Amino acid dipepetide frequency for Balneola sp. EhC07

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.222AlaAla: 4.222 ± 0.08	0.446AlaCys: 0.446 ± 0.023	3.689AlaAsp: 3.689 ± 0.065	4.494AlaGlu: 4.494 ± 0.077	3.293AlaPhe: 3.293 ± 0.063	4.654AlaGly: 4.654 ± 0.09	1.043AlaHis: 1.043 ± 0.035	4.615AlaIle: 4.615 ± 0.086	3.939AlaLys: 3.939 ± 0.078	6.203AlaLeu: 6.203 ± 0.105	1.442AlaMet: 1.442 ± 0.043	2.969AlaAsn: 2.969 ± 0.057	1.966AlaPro: 1.966 ± 0.047	2.422AlaGln: 2.422 ± 0.049	2.343AlaArg: 2.343 ± 0.054	4.518AlaSer: 4.518 ± 0.087	3.512AlaThr: 3.512 ± 0.077	4.308AlaVal: 4.308 ± 0.077	0.689AlaTrp: 0.689 ± 0.025	2.289AlaTyr: 2.289 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.384CysAla: 0.384 ± 0.022	0.082CysCys: 0.082 ± 0.009	0.363CysAsp: 0.363 ± 0.018	0.357CysGlu: 0.357 ± 0.019	0.336CysPhe: 0.336 ± 0.018	0.497CysGly: 0.497 ± 0.026	0.143CysHis: 0.143 ± 0.013	0.441CysIle: 0.441 ± 0.02	0.303CysLys: 0.303 ± 0.018	0.509CysLeu: 0.509 ± 0.023	0.102CysMet: 0.102 ± 0.01	0.239CysAsn: 0.239 ± 0.016	0.237CysPro: 0.237 ± 0.018	0.134CysGln: 0.134 ± 0.013	0.197CysArg: 0.197 ± 0.013	0.529CysSer: 0.529 ± 0.023	0.326CysThr: 0.326 ± 0.017	0.36CysVal: 0.36 ± 0.02	0.054CysTrp: 0.054 ± 0.007	0.199CysTyr: 0.199 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.62AspAla: 3.62 ± 0.068	0.3AspCys: 0.3 ± 0.019	3.26AspAsp: 3.26 ± 0.073	4.759AspGlu: 4.759 ± 0.07	3.497AspPhe: 3.497 ± 0.059	4.415AspGly: 4.415 ± 0.098	1.138AspHis: 1.138 ± 0.033	4.479AspIle: 4.479 ± 0.075	3.52AspLys: 3.52 ± 0.073	5.908AspLeu: 5.908 ± 0.076	1.221AspMet: 1.221 ± 0.038	2.761AspAsn: 2.761 ± 0.066	2.536AspPro: 2.536 ± 0.053	2.16AspGln: 2.16 ± 0.048	2.441AspArg: 2.441 ± 0.053	4.444AspSer: 4.444 ± 0.073	2.823AspThr: 2.823 ± 0.067	3.808AspVal: 3.808 ± 0.073	0.879AspTrp: 0.879 ± 0.036	2.369AspTyr: 2.369 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.792GluAla: 4.792 ± 0.082	0.328GluCys: 0.328 ± 0.019	4.165GluAsp: 4.165 ± 0.069	6.229GluGlu: 6.229 ± 0.12	3.593GluPhe: 3.593 ± 0.056	4.348GluGly: 4.348 ± 0.065	1.265GluHis: 1.265 ± 0.04	5.916GluIle: 5.916 ± 0.078	5.305GluLys: 5.305 ± 0.103	7.522GluLeu: 7.522 ± 0.106	1.812GluMet: 1.812 ± 0.049	4.495GluAsn: 4.495 ± 0.066	1.984GluPro: 1.984 ± 0.043	2.639GluGln: 2.639 ± 0.058	3.042GluArg: 3.042 ± 0.058	4.476GluSer: 4.476 ± 0.066	3.761GluThr: 3.761 ± 0.062	4.933GluVal: 4.933 ± 0.066	0.846GluTrp: 0.846 ± 0.029	2.74GluTyr: 2.74 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	2.991PheAla: 2.991 ± 0.055	0.353PheCys: 0.353 ± 0.02	3.583PheAsp: 3.583 ± 0.06	3.868PheGlu: 3.868 ± 0.069	2.606PhePhe: 2.606 ± 0.061	3.98PheGly: 3.98 ± 0.064	0.774PheHis: 0.774 ± 0.027	3.661PheIle: 3.661 ± 0.063	3.092PheLys: 3.092 ± 0.063	4.654PheLeu: 4.654 ± 0.088	1.076PheMet: 1.076 ± 0.036	2.836PheAsn: 2.836 ± 0.074	1.632PhePro: 1.632 ± 0.036	1.513PheGln: 1.513 ± 0.042	1.966PheArg: 1.966 ± 0.041	4.43PheSer: 4.43 ± 0.079	3.022PheThr: 3.022 ± 0.053	3.097PheVal: 3.097 ± 0.055	0.667PheTrp: 0.667 ± 0.026	1.922PheTyr: 1.922 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.434GlyAla: 4.434 ± 0.075	0.486GlyCys: 0.486 ± 0.022	3.852GlyAsp: 3.852 ± 0.081	4.275GlyGlu: 4.275 ± 0.065	4.013GlyPhe: 4.013 ± 0.068	4.98GlyGly: 4.98 ± 0.114	1.078GlyHis: 1.078 ± 0.037	5.739GlyIle: 5.739 ± 0.08	4.331GlyLys: 4.331 ± 0.075	6.46GlyLeu: 6.46 ± 0.098	1.739GlyMet: 1.739 ± 0.048	3.691GlyAsn: 3.691 ± 0.084	1.492GlyPro: 1.492 ± 0.04	1.848GlyGln: 1.848 ± 0.049	2.496GlyArg: 2.496 ± 0.051	5.07GlySer: 5.07 ± 0.088	4.335GlyThr: 4.335 ± 0.116	4.67GlyVal: 4.67 ± 0.063	0.903GlyTrp: 0.903 ± 0.037	2.768GlyTyr: 2.768 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.966HisAla: 0.966 ± 0.03	0.136HisCys: 0.136 ± 0.013	0.9HisAsp: 0.9 ± 0.03	1.061HisGlu: 1.061 ± 0.034	1.008HisPhe: 1.008 ± 0.038	1.076HisGly: 1.076 ± 0.035	0.44HisHis: 0.44 ± 0.022	1.234HisIle: 1.234 ± 0.04	0.98HisLys: 0.98 ± 0.03	1.659HisLeu: 1.659 ± 0.047	0.311HisMet: 0.311 ± 0.017	0.749HisAsn: 0.749 ± 0.028	0.941HisPro: 0.941 ± 0.032	0.613HisGln: 0.613 ± 0.026	0.744HisArg: 0.744 ± 0.029	1.209HisSer: 1.209 ± 0.042	0.892HisThr: 0.892 ± 0.024	0.948HisVal: 0.948 ± 0.03	0.225HisTrp: 0.225 ± 0.013	0.679HisTyr: 0.679 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.127IleAla: 5.127 ± 0.083	0.521IleCys: 0.521 ± 0.023	4.911IleAsp: 4.911 ± 0.072	5.857IleGlu: 5.857 ± 0.085	3.388IlePhe: 3.388 ± 0.067	5.187IleGly: 5.187 ± 0.088	1.327IleHis: 1.327 ± 0.044	5.205IleIle: 5.205 ± 0.092	4.637IleLys: 4.637 ± 0.076	6.493IleLeu: 6.493 ± 0.111	1.319IleMet: 1.319 ± 0.035	4.032IleAsn: 4.032 ± 0.062	3.308IlePro: 3.308 ± 0.065	2.607IleGln: 2.607 ± 0.053	3.05IleArg: 3.05 ± 0.057	6.277IleSer: 6.277 ± 0.088	4.61IleThr: 4.61 ± 0.081	4.32IleVal: 4.32 ± 0.072	0.779IleTrp: 0.779 ± 0.035	2.485IleTyr: 2.485 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.445LysAla: 4.445 ± 0.08	0.217LysCys: 0.217 ± 0.014	3.823LysAsp: 3.823 ± 0.062	5.947LysGlu: 5.947 ± 0.103	2.491LysPhe: 2.491 ± 0.052	3.757LysGly: 3.757 ± 0.07	1.071LysHis: 1.071 ± 0.032	4.708LysIle: 4.708 ± 0.078	5.487LysLys: 5.487 ± 0.11	5.684LysLeu: 5.684 ± 0.084	1.654LysMet: 1.654 ± 0.04	3.845LysAsn: 3.845 ± 0.073	2.203LysPro: 2.203 ± 0.053	2.107LysGln: 2.107 ± 0.053	2.68LysArg: 2.68 ± 0.056	4.135LysSer: 4.135 ± 0.07	3.631LysThr: 3.631 ± 0.065	4.2LysVal: 4.2 ± 0.06	0.697LysTrp: 0.697 ± 0.027	2.329LysTyr: 2.329 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	5.829LeuAla: 5.829 ± 0.099	0.584LeuCys: 0.584 ± 0.021	5.462LeuAsp: 5.462 ± 0.07	6.636LeuGlu: 6.636 ± 0.094	4.801LeuPhe: 4.801 ± 0.087	5.92LeuGly: 5.92 ± 0.075	1.46LeuHis: 1.46 ± 0.041	7.37LeuIle: 7.37 ± 0.119	6.549LeuLys: 6.549 ± 0.09	8.298LeuLeu: 8.298 ± 0.137	2.037LeuMet: 2.037 ± 0.046	5.373LeuAsn: 5.373 ± 0.079	3.451LeuPro: 3.451 ± 0.061	2.763LeuGln: 2.763 ± 0.055	3.658LeuArg: 3.658 ± 0.066	7.413LeuSer: 7.413 ± 0.097	5.141LeuThr: 5.141 ± 0.08	5.686LeuVal: 5.686 ± 0.081	0.853LeuTrp: 0.853 ± 0.031	2.981LeuTyr: 2.981 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.488MetAla: 1.488 ± 0.039	0.108MetCys: 0.108 ± 0.009	1.261MetAsp: 1.261 ± 0.04	1.418MetGlu: 1.418 ± 0.04	0.897MetPhe: 0.897 ± 0.058	1.419MetGly: 1.419 ± 0.044	0.351MetHis: 0.351 ± 0.017	1.707MetIle: 1.707 ± 0.042	1.997MetLys: 1.997 ± 0.046	1.852MetLeu: 1.852 ± 0.049	0.603MetMet: 0.603 ± 0.026	1.423MetAsn: 1.423 ± 0.038	0.849MetPro: 0.849 ± 0.029	0.684MetGln: 0.684 ± 0.027	0.853MetArg: 0.853 ± 0.028	1.561MetSer: 1.561 ± 0.042	1.08MetThr: 1.08 ± 0.031	1.329MetVal: 1.329 ± 0.039	0.168MetTrp: 0.168 ± 0.012	0.646MetTyr: 0.646 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.291AsnAla: 3.291 ± 0.065	0.293AsnCys: 0.293 ± 0.018	3.032AsnAsp: 3.032 ± 0.063	3.974AsnGlu: 3.974 ± 0.07	2.682AsnPhe: 2.682 ± 0.063	3.999AsnGly: 3.999 ± 0.076	0.902AsnHis: 0.902 ± 0.032	4.024AsnIle: 4.024 ± 0.067	3.204AsnLys: 3.204 ± 0.055	4.745AsnLeu: 4.745 ± 0.065	1.177AsnMet: 1.177 ± 0.04	2.947AsnAsn: 2.947 ± 0.074	2.749AsnPro: 2.749 ± 0.059	1.968AsnGln: 1.968 ± 0.047	2.323AsnArg: 2.323 ± 0.051	4.172AsnSer: 4.172 ± 0.082	3.05AsnThr: 3.05 ± 0.071	3.1AsnVal: 3.1 ± 0.055	0.745AsnTrp: 0.745 ± 0.034	2.287AsnTyr: 2.287 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.064ProAla: 2.064 ± 0.043	0.178ProCys: 0.178 ± 0.012	2.701ProAsp: 2.701 ± 0.057	3.364ProGlu: 3.364 ± 0.063	2.065ProPhe: 2.065 ± 0.049	2.408ProGly: 2.408 ± 0.05	0.606ProHis: 0.606 ± 0.026	2.515ProIle: 2.515 ± 0.049	2.152ProLys: 2.152 ± 0.046	2.882ProLeu: 2.882 ± 0.059	0.689ProMet: 0.689 ± 0.027	1.99ProAsn: 1.99 ± 0.043	1.0ProPro: 1.0 ± 0.035	1.039ProGln: 1.039 ± 0.034	1.11ProArg: 1.11 ± 0.031	2.466ProSer: 2.466 ± 0.053	1.897ProThr: 1.897 ± 0.047	2.776ProVal: 2.776 ± 0.049	0.361ProTrp: 0.361 ± 0.019	1.315ProTyr: 1.315 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.095GlnAla: 2.095 ± 0.047	0.105GlnCys: 0.105 ± 0.008	1.86GlnAsp: 1.86 ± 0.048	2.445GlnGlu: 2.445 ± 0.056	1.62GlnPhe: 1.62 ± 0.036	1.835GlnGly: 1.835 ± 0.041	0.53GlnHis: 0.53 ± 0.023	2.69GlnIle: 2.69 ± 0.053	2.474GlnLys: 2.474 ± 0.057	3.03GlnLeu: 3.03 ± 0.056	0.691GlnMet: 0.691 ± 0.025	2.092GlnAsn: 2.092 ± 0.045	1.073GlnPro: 1.073 ± 0.031	1.34GlnGln: 1.34 ± 0.041	1.369GlnArg: 1.369 ± 0.038	2.237GlnSer: 2.237 ± 0.047	1.942GlnThr: 1.942 ± 0.041	2.031GlnVal: 2.031 ± 0.044	0.333GlnTrp: 0.333 ± 0.023	1.082GlnTyr: 1.082 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.382ArgAla: 2.382 ± 0.055	0.172ArgCys: 0.172 ± 0.011	2.161ArgAsp: 2.161 ± 0.052	2.675ArgGlu: 2.675 ± 0.057	2.274ArgPhe: 2.274 ± 0.054	2.247ArgGly: 2.247 ± 0.052	0.633ArgHis: 0.633 ± 0.029	3.189ArgIle: 3.189 ± 0.062	2.692ArgLys: 2.692 ± 0.061	3.579ArgLeu: 3.579 ± 0.062	1.018ArgMet: 1.018 ± 0.032	2.232ArgAsn: 2.232 ± 0.049	1.293ArgPro: 1.293 ± 0.036	1.175ArgGln: 1.175 ± 0.039	1.679ArgArg: 1.679 ± 0.05	2.829ArgSer: 2.829 ± 0.049	2.171ArgThr: 2.171 ± 0.043	2.612ArgVal: 2.612 ± 0.059	0.426ArgTrp: 0.426 ± 0.02	1.637ArgTyr: 1.637 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	4.382SerAla: 4.382 ± 0.075	0.441SerCys: 0.441 ± 0.019	4.738SerAsp: 4.738 ± 0.083	5.379SerGlu: 5.379 ± 0.077	4.22SerPhe: 4.22 ± 0.076	6.062SerGly: 6.062 ± 0.129	1.107SerHis: 1.107 ± 0.039	5.662SerIle: 5.662 ± 0.088	4.528SerLys: 4.528 ± 0.071	6.819SerLeu: 6.819 ± 0.094	1.446SerMet: 1.446 ± 0.037	3.935SerAsn: 3.935 ± 0.084	2.44SerPro: 2.44 ± 0.049	2.14SerGln: 2.14 ± 0.046	2.708SerArg: 2.708 ± 0.052	5.907SerSer: 5.907 ± 0.129	4.14SerThr: 4.14 ± 0.073	4.976SerVal: 4.976 ± 0.085	0.854SerTrp: 0.854 ± 0.033	2.818SerTyr: 2.818 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	3.506ThrAla: 3.506 ± 0.083	0.282ThrCys: 0.282 ± 0.018	3.479ThrAsp: 3.479 ± 0.076	3.74ThrGlu: 3.74 ± 0.058	2.952ThrPhe: 2.952 ± 0.066	4.48ThrGly: 4.48 ± 0.097	0.906ThrHis: 0.906 ± 0.033	4.385ThrIle: 4.385 ± 0.073	3.208ThrLys: 3.208 ± 0.055	5.257ThrLeu: 5.257 ± 0.079	1.025ThrMet: 1.025 ± 0.03	2.977ThrAsn: 2.977 ± 0.075	2.359ThrPro: 2.359 ± 0.053	1.802ThrGln: 1.802 ± 0.046	1.843ThrArg: 1.843 ± 0.04	4.171ThrSer: 4.171 ± 0.082	3.223ThrThr: 3.223 ± 0.08	3.78ThrVal: 3.78 ± 0.088	0.608ThrTrp: 0.608 ± 0.023	2.014ThrTyr: 2.014 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.18ValAla: 4.18 ± 0.072	0.451ValCys: 0.451 ± 0.022	3.986ValAsp: 3.986 ± 0.066	4.517ValGlu: 4.517 ± 0.07	3.303ValPhe: 3.303 ± 0.056	4.188ValGly: 4.188 ± 0.076	1.082ValHis: 1.082 ± 0.029	4.8ValIle: 4.8 ± 0.073	3.756ValLys: 3.756 ± 0.059	6.108ValLeu: 6.108 ± 0.086	1.353ValMet: 1.353 ± 0.038	3.337ValAsn: 3.337 ± 0.058	2.293ValPro: 2.293 ± 0.046	2.166ValGln: 2.166 ± 0.048	2.421ValArg: 2.421 ± 0.054	5.011ValSer: 5.011 ± 0.086	3.745ValThr: 3.745 ± 0.087	4.184ValVal: 4.184 ± 0.071	0.72ValTrp: 0.72 ± 0.029	2.261ValTyr: 2.261 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.699TrpAla: 0.699 ± 0.027	0.07TrpCys: 0.07 ± 0.008	0.792TrpAsp: 0.792 ± 0.048	0.776TrpGlu: 0.776 ± 0.027	0.583TrpPhe: 0.583 ± 0.028	0.75TrpGly: 0.75 ± 0.026	0.211TrpHis: 0.211 ± 0.013	0.857TrpIle: 0.857 ± 0.029	0.742TrpLys: 0.742 ± 0.027	1.053TrpLeu: 1.053 ± 0.036	0.328TrpMet: 0.328 ± 0.019	0.771TrpAsn: 0.771 ± 0.032	0.286TrpPro: 0.286 ± 0.018	0.333TrpGln: 0.333 ± 0.017	0.466TrpArg: 0.466 ± 0.026	0.749TrpSer: 0.749 ± 0.031	0.618TrpThr: 0.618 ± 0.027	0.756TrpVal: 0.756 ± 0.032	0.167TrpTrp: 0.167 ± 0.013	0.456TrpTyr: 0.456 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.162TyrAla: 2.162 ± 0.042	0.24TyrCys: 0.24 ± 0.017	2.32TyrAsp: 2.32 ± 0.059	2.426TyrGlu: 2.426 ± 0.057	2.102TyrPhe: 2.102 ± 0.051	2.457TyrGly: 2.457 ± 0.048	0.704TyrHis: 0.704 ± 0.027	2.245TyrIle: 2.245 ± 0.048	2.212TyrLys: 2.212 ± 0.04	3.554TyrLeu: 3.554 ± 0.055	0.651TyrMet: 0.651 ± 0.024	1.969TyrAsn: 1.969 ± 0.047	1.484TyrPro: 1.484 ± 0.041	1.419TyrGln: 1.419 ± 0.034	1.688TyrArg: 1.688 ± 0.04	3.093TyrSer: 3.093 ± 0.069	2.076TyrThr: 2.076 ± 0.052	1.986TyrVal: 1.986 ± 0.045	0.489TyrTrp: 0.489 ± 0.022	1.477TyrTyr: 1.477 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3097 proteins (1091554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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