Amino acid dipepetide frequency for Norway phlebovirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.427AlaAla: 9.427 ± 7.407
0.377AlaCys: 0.377 ± 0.181
1.885AlaAsp: 1.885 ± 0.18
4.148AlaGlu: 4.148 ± 1.263
1.131AlaPhe: 1.131 ± 0.543
4.525AlaGly: 4.525 ± 1.082
2.262AlaHis: 2.262 ± 0.001
3.394AlaIle: 3.394 ± 1.625
4.525AlaLys: 4.525 ± 0.002
9.05AlaLeu: 9.05 ± 2.164
3.017AlaMet: 3.017 ± 0.721
2.262AlaAsn: 2.262 ± 1.083
2.262AlaPro: 2.262 ± 1.083
3.771AlaGln: 3.771 ± 0.36
4.902AlaArg: 4.902 ± 1.986
4.148AlaSer: 4.148 ± 1.263
4.525AlaThr: 4.525 ± 3.252
3.771AlaVal: 3.771 ± 3.614
1.131AlaTrp: 1.131 ± 1.626
2.64AlaTyr: 2.64 ± 1.987
0.0AlaXaa: 0.0 ± 0.0
Cys
1.508CysAla: 1.508 ± 0.724
0.0CysCys: 0.0 ± 0.0
1.885CysAsp: 1.885 ± 0.905
0.377CysGlu: 0.377 ± 0.181
0.754CysPhe: 0.754 ± 0.362
0.754CysGly: 0.754 ± 0.362
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.377CysLys: 0.377 ± 0.181
1.885CysLeu: 1.885 ± 0.905
0.377CysMet: 0.377 ± 0.181
0.0CysAsn: 0.0 ± 0.0
0.377CysPro: 0.377 ± 0.181
0.0CysGln: 0.0 ± 0.0
2.262CysArg: 2.262 ± 1.086
0.377CysSer: 0.377 ± 0.181
1.131CysThr: 1.131 ± 0.542
0.754CysVal: 0.754 ± 0.362
0.0CysTrp: 0.0 ± 0.0
0.377CysTyr: 0.377 ± 0.181
0.0CysXaa: 0.0 ± 0.0
Asp
3.771AspAla: 3.771 ± 2.529
0.0AspCys: 0.0 ± 0.0
3.771AspAsp: 3.771 ± 1.81
6.41AspGlu: 6.41 ± 0.907
1.131AspPhe: 1.131 ± 0.542
0.754AspGly: 0.754 ± 0.723
2.64AspHis: 2.64 ± 0.182
1.885AspIle: 1.885 ± 0.905
2.262AspLys: 2.262 ± 2.168
8.673AspLeu: 8.673 ± 4.163
0.0AspMet: 0.0 ± 0.0
3.017AspAsn: 3.017 ± 1.448
2.64AspPro: 2.64 ± 0.182
2.262AspGln: 2.262 ± 0.001
3.394AspArg: 3.394 ± 0.54
3.771AspSer: 3.771 ± 0.36
1.508AspThr: 1.508 ± 0.724
3.394AspVal: 3.394 ± 1.625
1.131AspTrp: 1.131 ± 0.542
2.262AspTyr: 2.262 ± 1.083
0.0AspXaa: 0.0 ± 0.0
Glu
7.919GluAla: 7.919 ± 4.877
0.754GluCys: 0.754 ± 0.362
3.771GluAsp: 3.771 ± 1.81
7.919GluGlu: 7.919 ± 2.707
5.279GluPhe: 5.279 ± 0.364
3.771GluGly: 3.771 ± 2.529
1.131GluHis: 1.131 ± 0.543
1.131GluIle: 1.131 ± 0.543
5.656GluLys: 5.656 ± 2.715
6.787GluLeu: 6.787 ± 3.25
2.262GluMet: 2.262 ± 0.001
3.394GluAsn: 3.394 ± 0.54
3.394GluPro: 3.394 ± 1.629
5.656GluGln: 5.656 ± 1.63
5.656GluArg: 5.656 ± 1.624
5.279GluSer: 5.279 ± 0.72
4.148GluThr: 4.148 ± 0.906
3.017GluVal: 3.017 ± 0.721
0.377GluTrp: 0.377 ± 0.181
1.508GluTyr: 1.508 ± 0.361
0.0GluXaa: 0.0 ± 0.0
Phe
3.771PheAla: 3.771 ± 0.36
0.377PheCys: 0.377 ± 0.181
2.262PheAsp: 2.262 ± 1.083
0.377PheGlu: 0.377 ± 0.181
1.885PhePhe: 1.885 ± 0.905
0.754PheGly: 0.754 ± 0.362
0.377PheHis: 0.377 ± 0.181
1.131PheIle: 1.131 ± 0.543
3.771PheLys: 3.771 ± 1.81
2.64PheLeu: 2.64 ± 1.267
1.885PheMet: 1.885 ± 0.905
2.262PheAsn: 2.262 ± 0.001
2.64PhePro: 2.64 ± 0.902
2.262PheGln: 2.262 ± 0.001
2.262PheArg: 2.262 ± 0.001
2.64PheSer: 2.64 ± 0.182
3.017PheThr: 3.017 ± 1.448
3.017PheVal: 3.017 ± 1.448
0.754PheTrp: 0.754 ± 0.362
1.131PheTyr: 1.131 ± 0.543
0.0PheXaa: 0.0 ± 0.0
Gly
1.885GlyAla: 1.885 ± 1.264
0.377GlyCys: 0.377 ± 0.181
3.394GlyAsp: 3.394 ± 1.625
4.148GlyGlu: 4.148 ± 3.433
2.64GlyPhe: 2.64 ± 0.902
3.394GlyGly: 3.394 ± 0.544
1.131GlyHis: 1.131 ± 0.543
2.64GlyIle: 2.64 ± 0.182
1.508GlyLys: 1.508 ± 0.724
6.787GlyLeu: 6.787 ± 1.081
1.508GlyMet: 1.508 ± 0.361
1.885GlyAsn: 1.885 ± 0.905
3.394GlyPro: 3.394 ± 1.625
1.508GlyGln: 1.508 ± 0.361
2.262GlyArg: 2.262 ± 0.001
3.017GlySer: 3.017 ± 1.448
3.394GlyThr: 3.394 ± 1.629
4.902GlyVal: 4.902 ± 1.268
0.754GlyTrp: 0.754 ± 0.723
1.131GlyTyr: 1.131 ± 0.543
0.0GlyXaa: 0.0 ± 0.0
His
1.131HisAla: 1.131 ± 0.543
0.754HisCys: 0.754 ± 0.362
0.754HisAsp: 0.754 ± 0.362
2.262HisGlu: 2.262 ± 1.086
1.131HisPhe: 1.131 ± 0.543
0.754HisGly: 0.754 ± 0.362
0.377HisHis: 0.377 ± 0.181
1.508HisIle: 1.508 ± 0.724
2.262HisLys: 2.262 ± 1.083
1.885HisLeu: 1.885 ± 0.18
0.377HisMet: 0.377 ± 0.181
0.754HisAsn: 0.754 ± 0.362
1.885HisPro: 1.885 ± 0.905
0.377HisGln: 0.377 ± 0.904
2.262HisArg: 2.262 ± 1.086
0.754HisSer: 0.754 ± 0.723
0.754HisThr: 0.754 ± 0.362
1.508HisVal: 1.508 ± 0.724
0.377HisTrp: 0.377 ± 0.181
2.262HisTyr: 2.262 ± 0.001
0.0HisXaa: 0.0 ± 0.0
Ile
0.377IleAla: 0.377 ± 0.181
1.131IleCys: 1.131 ± 0.542
2.262IleAsp: 2.262 ± 1.086
1.885IleGlu: 1.885 ± 0.905
0.754IlePhe: 0.754 ± 0.362
1.131IleGly: 1.131 ± 0.542
0.754IleHis: 0.754 ± 0.723
2.262IleIle: 2.262 ± 1.086
3.017IleLys: 3.017 ± 1.806
4.148IleLeu: 4.148 ± 0.906
1.885IleMet: 1.885 ± 0.905
1.508IleAsn: 1.508 ± 0.361
2.262IlePro: 2.262 ± 0.001
0.377IleGln: 0.377 ± 0.181
2.64IleArg: 2.64 ± 1.267
4.902IleSer: 4.902 ± 1.268
2.64IleThr: 2.64 ± 0.182
2.262IleVal: 2.262 ± 0.001
0.377IleTrp: 0.377 ± 0.181
1.131IleTyr: 1.131 ± 0.543
0.0IleXaa: 0.0 ± 0.0
Lys
6.787LysAla: 6.787 ± 5.42
1.131LysCys: 1.131 ± 0.543
1.885LysAsp: 1.885 ± 2.349
4.902LysGlu: 4.902 ± 3.071
3.394LysPhe: 3.394 ± 0.544
2.64LysGly: 2.64 ± 1.987
1.131LysHis: 1.131 ± 0.542
2.64LysIle: 2.64 ± 0.182
6.033LysLys: 6.033 ± 0.358
5.279LysLeu: 5.279 ± 0.364
1.131LysMet: 1.131 ± 0.162
2.262LysAsn: 2.262 ± 1.086
3.771LysPro: 3.771 ± 0.36
2.262LysGln: 2.262 ± 0.001
2.64LysArg: 2.64 ± 0.182
1.508LysSer: 1.508 ± 0.724
4.148LysThr: 4.148 ± 0.906
3.394LysVal: 3.394 ± 0.54
1.508LysTrp: 1.508 ± 0.361
3.017LysTyr: 3.017 ± 1.448
0.0LysXaa: 0.0 ± 0.0
Leu
7.919LeuAla: 7.919 ± 1.623
2.262LeuCys: 2.262 ± 1.086
6.033LeuAsp: 6.033 ± 1.443
9.05LeuGlu: 9.05 ± 2.174
3.771LeuPhe: 3.771 ± 0.725
8.296LeuGly: 8.296 ± 0.357
2.64LeuHis: 2.64 ± 1.267
3.771LeuIle: 3.771 ± 0.725
6.787LeuLys: 6.787 ± 1.081
9.427LeuLeu: 9.427 ± 1.271
3.771LeuMet: 3.771 ± 0.646
3.394LeuAsn: 3.394 ± 0.54
3.394LeuPro: 3.394 ± 0.544
3.017LeuGln: 3.017 ± 1.806
7.919LeuArg: 7.919 ± 1.631
6.787LeuSer: 6.787 ± 0.004
5.279LeuThr: 5.279 ± 1.449
7.541LeuVal: 7.541 ± 2.888
0.377LeuTrp: 0.377 ± 0.181
2.64LeuTyr: 2.64 ± 0.182
0.0LeuXaa: 0.0 ± 0.0
Met
1.508MetAla: 1.508 ± 0.724
0.377MetCys: 0.377 ± 0.181
2.262MetAsp: 2.262 ± 2.168
3.017MetGlu: 3.017 ± 0.363
1.508MetPhe: 1.508 ± 0.361
1.885MetGly: 1.885 ± 0.18
0.754MetHis: 0.754 ± 0.362
1.508MetIle: 1.508 ± 0.724
1.131MetLys: 1.131 ± 0.542
3.394MetLeu: 3.394 ± 1.629
1.885MetMet: 1.885 ± 0.18
0.377MetAsn: 0.377 ± 0.181
0.754MetPro: 0.754 ± 0.362
1.131MetGln: 1.131 ± 0.543
2.64MetArg: 2.64 ± 0.902
3.771MetSer: 3.771 ± 1.81
3.394MetThr: 3.394 ± 0.544
3.394MetVal: 3.394 ± 1.629
0.0MetTrp: 0.0 ± 0.0
1.131MetTyr: 1.131 ± 0.543
0.0MetXaa: 0.0 ± 0.0
Asn
0.754AsnAla: 0.754 ± 0.362
1.131AsnCys: 1.131 ± 0.543
3.017AsnAsp: 3.017 ± 1.448
0.754AsnGlu: 0.754 ± 0.362
1.508AsnPhe: 1.508 ± 0.724
2.262AsnGly: 2.262 ± 1.086
0.0AsnHis: 0.0 ± 0.0
1.508AsnIle: 1.508 ± 0.724
1.885AsnLys: 1.885 ± 0.18
5.656AsnLeu: 5.656 ± 0.545
1.508AsnMet: 1.508 ± 0.724
0.754AsnAsn: 0.754 ± 0.362
2.262AsnPro: 2.262 ± 1.086
1.131AsnGln: 1.131 ± 0.543
1.508AsnArg: 1.508 ± 1.445
2.64AsnSer: 2.64 ± 0.182
1.131AsnThr: 1.131 ± 0.543
2.262AsnVal: 2.262 ± 1.086
1.131AsnTrp: 1.131 ± 0.542
1.885AsnTyr: 1.885 ± 0.18
0.0AsnXaa: 0.0 ± 0.0
Pro
2.64ProAla: 2.64 ± 3.072
0.377ProCys: 0.377 ± 0.181
1.885ProAsp: 1.885 ± 0.905
4.525ProGlu: 4.525 ± 1.087
3.394ProPhe: 3.394 ± 1.629
2.64ProGly: 2.64 ± 0.182
1.508ProHis: 1.508 ± 0.724
1.508ProIle: 1.508 ± 0.361
3.394ProLys: 3.394 ± 0.54
1.508ProLeu: 1.508 ± 0.724
0.377ProMet: 0.377 ± 0.181
2.64ProAsn: 2.64 ± 1.267
1.885ProPro: 1.885 ± 0.18
1.508ProGln: 1.508 ± 0.724
4.148ProArg: 4.148 ± 1.263
3.771ProSer: 3.771 ± 0.36
1.508ProThr: 1.508 ± 0.724
3.771ProVal: 3.771 ± 2.529
1.885ProTrp: 1.885 ± 0.905
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.394GlnAla: 3.394 ± 2.71
0.0GlnCys: 0.0 ± 0.0
3.017GlnAsp: 3.017 ± 0.721
1.885GlnGlu: 1.885 ± 0.18
0.377GlnPhe: 0.377 ± 0.181
3.394GlnGly: 3.394 ± 0.544
2.262GlnHis: 2.262 ± 0.001
1.508GlnIle: 1.508 ± 0.724
1.885GlnLys: 1.885 ± 1.264
3.771GlnLeu: 3.771 ± 1.81
1.508GlnMet: 1.508 ± 0.724
1.508GlnAsn: 1.508 ± 0.724
0.754GlnPro: 0.754 ± 0.362
1.885GlnGln: 1.885 ± 0.18
1.885GlnArg: 1.885 ± 1.264
3.017GlnSer: 3.017 ± 0.363
0.754GlnThr: 0.754 ± 0.362
3.017GlnVal: 3.017 ± 0.721
0.377GlnTrp: 0.377 ± 0.181
0.377GlnTyr: 0.377 ± 0.181
0.0GlnXaa: 0.0 ± 0.0
Arg
2.64ArgAla: 2.64 ± 0.902
0.377ArgCys: 0.377 ± 0.181
3.394ArgAsp: 3.394 ± 0.544
4.902ArgGlu: 4.902 ± 1.986
2.262ArgPhe: 2.262 ± 1.086
4.902ArgGly: 4.902 ± 0.901
2.64ArgHis: 2.64 ± 0.182
3.394ArgIle: 3.394 ± 0.54
2.262ArgLys: 2.262 ± 1.083
9.05ArgLeu: 9.05 ± 2.164
2.262ArgMet: 2.262 ± 1.086
1.885ArgAsn: 1.885 ± 0.905
3.017ArgPro: 3.017 ± 1.448
1.508ArgGln: 1.508 ± 0.361
2.64ArgArg: 2.64 ± 1.267
6.033ArgSer: 6.033 ± 1.811
3.017ArgThr: 3.017 ± 1.806
5.656ArgVal: 5.656 ± 0.539
1.508ArgTrp: 1.508 ± 0.724
0.754ArgTyr: 0.754 ± 0.362
0.0ArgXaa: 0.0 ± 0.0
Ser
4.525SerAla: 4.525 ± 2.167
1.131SerCys: 1.131 ± 0.543
2.64SerAsp: 2.64 ± 0.182
6.787SerGlu: 6.787 ± 2.173
2.262SerPhe: 2.262 ± 0.001
2.64SerGly: 2.64 ± 1.267
1.508SerHis: 1.508 ± 0.724
3.017SerIle: 3.017 ± 0.363
4.902SerLys: 4.902 ± 3.071
6.787SerLeu: 6.787 ± 1.081
3.017SerMet: 3.017 ± 1.448
1.885SerAsn: 1.885 ± 0.905
3.394SerPro: 3.394 ± 0.54
3.017SerGln: 3.017 ± 0.363
4.902SerArg: 4.902 ± 1.268
9.427SerSer: 9.427 ± 2.355
4.902SerThr: 4.902 ± 0.183
5.656SerVal: 5.656 ± 2.715
0.754SerTrp: 0.754 ± 0.362
1.885SerTyr: 1.885 ± 0.18
0.0SerXaa: 0.0 ± 0.0
Thr
2.64ThrAla: 2.64 ± 1.267
1.131ThrCys: 1.131 ± 0.543
4.148ThrAsp: 4.148 ± 0.906
4.148ThrGlu: 4.148 ± 1.263
2.262ThrPhe: 2.262 ± 0.001
2.64ThrGly: 2.64 ± 0.182
0.377ThrHis: 0.377 ± 0.181
1.508ThrIle: 1.508 ± 0.724
2.64ThrLys: 2.64 ± 1.987
4.902ThrLeu: 4.902 ± 0.901
4.148ThrMet: 4.148 ± 0.179
2.64ThrAsn: 2.64 ± 1.267
2.262ThrPro: 2.262 ± 0.001
0.754ThrGln: 0.754 ± 0.362
4.148ThrArg: 4.148 ± 0.906
4.525ThrSer: 4.525 ± 0.002
3.771ThrThr: 3.771 ± 1.81
3.017ThrVal: 3.017 ± 1.448
1.885ThrTrp: 1.885 ± 0.905
0.754ThrTyr: 0.754 ± 0.723
0.0ThrXaa: 0.0 ± 0.0
Val
6.41ValAla: 6.41 ± 1.262
0.377ValCys: 0.377 ± 0.181
1.885ValAsp: 1.885 ± 1.264
6.787ValGlu: 6.787 ± 2.166
3.394ValPhe: 3.394 ± 1.629
1.885ValGly: 1.885 ± 0.905
1.885ValHis: 1.885 ± 0.905
2.64ValIle: 2.64 ± 0.902
5.656ValLys: 5.656 ± 0.539
7.164ValLeu: 7.164 ± 0.185
2.64ValMet: 2.64 ± 0.182
1.131ValAsn: 1.131 ± 0.543
2.64ValPro: 2.64 ± 0.182
2.64ValGln: 2.64 ± 0.902
3.771ValArg: 3.771 ± 0.36
6.787ValSer: 6.787 ± 0.004
3.771ValThr: 3.771 ± 1.444
5.279ValVal: 5.279 ± 1.805
1.885ValTrp: 1.885 ± 0.18
1.885ValTyr: 1.885 ± 0.905
0.0ValXaa: 0.0 ± 0.0
Trp
0.377TrpAla: 0.377 ± 0.181
0.377TrpCys: 0.377 ± 0.181
1.508TrpAsp: 1.508 ± 0.361
1.885TrpGlu: 1.885 ± 0.18
0.377TrpPhe: 0.377 ± 0.181
0.754TrpGly: 0.754 ± 0.723
0.377TrpHis: 0.377 ± 0.181
0.754TrpIle: 0.754 ± 0.362
1.131TrpLys: 1.131 ± 0.543
3.017TrpLeu: 3.017 ± 0.721
0.377TrpMet: 0.377 ± 0.181
0.754TrpAsn: 0.754 ± 0.362
0.377TrpPro: 0.377 ± 0.181
0.377TrpGln: 0.377 ± 0.181
0.754TrpArg: 0.754 ± 0.362
0.754TrpSer: 0.754 ± 0.362
0.754TrpThr: 0.754 ± 0.362
1.885TrpVal: 1.885 ± 1.264
0.754TrpTrp: 0.754 ± 0.362
0.754TrpTyr: 0.754 ± 0.362
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.771TyrAla: 3.771 ± 0.36
0.754TyrCys: 0.754 ± 0.362
3.017TyrAsp: 3.017 ± 1.448
2.64TyrGlu: 2.64 ± 0.182
0.0TyrPhe: 0.0 ± 0.0
1.885TyrGly: 1.885 ± 0.18
0.377TyrHis: 0.377 ± 0.181
0.0TyrIle: 0.0 ± 0.0
0.754TyrLys: 0.754 ± 0.362
2.262TyrLeu: 2.262 ± 0.001
1.508TyrMet: 1.508 ± 0.361
0.377TyrAsn: 0.377 ± 0.181
1.508TyrPro: 1.508 ± 1.445
1.131TyrGln: 1.131 ± 0.542
1.508TyrArg: 1.508 ± 0.361
1.131TyrSer: 1.131 ± 0.543
0.754TyrThr: 0.754 ± 0.362
3.017TyrVal: 3.017 ± 0.363
1.131TyrTrp: 1.131 ± 0.543
0.377TyrTyr: 0.377 ± 0.181
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2653 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski