Amino acid dipepetide frequency for Plasmodium knowlesi (strain H)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.915AlaAla: 1.915 ± 0.04	0.874AlaCys: 0.874 ± 0.021	2.208AlaAsp: 2.208 ± 0.026	2.741AlaGlu: 2.741 ± 0.037	1.578AlaPhe: 1.578 ± 0.022	2.013AlaGly: 2.013 ± 0.033	1.165AlaHis: 1.165 ± 0.017	2.194AlaIle: 2.194 ± 0.026	3.573AlaLys: 3.573 ± 0.039	3.291AlaLeu: 3.291 ± 0.037	0.85AlaMet: 0.85 ± 0.015	3.084AlaAsn: 3.084 ± 0.037	1.592AlaPro: 1.592 ± 0.029	1.587AlaGln: 1.587 ± 0.024	1.413AlaArg: 1.413 ± 0.022	3.225AlaSer: 3.225 ± 0.038	2.262AlaThr: 2.262 ± 0.034	1.835AlaVal: 1.835 ± 0.026	0.239AlaTrp: 0.239 ± 0.008	1.569AlaTyr: 1.569 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.031CysAla: 1.031 ± 0.019	0.316CysCys: 0.316 ± 0.009	1.113CysAsp: 1.113 ± 0.019	1.273CysGlu: 1.273 ± 0.022	0.958CysPhe: 0.958 ± 0.017	0.921CysGly: 0.921 ± 0.016	0.4CysHis: 0.4 ± 0.01	1.439CysIle: 1.439 ± 0.02	1.694CysLys: 1.694 ± 0.032	1.789CysLeu: 1.789 ± 0.023	0.404CysMet: 0.404 ± 0.01	1.484CysAsn: 1.484 ± 0.025	0.673CysPro: 0.673 ± 0.018	0.585CysGln: 0.585 ± 0.016	0.768CysArg: 0.768 ± 0.016	1.686CysSer: 1.686 ± 0.023	1.189CysThr: 1.189 ± 0.02	1.224CysVal: 1.224 ± 0.02	0.09CysTrp: 0.09 ± 0.005	0.696CysTyr: 0.696 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.676AspAla: 2.676 ± 0.032	0.763AspCys: 0.763 ± 0.015	4.779AspAsp: 4.779 ± 0.078	5.595AspGlu: 5.595 ± 0.059	2.144AspPhe: 2.144 ± 0.025	3.499AspGly: 3.499 ± 0.047	1.436AspHis: 1.436 ± 0.021	4.246AspIle: 4.246 ± 0.041	4.812AspLys: 4.812 ± 0.055	4.106AspLeu: 4.106 ± 0.038	1.412AspMet: 1.412 ± 0.02	4.199AspAsn: 4.199 ± 0.044	1.595AspPro: 1.595 ± 0.023	1.756AspGln: 1.756 ± 0.029	2.246AspArg: 2.246 ± 0.044	3.956AspSer: 3.956 ± 0.038	2.704AspThr: 2.704 ± 0.027	3.366AspVal: 3.366 ± 0.037	0.302AspTrp: 0.302 ± 0.01	2.186AspTyr: 2.186 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	2.926GluAla: 2.926 ± 0.044	1.21GluCys: 1.21 ± 0.022	5.12GluAsp: 5.12 ± 0.058	9.842GluGlu: 9.842 ± 0.142	2.116GluPhe: 2.116 ± 0.025	4.801GluGly: 4.801 ± 0.054	1.719GluHis: 1.719 ± 0.023	4.415GluIle: 4.415 ± 0.045	9.279GluLys: 9.279 ± 0.077	5.046GluLeu: 5.046 ± 0.051	1.844GluMet: 1.844 ± 0.023	6.511GluAsn: 6.511 ± 0.056	1.51GluPro: 1.51 ± 0.03	2.955GluGln: 2.955 ± 0.037	3.721GluArg: 3.721 ± 0.05	4.479GluSer: 4.479 ± 0.043	2.739GluThr: 2.739 ± 0.03	3.861GluVal: 3.861 ± 0.088	0.535GluTrp: 0.535 ± 0.013	2.619GluTyr: 2.619 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	1.418PheAla: 1.418 ± 0.019	1.018PheCys: 1.018 ± 0.017	2.3PheAsp: 2.3 ± 0.026	2.394PheGlu: 2.394 ± 0.029	3.236PhePhe: 3.236 ± 0.056	1.662PheGly: 1.662 ± 0.025	1.168PheHis: 1.168 ± 0.018	3.016PheIle: 3.016 ± 0.041	3.096PheLys: 3.096 ± 0.035	5.197PheLeu: 5.197 ± 0.059	0.946PheMet: 0.946 ± 0.016	2.943PheAsn: 2.943 ± 0.034	1.372PhePro: 1.372 ± 0.02	1.272PheGln: 1.272 ± 0.022	1.541PheArg: 1.541 ± 0.022	3.608PheSer: 3.608 ± 0.038	1.82PheThr: 1.82 ± 0.023	2.353PheVal: 2.353 ± 0.033	0.375PheTrp: 0.375 ± 0.01	2.319PheTyr: 2.319 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	2.634GlyAla: 2.634 ± 0.038	0.906GlyCys: 0.906 ± 0.019	3.643GlyAsp: 3.643 ± 0.041	5.156GlyGlu: 5.156 ± 0.061	1.42GlyPhe: 1.42 ± 0.024	5.568GlyGly: 5.568 ± 0.088	1.207GlyHis: 1.207 ± 0.021	3.035GlyIle: 3.035 ± 0.031	5.521GlyLys: 5.521 ± 0.048	2.856GlyLeu: 2.856 ± 0.033	1.22GlyMet: 1.22 ± 0.025	4.591GlyAsn: 4.591 ± 0.064	1.283GlyPro: 1.283 ± 0.025	1.582GlyGln: 1.582 ± 0.028	2.919GlyArg: 2.919 ± 0.037	4.804GlySer: 4.804 ± 0.067	3.087GlyThr: 3.087 ± 0.037	3.082GlyVal: 3.082 ± 0.038	0.281GlyTrp: 0.281 ± 0.01	1.644GlyTyr: 1.644 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.098HisAla: 1.098 ± 0.019	0.454HisCys: 0.454 ± 0.012	1.196HisAsp: 1.196 ± 0.019	1.437HisGlu: 1.437 ± 0.02	1.462HisPhe: 1.462 ± 0.022	1.332HisGly: 1.332 ± 0.021	0.861HisHis: 0.861 ± 0.021	1.89HisIle: 1.89 ± 0.021	1.714HisLys: 1.714 ± 0.024	2.644HisLeu: 2.644 ± 0.03	0.817HisMet: 0.817 ± 0.015	1.684HisAsn: 1.684 ± 0.028	1.034HisPro: 1.034 ± 0.019	0.806HisGln: 0.806 ± 0.016	1.128HisArg: 1.128 ± 0.023	1.997HisSer: 1.997 ± 0.028	1.308HisThr: 1.308 ± 0.023	1.658HisVal: 1.658 ± 0.025	0.161HisTrp: 0.161 ± 0.006	0.965HisTyr: 0.965 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	2.055IleAla: 2.055 ± 0.026	1.548IleCys: 1.548 ± 0.024	3.374IleAsp: 3.374 ± 0.039	3.95IleGlu: 3.95 ± 0.046	3.606IlePhe: 3.606 ± 0.051	2.687IleGly: 2.687 ± 0.032	1.799IleHis: 1.799 ± 0.022	4.661IleIle: 4.661 ± 0.05	6.128IleLys: 6.128 ± 0.051	6.336IleLeu: 6.336 ± 0.065	1.261IleMet: 1.261 ± 0.021	5.422IleAsn: 5.422 ± 0.047	2.309IlePro: 2.309 ± 0.028	2.082IleGln: 2.082 ± 0.026	2.551IleArg: 2.551 ± 0.027	5.09IleSer: 5.09 ± 0.042	2.921IleThr: 2.921 ± 0.029	2.913IleVal: 2.913 ± 0.032	0.416IleTrp: 0.416 ± 0.012	3.28IleTyr: 3.28 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	3.142LysAla: 3.142 ± 0.044	1.878LysCys: 1.878 ± 0.025	5.091LysAsp: 5.091 ± 0.05	8.915LysGlu: 8.915 ± 0.099	2.976LysPhe: 2.976 ± 0.036	5.523LysGly: 5.523 ± 0.053	1.967LysHis: 1.967 ± 0.024	6.524LysIle: 6.524 ± 0.052	13.8LysLys: 13.8 ± 0.111	6.72LysLeu: 6.72 ± 0.057	2.509LysMet: 2.509 ± 0.028	9.194LysAsn: 9.194 ± 0.077	1.664LysPro: 1.664 ± 0.028	2.779LysGln: 2.779 ± 0.031	5.115LysArg: 5.115 ± 0.053	5.739LysSer: 5.739 ± 0.049	3.925LysThr: 3.925 ± 0.037	4.213LysVal: 4.213 ± 0.035	0.908LysTrp: 0.908 ± 0.019	4.397LysTyr: 4.397 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	2.719LeuAla: 2.719 ± 0.03	2.049LeuCys: 2.049 ± 0.026	3.816LeuAsp: 3.816 ± 0.034	4.635LeuGlu: 4.635 ± 0.049	4.638LeuPhe: 4.638 ± 0.06	3.231LeuGly: 3.231 ± 0.038	2.413LeuHis: 2.413 ± 0.03	5.065LeuIle: 5.065 ± 0.052	8.102LeuLys: 8.102 ± 0.061	8.334LeuLeu: 8.334 ± 0.088	1.706LeuMet: 1.706 ± 0.021	6.603LeuAsn: 6.603 ± 0.05	2.711LeuPro: 2.711 ± 0.035	2.942LeuGln: 2.942 ± 0.032	3.688LeuArg: 3.688 ± 0.04	6.844LeuSer: 6.844 ± 0.05	3.63LeuThr: 3.63 ± 0.035	3.443LeuVal: 3.443 ± 0.038	0.655LeuTrp: 0.655 ± 0.014	3.839LeuTyr: 3.839 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	0.895MetAla: 0.895 ± 0.016	0.49MetCys: 0.49 ± 0.012	1.514MetAsp: 1.514 ± 0.02	2.103MetGlu: 2.103 ± 0.03	0.834MetPhe: 0.834 ± 0.015	1.308MetGly: 1.308 ± 0.024	0.664MetHis: 0.664 ± 0.015	1.078MetIle: 1.078 ± 0.016	2.583MetLys: 2.583 ± 0.029	1.66MetLeu: 1.66 ± 0.023	0.573MetMet: 0.573 ± 0.014	2.459MetAsn: 2.459 ± 0.037	0.605MetPro: 0.605 ± 0.016	0.848MetGln: 0.848 ± 0.017	1.015MetArg: 1.015 ± 0.019	1.644MetSer: 1.644 ± 0.026	0.849MetThr: 0.849 ± 0.015	0.966MetVal: 0.966 ± 0.018	0.158MetTrp: 0.158 ± 0.007	0.997MetTyr: 0.997 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.414AsnAla: 3.414 ± 0.043	1.516AsnCys: 1.516 ± 0.025	4.94AsnAsp: 4.94 ± 0.048	6.446AsnGlu: 6.446 ± 0.059	3.882AsnPhe: 3.882 ± 0.043	5.138AsnGly: 5.138 ± 0.077	1.866AsnHis: 1.866 ± 0.029	6.11AsnIle: 6.11 ± 0.063	6.899AsnLys: 6.899 ± 0.048	6.439AsnLeu: 6.439 ± 0.061	2.086AsnMet: 2.086 ± 0.031	6.946AsnAsn: 6.946 ± 0.102	2.256AsnPro: 2.256 ± 0.032	2.343AsnGln: 2.343 ± 0.033	3.325AsnArg: 3.325 ± 0.034	6.238AsnSer: 6.238 ± 0.076	3.658AsnThr: 3.658 ± 0.038	4.968AsnVal: 4.968 ± 0.043	0.496AsnTrp: 0.496 ± 0.012	3.875AsnTyr: 3.875 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	1.023ProAla: 1.023 ± 0.021	0.7ProCys: 0.7 ± 0.019	1.257ProAsp: 1.257 ± 0.02	1.612ProGlu: 1.612 ± 0.025	1.573ProPhe: 1.573 ± 0.022	1.387ProGly: 1.387 ± 0.026	0.977ProHis: 0.977 ± 0.02	1.779ProIle: 1.779 ± 0.023	2.053ProLys: 2.053 ± 0.03	2.797ProLeu: 2.797 ± 0.031	0.711ProMet: 0.711 ± 0.016	2.362ProAsn: 2.362 ± 0.034	1.886ProPro: 1.886 ± 0.043	1.154ProGln: 1.154 ± 0.02	1.248ProArg: 1.248 ± 0.023	3.062ProSer: 3.062 ± 0.031	1.744ProThr: 1.744 ± 0.027	1.54ProVal: 1.54 ± 0.035	0.23ProTrp: 0.23 ± 0.008	1.223ProTyr: 1.223 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	1.147GlnAla: 1.147 ± 0.019	0.664GlnCys: 0.664 ± 0.016	1.455GlnAsp: 1.455 ± 0.022	2.387GlnGlu: 2.387 ± 0.033	1.131GlnPhe: 1.131 ± 0.019	1.908GlnGly: 1.908 ± 0.031	0.779GlnHis: 0.779 ± 0.016	2.171GlnIle: 2.171 ± 0.026	3.313GlnLys: 3.313 ± 0.037	2.555GlnLeu: 2.555 ± 0.03	1.125GlnMet: 1.125 ± 0.02	3.048GlnAsn: 3.048 ± 0.035	0.891GlnPro: 0.891 ± 0.021	1.192GlnGln: 1.192 ± 0.027	1.635GlnArg: 1.635 ± 0.023	2.254GlnSer: 2.254 ± 0.028	1.607GlnThr: 1.607 ± 0.024	1.831GlnVal: 1.831 ± 0.026	0.282GlnTrp: 0.282 ± 0.008	1.085GlnTyr: 1.085 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	1.599ArgAla: 1.599 ± 0.021	0.787ArgCys: 0.787 ± 0.016	2.391ArgAsp: 2.391 ± 0.035	3.544ArgGlu: 3.544 ± 0.043	1.277ArgPhe: 1.277 ± 0.019	3.057ArgGly: 3.057 ± 0.037	1.014ArgHis: 1.014 ± 0.019	2.673ArgIle: 2.673 ± 0.027	5.523ArgLys: 5.523 ± 0.051	2.589ArgLeu: 2.589 ± 0.039	1.03ArgMet: 1.03 ± 0.021	4.007ArgAsn: 4.007 ± 0.048	0.87ArgPro: 0.87 ± 0.016	1.273ArgGln: 1.273 ± 0.018	3.504ArgArg: 3.504 ± 0.056	3.636ArgSer: 3.636 ± 0.043	2.172ArgThr: 2.172 ± 0.033	2.012ArgVal: 2.012 ± 0.028	0.314ArgTrp: 0.314 ± 0.009	1.502ArgTyr: 1.502 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	3.506SerAla: 3.506 ± 0.042	1.485SerCys: 1.485 ± 0.02	4.388SerAsp: 4.388 ± 0.043	4.844SerGlu: 4.844 ± 0.045	3.598SerPhe: 3.598 ± 0.033	4.9SerGly: 4.9 ± 0.062	1.956SerHis: 1.956 ± 0.028	4.807SerIle: 4.807 ± 0.041	5.852SerLys: 5.852 ± 0.049	6.021SerLeu: 6.021 ± 0.048	1.582SerMet: 1.582 ± 0.023	6.175SerAsn: 6.175 ± 0.071	2.72SerPro: 2.72 ± 0.031	2.181SerGln: 2.181 ± 0.025	3.225SerArg: 3.225 ± 0.046	8.277SerSer: 8.277 ± 0.079	4.405SerThr: 4.405 ± 0.041	4.101SerVal: 4.101 ± 0.036	0.453SerTrp: 0.453 ± 0.011	3.152SerTyr: 3.152 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	1.875ThrAla: 1.875 ± 0.03	1.013ThrCys: 1.013 ± 0.016	2.666ThrAsp: 2.666 ± 0.032	3.137ThrGlu: 3.137 ± 0.038	2.073ThrPhe: 2.073 ± 0.026	2.41ThrGly: 2.41 ± 0.031	1.444ThrHis: 1.444 ± 0.021	2.751ThrIle: 2.751 ± 0.031	3.914ThrLys: 3.914 ± 0.039	3.926ThrLeu: 3.926 ± 0.047	1.007ThrMet: 1.007 ± 0.019	4.143ThrAsn: 4.143 ± 0.043	2.109ThrPro: 2.109 ± 0.026	1.743ThrGln: 1.743 ± 0.024	1.693ThrArg: 1.693 ± 0.025	3.956ThrSer: 3.956 ± 0.039	2.85ThrThr: 2.85 ± 0.049	2.288ThrVal: 2.288 ± 0.025	0.384ThrTrp: 0.384 ± 0.011	2.008ThrTyr: 2.008 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	2.075ValAla: 2.075 ± 0.029	1.118ValCys: 1.118 ± 0.021	3.427ValAsp: 3.427 ± 0.033	3.954ValGlu: 3.954 ± 0.049	1.895ValPhe: 1.895 ± 0.026	2.833ValGly: 2.833 ± 0.036	1.636ValHis: 1.636 ± 0.024	2.909ValIle: 2.909 ± 0.03	4.986ValLys: 4.986 ± 0.084	4.184ValLeu: 4.184 ± 0.044	0.957ValMet: 0.957 ± 0.018	4.079ValAsn: 4.079 ± 0.041	1.874ValPro: 1.874 ± 0.025	2.055ValGln: 2.055 ± 0.025	2.092ValArg: 2.092 ± 0.03	3.7ValSer: 3.7 ± 0.038	2.294ValThr: 2.294 ± 0.025	2.683ValVal: 2.683 ± 0.041	0.298ValTrp: 0.298 ± 0.01	2.105ValTyr: 2.105 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	0.235TrpAla: 0.235 ± 0.007	0.175TrpCys: 0.175 ± 0.007	0.449TrpAsp: 0.449 ± 0.012	0.502TrpGlu: 0.502 ± 0.014	0.284TrpPhe: 0.284 ± 0.009	0.426TrpGly: 0.426 ± 0.011	0.123TrpHis: 0.123 ± 0.005	0.413TrpIle: 0.413 ± 0.013	0.831TrpLys: 0.831 ± 0.017	0.514TrpLeu: 0.514 ± 0.012	0.17TrpMet: 0.17 ± 0.008	0.648TrpAsn: 0.648 ± 0.013	0.145TrpPro: 0.145 ± 0.006	0.167TrpGln: 0.167 ± 0.007	0.342TrpArg: 0.342 ± 0.01	0.484TrpSer: 0.484 ± 0.013	0.331TrpThr: 0.331 ± 0.01	0.37TrpVal: 0.37 ± 0.01	0.057TrpTrp: 0.057 ± 0.004	0.213TrpTyr: 0.213 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.827TyrAla: 1.827 ± 0.023	0.763TyrCys: 0.763 ± 0.015	2.649TyrAsp: 2.649 ± 0.035	2.783TyrGlu: 2.783 ± 0.031	2.373TyrPhe: 2.373 ± 0.035	1.835TyrGly: 1.835 ± 0.025	1.051TyrHis: 1.051 ± 0.019	3.212TyrIle: 3.212 ± 0.039	3.306TyrLys: 3.306 ± 0.035	4.059TyrLeu: 4.059 ± 0.045	1.034TyrMet: 1.034 ± 0.019	3.259TyrAsn: 3.259 ± 0.041	1.221TyrPro: 1.221 ± 0.021	1.156TyrGln: 1.156 ± 0.016	1.607TyrArg: 1.607 ± 0.022	2.949TyrSer: 2.949 ± 0.03	1.897TyrThr: 1.897 ± 0.029	2.447TyrVal: 2.447 ± 0.028	0.244TyrTrp: 0.244 ± 0.008	2.096TyrTyr: 2.096 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5339 proteins (3890322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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