Amino acid dipepetide frequency for Selaginella moellendorffii (Spikemoss)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.694AlaAla: 9.694 ± 0.042	1.706AlaCys: 1.706 ± 0.013	3.517AlaAsp: 3.517 ± 0.017	4.785AlaGlu: 4.785 ± 0.024	3.309AlaPhe: 3.309 ± 0.018	5.697AlaGly: 5.697 ± 0.026	1.587AlaHis: 1.587 ± 0.011	4.103AlaIle: 4.103 ± 0.018	4.217AlaLys: 4.217 ± 0.019	8.644AlaLeu: 8.644 ± 0.032	2.359AlaMet: 2.359 ± 0.018	2.521AlaAsn: 2.521 ± 0.015	3.558AlaPro: 3.558 ± 0.02	2.771AlaGln: 2.771 ± 0.015	5.209AlaArg: 5.209 ± 0.023	6.764AlaSer: 6.764 ± 0.029	4.387AlaThr: 4.387 ± 0.021	6.058AlaVal: 6.058 ± 0.033	1.167AlaTrp: 1.167 ± 0.009	2.119AlaTyr: 2.119 ± 0.014	0.0AlaXaa: 0.0 ± 0.0
Cys	1.248CysAla: 1.248 ± 0.01	0.58CysCys: 0.58 ± 0.008	0.886CysAsp: 0.886 ± 0.007	0.912CysGlu: 0.912 ± 0.008	0.838CysPhe: 0.838 ± 0.007	1.608CysGly: 1.608 ± 0.013	0.478CysHis: 0.478 ± 0.007	0.887CysIle: 0.887 ± 0.008	1.155CysLys: 1.155 ± 0.011	1.86CysLeu: 1.86 ± 0.014	0.445CysMet: 0.445 ± 0.006	0.681CysAsn: 0.681 ± 0.008	0.94CysPro: 0.94 ± 0.009	0.631CysGln: 0.631 ± 0.008	1.143CysArg: 1.143 ± 0.009	1.819CysSer: 1.819 ± 0.012	0.846CysThr: 0.846 ± 0.008	1.262CysVal: 1.262 ± 0.011	0.299CysTrp: 0.299 ± 0.006	0.531CysTyr: 0.531 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.361AspAla: 4.361 ± 0.019	0.952AspCys: 0.952 ± 0.009	3.298AspAsp: 3.298 ± 0.022	4.006AspGlu: 4.006 ± 0.021	2.364AspPhe: 2.364 ± 0.015	3.994AspGly: 3.994 ± 0.018	1.288AspHis: 1.288 ± 0.011	2.448AspIle: 2.448 ± 0.015	2.617AspLys: 2.617 ± 0.015	5.212AspLeu: 5.212 ± 0.023	1.202AspMet: 1.202 ± 0.009	1.623AspAsn: 1.623 ± 0.012	2.724AspPro: 2.724 ± 0.017	1.653AspGln: 1.653 ± 0.012	2.882AspArg: 2.882 ± 0.017	3.679AspSer: 3.679 ± 0.019	2.241AspThr: 2.241 ± 0.014	3.875AspVal: 3.875 ± 0.017	0.782AspTrp: 0.782 ± 0.007	1.53AspTyr: 1.53 ± 0.012	0.0AspXaa: 0.0 ± 0.0
Glu	5.785GluAla: 5.785 ± 0.028	0.948GluCys: 0.948 ± 0.009	3.74GluAsp: 3.74 ± 0.021	6.199GluGlu: 6.199 ± 0.048	2.394GluPhe: 2.394 ± 0.013	3.581GluGly: 3.581 ± 0.019	1.427GluHis: 1.427 ± 0.01	3.332GluIle: 3.332 ± 0.019	3.951GluLys: 3.951 ± 0.024	6.692GluLeu: 6.692 ± 0.027	1.677GluMet: 1.677 ± 0.013	2.358GluAsn: 2.358 ± 0.016	2.171GluPro: 2.171 ± 0.026	2.565GluGln: 2.565 ± 0.017	3.974GluArg: 3.974 ± 0.018	4.154GluSer: 4.154 ± 0.021	2.81GluThr: 2.81 ± 0.016	4.244GluVal: 4.244 ± 0.028	0.851GluTrp: 0.851 ± 0.008	1.433GluTyr: 1.433 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	3.01PheAla: 3.01 ± 0.018	0.835PheCys: 0.835 ± 0.009	2.338PheAsp: 2.338 ± 0.014	2.208PheGlu: 2.208 ± 0.015	1.975PhePhe: 1.975 ± 0.014	2.967PheGly: 2.967 ± 0.018	1.129PheHis: 1.129 ± 0.009	1.69PheIle: 1.69 ± 0.013	1.898PheLys: 1.898 ± 0.012	4.359PheLeu: 4.359 ± 0.02	0.911PheMet: 0.911 ± 0.009	1.365PheAsn: 1.365 ± 0.01	1.9PhePro: 1.9 ± 0.014	1.733PheGln: 1.733 ± 0.012	2.149PheArg: 2.149 ± 0.013	3.48PheSer: 3.48 ± 0.016	1.971PheThr: 1.971 ± 0.013	3.117PheVal: 3.117 ± 0.016	0.615PheTrp: 0.615 ± 0.008	1.308PheTyr: 1.308 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	5.05GlyAla: 5.05 ± 0.024	1.372GlyCys: 1.372 ± 0.011	3.813GlyAsp: 3.813 ± 0.019	3.737GlyGlu: 3.737 ± 0.021	3.057GlyPhe: 3.057 ± 0.015	6.0GlyGly: 6.0 ± 0.036	1.691GlyHis: 1.691 ± 0.012	3.594GlyIle: 3.594 ± 0.015	3.89GlyLys: 3.89 ± 0.019	6.252GlyLeu: 6.252 ± 0.024	1.658GlyMet: 1.658 ± 0.011	2.633GlyAsn: 2.633 ± 0.017	2.376GlyPro: 2.376 ± 0.015	2.19GlyGln: 2.19 ± 0.015	4.255GlyArg: 4.255 ± 0.018	5.812GlySer: 5.812 ± 0.024	3.418GlyThr: 3.418 ± 0.016	4.645GlyVal: 4.645 ± 0.022	1.014GlyTrp: 1.014 ± 0.01	2.008GlyTyr: 2.008 ± 0.014	0.0GlyXaa: 0.0 ± 0.0
His	1.774HisAla: 1.774 ± 0.012	0.555HisCys: 0.555 ± 0.007	1.19HisAsp: 1.19 ± 0.01	1.34HisGlu: 1.34 ± 0.015	1.021HisPhe: 1.021 ± 0.009	1.922HisGly: 1.922 ± 0.015	0.955HisHis: 0.955 ± 0.012	1.08HisIle: 1.08 ± 0.01	1.159HisLys: 1.159 ± 0.01	2.367HisLeu: 2.367 ± 0.014	0.458HisMet: 0.458 ± 0.006	0.778HisAsn: 0.778 ± 0.009	1.34HisPro: 1.34 ± 0.01	0.951HisGln: 0.951 ± 0.009	1.628HisArg: 1.628 ± 0.013	1.886HisSer: 1.886 ± 0.015	1.046HisThr: 1.046 ± 0.009	1.46HisVal: 1.46 ± 0.012	0.371HisTrp: 0.371 ± 0.006	0.734HisTyr: 0.734 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	4.058IleAla: 4.058 ± 0.017	0.908IleCys: 0.908 ± 0.009	2.599IleAsp: 2.599 ± 0.015	2.669IleGlu: 2.669 ± 0.017	2.031IlePhe: 2.031 ± 0.015	3.001IleGly: 3.001 ± 0.018	1.322IleHis: 1.322 ± 0.009	2.077IleIle: 2.077 ± 0.013	2.333IleLys: 2.333 ± 0.017	4.751IleLeu: 4.751 ± 0.022	0.926IleMet: 0.926 ± 0.008	1.585IleAsn: 1.585 ± 0.011	2.615IlePro: 2.615 ± 0.018	2.019IleGln: 2.019 ± 0.014	2.495IleArg: 2.495 ± 0.016	3.803IleSer: 3.803 ± 0.019	2.417IleThr: 2.417 ± 0.013	3.538IleVal: 3.538 ± 0.018	0.622IleTrp: 0.622 ± 0.007	1.284IleTyr: 1.284 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	4.311LysAla: 4.311 ± 0.018	0.909LysCys: 0.909 ± 0.01	2.889LysAsp: 2.889 ± 0.016	3.884LysGlu: 3.884 ± 0.024	1.959LysPhe: 1.959 ± 0.013	2.941LysGly: 2.941 ± 0.016	1.25LysHis: 1.25 ± 0.011	2.581LysIle: 2.581 ± 0.014	3.608LysLys: 3.608 ± 0.027	5.774LysLeu: 5.774 ± 0.023	1.282LysMet: 1.282 ± 0.01	2.111LysAsn: 2.111 ± 0.013	2.345LysPro: 2.345 ± 0.016	2.168LysGln: 2.168 ± 0.013	3.519LysArg: 3.519 ± 0.017	3.876LysSer: 3.876 ± 0.019	2.465LysThr: 2.465 ± 0.014	3.57LysVal: 3.57 ± 0.023	0.703LysTrp: 0.703 ± 0.007	1.368LysTyr: 1.368 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	8.51LeuAla: 8.51 ± 0.03	1.946LeuCys: 1.946 ± 0.016	5.674LeuAsp: 5.674 ± 0.024	7.292LeuGlu: 7.292 ± 0.026	3.884LeuPhe: 3.884 ± 0.02	6.583LeuGly: 6.583 ± 0.025	2.667LeuHis: 2.667 ± 0.017	3.927LeuIle: 3.927 ± 0.017	5.363LeuLys: 5.363 ± 0.024	11.057LeuLeu: 11.057 ± 0.041	2.062LeuMet: 2.062 ± 0.012	2.989LeuAsn: 2.989 ± 0.017	5.052LeuPro: 5.052 ± 0.022	4.684LeuGln: 4.684 ± 0.022	6.089LeuArg: 6.089 ± 0.023	7.832LeuSer: 7.832 ± 0.028	4.299LeuThr: 4.299 ± 0.022	7.467LeuVal: 7.467 ± 0.027	1.382LeuTrp: 1.382 ± 0.012	2.564LeuTyr: 2.564 ± 0.014	0.0LeuXaa: 0.0 ± 0.0
Met	2.364MetAla: 2.364 ± 0.014	0.324MetCys: 0.324 ± 0.005	1.47MetAsp: 1.47 ± 0.011	1.957MetGlu: 1.957 ± 0.013	0.795MetPhe: 0.795 ± 0.007	1.371MetGly: 1.371 ± 0.011	0.51MetHis: 0.51 ± 0.008	1.207MetIle: 1.207 ± 0.009	1.298MetLys: 1.298 ± 0.011	2.402MetLeu: 2.402 ± 0.014	0.531MetMet: 0.531 ± 0.006	0.707MetAsn: 0.707 ± 0.006	1.247MetPro: 1.247 ± 0.012	0.915MetGln: 0.915 ± 0.009	1.334MetArg: 1.334 ± 0.009	1.459MetSer: 1.459 ± 0.01	1.016MetThr: 1.016 ± 0.01	1.777MetVal: 1.777 ± 0.012	0.267MetTrp: 0.267 ± 0.005	0.624MetTyr: 0.624 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.968AsnAla: 2.968 ± 0.013	0.66AsnCys: 0.66 ± 0.008	1.52AsnAsp: 1.52 ± 0.012	1.86AsnGlu: 1.86 ± 0.013	1.559AsnPhe: 1.559 ± 0.011	2.575AsnGly: 2.575 ± 0.016	0.778AsnHis: 0.778 ± 0.008	1.718AsnIle: 1.718 ± 0.013	1.671AsnLys: 1.671 ± 0.012	3.649AsnLeu: 3.649 ± 0.02	0.822AsnMet: 0.822 ± 0.008	1.331AsnAsn: 1.331 ± 0.012	1.855AsnPro: 1.855 ± 0.013	1.181AsnGln: 1.181 ± 0.01	1.786AsnArg: 1.786 ± 0.013	2.744AsnSer: 2.744 ± 0.017	1.677AsnThr: 1.677 ± 0.012	2.551AsnVal: 2.551 ± 0.017	0.506AsnTrp: 0.506 ± 0.007	0.956AsnTyr: 0.956 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.024ProAla: 4.024 ± 0.024	0.79ProCys: 0.79 ± 0.009	2.727ProAsp: 2.727 ± 0.016	3.263ProGlu: 3.263 ± 0.024	1.833ProPhe: 1.833 ± 0.014	3.475ProGly: 3.475 ± 0.022	0.996ProHis: 0.996 ± 0.009	1.795ProIle: 1.795 ± 0.012	2.197ProLys: 2.197 ± 0.016	4.241ProLeu: 4.241 ± 0.02	0.879ProMet: 0.879 ± 0.009	1.587ProAsn: 1.587 ± 0.011	3.953ProPro: 3.953 ± 0.058	1.743ProGln: 1.743 ± 0.016	2.87ProArg: 2.87 ± 0.016	4.468ProSer: 4.468 ± 0.022	2.171ProThr: 2.171 ± 0.014	3.324ProVal: 3.324 ± 0.022	0.726ProTrp: 0.726 ± 0.008	1.194ProTyr: 1.194 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	3.406GlnAla: 3.406 ± 0.018	0.667GlnCys: 0.667 ± 0.007	1.851GlnAsp: 1.851 ± 0.012	2.852GlnGlu: 2.852 ± 0.02	1.23GlnPhe: 1.23 ± 0.01	2.499GlnGly: 2.499 ± 0.015	1.107GlnHis: 1.107 ± 0.01	1.694GlnIle: 1.694 ± 0.013	1.888GlnLys: 1.888 ± 0.013	3.842GlnLeu: 3.842 ± 0.02	0.9GlnMet: 0.9 ± 0.009	1.305GlnAsn: 1.305 ± 0.01	1.645GlnPro: 1.645 ± 0.015	2.595GlnGln: 2.595 ± 0.032	2.634GlnArg: 2.634 ± 0.014	2.548GlnSer: 2.548 ± 0.015	1.561GlnThr: 1.561 ± 0.013	2.575GlnVal: 2.575 ± 0.016	0.531GlnTrp: 0.531 ± 0.007	0.842GlnTyr: 0.842 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	4.636ArgAla: 4.636 ± 0.021	1.159ArgCys: 1.159 ± 0.01	3.306ArgAsp: 3.306 ± 0.017	3.887ArgGlu: 3.887 ± 0.02	2.362ArgPhe: 2.362 ± 0.015	3.789ArgGly: 3.789 ± 0.021	1.468ArgHis: 1.468 ± 0.012	3.083ArgIle: 3.083 ± 0.018	3.651ArgLys: 3.651 ± 0.022	6.036ArgLeu: 6.036 ± 0.026	1.593ArgMet: 1.593 ± 0.011	2.245ArgAsn: 2.245 ± 0.016	2.64ArgPro: 2.64 ± 0.015	2.242ArgGln: 2.242 ± 0.015	4.402ArgArg: 4.402 ± 0.024	4.667ArgSer: 4.667 ± 0.022	2.567ArgThr: 2.567 ± 0.014	3.843ArgVal: 3.843 ± 0.017	0.882ArgTrp: 0.882 ± 0.008	1.561ArgTyr: 1.561 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	5.697SerAla: 5.697 ± 0.022	1.711SerCys: 1.711 ± 0.014	3.736SerAsp: 3.736 ± 0.017	3.941SerGlu: 3.941 ± 0.02	3.498SerPhe: 3.498 ± 0.019	5.776SerGly: 5.776 ± 0.026	1.768SerHis: 1.768 ± 0.013	3.921SerIle: 3.921 ± 0.016	4.27SerLys: 4.27 ± 0.017	8.052SerLeu: 8.052 ± 0.03	1.998SerMet: 1.998 ± 0.012	2.803SerAsn: 2.803 ± 0.016	4.171SerPro: 4.171 ± 0.027	2.784SerGln: 2.784 ± 0.013	4.871SerArg: 4.871 ± 0.02	9.7SerSer: 9.7 ± 0.047	4.222SerThr: 4.222 ± 0.022	4.865SerVal: 4.865 ± 0.019	1.445SerTrp: 1.445 ± 0.012	2.067SerTyr: 2.067 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	4.119ThrAla: 4.119 ± 0.021	0.846ThrCys: 0.846 ± 0.008	2.085ThrAsp: 2.085 ± 0.014	2.359ThrGlu: 2.359 ± 0.015	2.061ThrPhe: 2.061 ± 0.014	3.652ThrGly: 3.652 ± 0.019	0.949ThrHis: 0.949 ± 0.01	2.53ThrIle: 2.53 ± 0.016	2.391ThrLys: 2.391 ± 0.016	4.782ThrLeu: 4.782 ± 0.02	1.224ThrMet: 1.224 ± 0.009	1.585ThrAsn: 1.585 ± 0.013	2.557ThrPro: 2.557 ± 0.017	1.491ThrGln: 1.491 ± 0.012	2.645ThrArg: 2.645 ± 0.015	4.108ThrSer: 4.108 ± 0.021	2.817ThrThr: 2.817 ± 0.017	3.468ThrVal: 3.468 ± 0.016	0.74ThrTrp: 0.74 ± 0.008	1.338ThrTyr: 1.338 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	6.206ValAla: 6.206 ± 0.027	1.33ValCys: 1.33 ± 0.01	3.881ValAsp: 3.881 ± 0.019	4.802ValGlu: 4.802 ± 0.038	3.032ValPhe: 3.032 ± 0.016	4.135ValGly: 4.135 ± 0.021	1.623ValHis: 1.623 ± 0.012	3.262ValIle: 3.262 ± 0.018	3.544ValLys: 3.544 ± 0.018	7.375ValLeu: 7.375 ± 0.028	1.585ValMet: 1.585 ± 0.012	2.128ValAsn: 2.128 ± 0.014	3.489ValPro: 3.489 ± 0.034	2.399ValGln: 2.399 ± 0.014	3.612ValArg: 3.612 ± 0.019	5.296ValSer: 5.296 ± 0.018	3.599ValThr: 3.599 ± 0.018	5.536ValVal: 5.536 ± 0.025	0.953ValTrp: 0.953 ± 0.01	1.981ValTyr: 1.981 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.866TrpAla: 0.866 ± 0.009	0.257TrpCys: 0.257 ± 0.005	0.765TrpAsp: 0.765 ± 0.008	0.85TrpGlu: 0.85 ± 0.008	0.535TrpPhe: 0.535 ± 0.008	0.804TrpGly: 0.804 ± 0.009	0.345TrpHis: 0.345 ± 0.005	0.844TrpIle: 0.844 ± 0.008	0.987TrpLys: 0.987 ± 0.01	1.395TrpLeu: 1.395 ± 0.011	0.412TrpMet: 0.412 ± 0.005	0.887TrpAsn: 0.887 ± 0.01	0.582TrpPro: 0.582 ± 0.007	0.563TrpGln: 0.563 ± 0.006	0.994TrpArg: 0.994 ± 0.009	1.205TrpSer: 1.205 ± 0.009	0.866TrpThr: 0.866 ± 0.009	0.729TrpVal: 0.729 ± 0.008	0.278TrpTrp: 0.278 ± 0.005	0.381TrpTyr: 0.381 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.088TyrAla: 2.088 ± 0.014	0.596TyrCys: 0.596 ± 0.007	1.446TyrAsp: 1.446 ± 0.011	1.484TyrGlu: 1.484 ± 0.012	1.219TyrPhe: 1.219 ± 0.011	2.097TyrGly: 2.097 ± 0.015	0.678TyrHis: 0.678 ± 0.007	1.282TyrIle: 1.282 ± 0.01	1.426TyrLys: 1.426 ± 0.017	2.58TyrLeu: 2.58 ± 0.014	0.649TyrMet: 0.649 ± 0.007	1.145TyrAsn: 1.145 ± 0.01	1.097TyrPro: 1.097 ± 0.011	0.891TyrGln: 0.891 ± 0.008	1.528TyrArg: 1.528 ± 0.011	1.995TyrSer: 1.995 ± 0.013	1.348TyrThr: 1.348 ± 0.011	1.864TyrVal: 1.864 ± 0.011	0.41TyrTrp: 0.41 ± 0.005	0.867TyrTyr: 0.867 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 33150 proteins (13328660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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