Amino acid dipepetide frequency for Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.226AlaAla: 6.226 ± 0.14	0.46AlaCys: 0.46 ± 0.029	4.312AlaAsp: 4.312 ± 0.096	4.406AlaGlu: 4.406 ± 0.104	3.448AlaPhe: 3.448 ± 0.078	5.171AlaGly: 5.171 ± 0.111	1.329AlaHis: 1.329 ± 0.053	5.991AlaIle: 5.991 ± 0.116	5.424AlaLys: 5.424 ± 0.098	7.593AlaLeu: 7.593 ± 0.125	1.787AlaMet: 1.787 ± 0.059	3.4AlaAsn: 3.4 ± 0.093	1.877AlaPro: 1.877 ± 0.059	3.279AlaGln: 3.279 ± 0.077	2.805AlaArg: 2.805 ± 0.078	4.539AlaSer: 4.539 ± 0.092	3.885AlaThr: 3.885 ± 0.09	5.356AlaVal: 5.356 ± 0.116	0.579AlaTrp: 0.579 ± 0.036	2.867AlaTyr: 2.867 ± 0.07	0.0AlaXaa: 0.0 ± 0.0
Cys	0.346CysAla: 0.346 ± 0.021	0.06CysCys: 0.06 ± 0.01	0.282CysAsp: 0.282 ± 0.026	0.266CysGlu: 0.266 ± 0.023	0.363CysPhe: 0.363 ± 0.026	0.472CysGly: 0.472 ± 0.031	0.19CysHis: 0.19 ± 0.021	0.358CysIle: 0.358 ± 0.025	0.254CysLys: 0.254 ± 0.023	0.71CysLeu: 0.71 ± 0.04	0.133CysMet: 0.133 ± 0.015	0.183CysAsn: 0.183 ± 0.018	0.259CysPro: 0.259 ± 0.021	0.365CysGln: 0.365 ± 0.028	0.18CysArg: 0.18 ± 0.019	0.399CysSer: 0.399 ± 0.03	0.259CysThr: 0.259 ± 0.02	0.327CysVal: 0.327 ± 0.024	0.05CysTrp: 0.05 ± 0.009	0.266CysTyr: 0.266 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.514AspAla: 3.514 ± 0.099	0.365AspCys: 0.365 ± 0.027	3.099AspAsp: 3.099 ± 0.082	3.657AspGlu: 3.657 ± 0.084	3.372AspPhe: 3.372 ± 0.071	3.479AspGly: 3.479 ± 0.104	0.99AspHis: 0.99 ± 0.04	4.71AspIle: 4.71 ± 0.081	4.56AspLys: 4.56 ± 0.097	5.935AspLeu: 5.935 ± 0.115	1.436AspMet: 1.436 ± 0.05	2.843AspAsn: 2.843 ± 0.085	1.542AspPro: 1.542 ± 0.051	1.804AspGln: 1.804 ± 0.062	2.064AspArg: 2.064 ± 0.064	3.381AspSer: 3.381 ± 0.086	2.691AspThr: 2.691 ± 0.062	3.562AspVal: 3.562 ± 0.083	0.61AspTrp: 0.61 ± 0.031	3.006AspTyr: 3.006 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	5.08GluAla: 5.08 ± 0.114	0.254GluCys: 0.254 ± 0.02	3.422GluAsp: 3.422 ± 0.084	5.197GluGlu: 5.197 ± 0.114	2.447GluPhe: 2.447 ± 0.067	3.206GluGly: 3.206 ± 0.074	1.322GluHis: 1.322 ± 0.046	5.083GluIle: 5.083 ± 0.103	6.113GluLys: 6.113 ± 0.118	6.221GluLeu: 6.221 ± 0.109	1.62GluMet: 1.62 ± 0.056	3.79GluAsn: 3.79 ± 0.093	1.4GluPro: 1.4 ± 0.051	2.522GluGln: 2.522 ± 0.069	3.054GluArg: 3.054 ± 0.073	3.007GluSer: 3.007 ± 0.071	3.683GluThr: 3.683 ± 0.085	4.145GluVal: 4.145 ± 0.096	0.534GluTrp: 0.534 ± 0.032	1.77GluTyr: 1.77 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.567PheAla: 3.567 ± 0.092	0.339PheCys: 0.339 ± 0.026	3.203PheAsp: 3.203 ± 0.073	3.056PheGlu: 3.056 ± 0.079	2.363PhePhe: 2.363 ± 0.08	3.227PheGly: 3.227 ± 0.088	0.845PheHis: 0.845 ± 0.043	3.728PheIle: 3.728 ± 0.106	2.949PheLys: 2.949 ± 0.075	4.909PheLeu: 4.909 ± 0.117	1.101PheMet: 1.101 ± 0.045	2.216PheAsn: 2.216 ± 0.067	1.594PhePro: 1.594 ± 0.05	1.476PheGln: 1.476 ± 0.052	1.443PheArg: 1.443 ± 0.052	3.393PheSer: 3.393 ± 0.082	2.539PheThr: 2.539 ± 0.069	3.177PheVal: 3.177 ± 0.07	0.496PheTrp: 0.496 ± 0.033	1.967PheTyr: 1.967 ± 0.063	0.0PheXaa: 0.0 ± 0.0
Gly	4.399GlyAla: 4.399 ± 0.107	0.427GlyCys: 0.427 ± 0.028	3.218GlyAsp: 3.218 ± 0.082	3.348GlyGlu: 3.348 ± 0.086	3.21GlyPhe: 3.21 ± 0.08	4.02GlyGly: 4.02 ± 0.094	1.298GlyHis: 1.298 ± 0.043	5.324GlyIle: 5.324 ± 0.105	4.668GlyLys: 4.668 ± 0.107	6.582GlyLeu: 6.582 ± 0.134	1.62GlyMet: 1.62 ± 0.054	2.769GlyAsn: 2.769 ± 0.075	1.321GlyPro: 1.321 ± 0.054	3.009GlyGln: 3.009 ± 0.086	2.646GlyArg: 2.646 ± 0.069	3.834GlySer: 3.834 ± 0.093	3.381GlyThr: 3.381 ± 0.086	4.421GlyVal: 4.421 ± 0.1	0.589GlyTrp: 0.589 ± 0.033	2.598GlyTyr: 2.598 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.163HisAla: 1.163 ± 0.052	0.137HisCys: 0.137 ± 0.016	0.996HisAsp: 0.996 ± 0.046	0.996HisGlu: 0.996 ± 0.048	1.346HisPhe: 1.346 ± 0.048	1.201HisGly: 1.201 ± 0.049	0.563HisHis: 0.563 ± 0.033	1.483HisIle: 1.483 ± 0.048	1.087HisLys: 1.087 ± 0.047	2.321HisLeu: 2.321 ± 0.063	0.432HisMet: 0.432 ± 0.028	0.776HisAsn: 0.776 ± 0.039	0.876HisPro: 0.876 ± 0.038	0.947HisGln: 0.947 ± 0.039	0.824HisArg: 0.824 ± 0.044	1.134HisSer: 1.134 ± 0.045	0.875HisThr: 0.875 ± 0.041	1.117HisVal: 1.117 ± 0.047	0.202HisTrp: 0.202 ± 0.02	1.092HisTyr: 1.092 ± 0.044	0.0HisXaa: 0.0 ± 0.0
Ile	6.361IleAla: 6.361 ± 0.117	0.627IleCys: 0.627 ± 0.037	4.463IleAsp: 4.463 ± 0.095	4.933IleGlu: 4.933 ± 0.112	3.811IlePhe: 3.811 ± 0.097	4.931IleGly: 4.931 ± 0.115	1.279IleHis: 1.279 ± 0.048	6.039IleIle: 6.039 ± 0.143	5.465IleLys: 5.465 ± 0.088	7.811IleLeu: 7.811 ± 0.159	1.827IleMet: 1.827 ± 0.061	3.621IleAsn: 3.621 ± 0.096	2.895IlePro: 2.895 ± 0.081	2.537IleGln: 2.537 ± 0.083	2.961IleArg: 2.961 ± 0.069	5.299IleSer: 5.299 ± 0.102	4.148IleThr: 4.148 ± 0.081	5.03IleVal: 5.03 ± 0.093	0.702IleTrp: 0.702 ± 0.035	2.696IleTyr: 2.696 ± 0.083	0.0IleXaa: 0.0 ± 0.0
Lys	5.384LysAla: 5.384 ± 0.126	0.242LysCys: 0.242 ± 0.024	4.319LysAsp: 4.319 ± 0.095	6.005LysGlu: 6.005 ± 0.097	2.396LysPhe: 2.396 ± 0.066	4.15LysGly: 4.15 ± 0.086	1.362LysHis: 1.362 ± 0.045	5.754LysIle: 5.754 ± 0.112	6.482LysLys: 6.482 ± 0.121	6.335LysLeu: 6.335 ± 0.114	2.084LysMet: 2.084 ± 0.057	4.207LysAsn: 4.207 ± 0.094	2.169LysPro: 2.169 ± 0.065	3.018LysGln: 3.018 ± 0.081	3.403LysArg: 3.403 ± 0.076	4.214LysSer: 4.214 ± 0.108	4.598LysThr: 4.598 ± 0.088	4.867LysVal: 4.867 ± 0.1	0.589LysTrp: 0.589 ± 0.036	2.494LysTyr: 2.494 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	8.689LeuAla: 8.689 ± 0.136	0.539LeuCys: 0.539 ± 0.034	5.697LeuAsp: 5.697 ± 0.091	6.615LeuGlu: 6.615 ± 0.127	4.611LeuPhe: 4.611 ± 0.109	6.198LeuGly: 6.198 ± 0.124	1.666LeuHis: 1.666 ± 0.054	7.384LeuIle: 7.384 ± 0.125	7.27LeuLys: 7.27 ± 0.112	10.467LeuLeu: 10.467 ± 0.191	2.404LeuMet: 2.404 ± 0.059	4.56LeuAsn: 4.56 ± 0.088	3.92LeuPro: 3.92 ± 0.09	3.484LeuGln: 3.484 ± 0.079	3.567LeuArg: 3.567 ± 0.085	7.391LeuSer: 7.391 ± 0.142	6.463LeuThr: 6.463 ± 0.107	6.532LeuVal: 6.532 ± 0.135	0.672LeuTrp: 0.672 ± 0.031	3.165LeuTyr: 3.165 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	1.977MetAla: 1.977 ± 0.057	0.128MetCys: 0.128 ± 0.014	1.201MetAsp: 1.201 ± 0.042	1.317MetGlu: 1.317 ± 0.05	0.854MetPhe: 0.854 ± 0.042	1.575MetGly: 1.575 ± 0.058	0.34MetHis: 0.34 ± 0.024	1.936MetIle: 1.936 ± 0.061	1.982MetLys: 1.982 ± 0.055	2.254MetLeu: 2.254 ± 0.066	0.714MetMet: 0.714 ± 0.038	1.246MetAsn: 1.246 ± 0.045	0.823MetPro: 0.823 ± 0.04	0.856MetGln: 0.856 ± 0.039	1.015MetArg: 1.015 ± 0.043	1.594MetSer: 1.594 ± 0.059	2.107MetThr: 2.107 ± 0.065	1.575MetVal: 1.575 ± 0.059	0.171MetTrp: 0.171 ± 0.019	0.586MetTyr: 0.586 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.077AsnAla: 3.077 ± 0.082	0.311AsnCys: 0.311 ± 0.026	2.648AsnAsp: 2.648 ± 0.079	2.589AsnGlu: 2.589 ± 0.076	2.307AsnPhe: 2.307 ± 0.075	3.353AsnGly: 3.353 ± 0.091	1.293AsnHis: 1.293 ± 0.05	3.567AsnIle: 3.567 ± 0.088	3.3AsnLys: 3.3 ± 0.08	4.807AsnLeu: 4.807 ± 0.102	1.191AsnMet: 1.191 ± 0.045	2.413AsnAsn: 2.413 ± 0.077	2.266AsnPro: 2.266 ± 0.061	2.432AsnGln: 2.432 ± 0.075	2.069AsnArg: 2.069 ± 0.074	2.919AsnSer: 2.919 ± 0.09	2.423AsnThr: 2.423 ± 0.07	2.797AsnVal: 2.797 ± 0.072	0.576AsnTrp: 0.576 ± 0.037	2.18AsnTyr: 2.18 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	2.214ProAla: 2.214 ± 0.075	0.15ProCys: 0.15 ± 0.015	1.984ProAsp: 1.984 ± 0.06	2.368ProGlu: 2.368 ± 0.06	1.722ProPhe: 1.722 ± 0.047	1.505ProGly: 1.505 ± 0.055	0.638ProHis: 0.638 ± 0.038	2.575ProIle: 2.575 ± 0.072	2.283ProLys: 2.283 ± 0.058	2.997ProLeu: 2.997 ± 0.068	0.681ProMet: 0.681 ± 0.036	1.728ProAsn: 1.728 ± 0.053	0.565ProPro: 0.565 ± 0.036	1.447ProGln: 1.447 ± 0.049	0.944ProArg: 0.944 ± 0.043	2.029ProSer: 2.029 ± 0.052	1.791ProThr: 1.791 ± 0.067	2.32ProVal: 2.32 ± 0.058	0.271ProTrp: 0.271 ± 0.02	1.352ProTyr: 1.352 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	3.464GlnAla: 3.464 ± 0.088	0.123GlnCys: 0.123 ± 0.016	2.008GlnAsp: 2.008 ± 0.064	3.234GlnGlu: 3.234 ± 0.075	1.747GlnPhe: 1.747 ± 0.056	2.252GlnGly: 2.252 ± 0.064	0.721GlnHis: 0.721 ± 0.036	3.149GlnIle: 3.149 ± 0.074	3.486GlnLys: 3.486 ± 0.08	4.157GlnLeu: 4.157 ± 0.086	1.018GlnMet: 1.018 ± 0.048	1.934GlnAsn: 1.934 ± 0.071	1.115GlnPro: 1.115 ± 0.05	1.545GlnGln: 1.545 ± 0.058	1.428GlnArg: 1.428 ± 0.053	2.219GlnSer: 2.219 ± 0.062	2.485GlnThr: 2.485 ± 0.085	3.006GlnVal: 3.006 ± 0.068	0.318GlnTrp: 0.318 ± 0.023	1.352GlnTyr: 1.352 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.425ArgAla: 2.425 ± 0.062	0.166ArgCys: 0.166 ± 0.017	2.261ArgAsp: 2.261 ± 0.068	2.684ArgGlu: 2.684 ± 0.073	2.022ArgPhe: 2.022 ± 0.057	2.136ArgGly: 2.136 ± 0.07	0.901ArgHis: 0.901 ± 0.042	2.916ArgIle: 2.916 ± 0.074	3.113ArgLys: 3.113 ± 0.082	4.134ArgLeu: 4.134 ± 0.103	0.997ArgMet: 0.997 ± 0.045	1.723ArgAsn: 1.723 ± 0.057	1.179ArgPro: 1.179 ± 0.054	2.041ArgGln: 2.041 ± 0.059	1.979ArgArg: 1.979 ± 0.063	2.097ArgSer: 2.097 ± 0.061	1.938ArgThr: 1.938 ± 0.062	2.562ArgVal: 2.562 ± 0.072	0.273ArgTrp: 0.273 ± 0.02	1.542ArgTyr: 1.542 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	3.994SerAla: 3.994 ± 0.098	0.337SerCys: 0.337 ± 0.027	3.6SerAsp: 3.6 ± 0.085	3.395SerGlu: 3.395 ± 0.08	3.341SerPhe: 3.341 ± 0.088	4.611SerGly: 4.611 ± 0.093	1.459SerHis: 1.459 ± 0.047	4.475SerIle: 4.475 ± 0.08	4.33SerLys: 4.33 ± 0.086	6.658SerLeu: 6.658 ± 0.108	1.397SerMet: 1.397 ± 0.047	3.068SerAsn: 3.068 ± 0.099	1.811SerPro: 1.811 ± 0.053	3.218SerGln: 3.218 ± 0.082	2.392SerArg: 2.392 ± 0.071	4.494SerSer: 4.494 ± 0.117	3.045SerThr: 3.045 ± 0.08	3.941SerVal: 3.941 ± 0.073	0.6SerTrp: 0.6 ± 0.033	2.669SerTyr: 2.669 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	4.509ThrAla: 4.509 ± 0.105	0.316ThrCys: 0.316 ± 0.024	3.237ThrAsp: 3.237 ± 0.081	3.144ThrGlu: 3.144 ± 0.069	2.715ThrPhe: 2.715 ± 0.07	3.927ThrGly: 3.927 ± 0.084	1.053ThrHis: 1.053 ± 0.039	4.675ThrIle: 4.675 ± 0.085	3.718ThrLys: 3.718 ± 0.087	5.486ThrLeu: 5.486 ± 0.1	1.137ThrMet: 1.137 ± 0.039	2.644ThrAsn: 2.644 ± 0.071	2.1ThrPro: 2.1 ± 0.069	1.977ThrGln: 1.977 ± 0.055	1.858ThrArg: 1.858 ± 0.056	3.557ThrSer: 3.557 ± 0.087	3.123ThrThr: 3.123 ± 0.092	4.257ThrVal: 4.257 ± 0.09	0.503ThrTrp: 0.503 ± 0.032	2.297ThrTyr: 2.297 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	5.311ValAla: 5.311 ± 0.102	0.458ValCys: 0.458 ± 0.03	3.732ValAsp: 3.732 ± 0.087	3.97ValGlu: 3.97 ± 0.096	2.982ValPhe: 2.982 ± 0.075	4.217ValGly: 4.217 ± 0.089	1.077ValHis: 1.077 ± 0.045	5.071ValIle: 5.071 ± 0.089	4.791ValLys: 4.791 ± 0.094	6.661ValLeu: 6.661 ± 0.103	1.618ValMet: 1.618 ± 0.054	3.151ValAsn: 3.151 ± 0.08	2.29ValPro: 2.29 ± 0.06	2.123ValGln: 2.123 ± 0.06	2.482ValArg: 2.482 ± 0.07	4.461ValSer: 4.461 ± 0.092	4.421ValThr: 4.421 ± 0.082	4.359ValVal: 4.359 ± 0.099	0.508ValTrp: 0.508 ± 0.035	2.302ValTyr: 2.302 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.506TrpAla: 0.506 ± 0.029	0.064TrpCys: 0.064 ± 0.012	0.423TrpAsp: 0.423 ± 0.027	0.494TrpGlu: 0.494 ± 0.03	0.465TrpPhe: 0.465 ± 0.033	0.598TrpGly: 0.598 ± 0.034	0.211TrpHis: 0.211 ± 0.019	0.595TrpIle: 0.595 ± 0.034	0.517TrpLys: 0.517 ± 0.031	1.047TrpLeu: 1.047 ± 0.041	0.232TrpMet: 0.232 ± 0.02	0.479TrpAsn: 0.479 ± 0.031	0.176TrpPro: 0.176 ± 0.018	0.517TrpGln: 0.517 ± 0.032	0.33TrpArg: 0.33 ± 0.026	0.581TrpSer: 0.581 ± 0.035	0.508TrpThr: 0.508 ± 0.029	0.503TrpVal: 0.503 ± 0.03	0.109TrpTrp: 0.109 ± 0.016	0.361TrpTyr: 0.361 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.529TyrAla: 2.529 ± 0.071	0.22TyrCys: 0.22 ± 0.02	2.515TyrAsp: 2.515 ± 0.063	2.199TyrGlu: 2.199 ± 0.065	2.064TyrPhe: 2.064 ± 0.067	2.449TyrGly: 2.449 ± 0.072	1.032TyrHis: 1.032 ± 0.04	2.624TyrIle: 2.624 ± 0.064	2.28TyrLys: 2.28 ± 0.063	4.209TyrLeu: 4.209 ± 0.089	0.819TyrMet: 0.819 ± 0.036	1.766TyrAsn: 1.766 ± 0.064	1.386TyrPro: 1.386 ± 0.047	2.164TyrGln: 2.164 ± 0.068	1.644TyrArg: 1.644 ± 0.059	2.294TyrSer: 2.294 ± 0.067	1.872TyrThr: 1.872 ± 0.058	2.135TyrVal: 2.135 ± 0.067	0.363TyrTrp: 0.363 ± 0.023	1.894TyrTyr: 1.894 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1953 proteins (578564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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