Amino acid dipepetide frequency for Nostoc azollae (strain 0708) (Anabaena azollae (strain 0708))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.104AlaAla: 7.104 ± 0.117	0.846AlaCys: 0.846 ± 0.03	3.804AlaAsp: 3.804 ± 0.073	5.013AlaGlu: 5.013 ± 0.083	2.712AlaPhe: 2.712 ± 0.065	5.27AlaGly: 5.27 ± 0.087	1.271AlaHis: 1.271 ± 0.043	6.441AlaIle: 6.441 ± 0.088	4.204AlaLys: 4.204 ± 0.08	8.127AlaLeu: 8.127 ± 0.1	1.632AlaMet: 1.632 ± 0.05	3.362AlaAsn: 3.362 ± 0.075	2.608AlaPro: 2.608 ± 0.057	3.645AlaGln: 3.645 ± 0.075	3.274AlaArg: 3.274 ± 0.055	4.351AlaSer: 4.351 ± 0.067	4.423AlaThr: 4.423 ± 0.078	5.62AlaVal: 5.62 ± 0.085	0.955AlaTrp: 0.955 ± 0.036	2.252AlaTyr: 2.252 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.647CysAla: 0.647 ± 0.025	0.171CysCys: 0.171 ± 0.013	0.586CysAsp: 0.586 ± 0.023	0.541CysGlu: 0.541 ± 0.026	0.421CysPhe: 0.421 ± 0.022	0.8CysGly: 0.8 ± 0.037	0.29CysHis: 0.29 ± 0.019	0.638CysIle: 0.638 ± 0.025	0.38CysLys: 0.38 ± 0.019	1.252CysLeu: 1.252 ± 0.04	0.217CysMet: 0.217 ± 0.015	0.44CysAsn: 0.44 ± 0.024	0.592CysPro: 0.592 ± 0.024	0.647CysGln: 0.647 ± 0.03	0.507CysArg: 0.507 ± 0.023	0.715CysSer: 0.715 ± 0.033	0.509CysThr: 0.509 ± 0.024	0.589CysVal: 0.589 ± 0.026	0.155CysTrp: 0.155 ± 0.013	0.371CysTyr: 0.371 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.41AspAla: 3.41 ± 0.06	0.518AspCys: 0.518 ± 0.022	2.064AspAsp: 2.064 ± 0.06	2.735AspGlu: 2.735 ± 0.062	2.246AspPhe: 2.246 ± 0.055	3.028AspGly: 3.028 ± 0.066	0.893AspHis: 0.893 ± 0.033	3.705AspIle: 3.705 ± 0.067	2.389AspLys: 2.389 ± 0.046	5.606AspLeu: 5.606 ± 0.081	0.901AspMet: 0.901 ± 0.034	1.976AspAsn: 1.976 ± 0.048	2.119AspPro: 2.119 ± 0.052	1.838AspGln: 1.838 ± 0.049	2.501AspArg: 2.501 ± 0.055	2.786AspSer: 2.786 ± 0.056	2.414AspThr: 2.414 ± 0.053	2.911AspVal: 2.911 ± 0.059	0.824AspTrp: 0.824 ± 0.029	1.817AspTyr: 1.817 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.996GluAla: 4.996 ± 0.08	0.503GluCys: 0.503 ± 0.027	2.638GluAsp: 2.638 ± 0.059	4.171GluGlu: 4.171 ± 0.078	2.41GluPhe: 2.41 ± 0.054	3.24GluGly: 3.24 ± 0.063	1.046GluHis: 1.046 ± 0.035	5.31GluIle: 5.31 ± 0.093	3.761GluLys: 3.761 ± 0.068	7.093GluLeu: 7.093 ± 0.103	1.458GluMet: 1.458 ± 0.038	2.913GluAsn: 2.913 ± 0.063	2.269GluPro: 2.269 ± 0.05	3.267GluGln: 3.267 ± 0.064	3.3GluArg: 3.3 ± 0.059	3.241GluSer: 3.241 ± 0.066	3.596GluThr: 3.596 ± 0.069	4.516GluVal: 4.516 ± 0.08	0.746GluTrp: 0.746 ± 0.028	1.878GluTyr: 1.878 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.817PheAla: 2.817 ± 0.055	0.555PheCys: 0.555 ± 0.026	2.118PheAsp: 2.118 ± 0.045	1.916PheGlu: 1.916 ± 0.049	1.556PhePhe: 1.556 ± 0.047	2.891PheGly: 2.891 ± 0.067	0.876PheHis: 0.876 ± 0.024	2.557PheIle: 2.557 ± 0.062	1.588PheLys: 1.588 ± 0.041	4.245PheLeu: 4.245 ± 0.088	0.837PheMet: 0.837 ± 0.03	1.76PheAsn: 1.76 ± 0.049	1.888PhePro: 1.888 ± 0.043	1.69PheGln: 1.69 ± 0.039	1.744PheArg: 1.744 ± 0.041	2.95PheSer: 2.95 ± 0.065	2.382PheThr: 2.382 ± 0.05	2.276PheVal: 2.276 ± 0.05	0.709PheTrp: 0.709 ± 0.03	1.263PheTyr: 1.263 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.696GlyAla: 4.696 ± 0.092	0.86GlyCys: 0.86 ± 0.031	3.253GlyAsp: 3.253 ± 0.057	4.046GlyGlu: 4.046 ± 0.065	2.886GlyPhe: 2.886 ± 0.056	4.754GlyGly: 4.754 ± 0.101	1.284GlyHis: 1.284 ± 0.039	5.563GlyIle: 5.563 ± 0.087	4.339GlyLys: 4.339 ± 0.077	7.05GlyLeu: 7.05 ± 0.106	1.603GlyMet: 1.603 ± 0.051	2.893GlyAsn: 2.893 ± 0.06	1.38GlyPro: 1.38 ± 0.043	2.787GlyGln: 2.787 ± 0.061	3.187GlyArg: 3.187 ± 0.065	3.993GlySer: 3.993 ± 0.071	3.79GlyThr: 3.79 ± 0.066	5.026GlyVal: 5.026 ± 0.078	1.101GlyTrp: 1.101 ± 0.035	2.385GlyTyr: 2.385 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.067HisAla: 1.067 ± 0.042	0.263HisCys: 0.263 ± 0.017	0.775HisAsp: 0.775 ± 0.028	0.93HisGlu: 0.93 ± 0.036	0.937HisPhe: 0.937 ± 0.031	1.165HisGly: 1.165 ± 0.034	0.647HisHis: 0.647 ± 0.033	1.343HisIle: 1.343 ± 0.039	0.836HisLys: 0.836 ± 0.03	2.445HisLeu: 2.445 ± 0.061	0.281HisMet: 0.281 ± 0.018	0.842HisAsn: 0.842 ± 0.031	1.362HisPro: 1.362 ± 0.038	1.255HisGln: 1.255 ± 0.041	1.165HisArg: 1.165 ± 0.038	1.223HisSer: 1.223 ± 0.039	1.038HisThr: 1.038 ± 0.033	0.939HisVal: 0.939 ± 0.038	0.338HisTrp: 0.338 ± 0.021	0.699HisTyr: 0.699 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.68IleAla: 6.68 ± 0.088	0.848IleCys: 0.848 ± 0.033	3.682IleAsp: 3.682 ± 0.071	4.211IleGlu: 4.211 ± 0.086	2.987IlePhe: 2.987 ± 0.064	4.878IleGly: 4.878 ± 0.074	1.397IleHis: 1.397 ± 0.04	4.531IleIle: 4.531 ± 0.083	3.372IleLys: 3.372 ± 0.064	7.59IleLeu: 7.59 ± 0.086	1.142IleMet: 1.142 ± 0.039	3.439IleAsn: 3.439 ± 0.069	3.909IlePro: 3.909 ± 0.073	3.244IleGln: 3.244 ± 0.069	3.18IleArg: 3.18 ± 0.064	5.077IleSer: 5.077 ± 0.088	4.43IleThr: 4.43 ± 0.083	4.407IleVal: 4.407 ± 0.068	0.944IleTrp: 0.944 ± 0.036	2.205IleTyr: 2.205 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	3.87LysAla: 3.87 ± 0.082	0.351LysCys: 0.351 ± 0.02	2.172LysAsp: 2.172 ± 0.056	2.962LysGlu: 2.962 ± 0.06	1.887LysPhe: 1.887 ± 0.041	2.9LysGly: 2.9 ± 0.063	0.846LysHis: 0.846 ± 0.03	4.055LysIle: 4.055 ± 0.071	2.455LysLys: 2.455 ± 0.059	5.892LysLeu: 5.892 ± 0.087	1.108LysMet: 1.108 ± 0.035	2.239LysAsn: 2.239 ± 0.05	2.597LysPro: 2.597 ± 0.056	2.666LysGln: 2.666 ± 0.049	2.42LysArg: 2.42 ± 0.059	3.245LysSer: 3.245 ± 0.061	3.022LysThr: 3.022 ± 0.059	3.427LysVal: 3.427 ± 0.067	0.571LysTrp: 0.571 ± 0.028	1.598LysTyr: 1.598 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	9.222LeuAla: 9.222 ± 0.106	1.039LeuCys: 1.039 ± 0.035	5.088LeuAsp: 5.088 ± 0.074	7.563LeuGlu: 7.563 ± 0.108	3.786LeuPhe: 3.786 ± 0.076	8.102LeuGly: 8.102 ± 0.099	2.053LeuHis: 2.053 ± 0.052	7.292LeuIle: 7.292 ± 0.09	5.518LeuLys: 5.518 ± 0.092	11.695LeuLeu: 11.695 ± 0.14	2.333LeuMet: 2.333 ± 0.057	4.634LeuAsn: 4.634 ± 0.076	5.805LeuPro: 5.805 ± 0.099	5.931LeuGln: 5.931 ± 0.084	5.443LeuArg: 5.443 ± 0.08	7.384LeuSer: 7.384 ± 0.099	6.687LeuThr: 6.687 ± 0.092	7.561LeuVal: 7.561 ± 0.09	1.367LeuTrp: 1.367 ± 0.041	2.658LeuTyr: 2.658 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.795MetAla: 1.795 ± 0.048	0.17MetCys: 0.17 ± 0.013	0.792MetAsp: 0.792 ± 0.031	1.165MetGlu: 1.165 ± 0.034	0.639MetPhe: 0.639 ± 0.027	1.529MetGly: 1.529 ± 0.046	0.291MetHis: 0.291 ± 0.016	1.386MetIle: 1.386 ± 0.042	1.018MetLys: 1.018 ± 0.032	2.234MetLeu: 2.234 ± 0.057	0.53MetMet: 0.53 ± 0.029	0.957MetAsn: 0.957 ± 0.036	0.961MetPro: 0.961 ± 0.038	0.964MetGln: 0.964 ± 0.033	1.043MetArg: 1.043 ± 0.034	1.435MetSer: 1.435 ± 0.04	1.432MetThr: 1.432 ± 0.036	1.471MetVal: 1.471 ± 0.041	0.165MetTrp: 0.165 ± 0.012	0.427MetTyr: 0.427 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.784AsnAla: 2.784 ± 0.061	0.527AsnCys: 0.527 ± 0.022	1.568AsnAsp: 1.568 ± 0.044	1.9AsnGlu: 1.9 ± 0.049	1.966AsnPhe: 1.966 ± 0.045	2.469AsnGly: 2.469 ± 0.054	1.058AsnHis: 1.058 ± 0.039	3.211AsnIle: 3.211 ± 0.06	1.96AsnLys: 1.96 ± 0.049	5.598AsnLeu: 5.598 ± 0.101	0.79AsnMet: 0.79 ± 0.031	2.126AsnAsn: 2.126 ± 0.054	2.767AsnPro: 2.767 ± 0.054	2.771AsnGln: 2.771 ± 0.068	2.341AsnArg: 2.341 ± 0.054	3.149AsnSer: 3.149 ± 0.068	2.496AsnThr: 2.496 ± 0.05	2.295AsnVal: 2.295 ± 0.049	0.737AsnTrp: 0.737 ± 0.027	1.644AsnTyr: 1.644 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.089ProAla: 3.089 ± 0.063	0.372ProCys: 0.372 ± 0.019	2.687ProAsp: 2.687 ± 0.052	3.81ProGlu: 3.81 ± 0.063	1.599ProPhe: 1.599 ± 0.042	3.17ProGly: 3.17 ± 0.067	1.0ProHis: 1.0 ± 0.032	3.33ProIle: 3.33 ± 0.063	2.239ProLys: 2.239 ± 0.045	4.613ProLeu: 4.613 ± 0.073	0.788ProMet: 0.788 ± 0.028	2.204ProAsn: 2.204 ± 0.059	2.204ProPro: 2.204 ± 0.058	2.513ProGln: 2.513 ± 0.056	1.756ProArg: 1.756 ± 0.047	2.781ProSer: 2.781 ± 0.06	3.006ProThr: 3.006 ± 0.065	3.309ProVal: 3.309 ± 0.066	0.668ProTrp: 0.668 ± 0.031	1.414ProTyr: 1.414 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.456GlnAla: 4.456 ± 0.082	0.398GlnCys: 0.398 ± 0.021	2.014GlnAsp: 2.014 ± 0.047	3.821GlnGlu: 3.821 ± 0.078	1.616GlnPhe: 1.616 ± 0.04	3.189GlnGly: 3.189 ± 0.061	0.909GlnHis: 0.909 ± 0.034	3.772GlnIle: 3.772 ± 0.07	2.935GlnLys: 2.935 ± 0.066	5.765GlnLeu: 5.765 ± 0.093	1.106GlnMet: 1.106 ± 0.031	2.128GlnAsn: 2.128 ± 0.042	2.574GlnPro: 2.574 ± 0.05	3.497GlnGln: 3.497 ± 0.084	2.703GlnArg: 2.703 ± 0.062	2.783GlnSer: 2.783 ± 0.063	2.906GlnThr: 2.906 ± 0.059	3.925GlnVal: 3.925 ± 0.07	0.643GlnTrp: 0.643 ± 0.026	1.26GlnTyr: 1.26 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.984ArgAla: 2.984 ± 0.06	0.51ArgCys: 0.51 ± 0.022	2.364ArgAsp: 2.364 ± 0.053	3.295ArgGlu: 3.295 ± 0.068	1.958ArgPhe: 1.958 ± 0.046	2.849ArgGly: 2.849 ± 0.054	0.96ArgHis: 0.96 ± 0.033	3.422ArgIle: 3.422 ± 0.058	2.389ArgLys: 2.389 ± 0.053	5.623ArgLeu: 5.623 ± 0.081	1.086ArgMet: 1.086 ± 0.03	2.208ArgAsn: 2.208 ± 0.052	1.966ArgPro: 1.966 ± 0.047	2.97ArgGln: 2.97 ± 0.066	2.915ArgArg: 2.915 ± 0.064	3.033ArgSer: 3.033 ± 0.053	2.513ArgThr: 2.513 ± 0.049	3.291ArgVal: 3.291 ± 0.072	0.707ArgTrp: 0.707 ± 0.033	1.781ArgTyr: 1.781 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.203SerAla: 4.203 ± 0.079	0.703SerCys: 0.703 ± 0.028	2.819SerAsp: 2.819 ± 0.057	3.705SerGlu: 3.705 ± 0.067	2.4SerPhe: 2.4 ± 0.049	4.535SerGly: 4.535 ± 0.072	1.357SerHis: 1.357 ± 0.037	4.083SerIle: 4.083 ± 0.078	2.753SerLys: 2.753 ± 0.05	7.588SerLeu: 7.588 ± 0.101	1.325SerMet: 1.325 ± 0.037	2.641SerAsn: 2.641 ± 0.052	3.284SerPro: 3.284 ± 0.06	3.687SerGln: 3.687 ± 0.065	3.163SerArg: 3.163 ± 0.054	4.377SerSer: 4.377 ± 0.086	3.589SerThr: 3.589 ± 0.066	4.014SerVal: 4.014 ± 0.078	0.915SerTrp: 0.915 ± 0.031	1.968SerTyr: 1.968 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.858ThrAla: 4.858 ± 0.079	0.507ThrCys: 0.507 ± 0.024	2.91ThrAsp: 2.91 ± 0.07	3.5ThrGlu: 3.5 ± 0.06	2.13ThrPhe: 2.13 ± 0.045	4.442ThrGly: 4.442 ± 0.069	1.055ThrHis: 1.055 ± 0.039	3.855ThrIle: 3.855 ± 0.068	2.651ThrLys: 2.651 ± 0.053	6.263ThrLeu: 6.263 ± 0.083	0.909ThrMet: 0.909 ± 0.033	2.449ThrAsn: 2.449 ± 0.055	3.507ThrPro: 3.507 ± 0.065	2.941ThrGln: 2.941 ± 0.068	2.384ThrArg: 2.384 ± 0.045	3.538ThrSer: 3.538 ± 0.065	3.575ThrThr: 3.575 ± 0.071	4.075ThrVal: 4.075 ± 0.06	0.68ThrTrp: 0.68 ± 0.032	1.638ThrTyr: 1.638 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.498ValAla: 5.498 ± 0.085	0.718ValCys: 0.718 ± 0.027	3.397ValAsp: 3.397 ± 0.065	4.43ValGlu: 4.43 ± 0.078	2.575ValPhe: 2.575 ± 0.055	4.672ValGly: 4.672 ± 0.068	1.138ValHis: 1.138 ± 0.035	4.96ValIle: 4.96 ± 0.082	3.596ValLys: 3.596 ± 0.064	6.918ValLeu: 6.918 ± 0.091	1.501ValMet: 1.501 ± 0.039	3.056ValAsn: 3.056 ± 0.055	2.814ValPro: 2.814 ± 0.059	2.841ValGln: 2.841 ± 0.063	3.234ValArg: 3.234 ± 0.067	4.28ValSer: 4.28 ± 0.076	3.951ValThr: 3.951 ± 0.062	4.871ValVal: 4.871 ± 0.071	0.819ValTrp: 0.819 ± 0.028	1.862ValTyr: 1.862 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.765TrpAla: 0.765 ± 0.031	0.169TrpCys: 0.169 ± 0.013	0.584TrpAsp: 0.584 ± 0.027	0.98TrpGlu: 0.98 ± 0.036	0.646TrpPhe: 0.646 ± 0.03	0.952TrpGly: 0.952 ± 0.035	0.364TrpHis: 0.364 ± 0.022	0.848TrpIle: 0.848 ± 0.035	0.592TrpLys: 0.592 ± 0.027	1.808TrpLeu: 1.808 ± 0.05	0.325TrpMet: 0.325 ± 0.018	0.592TrpAsn: 0.592 ± 0.024	0.302TrpPro: 0.302 ± 0.02	1.165TrpGln: 1.165 ± 0.039	0.738TrpArg: 0.738 ± 0.027	0.757TrpSer: 0.757 ± 0.033	0.566TrpThr: 0.566 ± 0.025	0.997TrpVal: 0.997 ± 0.034	0.226TrpTrp: 0.226 ± 0.016	0.414TrpTyr: 0.414 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.976TyrAla: 1.976 ± 0.049	0.441TyrCys: 0.441 ± 0.023	1.363TyrAsp: 1.363 ± 0.038	1.66TyrGlu: 1.66 ± 0.05	1.26TyrPhe: 1.26 ± 0.037	2.039TyrGly: 2.039 ± 0.049	0.815TyrHis: 0.815 ± 0.029	1.852TyrIle: 1.852 ± 0.051	1.309TyrLys: 1.309 ± 0.039	3.755TyrLeu: 3.755 ± 0.067	0.532TyrMet: 0.532 ± 0.025	1.3TyrAsn: 1.3 ± 0.036	1.645TyrPro: 1.645 ± 0.05	2.079TyrGln: 2.079 ± 0.048	1.823TyrArg: 1.823 ± 0.047	2.012TyrSer: 2.012 ± 0.051	1.541TyrThr: 1.541 ± 0.045	1.613TyrVal: 1.613 ± 0.038	0.52TyrTrp: 0.52 ± 0.023	1.187TyrTyr: 1.187 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3646 proteins (942988 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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