Amino acid dipepetide frequency for Brevefilum fermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.637AlaAla: 7.637 ± 0.146
0.948AlaCys: 0.948 ± 0.042
4.497AlaAsp: 4.497 ± 0.078
5.674AlaGlu: 5.674 ± 0.103
3.681AlaPhe: 3.681 ± 0.071
6.52AlaGly: 6.52 ± 0.103
1.854AlaHis: 1.854 ± 0.048
5.876AlaIle: 5.876 ± 0.105
3.069AlaLys: 3.069 ± 0.062
9.896AlaLeu: 9.896 ± 0.14
2.055AlaMet: 2.055 ± 0.05
2.672AlaAsn: 2.672 ± 0.054
3.253AlaPro: 3.253 ± 0.085
3.318AlaGln: 3.318 ± 0.067
4.663AlaArg: 4.663 ± 0.09
4.491AlaSer: 4.491 ± 0.079
3.74AlaThr: 3.74 ± 0.089
5.874AlaVal: 5.874 ± 0.104
1.254AlaTrp: 1.254 ± 0.047
2.797AlaTyr: 2.797 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.64CysAla: 0.64 ± 0.028
0.106CysCys: 0.106 ± 0.014
0.506CysAsp: 0.506 ± 0.025
0.516CysGlu: 0.516 ± 0.026
0.351CysPhe: 0.351 ± 0.023
0.857CysGly: 0.857 ± 0.036
0.229CysHis: 0.229 ± 0.018
0.503CysIle: 0.503 ± 0.024
0.251CysLys: 0.251 ± 0.02
0.909CysLeu: 0.909 ± 0.034
0.172CysMet: 0.172 ± 0.014
0.328CysAsn: 0.328 ± 0.024
0.553CysPro: 0.553 ± 0.031
0.445CysGln: 0.445 ± 0.028
0.436CysArg: 0.436 ± 0.027
0.502CysSer: 0.502 ± 0.03
0.421CysThr: 0.421 ± 0.027
0.587CysVal: 0.587 ± 0.025
0.119CysTrp: 0.119 ± 0.012
0.276CysTyr: 0.276 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.488AspAla: 4.488 ± 0.075
0.515AspCys: 0.515 ± 0.026
2.994AspAsp: 2.994 ± 0.082
3.992AspGlu: 3.992 ± 0.076
2.619AspPhe: 2.619 ± 0.054
3.874AspGly: 3.874 ± 0.09
1.339AspHis: 1.339 ± 0.043
3.6AspIle: 3.6 ± 0.075
1.832AspLys: 1.832 ± 0.051
6.336AspLeu: 6.336 ± 0.082
1.244AspMet: 1.244 ± 0.037
1.604AspAsn: 1.604 ± 0.055
3.521AspPro: 3.521 ± 0.082
2.504AspGln: 2.504 ± 0.061
2.976AspArg: 2.976 ± 0.066
2.406AspSer: 2.406 ± 0.065
2.443AspThr: 2.443 ± 0.065
3.696AspVal: 3.696 ± 0.074
0.959AspTrp: 0.959 ± 0.033
1.994AspTyr: 1.994 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
5.708GluAla: 5.708 ± 0.102
0.372GluCys: 0.372 ± 0.023
3.526GluAsp: 3.526 ± 0.075
4.346GluGlu: 4.346 ± 0.109
2.291GluPhe: 2.291 ± 0.057
4.166GluGly: 4.166 ± 0.086
1.347GluHis: 1.347 ± 0.045
5.369GluIle: 5.369 ± 0.095
3.806GluLys: 3.806 ± 0.092
5.888GluLeu: 5.888 ± 0.099
1.826GluMet: 1.826 ± 0.058
2.896GluAsn: 2.896 ± 0.066
2.763GluPro: 2.763 ± 0.069
2.346GluGln: 2.346 ± 0.056
3.627GluArg: 3.627 ± 0.077
3.107GluSer: 3.107 ± 0.064
3.709GluThr: 3.709 ± 0.075
4.414GluVal: 4.414 ± 0.094
0.742GluTrp: 0.742 ± 0.032
1.709GluTyr: 1.709 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.047PheAla: 3.047 ± 0.067
0.434PheCys: 0.434 ± 0.027
2.73PheAsp: 2.73 ± 0.062
2.508PheGlu: 2.508 ± 0.066
2.105PhePhe: 2.105 ± 0.063
3.359PheGly: 3.359 ± 0.075
0.857PheHis: 0.857 ± 0.04
2.919PheIle: 2.919 ± 0.066
1.65PheLys: 1.65 ± 0.044
4.555PheLeu: 4.555 ± 0.115
0.908PheMet: 0.908 ± 0.037
1.843PheAsn: 1.843 ± 0.049
2.054PhePro: 2.054 ± 0.048
1.351PheGln: 1.351 ± 0.041
1.799PheArg: 1.799 ± 0.05
3.517PheSer: 3.517 ± 0.079
2.508PheThr: 2.508 ± 0.062
2.725PheVal: 2.725 ± 0.062
0.651PheTrp: 0.651 ± 0.035
1.56PheTyr: 1.56 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.632GlyAla: 5.632 ± 0.106
0.73GlyCys: 0.73 ± 0.033
3.892GlyAsp: 3.892 ± 0.085
4.69GlyGlu: 4.69 ± 0.091
3.53GlyPhe: 3.53 ± 0.072
5.44GlyGly: 5.44 ± 0.131
1.485GlyHis: 1.485 ± 0.044
5.137GlyIle: 5.137 ± 0.1
3.628GlyLys: 3.628 ± 0.076
7.819GlyLeu: 7.819 ± 0.121
2.154GlyMet: 2.154 ± 0.059
2.532GlyAsn: 2.532 ± 0.066
2.259GlyPro: 2.259 ± 0.054
2.639GlyGln: 2.639 ± 0.059
3.612GlyArg: 3.612 ± 0.061
4.106GlySer: 4.106 ± 0.087
3.986GlyThr: 3.986 ± 0.095
5.53GlyVal: 5.53 ± 0.095
1.38GlyTrp: 1.38 ± 0.046
2.726GlyTyr: 2.726 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.714HisAla: 1.714 ± 0.049
0.261HisCys: 0.261 ± 0.02
0.995HisAsp: 0.995 ± 0.036
1.079HisGlu: 1.079 ± 0.042
1.06HisPhe: 1.06 ± 0.036
1.48HisGly: 1.48 ± 0.044
0.604HisHis: 0.604 ± 0.028
1.41HisIle: 1.41 ± 0.048
0.76HisLys: 0.76 ± 0.034
2.447HisLeu: 2.447 ± 0.06
0.466HisMet: 0.466 ± 0.026
0.807HisAsn: 0.807 ± 0.031
1.585HisPro: 1.585 ± 0.048
0.994HisGln: 0.994 ± 0.036
1.199HisArg: 1.199 ± 0.044
1.14HisSer: 1.14 ± 0.04
1.137HisThr: 1.137 ± 0.04
1.245HisVal: 1.245 ± 0.043
0.332HisTrp: 0.332 ± 0.02
0.805HisTyr: 0.805 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.895IleAla: 5.895 ± 0.11
0.628IleCys: 0.628 ± 0.026
4.312IleAsp: 4.312 ± 0.09
4.647IleGlu: 4.647 ± 0.096
2.981IlePhe: 2.981 ± 0.063
5.231IleGly: 5.231 ± 0.097
1.421IleHis: 1.421 ± 0.038
4.8IleIle: 4.8 ± 0.095
3.138IleLys: 3.138 ± 0.065
7.219IleLeu: 7.219 ± 0.117
1.301IleMet: 1.301 ± 0.048
3.228IleAsn: 3.228 ± 0.072
3.872IlePro: 3.872 ± 0.066
2.621IleGln: 2.621 ± 0.061
3.491IleArg: 3.491 ± 0.066
4.622IleSer: 4.622 ± 0.077
4.137IleThr: 4.137 ± 0.092
4.363IleVal: 4.363 ± 0.08
0.818IleTrp: 0.818 ± 0.033
2.068IleTyr: 2.068 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
3.715LysAla: 3.715 ± 0.081
0.238LysCys: 0.238 ± 0.018
2.226LysAsp: 2.226 ± 0.059
2.623LysGlu: 2.623 ± 0.069
1.478LysPhe: 1.478 ± 0.043
2.612LysGly: 2.612 ± 0.067
0.887LysHis: 0.887 ± 0.032
3.243LysIle: 3.243 ± 0.069
2.406LysLys: 2.406 ± 0.072
3.872LysLeu: 3.872 ± 0.076
1.078LysMet: 1.078 ± 0.036
1.875LysAsn: 1.875 ± 0.055
2.271LysPro: 2.271 ± 0.056
1.685LysGln: 1.685 ± 0.047
2.389LysArg: 2.389 ± 0.065
2.37LysSer: 2.37 ± 0.061
2.791LysThr: 2.791 ± 0.066
2.706LysVal: 2.706 ± 0.065
0.472LysTrp: 0.472 ± 0.026
1.263LysTyr: 1.263 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
9.72LeuAla: 9.72 ± 0.161
0.83LeuCys: 0.83 ± 0.034
5.733LeuAsp: 5.733 ± 0.096
6.745LeuGlu: 6.745 ± 0.108
4.353LeuPhe: 4.353 ± 0.092
7.661LeuGly: 7.661 ± 0.124
1.996LeuHis: 1.996 ± 0.047
7.865LeuIle: 7.865 ± 0.132
4.58LeuLys: 4.58 ± 0.086
10.837LeuLeu: 10.837 ± 0.195
2.593LeuMet: 2.593 ± 0.066
3.973LeuAsn: 3.973 ± 0.076
5.629LeuPro: 5.629 ± 0.1
3.701LeuGln: 3.701 ± 0.078
5.388LeuArg: 5.388 ± 0.095
7.064LeuSer: 7.064 ± 0.092
6.203LeuThr: 6.203 ± 0.097
7.648LeuVal: 7.648 ± 0.103
1.323LeuTrp: 1.323 ± 0.05
2.785LeuTyr: 2.785 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
2.183MetAla: 2.183 ± 0.057
0.133MetCys: 0.133 ± 0.014
1.35MetAsp: 1.35 ± 0.039
1.312MetGlu: 1.312 ± 0.042
0.721MetPhe: 0.721 ± 0.033
1.82MetGly: 1.82 ± 0.049
0.478MetHis: 0.478 ± 0.028
1.762MetIle: 1.762 ± 0.049
1.223MetLys: 1.223 ± 0.045
2.393MetLeu: 2.393 ± 0.06
0.683MetMet: 0.683 ± 0.031
0.931MetAsn: 0.931 ± 0.032
1.291MetPro: 1.291 ± 0.04
0.938MetGln: 0.938 ± 0.035
1.28MetArg: 1.28 ± 0.041
1.34MetSer: 1.34 ± 0.041
1.555MetThr: 1.555 ± 0.047
1.961MetVal: 1.961 ± 0.052
0.2MetTrp: 0.2 ± 0.018
0.46MetTyr: 0.46 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.094AsnAla: 3.094 ± 0.057
0.348AsnCys: 0.348 ± 0.022
1.738AsnAsp: 1.738 ± 0.052
1.953AsnGlu: 1.953 ± 0.055
1.694AsnPhe: 1.694 ± 0.05
2.268AsnGly: 2.268 ± 0.06
0.856AsnHis: 0.856 ± 0.035
2.61AsnIle: 2.61 ± 0.064
1.472AsnLys: 1.472 ± 0.049
4.67AsnLeu: 4.67 ± 0.079
0.8AsnMet: 0.8 ± 0.031
1.544AsnAsn: 1.544 ± 0.056
2.689AsnPro: 2.689 ± 0.056
1.821AsnGln: 1.821 ± 0.053
2.106AsnArg: 2.106 ± 0.049
1.839AsnSer: 1.839 ± 0.058
2.102AsnThr: 2.102 ± 0.057
2.152AsnVal: 2.152 ± 0.05
0.609AsnTrp: 0.609 ± 0.031
1.359AsnTyr: 1.359 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
3.978ProAla: 3.978 ± 0.092
0.358ProCys: 0.358 ± 0.023
3.478ProAsp: 3.478 ± 0.077
4.365ProGlu: 4.365 ± 0.074
2.161ProPhe: 2.161 ± 0.062
4.051ProGly: 4.051 ± 0.072
1.1ProHis: 1.1 ± 0.04
3.212ProIle: 3.212 ± 0.068
1.778ProLys: 1.778 ± 0.051
4.829ProLeu: 4.829 ± 0.088
1.108ProMet: 1.108 ± 0.037
1.824ProAsn: 1.824 ± 0.056
2.363ProPro: 2.363 ± 0.066
1.964ProGln: 1.964 ± 0.056
2.03ProArg: 2.03 ± 0.065
2.672ProSer: 2.672 ± 0.061
3.031ProThr: 3.031 ± 0.087
3.866ProVal: 3.866 ± 0.087
0.719ProTrp: 0.719 ± 0.03
1.626ProTyr: 1.626 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.097GlnAla: 4.097 ± 0.085
0.24GlnCys: 0.24 ± 0.018
1.939GlnAsp: 1.939 ± 0.051
2.401GlnGlu: 2.401 ± 0.06
1.365GlnPhe: 1.365 ± 0.043
2.595GlnGly: 2.595 ± 0.056
0.784GlnHis: 0.784 ± 0.031
2.763GlnIle: 2.763 ± 0.067
1.832GlnLys: 1.832 ± 0.055
3.627GlnLeu: 3.627 ± 0.074
0.956GlnMet: 0.956 ± 0.033
1.485GlnAsn: 1.485 ± 0.048
2.243GlnPro: 2.243 ± 0.06
1.633GlnGln: 1.633 ± 0.055
2.248GlnArg: 2.248 ± 0.057
2.269GlnSer: 2.269 ± 0.06
2.182GlnThr: 2.182 ± 0.066
3.156GlnVal: 3.156 ± 0.068
0.448GlnTrp: 0.448 ± 0.027
0.992GlnTyr: 0.992 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
4.192ArgAla: 4.192 ± 0.083
0.499ArgCys: 0.499 ± 0.032
2.527ArgAsp: 2.527 ± 0.053
3.401ArgGlu: 3.401 ± 0.085
2.414ArgPhe: 2.414 ± 0.055
3.303ArgGly: 3.303 ± 0.077
1.062ArgHis: 1.062 ± 0.039
3.624ArgIle: 3.624 ± 0.07
2.405ArgLys: 2.405 ± 0.06
6.079ArgLeu: 6.079 ± 0.1
1.518ArgMet: 1.518 ± 0.046
1.813ArgAsn: 1.813 ± 0.053
2.109ArgPro: 2.109 ± 0.059
2.375ArgGln: 2.375 ± 0.057
3.13ArgArg: 3.13 ± 0.068
2.864ArgSer: 2.864 ± 0.07
2.61ArgThr: 2.61 ± 0.055
3.87ArgVal: 3.87 ± 0.083
0.894ArgTrp: 0.894 ± 0.036
1.808ArgTyr: 1.808 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.706SerAla: 4.706 ± 0.084
0.481SerCys: 0.481 ± 0.025
2.928SerAsp: 2.928 ± 0.068
3.425SerGlu: 3.425 ± 0.072
2.656SerPhe: 2.656 ± 0.074
4.958SerGly: 4.958 ± 0.081
1.206SerHis: 1.206 ± 0.04
3.981SerIle: 3.981 ± 0.073
2.259SerLys: 2.259 ± 0.06
6.371SerLeu: 6.371 ± 0.107
1.356SerMet: 1.356 ± 0.048
1.982SerAsn: 1.982 ± 0.056
3.036SerPro: 3.036 ± 0.078
2.375SerGln: 2.375 ± 0.051
2.992SerArg: 2.992 ± 0.058
3.344SerSer: 3.344 ± 0.069
3.18SerThr: 3.18 ± 0.07
3.7SerVal: 3.7 ± 0.063
0.758SerTrp: 0.758 ± 0.032
1.739SerTyr: 1.739 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.596ThrAla: 4.596 ± 0.094
0.482ThrCys: 0.482 ± 0.03
2.781ThrAsp: 2.781 ± 0.063
2.895ThrGlu: 2.895 ± 0.067
2.331ThrPhe: 2.331 ± 0.062
4.454ThrGly: 4.454 ± 0.089
1.321ThrHis: 1.321 ± 0.04
3.938ThrIle: 3.938 ± 0.081
1.707ThrLys: 1.707 ± 0.056
6.22ThrLeu: 6.22 ± 0.089
1.173ThrMet: 1.173 ± 0.043
1.854ThrAsn: 1.854 ± 0.05
3.659ThrPro: 3.659 ± 0.092
1.948ThrGln: 1.948 ± 0.057
2.926ThrArg: 2.926 ± 0.063
3.141ThrSer: 3.141 ± 0.076
2.904ThrThr: 2.904 ± 0.084
3.772ThrVal: 3.772 ± 0.083
0.901ThrTrp: 0.901 ± 0.04
1.889ThrTyr: 1.889 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.219ValAla: 5.219 ± 0.101
0.675ValCys: 0.675 ± 0.031
4.328ValAsp: 4.328 ± 0.079
4.668ValGlu: 4.668 ± 0.105
3.158ValPhe: 3.158 ± 0.061
4.894ValGly: 4.894 ± 0.084
1.433ValHis: 1.433 ± 0.047
5.431ValIle: 5.431 ± 0.078
2.787ValLys: 2.787 ± 0.073
7.325ValLeu: 7.325 ± 0.123
1.668ValMet: 1.668 ± 0.051
2.869ValAsn: 2.869 ± 0.064
3.146ValPro: 3.146 ± 0.064
2.148ValGln: 2.148 ± 0.056
3.322ValArg: 3.322 ± 0.059
4.16ValSer: 4.16 ± 0.077
3.902ValThr: 3.902 ± 0.084
5.057ValVal: 5.057 ± 0.089
0.969ValTrp: 0.969 ± 0.04
2.071ValTyr: 2.071 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.037TrpAla: 1.037 ± 0.046
0.116TrpCys: 0.116 ± 0.013
0.717TrpAsp: 0.717 ± 0.038
0.942TrpGlu: 0.942 ± 0.038
0.538TrpPhe: 0.538 ± 0.028
1.015TrpGly: 1.015 ± 0.038
0.361TrpHis: 0.361 ± 0.026
0.937TrpIle: 0.937 ± 0.036
0.57TrpLys: 0.57 ± 0.027
1.717TrpLeu: 1.717 ± 0.062
0.43TrpMet: 0.43 ± 0.023
0.511TrpAsn: 0.511 ± 0.027
0.564TrpPro: 0.564 ± 0.031
0.76TrpGln: 0.76 ± 0.031
0.896TrpArg: 0.896 ± 0.033
0.76TrpSer: 0.76 ± 0.03
0.692TrpThr: 0.692 ± 0.034
1.095TrpVal: 1.095 ± 0.038
0.256TrpTrp: 0.256 ± 0.018
0.435TrpTyr: 0.435 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.473TyrAla: 2.473 ± 0.06
0.311TyrCys: 0.311 ± 0.02
1.74TyrAsp: 1.74 ± 0.05
1.777TyrGlu: 1.777 ± 0.052
1.591TyrPhe: 1.591 ± 0.052
2.352TyrGly: 2.352 ± 0.055
0.901TyrHis: 0.901 ± 0.033
1.816TyrIle: 1.816 ± 0.049
1.046TyrLys: 1.046 ± 0.04
3.616TyrLeu: 3.616 ± 0.074
0.523TyrMet: 0.523 ± 0.026
1.151TyrAsn: 1.151 ± 0.046
1.653TyrPro: 1.653 ± 0.05
1.688TyrGln: 1.688 ± 0.053
1.984TyrArg: 1.984 ± 0.053
1.718TyrSer: 1.718 ± 0.054
1.659TyrThr: 1.659 ± 0.053
1.815TyrVal: 1.815 ± 0.043
0.547TyrTrp: 0.547 ± 0.026
1.241TyrTyr: 1.241 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2283 proteins (765455 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski