± 0.079
2.649GlnSer: 2.649 ± 0.057
2.61GlnThr: 2.61 ± 0.054
3.802GlnVal: 3.802 ± 0.091
0.84GlnTrp: 0.84 ± 0.03
0.802GlnTyr: 0.802 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.731ArgAla: 5.731 ± 0.091
0.537ArgCys: 0.537 ± 0.026
2.986ArgAsp: 2.986 ± 0.061
3.437ArgGlu: 3.437 ± 0.076
2.364ArgPhe: 2.364 ± 0.054
3.79ArgGly: 3.79 ± 0.067
1.535ArgHis: 1.535 ± 0.047
3.041ArgIle: 3.041 ± 0.056
2.094ArgLys: 2.094 ± 0.051
6.568ArgLeu: 6.568 ± 0.124
1.985ArgMet: 1.985 ± 0.048
1.605ArgAsn: 1.605 ± 0.042
2.605ArgPro: 2.605 ± 0.057
3.203ArgGln: 3.203 ± 0.071
3.388ArgArg: 3.388 ± 0.069
3.107ArgSer: 3.107 ± 0.058
2.767ArgThr: 2.767 ± 0.049
4.493ArgVal: 4.493 ± 0.082
1.13ArgTrp: 1.13 ± 0.036
1.537ArgTyr: 1.537 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.777SerAla: 6.777 ± 0.123
0.446SerCys: 0.446 ± 0.024
2.738SerAsp: 2.738 ± 0.058
2.621SerGlu: 2.621 ± 0.059
2.081SerPhe: 2.081 ± 0.051
5.448SerGly: 5.448 ± 0.128
1.274SerHis: 1.274 ± 0.037
2.438SerIle: 2.438 ± 0.058
1.947SerLys: 1.947 ± 0.054
6.173SerLeu: 6.173 ± 0.093
1.559SerMet: 1.559 ± 0.033
1.636SerAsn: 1.636 ± 0.071
3.076SerPro: 3.076 ± 0.057
2.48SerGln: 2.48 ± 0.071
3.205SerArg: 3.205 ± 0.064
3.256SerSer: 3.256 ± 0.092
3.317SerThr: 3.317 ± 0.125
4.327SerVal: 4.327 ± 0.08
0.877SerTrp: 0.877 ± 0.033
1.19SerTyr: 1.19 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.224ThrAla: 6.224 ± 0.191
0.454ThrCys: 0.454 ± 0.019
2.836ThrAsp: 2.836 ± 0.108
2.599ThrGlu: 2.599 ± 0.051
1.935ThrPhe: 1.935 ± 0.069
5.007ThrGly: 5.007 ± 0.163
1.3ThrHis: 1.3 ± 0.035
2.177ThrIle: 2.177 ± 0.073
1.541ThrLys: 1.541 ± 0.036
6.487ThrLeu: 6.487 ± 0.139
1.136ThrMet: 1.136 ± 0.037
1.459ThrAsn: 1.459 ± 0.085
3.887ThrPro: 3.887 ± 0.076
2.492ThrGln: 2.492 ± 0.055
3.07ThrArg: 3.07 ± 0.062
3.1ThrSer: 3.1 ± 0.123
3.146ThrThr: 3.146 ± 0.172
4.432ThrVal: 4.432 ± 0.138
0.763ThrTrp: 0.763 ± 0.032
1.126ThrTyr: 1.126 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
8.582ValAla: 8.582 ± 0.111
0.766ValCys: 0.766 ± 0.028
3.826ValAsp: 3.826 ± 0.068
3.551ValGlu: 3.551 ± 0.054
2.852ValPhe: 2.852 ± 0.061
5.715ValGly: 5.715 ± 0.072
1.751ValHis: 1.751 ± 0.048
3.595ValIle: 3.595 ± 0.063
2.984ValLys: 2.984 ± 0.062
8.414ValLeu: 8.414 ± 0.121
2.325ValMet: 2.325 ± 0.055
2.498ValAsn: 2.498 ± 0.065
3.965ValPro: 3.965 ± 0.069
3.629ValGln: 3.629 ± 0.072
4.392ValArg: 4.392 ± 0.077
4.51ValSer: 4.51 ± 0.087
4.137ValThr: 4.137 ± 0.124
6.412ValVal: 6.412 ± 0.087
1.173ValTrp: 1.173 ± 0.04
1.625ValTyr: 1.625 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
1.589TrpAla: 1.589 ± 0.047
0.199TrpCys: 0.199 ± 0.013
0.672TrpAsp: 0.672 ± 0.026
0.492TrpGlu: 0.492 ± 0.024
0.593TrpPhe: 0.593 ± 0.023
1.22TrpGly: 1.22 ± 0.038
0.406TrpHis: 0.406 ± 0.023
0.632TrpIle: 0.632 ± 0.025
0.476TrpLys: 0.476 ± 0.021
2.265TrpLeu: 2.265 ± 0.055
0.56TrpMet: 0.56 ± 0.027
0.381TrpAsn: 0.381 ± 0.019
0.798TrpPro: 0.798 ± 0.031
1.022TrpGln: 1.022 ± 0.038
1.188TrpArg: 1.188 ± 0.04
0.868TrpSer: 0.868 ± 0.031
0.842TrpThr: 0.842 ± 0.028
1.227TrpVal: 1.227 ± 0.036
0.33TrpTrp: 0.33 ± 0.021
0.265TrpTyr: 0.265 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.337TyrAla: 2.337 ± 0.051
0.219TyrCys: 0.219 ± 0.013
1.096TyrAsp: 1.096 ± 0.033
1.145TyrGlu: 1.145 ± 0.036
0.919TyrPhe: 0.919 ± 0.032
1.917TyrGly: 1.917 ± 0.051
0.435TyrHis: 0.435 ± 0.02
0.789TyrIle: 0.789 ± 0.032
0.907TyrLys: 0.907 ± 0.033
2.206TyrLeu: 2.206 ± 0.043
0.491TyrMet: 0.491 ± 0.023
0.667TyrAsn: 0.667 ± 0.029
1.077TyrPro: 1.077 ± 0.036
0.909TyrGln: 0.909 ± 0.029
1.345TyrArg: 1.345 ± 0.042
1.232TyrSer: 1.232 ± 0.034
1.311TyrThr: 1.311 ± 0.045
1.517TyrVal: 1.517 ± 0.048
0.363TyrTrp: 0.363 ± 0.022
0.522TyrTyr: 0.522 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3169 proteins (1029165 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski