Amino acid dipepetide frequency for Bordetella sp. H567

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.002AlaAla: 19.002 ± 0.2
1.357AlaCys: 1.357 ± 0.031
7.073AlaAsp: 7.073 ± 0.071
6.018AlaGlu: 6.018 ± 0.083
3.918AlaPhe: 3.918 ± 0.05
11.813AlaGly: 11.813 ± 0.113
2.769AlaHis: 2.769 ± 0.042
5.77AlaIle: 5.77 ± 0.068
3.1AlaLys: 3.1 ± 0.053
14.524AlaLeu: 14.524 ± 0.13
3.88AlaMet: 3.88 ± 0.058
2.79AlaAsn: 2.79 ± 0.043
6.535AlaPro: 6.535 ± 0.089
5.313AlaGln: 5.313 ± 0.063
10.376AlaArg: 10.376 ± 0.109
6.482AlaSer: 6.482 ± 0.068
6.108AlaThr: 6.108 ± 0.07
9.402AlaVal: 9.402 ± 0.083
1.882AlaTrp: 1.882 ± 0.037
2.935AlaTyr: 2.935 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.247CysAla: 1.247 ± 0.028
0.12CysCys: 0.12 ± 0.01
0.53CysAsp: 0.53 ± 0.021
0.435CysGlu: 0.435 ± 0.018
0.281CysPhe: 0.281 ± 0.013
0.989CysGly: 0.989 ± 0.028
0.255CysHis: 0.255 ± 0.014
0.386CysIle: 0.386 ± 0.016
0.177CysLys: 0.177 ± 0.011
0.852CysLeu: 0.852 ± 0.024
0.23CysMet: 0.23 ± 0.012
0.223CysAsn: 0.223 ± 0.013
0.458CysPro: 0.458 ± 0.019
0.225CysGln: 0.225 ± 0.01
0.61CysArg: 0.61 ± 0.018
0.424CysSer: 0.424 ± 0.018
0.486CysThr: 0.486 ± 0.016
0.749CysVal: 0.749 ± 0.022
0.121CysTrp: 0.121 ± 0.008
0.242CysTyr: 0.242 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.654AspAla: 7.654 ± 0.093
0.476AspCys: 0.476 ± 0.017
2.904AspAsp: 2.904 ± 0.048
3.024AspGlu: 3.024 ± 0.047
2.064AspPhe: 2.064 ± 0.042
5.032AspGly: 5.032 ± 0.075
1.159AspHis: 1.159 ± 0.031
3.018AspIle: 3.018 ± 0.045
1.605AspLys: 1.605 ± 0.037
5.373AspLeu: 5.373 ± 0.055
1.453AspMet: 1.453 ± 0.03
1.248AspAsn: 1.248 ± 0.033
3.379AspPro: 3.379 ± 0.047
1.609AspGln: 1.609 ± 0.037
3.827AspArg: 3.827 ± 0.063
2.142AspSer: 2.142 ± 0.035
3.012AspThr: 3.012 ± 0.06
4.499AspVal: 4.499 ± 0.054
0.888AspTrp: 0.888 ± 0.025
1.551AspTyr: 1.551 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
5.982GluAla: 5.982 ± 0.08
0.403GluCys: 0.403 ± 0.018
2.295GluAsp: 2.295 ± 0.045
2.353GluGlu: 2.353 ± 0.047
1.605GluPhe: 1.605 ± 0.037
3.435GluGly: 3.435 ± 0.059
1.274GluHis: 1.274 ± 0.029
2.606GluIle: 2.606 ± 0.051
1.642GluLys: 1.642 ± 0.041
5.126GluLeu: 5.126 ± 0.065
1.245GluMet: 1.245 ± 0.031
1.357GluAsn: 1.357 ± 0.031
2.389GluPro: 2.389 ± 0.05
2.254GluGln: 2.254 ± 0.04
4.245GluArg: 4.245 ± 0.064
2.471GluSer: 2.471 ± 0.046
2.595GluThr: 2.595 ± 0.041
3.333GluVal: 3.333 ± 0.049
0.651GluTrp: 0.651 ± 0.022
1.166GluTyr: 1.166 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.877PheAla: 3.877 ± 0.059
0.366PheCys: 0.366 ± 0.015
2.381PheAsp: 2.381 ± 0.042
1.773PheGlu: 1.773 ± 0.033
1.248PhePhe: 1.248 ± 0.03
3.203PheGly: 3.203 ± 0.046
0.768PheHis: 0.768 ± 0.024
1.53PheIle: 1.53 ± 0.032
0.976PheLys: 0.976 ± 0.025
2.999PheLeu: 2.999 ± 0.048
0.809PheMet: 0.809 ± 0.024
0.996PheAsn: 0.996 ± 0.026
1.633PhePro: 1.633 ± 0.029
1.119PheGln: 1.119 ± 0.03
1.928PheArg: 1.928 ± 0.038
2.013PheSer: 2.013 ± 0.04
1.814PheThr: 1.814 ± 0.037
2.667PheVal: 2.667 ± 0.044
0.495PheTrp: 0.495 ± 0.018
0.815PheTyr: 0.815 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
9.978GlyAla: 9.978 ± 0.104
0.843GlyCys: 0.843 ± 0.024
4.243GlyAsp: 4.243 ± 0.056
4.023GlyGlu: 4.023 ± 0.06
3.106GlyPhe: 3.106 ± 0.048
7.412GlyGly: 7.412 ± 0.096
1.992GlyHis: 1.992 ± 0.039
4.357GlyIle: 4.357 ± 0.063
3.294GlyLys: 3.294 ± 0.054
8.846GlyLeu: 8.846 ± 0.097
2.707GlyMet: 2.707 ± 0.043
2.204GlyAsn: 2.204 ± 0.051
3.542GlyPro: 3.542 ± 0.054
3.395GlyGln: 3.395 ± 0.063
5.987GlyArg: 5.987 ± 0.078
4.519GlySer: 4.519 ± 0.062
4.916GlyThr: 4.916 ± 0.108
6.743GlyVal: 6.743 ± 0.069
1.413GlyTrp: 1.413 ± 0.039
2.659GlyTyr: 2.659 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
3.155HisAla: 3.155 ± 0.05
0.256HisCys: 0.256 ± 0.012
1.338HisAsp: 1.338 ± 0.031
1.04HisGlu: 1.04 ± 0.026
0.819HisPhe: 0.819 ± 0.026
2.344HisGly: 2.344 ± 0.045
0.57HisHis: 0.57 ± 0.02
1.107HisIle: 1.107 ± 0.028
0.497HisLys: 0.497 ± 0.021
2.028HisLeu: 2.028 ± 0.04
0.556HisMet: 0.556 ± 0.021
0.491HisAsn: 0.491 ± 0.02
1.616HisPro: 1.616 ± 0.038
0.635HisGln: 0.635 ± 0.022
1.53HisArg: 1.53 ± 0.03
0.911HisSer: 0.911 ± 0.029
1.105HisThr: 1.105 ± 0.027
1.769HisVal: 1.769 ± 0.035
0.339HisTrp: 0.339 ± 0.017
0.583HisTyr: 0.583 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.568IleAla: 6.568 ± 0.07
0.427IleCys: 0.427 ± 0.017
3.157IleAsp: 3.157 ± 0.043
2.721IleGlu: 2.721 ± 0.052
1.346IlePhe: 1.346 ± 0.033
4.393IleGly: 4.393 ± 0.06
0.91IleHis: 0.91 ± 0.025
1.777IleIle: 1.777 ± 0.04
1.439IleLys: 1.439 ± 0.034
3.974IleLeu: 3.974 ± 0.062
0.876IleMet: 0.876 ± 0.027
1.267IleAsn: 1.267 ± 0.029
2.397IlePro: 2.397 ± 0.035
1.381IleGln: 1.381 ± 0.029
2.902IleArg: 2.902 ± 0.043
2.446IleSer: 2.446 ± 0.043
2.355IleThr: 2.355 ± 0.053
4.1IleVal: 4.1 ± 0.053
0.519IleTrp: 0.519 ± 0.02
0.983IleTyr: 0.983 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.465LysAla: 3.465 ± 0.069
0.152LysCys: 0.152 ± 0.01
1.543LysAsp: 1.543 ± 0.037
1.28LysGlu: 1.28 ± 0.032
0.774LysPhe: 0.774 ± 0.026
2.148LysGly: 2.148 ± 0.041
0.538LysHis: 0.538 ± 0.02
1.218LysIle: 1.218 ± 0.031
0.994LysLys: 0.994 ± 0.034
3.096LysLeu: 3.096 ± 0.048
0.691LysMet: 0.691 ± 0.025
0.712LysAsn: 0.712 ± 0.021
1.812LysPro: 1.812 ± 0.041
1.153LysGln: 1.153 ± 0.029
2.056LysArg: 2.056 ± 0.04
1.526LysSer: 1.526 ± 0.037
1.676LysThr: 1.676 ± 0.041
2.287LysVal: 2.287 ± 0.046
0.39LysTrp: 0.39 ± 0.016
0.625LysTyr: 0.625 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.999LeuAla: 14.999 ± 0.122
1.045LeuCys: 1.045 ± 0.028
6.093LeuAsp: 6.093 ± 0.071
4.718LeuGlu: 4.718 ± 0.063
3.399LeuPhe: 3.399 ± 0.053
8.559LeuGly: 8.559 ± 0.097
2.313LeuHis: 2.313 ± 0.039
4.338LeuIle: 4.338 ± 0.065
2.971LeuLys: 2.971 ± 0.051
10.529LeuLeu: 10.529 ± 0.13
2.462LeuMet: 2.462 ± 0.043
2.633LeuAsn: 2.633 ± 0.045
6.23LeuPro: 6.23 ± 0.072
3.398LeuGln: 3.398 ± 0.054
8.186LeuArg: 8.186 ± 0.087
5.907LeuSer: 5.907 ± 0.063
5.228LeuThr: 5.228 ± 0.06
7.441LeuVal: 7.441 ± 0.081
1.199LeuTrp: 1.199 ± 0.029
2.278LeuTyr: 2.278 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.308MetAla: 3.308 ± 0.05
0.184MetCys: 0.184 ± 0.012
1.274MetAsp: 1.274 ± 0.033
1.117MetGlu: 1.117 ± 0.029
0.717MetPhe: 0.717 ± 0.023
1.911MetGly: 1.911 ± 0.037
0.611MetHis: 0.611 ± 0.02
1.059MetIle: 1.059 ± 0.029
0.916MetLys: 0.916 ± 0.025
2.888MetLeu: 2.888 ± 0.051
0.681MetMet: 0.681 ± 0.024
0.82MetAsn: 0.82 ± 0.023
1.707MetPro: 1.707 ± 0.033
1.047MetGln: 1.047 ± 0.026
2.033MetArg: 2.033 ± 0.036
1.606MetSer: 1.606 ± 0.029
1.603MetThr: 1.603 ± 0.032
1.81MetVal: 1.81 ± 0.034
0.204MetTrp: 0.204 ± 0.011
0.431MetTyr: 0.431 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.159AsnAla: 3.159 ± 0.052
0.212AsnCys: 0.212 ± 0.011
1.284AsnAsp: 1.284 ± 0.045
1.062AsnGlu: 1.062 ± 0.029
0.885AsnPhe: 0.885 ± 0.023
2.31AsnGly: 2.31 ± 0.061
0.506AsnHis: 0.506 ± 0.019
1.28AsnIle: 1.28 ± 0.035
0.726AsnLys: 0.726 ± 0.027
2.45AsnLeu: 2.45 ± 0.041
0.619AsnMet: 0.619 ± 0.022
0.707AsnAsn: 0.707 ± 0.03
1.83AsnPro: 1.83 ± 0.037
0.767AsnGln: 0.767 ± 0.025
1.702AsnArg: 1.702 ± 0.037
1.111AsnSer: 1.111 ± 0.029
1.401AsnThr: 1.401 ± 0.031
1.959AsnVal: 1.959 ± 0.038
0.371AsnTrp: 0.371 ± 0.018
0.651AsnTyr: 0.651 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.781ProAla: 7.781 ± 0.09
0.39ProCys: 0.39 ± 0.016
4.003ProAsp: 4.003 ± 0.048
3.193ProGlu: 3.193 ± 0.052
1.769ProPhe: 1.769 ± 0.036
5.28ProGly: 5.28 ± 0.066
1.305ProHis: 1.305 ± 0.028
2.148ProIle: 2.148 ± 0.039
1.26ProLys: 1.26 ± 0.034
5.313ProLeu: 5.313 ± 0.066
1.359ProMet: 1.359 ± 0.028
1.269ProAsn: 1.269 ± 0.032
3.055ProPro: 3.055 ± 0.049
1.885ProGln: 1.885 ± 0.036
3.568ProArg: 3.568 ± 0.054
2.866ProSer: 2.866 ± 0.045
2.599ProThr: 2.599 ± 0.042
4.457ProVal: 4.457 ± 0.054
0.814ProTrp: 0.814 ± 0.026
1.628ProTyr: 1.628 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
5.837GlnAla: 5.837 ± 0.07
0.261GlnCys: 0.261 ± 0.013
1.791GlnAsp: 1.791 ± 0.038
1.626GlnGlu: 1.626 ± 0.035
1.081GlnPhe: 1.081 ± 0.027
3.177GlnGly: 3.177 ± 0.048
0.826GlnHis: 0.826 ± 0.022
1.659GlnIle: 1.659 ± 0.037
0.88GlnLys: 0.88 ± 0.027
3.431GlnLeu: 3.431 ± 0.055
0.897GlnMet: 0.897 ± 0.026
0.803GlnAsn: 0.803 ± 0.031
2.139GlnPro: 2.139 ± 0.038
1.579GlnGln: 1.579 ± 0.04
2.935GlnArg: 2.935 ± 0.046
1.737GlnSer: 1.737 ± 0.034
1.742GlnThr: 1.742 ± 0.037
2.787GlnVal: 2.787 ± 0.041
0.586GlnTrp: 0.586 ± 0.02
0.788GlnTyr: 0.788 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.903ArgAla: 8.903 ± 0.09
0.581ArgCys: 0.581 ± 0.023
4.363ArgAsp: 4.363 ± 0.054
4.205ArgGlu: 4.205 ± 0.065
2.629ArgPhe: 2.629 ± 0.044
5.208ArgGly: 5.208 ± 0.066
1.985ArgHis: 1.985 ± 0.041
3.914ArgIle: 3.914 ± 0.051
2.137ArgLys: 2.137 ± 0.038
8.145ArgLeu: 8.145 ± 0.105
2.131ArgMet: 2.131 ± 0.037
1.868ArgAsn: 1.868 ± 0.029
3.738ArgPro: 3.738 ± 0.053
3.044ArgGln: 3.044 ± 0.055
5.854ArgArg: 5.854 ± 0.074
3.073ArgSer: 3.073 ± 0.047
3.433ArgThr: 3.433 ± 0.049
5.374ArgVal: 5.374 ± 0.06
1.068ArgTrp: 1.068 ± 0.031
2.148ArgTyr: 2.148 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.041SerAla: 6.041 ± 0.062
0.427SerCys: 0.427 ± 0.018
2.452SerAsp: 2.452 ± 0.044
2.11SerGlu: 2.11 ± 0.041
1.853SerPhe: 1.853 ± 0.036
5.132SerGly: 5.132 ± 0.069
1.189SerHis: 1.189 ± 0.026
2.355SerIle: 2.355 ± 0.042
1.26SerLys: 1.26 ± 0.03
5.394SerLeu: 5.394 ± 0.066
1.399SerMet: 1.399 ± 0.03
1.329SerAsn: 1.329 ± 0.032
2.937SerPro: 2.937 ± 0.047
1.709SerGln: 1.709 ± 0.036
3.714SerArg: 3.714 ± 0.058
2.891SerSer: 2.891 ± 0.047
2.769SerThr: 2.769 ± 0.044
3.959SerVal: 3.959 ± 0.05
0.734SerTrp: 0.734 ± 0.021
1.276SerTyr: 1.276 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.924ThrAla: 5.924 ± 0.065
0.363ThrCys: 0.363 ± 0.015
2.646ThrAsp: 2.646 ± 0.05
2.185ThrGlu: 2.185 ± 0.046
1.694ThrPhe: 1.694 ± 0.039
4.797ThrGly: 4.797 ± 0.077
1.196ThrHis: 1.196 ± 0.03
2.372ThrIle: 2.372 ± 0.064
0.913ThrLys: 0.913 ± 0.027
6.435ThrLeu: 6.435 ± 0.072
1.166ThrMet: 1.166 ± 0.026
1.139ThrAsn: 1.139 ± 0.042
3.802ThrPro: 3.802 ± 0.058
1.792ThrGln: 1.792 ± 0.039
3.601ThrArg: 3.601 ± 0.057
2.653ThrSer: 2.653 ± 0.05
2.581ThrThr: 2.581 ± 0.055
4.491ThrVal: 4.491 ± 0.081
0.71ThrTrp: 0.71 ± 0.023
1.13ThrTyr: 1.13 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
9.795ValAla: 9.795 ± 0.089
0.766ValCys: 0.766 ± 0.024
4.451ValAsp: 4.451 ± 0.058
3.803ValGlu: 3.803 ± 0.058
2.768ValPhe: 2.768 ± 0.046
5.73ValGly: 5.73 ± 0.07
1.636ValHis: 1.636 ± 0.03
3.467ValIle: 3.467 ± 0.046
2.225ValLys: 2.225 ± 0.046
8.245ValLeu: 8.245 ± 0.093
1.879ValMet: 1.879 ± 0.037
2.11ValAsn: 2.11 ± 0.042
4.509ValPro: 4.509 ± 0.056
2.8ValGln: 2.8 ± 0.056
5.523ValArg: 5.523 ± 0.062
4.254ValSer: 4.254 ± 0.051
3.932ValThr: 3.932 ± 0.077
6.455ValVal: 6.455 ± 0.076
0.929ValTrp: 0.929 ± 0.025
1.769ValTyr: 1.769 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.292TrpAla: 1.292 ± 0.034
0.132TrpCys: 0.132 ± 0.009
0.632TrpAsp: 0.632 ± 0.02
0.542TrpGlu: 0.542 ± 0.02
0.521TrpPhe: 0.521 ± 0.017
0.968TrpGly: 0.968 ± 0.03
0.395TrpHis: 0.395 ± 0.015
0.663TrpIle: 0.663 ± 0.023
0.405TrpLys: 0.405 ± 0.016
1.862TrpLeu: 1.862 ± 0.038
0.413TrpMet: 0.413 ± 0.017
0.449TrpAsn: 0.449 ± 0.017
0.741TrpPro: 0.741 ± 0.022
0.628TrpGln: 0.628 ± 0.018
1.306TrpArg: 1.306 ± 0.031
0.74TrpSer: 0.74 ± 0.022
0.733TrpThr: 0.733 ± 0.028
0.91TrpVal: 0.91 ± 0.03
0.208TrpTrp: 0.208 ± 0.011
0.332TrpTyr: 0.332 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.081TyrAla: 3.081 ± 0.051
0.277TyrCys: 0.277 ± 0.013
1.464TyrAsp: 1.464 ± 0.034
1.199TyrGlu: 1.199 ± 0.034
0.935TyrPhe: 0.935 ± 0.024
2.338TyrGly: 2.338 ± 0.038
0.492TyrHis: 0.492 ± 0.02
0.913TyrIle: 0.913 ± 0.025
0.717TyrLys: 0.717 ± 0.021
2.417TyrLeu: 2.417 ± 0.041
0.476TyrMet: 0.476 ± 0.017
0.58TyrAsn: 0.58 ± 0.02
1.489TyrPro: 1.489 ± 0.032
0.831TyrGln: 0.831 ± 0.022
1.917TyrArg: 1.917 ± 0.04
1.157TyrSer: 1.157 ± 0.028
1.5TyrThr: 1.5 ± 0.033
1.855TyrVal: 1.855 ± 0.036
0.354TyrTrp: 0.354 ± 0.013
0.636TyrTyr: 0.636 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4617 proteins (1532342 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski