Amino acid dipepetide frequency for Pseudoalteromonas piscicida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.842AlaAla: 7.842 ± 0.098	1.007AlaCys: 1.007 ± 0.032	4.507AlaAsp: 4.507 ± 0.054	5.636AlaGlu: 5.636 ± 0.07	3.616AlaPhe: 3.616 ± 0.046	5.669AlaGly: 5.669 ± 0.075	1.935AlaHis: 1.935 ± 0.04	5.991AlaIle: 5.991 ± 0.079	5.632AlaLys: 5.632 ± 0.07	10.595AlaLeu: 10.595 ± 0.126	2.407AlaMet: 2.407 ± 0.044	3.938AlaAsn: 3.938 ± 0.054	3.07AlaPro: 3.07 ± 0.048	4.642AlaGln: 4.642 ± 0.074	3.586AlaArg: 3.586 ± 0.055	5.424AlaSer: 5.424 ± 0.069	4.668AlaThr: 4.668 ± 0.065	5.788AlaVal: 5.788 ± 0.068	0.953AlaTrp: 0.953 ± 0.027	2.589AlaTyr: 2.589 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.817CysAla: 0.817 ± 0.023	0.151CysCys: 0.151 ± 0.01	0.633CysAsp: 0.633 ± 0.022	0.671CysGlu: 0.671 ± 0.02	0.481CysPhe: 0.481 ± 0.019	0.784CysGly: 0.784 ± 0.027	0.337CysHis: 0.337 ± 0.016	0.598CysIle: 0.598 ± 0.019	0.462CysLys: 0.462 ± 0.018	0.961CysLeu: 0.961 ± 0.028	0.231CysMet: 0.231 ± 0.011	0.388CysAsn: 0.388 ± 0.014	0.415CysPro: 0.415 ± 0.019	0.514CysGln: 0.514 ± 0.02	0.434CysArg: 0.434 ± 0.019	0.658CysSer: 0.658 ± 0.022	0.437CysThr: 0.437 ± 0.018	0.646CysVal: 0.646 ± 0.025	0.122CysTrp: 0.122 ± 0.01	0.373CysTyr: 0.373 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.614AspAla: 4.614 ± 0.06	0.526AspCys: 0.526 ± 0.02	3.098AspAsp: 3.098 ± 0.059	4.065AspGlu: 4.065 ± 0.068	2.566AspPhe: 2.566 ± 0.046	3.679AspGly: 3.679 ± 0.058	1.04AspHis: 1.04 ± 0.027	4.022AspIle: 4.022 ± 0.054	3.62AspLys: 3.62 ± 0.055	5.103AspLeu: 5.103 ± 0.057	1.298AspMet: 1.298 ± 0.029	2.625AspAsn: 2.625 ± 0.045	1.939AspPro: 1.939 ± 0.041	1.723AspGln: 1.723 ± 0.036	1.905AspArg: 1.905 ± 0.04	3.328AspSer: 3.328 ± 0.052	2.848AspThr: 2.848 ± 0.056	3.688AspVal: 3.688 ± 0.055	0.789AspTrp: 0.789 ± 0.027	2.118AspTyr: 2.118 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.493GluAla: 5.493 ± 0.066	0.488GluCys: 0.488 ± 0.02	2.874GluAsp: 2.874 ± 0.062	3.53GluGlu: 3.53 ± 0.071	2.676GluPhe: 2.676 ± 0.043	3.389GluGly: 3.389 ± 0.053	1.75GluHis: 1.75 ± 0.038	3.968GluIle: 3.968 ± 0.055	3.683GluLys: 3.683 ± 0.055	7.603GluLeu: 7.603 ± 0.086	1.466GluMet: 1.466 ± 0.032	2.678GluAsn: 2.678 ± 0.044	1.976GluPro: 1.976 ± 0.041	4.829GluGln: 4.829 ± 0.078	3.263GluArg: 3.263 ± 0.049	3.75GluSer: 3.75 ± 0.059	2.922GluThr: 2.922 ± 0.05	4.562GluVal: 4.562 ± 0.058	0.644GluTrp: 0.644 ± 0.023	1.991GluTyr: 1.991 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.059PheAla: 4.059 ± 0.061	0.508PheCys: 0.508 ± 0.018	3.028PheAsp: 3.028 ± 0.053	2.868PheGlu: 2.868 ± 0.043	1.703PhePhe: 1.703 ± 0.037	3.015PheGly: 3.015 ± 0.048	0.8PheHis: 0.8 ± 0.024	2.923PheIle: 2.923 ± 0.046	2.198PheLys: 2.198 ± 0.039	3.239PheLeu: 3.239 ± 0.05	0.956PheMet: 0.956 ± 0.029	2.249PheAsn: 2.249 ± 0.037	1.31PhePro: 1.31 ± 0.034	1.21PheGln: 1.21 ± 0.03	1.369PheArg: 1.369 ± 0.031	3.606PheSer: 3.606 ± 0.052	2.535PheThr: 2.535 ± 0.042	2.934PheVal: 2.934 ± 0.05	0.537PheTrp: 0.537 ± 0.021	1.562PheTyr: 1.562 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.138GlyAla: 5.138 ± 0.08	0.798GlyCys: 0.798 ± 0.026	3.513GlyAsp: 3.513 ± 0.047	4.325GlyGlu: 4.325 ± 0.055	3.292GlyPhe: 3.292 ± 0.056	4.298GlyGly: 4.298 ± 0.068	1.517GlyHis: 1.517 ± 0.039	4.118GlyIle: 4.118 ± 0.055	3.909GlyLys: 3.909 ± 0.062	6.613GlyLeu: 6.613 ± 0.08	1.647GlyMet: 1.647 ± 0.036	2.616GlyAsn: 2.616 ± 0.053	1.513GlyPro: 1.513 ± 0.032	2.773GlyGln: 2.773 ± 0.043	2.703GlyArg: 2.703 ± 0.052	3.958GlySer: 3.958 ± 0.066	3.179GlyThr: 3.179 ± 0.068	4.845GlyVal: 4.845 ± 0.061	0.817GlyTrp: 0.817 ± 0.023	2.467GlyTyr: 2.467 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.707HisAla: 1.707 ± 0.036	0.335HisCys: 0.335 ± 0.016	1.151HisAsp: 1.151 ± 0.027	1.265HisGlu: 1.265 ± 0.034	1.248HisPhe: 1.248 ± 0.036	1.539HisGly: 1.539 ± 0.036	0.806HisHis: 0.806 ± 0.026	1.59HisIle: 1.59 ± 0.035	1.098HisLys: 1.098 ± 0.026	2.382HisLeu: 2.382 ± 0.046	0.458HisMet: 0.458 ± 0.019	0.969HisAsn: 0.969 ± 0.027	1.067HisPro: 1.067 ± 0.029	1.3HisGln: 1.3 ± 0.032	0.968HisArg: 0.968 ± 0.027	1.53HisSer: 1.53 ± 0.037	1.194HisThr: 1.194 ± 0.029	1.252HisVal: 1.252 ± 0.032	0.366HisTrp: 0.366 ± 0.016	0.997HisTyr: 0.997 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.594IleAla: 6.594 ± 0.092	0.655IleCys: 0.655 ± 0.019	4.072IleAsp: 4.072 ± 0.056	4.747IleGlu: 4.747 ± 0.065	2.155IlePhe: 2.155 ± 0.044	4.087IleGly: 4.087 ± 0.06	1.201IleHis: 1.201 ± 0.033	3.249IleIle: 3.249 ± 0.052	3.579IleLys: 3.579 ± 0.057	5.005IleLeu: 5.005 ± 0.057	1.121IleMet: 1.121 ± 0.028	3.116IleAsn: 3.116 ± 0.045	2.337IlePro: 2.337 ± 0.041	2.223IleGln: 2.223 ± 0.04	2.537IleArg: 2.537 ± 0.046	4.413IleSer: 4.413 ± 0.065	3.802IleThr: 3.802 ± 0.067	3.933IleVal: 3.933 ± 0.061	0.647IleTrp: 0.647 ± 0.024	1.76IleTyr: 1.76 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	5.224LysAla: 5.224 ± 0.065	0.349LysCys: 0.349 ± 0.018	2.73LysAsp: 2.73 ± 0.049	3.314LysGlu: 3.314 ± 0.055	1.706LysPhe: 1.706 ± 0.037	3.257LysGly: 3.257 ± 0.047	1.457LysHis: 1.457 ± 0.037	2.859LysIle: 2.859 ± 0.048	2.889LysLys: 2.889 ± 0.057	6.124LysLeu: 6.124 ± 0.068	1.277LysMet: 1.277 ± 0.029	2.166LysAsn: 2.166 ± 0.04	2.48LysPro: 2.48 ± 0.044	3.58LysGln: 3.58 ± 0.057	2.875LysArg: 2.875 ± 0.051	3.442LysSer: 3.442 ± 0.057	2.929LysThr: 2.929 ± 0.046	4.023LysVal: 4.023 ± 0.063	0.558LysTrp: 0.558 ± 0.022	1.507LysTyr: 1.507 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	10.502LeuAla: 10.502 ± 0.121	1.195LeuCys: 1.195 ± 0.033	5.917LeuAsp: 5.917 ± 0.067	6.426LeuGlu: 6.426 ± 0.075	4.409LeuPhe: 4.409 ± 0.067	6.765LeuGly: 6.765 ± 0.07	2.191LeuHis: 2.191 ± 0.045	6.065LeuIle: 6.065 ± 0.07	5.679LeuLys: 5.679 ± 0.079	10.895LeuLeu: 10.895 ± 0.135	2.38LeuMet: 2.38 ± 0.044	4.874LeuAsn: 4.874 ± 0.059	4.736LeuPro: 4.736 ± 0.064	4.28LeuGln: 4.28 ± 0.069	4.12LeuArg: 4.12 ± 0.055	8.462LeuSer: 8.462 ± 0.096	6.347LeuThr: 6.347 ± 0.07	6.983LeuVal: 6.983 ± 0.075	0.972LeuTrp: 0.972 ± 0.025	2.976LeuTyr: 2.976 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.262MetAla: 2.262 ± 0.039	0.172MetCys: 0.172 ± 0.01	1.11MetAsp: 1.11 ± 0.028	1.112MetGlu: 1.112 ± 0.032	0.753MetPhe: 0.753 ± 0.025	1.362MetGly: 1.362 ± 0.031	0.488MetHis: 0.488 ± 0.022	1.216MetIle: 1.216 ± 0.028	1.326MetLys: 1.326 ± 0.029	2.762MetLeu: 2.762 ± 0.05	0.64MetMet: 0.64 ± 0.024	0.895MetAsn: 0.895 ± 0.026	1.112MetPro: 1.112 ± 0.028	1.192MetGln: 1.192 ± 0.026	1.06MetArg: 1.06 ± 0.026	1.787MetSer: 1.787 ± 0.036	1.382MetThr: 1.382 ± 0.031	1.505MetVal: 1.505 ± 0.033	0.212MetTrp: 0.212 ± 0.013	0.501MetTyr: 0.501 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.766AsnAla: 3.766 ± 0.054	0.406AsnCys: 0.406 ± 0.019	2.315AsnAsp: 2.315 ± 0.049	2.639AsnGlu: 2.639 ± 0.041	1.648AsnPhe: 1.648 ± 0.038	2.931AsnGly: 2.931 ± 0.058	1.05AsnHis: 1.05 ± 0.028	2.755AsnIle: 2.755 ± 0.041	2.383AsnLys: 2.383 ± 0.044	4.225AsnLeu: 4.225 ± 0.056	1.024AsnMet: 1.024 ± 0.026	2.15AsnAsn: 2.15 ± 0.042	1.972AsnPro: 1.972 ± 0.041	2.329AsnGln: 2.329 ± 0.046	1.964AsnArg: 1.964 ± 0.036	2.66AsnSer: 2.66 ± 0.051	2.645AsnThr: 2.645 ± 0.046	2.632AsnVal: 2.632 ± 0.049	0.628AsnTrp: 0.628 ± 0.021	1.519AsnTyr: 1.519 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	2.959ProAla: 2.959 ± 0.049	0.342ProCys: 0.342 ± 0.014	2.222ProAsp: 2.222 ± 0.046	3.175ProGlu: 3.175 ± 0.056	1.739ProPhe: 1.739 ± 0.034	2.005ProGly: 2.005 ± 0.04	0.889ProHis: 0.889 ± 0.027	2.438ProIle: 2.438 ± 0.047	2.098ProLys: 2.098 ± 0.039	3.982ProLeu: 3.982 ± 0.067	0.85ProMet: 0.85 ± 0.023	1.755ProAsn: 1.755 ± 0.036	1.03ProPro: 1.03 ± 0.033	1.66ProGln: 1.66 ± 0.042	1.233ProArg: 1.233 ± 0.032	2.672ProSer: 2.672 ± 0.046	2.037ProThr: 2.037 ± 0.037	2.751ProVal: 2.751 ± 0.045	0.49ProTrp: 0.49 ± 0.02	1.267ProTyr: 1.267 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.982GlnAla: 4.982 ± 0.078	0.413GlnCys: 0.413 ± 0.018	2.234GlnAsp: 2.234 ± 0.039	2.45GlnGlu: 2.45 ± 0.044	2.184GlnPhe: 2.184 ± 0.041	3.191GlnGly: 3.191 ± 0.05	1.353GlnHis: 1.353 ± 0.033	2.658GlnIle: 2.658 ± 0.043	2.257GlnLys: 2.257 ± 0.038	6.04GlnLeu: 6.04 ± 0.091	0.948GlnMet: 0.948 ± 0.027	1.821GlnAsn: 1.821 ± 0.039	1.757GlnPro: 1.757 ± 0.038	3.826GlnGln: 3.826 ± 0.082	2.148GlnArg: 2.148 ± 0.045	3.42GlnSer: 3.42 ± 0.055	2.573GlnThr: 2.573 ± 0.047	3.675GlnVal: 3.675 ± 0.048	0.616GlnTrp: 0.616 ± 0.024	1.65GlnTyr: 1.65 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.561ArgAla: 3.561 ± 0.047	0.385ArgCys: 0.385 ± 0.017	2.324ArgAsp: 2.324 ± 0.046	2.7ArgGlu: 2.7 ± 0.051	2.248ArgPhe: 2.248 ± 0.038	2.438ArgGly: 2.438 ± 0.044	1.031ArgHis: 1.031 ± 0.026	2.674ArgIle: 2.674 ± 0.044	2.156ArgLys: 2.156 ± 0.041	4.785ArgLeu: 4.785 ± 0.071	0.965ArgMet: 0.965 ± 0.023	1.688ArgAsn: 1.688 ± 0.04	1.41ArgPro: 1.41 ± 0.036	2.022ArgGln: 2.022 ± 0.044	1.971ArgArg: 1.971 ± 0.044	2.384ArgSer: 2.384 ± 0.043	1.989ArgThr: 1.989 ± 0.035	3.059ArgVal: 3.059 ± 0.048	0.53ArgTrp: 0.53 ± 0.02	1.702ArgTyr: 1.702 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.979SerAla: 5.979 ± 0.072	0.674SerCys: 0.674 ± 0.023	3.876SerAsp: 3.876 ± 0.063	4.347SerGlu: 4.347 ± 0.052	2.99SerPhe: 2.99 ± 0.048	4.993SerGly: 4.993 ± 0.07	1.642SerHis: 1.642 ± 0.035	3.916SerIle: 3.916 ± 0.055	3.456SerLys: 3.456 ± 0.057	7.114SerLeu: 7.114 ± 0.083	1.501SerMet: 1.501 ± 0.033	2.889SerAsn: 2.889 ± 0.05	2.388SerPro: 2.388 ± 0.037	3.42SerGln: 3.42 ± 0.053	2.73SerArg: 2.73 ± 0.047	4.426SerSer: 4.426 ± 0.068	3.416SerThr: 3.416 ± 0.052	4.592SerVal: 4.592 ± 0.062	0.809SerTrp: 0.809 ± 0.027	2.309SerTyr: 2.309 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	4.563ThrAla: 4.563 ± 0.06	0.459ThrCys: 0.459 ± 0.019	2.759ThrAsp: 2.759 ± 0.051	3.3ThrGlu: 3.3 ± 0.053	2.099ThrPhe: 2.099 ± 0.042	3.717ThrGly: 3.717 ± 0.066	1.277ThrHis: 1.277 ± 0.031	3.302ThrIle: 3.302 ± 0.057	2.49ThrLys: 2.49 ± 0.045	6.749ThrLeu: 6.749 ± 0.076	1.075ThrMet: 1.075 ± 0.028	1.994ThrAsn: 1.994 ± 0.038	2.844ThrPro: 2.844 ± 0.049	2.882ThrGln: 2.882 ± 0.056	2.132ThrArg: 2.132 ± 0.04	3.529ThrSer: 3.529 ± 0.064	3.079ThrThr: 3.079 ± 0.059	3.677ThrVal: 3.677 ± 0.063	0.628ThrTrp: 0.628 ± 0.019	1.589ThrTyr: 1.589 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.287ValAla: 6.287 ± 0.081	0.737ValCys: 0.737 ± 0.022	3.935ValAsp: 3.935 ± 0.06	4.774ValGlu: 4.774 ± 0.063	2.877ValPhe: 2.877 ± 0.045	4.18ValGly: 4.18 ± 0.064	1.244ValHis: 1.244 ± 0.03	4.508ValIle: 4.508 ± 0.061	3.877ValLys: 3.877 ± 0.051	6.71ValLeu: 6.71 ± 0.085	1.714ValMet: 1.714 ± 0.033	3.205ValAsn: 3.205 ± 0.048	2.455ValPro: 2.455 ± 0.046	2.325ValGln: 2.325 ± 0.046	2.658ValArg: 2.658 ± 0.041	5.095ValSer: 5.095 ± 0.07	4.054ValThr: 4.054 ± 0.067	5.021ValVal: 5.021 ± 0.083	0.71ValTrp: 0.71 ± 0.022	1.948ValTyr: 1.948 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.666TrpAla: 0.666 ± 0.021	0.126TrpCys: 0.126 ± 0.01	0.536TrpAsp: 0.536 ± 0.018	0.471TrpGlu: 0.471 ± 0.02	0.613TrpPhe: 0.613 ± 0.022	0.658TrpGly: 0.658 ± 0.023	0.374TrpHis: 0.374 ± 0.016	0.568TrpIle: 0.568 ± 0.02	0.388TrpLys: 0.388 ± 0.016	1.719TrpLeu: 1.719 ± 0.043	0.283TrpMet: 0.283 ± 0.014	0.377TrpAsn: 0.377 ± 0.017	0.448TrpPro: 0.448 ± 0.022	1.305TrpGln: 1.305 ± 0.03	0.628TrpArg: 0.628 ± 0.023	0.729TrpSer: 0.729 ± 0.022	0.437TrpThr: 0.437 ± 0.019	0.773TrpVal: 0.773 ± 0.024	0.176TrpTrp: 0.176 ± 0.012	0.4TrpTyr: 0.4 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.481TyrAla: 2.481 ± 0.042	0.387TyrCys: 0.387 ± 0.018	1.76TyrAsp: 1.76 ± 0.038	1.719TyrGlu: 1.719 ± 0.037	1.603TyrPhe: 1.603 ± 0.038	2.082TyrGly: 2.082 ± 0.041	0.842TyrHis: 0.842 ± 0.025	1.818TyrIle: 1.818 ± 0.036	1.562TyrLys: 1.562 ± 0.032	3.57TyrLeu: 3.57 ± 0.051	0.607TyrMet: 0.607 ± 0.021	1.244TyrAsn: 1.244 ± 0.033	1.334TyrPro: 1.334 ± 0.032	2.164TyrGln: 2.164 ± 0.039	1.737TyrArg: 1.737 ± 0.035	2.194TyrSer: 2.194 ± 0.041	1.671TyrThr: 1.671 ± 0.038	1.977TyrVal: 1.977 ± 0.035	0.471TyrTrp: 0.471 ± 0.019	1.135TyrTyr: 1.135 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4134 proteins (1440159 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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